AutismKB 2.0

Annotation Detail for PPME1


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Basic Information Top
Gene Symbol:PPME1 ( FLJ22226,PME-1 )
Gene Full Name: protein phosphatase methylesterase 1
Band: 11q13.4
Quick LinksEntrez ID:51400; OMIM: 611117; Uniprot ID:PPME1_HUMAN; ENSEMBL ID: ENSG00000214517; HGNC ID: 30178
Relate to Another Database: SFARIGene; denovo-db
Related Pathway Information Top
Related Diseases/Disorders Top
Comparative Toxicogenomics Database Top
Chemical ID Chemical Name Interaction Interaction Action Publication
D000082 Acetaminophen Acetaminophen affects the expression of PPME1 mRNAaffects expression 17562736
C006632 arsenic trioxide arsenic trioxide results in increased expression of PPME1 mRNAincreases expression 20458559
D012643 Selenium [Selenium co-treated with Vitamin E] results in increased expression of PPME1 mRNAaffects cotreatment|increases expression 19244175
D012643 Selenium Selenium results in increased expression of PPME1 mRNAincreases expression 19244175
D014810 Vitamin E [Selenium co-treated with Vitamin E] results in increased expression of PPME1 mRNAaffects cotreatment|increases expression 19244175
D014810 Vitamin E Vitamin E results in increased expression of PPME1 mRNAincreases expression 19244175
Disease ID Disease Name Direct Evidence Inference Chemical Name Inference Score Publication
MESH:D000230 Adenocarcinoma arsenic trioxide 2.3619825857 11798837
MESH:D000799 Angioedema Acetaminophen 4.5710982225
MESH:D001321 Autistic Disorder Acetaminophen 1.4018445737
MESH:D001778 Blood Coagulation Disorders arsenic trioxide 4.1016206674
MESH:D002051 Burkitt Lymphoma arsenic trioxide 4.7911589617
MESH:D002252 Carbon Tetrachloride Poisoning Vitamin E 4.4916050911
MESH:D006528 Carcinoma, Hepatocellular Acetaminophen 3.033084413
MESH:D006528 Carcinoma, Hepatocellular arsenic trioxide 3.0315073043 16217749 15553829 11135700 14691202
MESH:D002291 Carcinoma, Papillary arsenic trioxide 5.6019014326
MESH:D018288 Carcinoma, Small Cell arsenic trioxide 4.5112490120
MESH:D002386 Cataract Acetaminophen 2.7910977129
MESH:D003092 Colitis Selenium 4.3417936198
MESH:D015179 Colorectal Neoplasms arsenic trioxide 1.8620501625
MESH:D023903 Coronary Restenosis arsenic trioxide 4.6912609071
MESH:D019465 Craniofacial Abnormalities arsenic trioxide 2.8010525206
MESH:D019465 Craniofacial Abnormalities Vitamin E 2.8019769572
MESH:D016757 Death, Sudden, Cardiac arsenic trioxide 4.5615213294
MESH:D056486 Drug-Induced Liver Injury Acetaminophen 4.1014986274 14550746 16227642 19923254 16109766 17562736 17522070 15619225 16781746 10663392 12958197 19370779 19420014 11529661 10774834 10915739 11834606 12153990 16081117 17906064 12705907 16393943 11421492 18713872 19085960 19739265 15968718 12594235 12392966 11739529 16177239 12540782 19416960 19164858 14725611 11743745 11461765 2444490 18071297 11287661 16485898
MESH:D056486 Drug-Induced Liver Injury Selenium 4.1015131321
MESH:D056487 Drug-Induced Liver Injury, Chronic Acetaminophen 4.8219426721
MESH:C538011 Eales disease Vitamin E 5.439068938
MESH:D004938 Esophageal Neoplasms arsenic trioxide 2.3812903497
MESH:D005234 Fatty Liver arsenic trioxide 3.7115073043
MESH:D005706 Gallbladder Neoplasms arsenic trioxide 4.7716904648
MESH:D005756 Gastritis Acetaminophen 4.4016983495
MESH:D006330 Heart Defects, Congenital Vitamin E 3.1716080930
MESH:D006333 Heart Failure Selenium 3.2917162251
MESH:D006548 Hernia, Diaphragmatic Vitamin E 2.8116863852 16490937
MESH:D019584 Hot Flashes Vitamin E 4.6914716179
MESH:D006930 Hyperalgesia Acetaminophen 3.0216870215
MESH:D007251 Influenza, Human Selenium 13.5016624496
MESH:D007251 Influenza, Human Vitamin E 13.5016624496
MESH:D007674 Kidney Diseases Acetaminophen 6.6515629191 12587719
MESH:D007674 Kidney Diseases Vitamin E 6.6512488133
MESH:D007676 Kidney Failure, Chronic Selenium 4.3116518626
MESH:D007938 Leukemia arsenic trioxide 3.0015070760
MESH:D015459 Leukemia-Lymphoma, Adult T-Cell arsenic trioxide 4.2212560223 17077332
MESH:D007948 Leukemia, Monocytic, Acute arsenic trioxide 4.9416972261
MESH:D015464 Leukemia, Myelogenous, Chronic, BCR-ABL Positive arsenic trioxide 3.7214633726
MESH:D007951 Leukemia, Myeloid arsenic trioxide 4.1919077051
MESH:D015470 Leukemia, Myeloid, Acute arsenic trioxide 2.1917050201 16968895 19850784 16467208 20471514
MESH:D015473 Leukemia, Promyelocytic, Acute arsenic trioxide 3.469834237 17649720 19075265 12679006 12712474 16331271 17712046 16823087 19035177 15213294 16330433 16966277 17107899 15748426 19642359 12018890 16112521 15622746 11468182 17217047 11161223 19225113 17869043 15336539 16891316
MESH:D015458 Leukemia, T-Cell arsenic trioxide 4.8616882451
MESH:D008106 Liver Cirrhosis, Experimental Vitamin E 1.9116169303
MESH:D008107 Liver Diseases Acetaminophen 1.7019014921 12587719 19460945 16611625 12969438 11587558 16610002 19784758
MESH:D017114 Liver Failure, Acute Acetaminophen 3.6317185352 16871587
MESH:D008113 Liver Neoplasms arsenic trioxide 2.4614682389
MESH:D008114 Liver Neoplasms, Experimental arsenic trioxide 2.9620377131
MESH:D008133 Long QT Syndrome arsenic trioxide 3.6615213294
MESH:D008171 Lung Diseases Vitamin E 3.4316863852
MESH:D008175 Lung Neoplasms arsenic trioxide 2.6211798837 19825857
MESH:D008175 Lung Neoplasms Vitamin E 2.6211062179
MESH:D008325 Mammary Neoplasms, Experimental Selenium 2.9915318939
MESH:D008546 Melanoma, Experimental Acetaminophen 4.1319513568
MESH:D008654 Mesothelioma Selenium 2.9215107826
MESH:D009101 Multiple Myeloma arsenic trioxide 3.3811468182 19417148 19549372 15949261 14977855
MESH:D009182 Mycosis Fungoides arsenic trioxide 5.4018349030
MESH:D009190 Myelodysplastic Syndromes arsenic trioxide 3.3416882451 16105982
MESH:D009361 Neoplasm Invasiveness arsenic trioxide 4.4716624393
MESH:D009436 Neural Tube Defects arsenic trioxide 3.3610525206
MESH:D019636 Neurodegenerative Diseases Acetaminophen 3.2118514411
MESH:D010051 Ovarian Neoplasms arsenic trioxide 2.5019769630 16624393 12452020
MESH:D010146 Pain Acetaminophen 2.7316870215
MESH:D010190 Pancreatic Neoplasms arsenic trioxide 2.6315580305
MESH:D010235 Paraganglioma arsenic trioxide 4.6319927285
MESH:D010954 Plasmacytoma Selenium 5.6115087411
MESH:D011471 Prostatic Neoplasms arsenic trioxide 3.2219131511
MESH:D011471 Prostatic Neoplasms Vitamin E 3.2215084515
MESH:D012512 Sarcoma, Ewing's arsenic trioxide 4.4716646077
MESH:D012871 Skin Diseases Vitamin E 2.5218709164
MESH:D013274 Stomach Neoplasms arsenic trioxide 1.8617007042
MESH:D020521 Stroke Vitamin E 3.8416517955
MESH:D013964 Thyroid Neoplasms arsenic trioxide 3.3919014326
MESH:D016171 Torsades de Pointes arsenic trioxide 4.5915213294
MESH:D001749 Urinary Bladder Neoplasms arsenic trioxide 2.6012973940 12845720 11780464 20435036
MESH:D014581 Urticaria Acetaminophen 3.4410982225
No data
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AutismKB Statistics

  • Studies: 1,036
  • Genes: 1,379
  • CNVs/SVs: 5,420
  • SNVs/Indels: 11,669
  • de novo Mutations: 5,669
  • Mosaics: 789
  • Linkage Regions: 172
  • Paper Collected: 6/30/2018
  • Last Update: 8/26/2018


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