AutismKB 2.0

Annotation Detail for PDE4A


View Evidences View Variants View Annotations
Basic Information Top
Gene Symbol:PDE4A ( DPDE2,PDE4,PDE46 )
Gene Full Name: phosphodiesterase 4A, cAMP-specific
Band: 19p13.2
Quick LinksEntrez ID:5141; OMIM: 600126; Uniprot ID:PDE4A_HUMAN; ENSEMBL ID: ENSG00000065989; HGNC ID: 8780
Relate to Another Database: SFARIGene; denovo-db
Related Pathway Information Top
No data
Pathway IDPathway Name
hsa00230Purine metabolism
Pathway IDPathway Name
Signaling by GPCR
Opioid Signalling
No data
No data
No data
Related Diseases/Disorders Top
No data
Desease IDDesease Name
1804Chronic obstructive airway disease
2051Leukemia
No data
No data
No data
Comparative Toxicogenomics Database Top
Chemical ID Chemical Name Interaction Interaction Action Publication
C009505 4,4'-diaminodiphenylmethane 4,4'-diaminodiphenylmethane results in increased expression of PDE4A mRNAincreases expression 18648102
D000082 Acetaminophen Acetaminophen affects the expression of PDE4A mRNAaffects expression 17562736
D000420 Albuterol [Albuterol co-treated with Rolipram] results in increased expression of PDE4A mRNAaffects cotreatment|increases expression 10763856
D000641 Ammonia PDE4A protein affects the susceptibility to Ammoniaaffects response to substance 17445227
D000643 Ammonium Chloride Ammonium Chloride affects the expression of PDE4A mRNAaffects expression 16483693
C006632 arsenic trioxide arsenic trioxide results in decreased expression of PDE4A mRNAdecreases expression 15070760
D003024 Clozapine Clozapine results in decreased expression of PDE4A proteindecreases expression 20222156
D006220 Haloperidol Haloperidol results in decreased expression of PDE4A proteindecreases expression 20222156
C459562 L-826,141 L-826,141 results in decreased activity of PDE4A proteindecreases activity 15901792
D008094 Lithium Lithium results in decreased expression of PDE4A proteindecreases expression 20222156
D010126 Ozone Ozone results in decreased expression of PDE4A mRNAdecreases expression 16330353
C424423 Roflumilast Roflumilast results in decreased activity of PDE4A proteindecreases activity 15901792
D020889 Rolipram [Albuterol co-treated with Rolipram] results in increased expression of PDE4A mRNAaffects cotreatment|increases expression 10763856
D020889 Rolipram Rolipram results in decreased activity of PDE4A proteindecreases activity 19167487
C035964 trequinsin trequinsin results in decreased activity of PDE4A proteindecreases activity 15901792
D014635 Valproic Acid Valproic Acid results in increased expression of PDE4A mRNAincreases expression 19101580
D014635 Valproic Acid Valproic Acid results in decreased expression of PDE4A proteindecreases expression 20222156
Disease ID Disease Name Direct Evidence Inference Chemical Name Inference Score Publication
MESH:D000014 Abnormalities, Drug-Induced Valproic Acid 3.548875741
MESH:D000015 Abnormalities, Multiple Valproic Acid 3.9619490988
MESH:D000138 Acidosis Ammonium Chloride 3.6118287403
MESH:D000230 Adenocarcinoma arsenic trioxide 2.2919825857 11798837
MESH:D000236 Adenoma 4,4'-diaminodiphenylmethane 2.773712494
MESH:D000380 Agranulocytosis Clozapine 5.1012649775 14617031 16160616
MESH:D000544 Alzheimer Disease Lithium 4.7319621015
MESH:D000544 Alzheimer Disease Ozone 4.7315513908
MESH:D000550 Amblyopia Valproic Acid 5.3017688650
MESH:D000799 Angioedema Acetaminophen 3.9110982225
MESH:D001008 Anxiety Disorders Valproic Acid 3.5917497229
MESH:D001172 Arthritis, Rheumatoid Ozone 2.5615570426
MESH:D001249 Asthma Albuterol 5.6911991558 9949315
MESH:D001249 Asthma Ozone 5.6917854713 16373670
MESH:D001321 Autistic Disorder marker/mechanism 18090323
MESH:D001321 Autistic Disorder Acetaminophen 2.2118445737
MESH:D001321 Autistic Disorder Haloperidol 2.2118080171 19368416
MESH:D001321 Autistic Disorder Valproic Acid 2.2118775368 17507914 18177632 18985861 18396377 15238991 17688650 18316065 19232924 18558336 16609825 18940202 17157402 20603192 19460635
MESH:D001660 Biliary Tract Diseases 4,4'-diaminodiphenylmethane 5.081440618 11289319
MESH:D001714 Bipolar Disorder Lithium 7.6619153942 17594078 20046352 20338123
MESH:D001714 Bipolar Disorder Valproic Acid 7.6617594078 20046352
MESH:D001778 Blood Coagulation Disorders arsenic trioxide 3.7016206674
MESH:D001848 Bone Diseases, Developmental Valproic Acid 3.428888407
MESH:D001929 Brain Edema Ammonia 6.3411481608 19393034 20217200
MESH:D016535 Bronchial Hyperreactivity Ozone 3.7014754758 17626835 18315731 18417511 19059883 15516495 16777450
MESH:D002051 Burkitt Lymphoma arsenic trioxide 4.3611589617
MESH:D002100 Cachexia Ozone 4.7916183385
MESH:D006528 Carcinoma, Hepatocellular 4,4'-diaminodiphenylmethane 4.557296757 3581430
MESH:D006528 Carcinoma, Hepatocellular Acetaminophen 4.553084413
MESH:D006528 Carcinoma, Hepatocellular arsenic trioxide 4.5515073043 14691202 15553829 16217749 11135700
MESH:D002291 Carcinoma, Papillary arsenic trioxide 4.9419014326
MESH:D002292 Carcinoma, Renal Cell 4,4'-diaminodiphenylmethane 2.697296757
MESH:D018288 Carcinoma, Small Cell arsenic trioxide 4.1412490120
MESH:D002375 Catalepsy Haloperidol 4.9615215559 1977408
MESH:D002386 Cataract Acetaminophen 2.6010977129
MESH:D002471 Cell Transformation, Neoplastic 4,4'-diaminodiphenylmethane 2.787505956
MESH:D002659 Child Development Disorders, Pervasive Valproic Acid 2.7220734317
MESH:D002779 Cholestasis 4,4'-diaminodiphenylmethane 3.179022650 19486331
MESH:D003072 Cognition Disorders Clozapine 5.0117123785
MESH:D015179 Colorectal Neoplasms arsenic trioxide 1.8620501625
MESH:D023903 Coronary Restenosis arsenic trioxide 4.2212609071
MESH:D019465 Craniofacial Abnormalities arsenic trioxide 2.7110525206
MESH:D019465 Craniofacial Abnormalities Valproic Acid 2.718888407 17688650 16575769
MESH:D003556 Cystitis Rolipram 6.2718710439
MESH:D007644 Darier Disease Lithium 5.9620338123
MESH:D016757 Death, Sudden, Cardiac arsenic trioxide 11.0315213294
MESH:D016757 Death, Sudden, Cardiac Haloperidol 11.0320210726
MESH:D003704 Dementia Haloperidol 4.6111575062
MESH:D003872 Dermatitis Rolipram 6.1316442096
MESH:D017449 Dermatitis, Allergic Contact 4,4'-diaminodiphenylmethane 7.688156756 14531868 2524372 18759878 12868966 11906362 11298694 8970840
MESH:D017449 Dermatitis, Allergic Contact Ammonia 7.6816823706
MESH:D003877 Dermatitis, Contact 4,4'-diaminodiphenylmethane 3.522952479 3621924
MESH:D018500 Diabetes Insipidus, Nephrogenic Lithium 5.7919244398
MESH:D003924 Diabetes Mellitus, Type 2 Clozapine 2.9816402076
MESH:D006970 Disorders of Excessive Somnolence Clozapine 5.6215331141
MESH:D056486 Drug-Induced Liver Injury 4,4'-diaminodiphenylmethane 6.259328219 18289764 6482804 1440618 18648102 18692083 11289319 7440962 16192314 6679447 9022650 9653073 8291058
MESH:D056486 Drug-Induced Liver Injury Acetaminophen 6.2516393943 16109766 12392966 16177239 12705907 11287661 14550746 19739265 11739529 16227642 19370779 12958197 12153990 16081117 10663392 14986274 12594235 11834606 10774834 2444490 19164858 17522070 11529661 15619225 18071297 19420014 17562736 11421492 11743745 11461765 12540782 14725611 18713872 19416960 10915739 19923254 16485898 16781746 17906064 19085960 15968718
MESH:D056486 Drug-Induced Liver Injury Valproic Acid 6.2519641884 1733752
MESH:D056487 Drug-Induced Liver Injury, Chronic Acetaminophen 4.1619426721
MESH:D050171 Dyslipidemias Clozapine 4.2016402076
MESH:D004417 Dyspnea Albuterol 5.8820016425
MESH:D004421 Dystonia Valproic Acid 4.081851702
MESH:D004831 Epilepsies, Myoclonic Valproic Acid 4.1917275665 3659116
MESH:D004828 Epilepsies, Partial Valproic Acid 3.983922381 16628512
MESH:D004827 Epilepsy Valproic Acid 2.9520417680 18234410
MESH:D004832 Epilepsy, Absence Valproic Acid 3.616426943 7562514 6254150
MESH:D017029 Epilepsy, Complex Partial Valproic Acid 4.347750514
MESH:D004830 Epilepsy, Tonic-Clonic Valproic Acid 4.113659116
MESH:D004938 Esophageal Neoplasms 4,4'-diaminodiphenylmethane 4.493581430
MESH:D004938 Esophageal Neoplasms arsenic trioxide 4.4912903497
MESH:D005234 Fatty Liver arsenic trioxide 8.0115073043
MESH:D005234 Fatty Liver Valproic Acid 8.0119224547 14986274
MESH:D005315 Fetal Diseases Valproic Acid 4.9516575769
MESH:D005317 Fetal Growth Retardation Valproic Acid 4.178888407 18558336
MESH:D005350 Fibroma 4,4'-diaminodiphenylmethane 5.086705139
MESH:D005355 Fibrosis Albuterol 5.4915467267
MESH:D005706 Gallbladder Neoplasms arsenic trioxide 4.3016904648
MESH:D005739 Gas Poisoning Albuterol 6.2720016425
MESH:D005756 Gastritis Acetaminophen 3.7416983495
MESH:D006042 Goiter 4,4'-diaminodiphenylmethane 4.077505956
MESH:D006330 Heart Defects, Congenital Lithium 4.2319638421
MESH:D006501 Hepatic Encephalopathy Ammonia 5.8516338762 20549931 12420312
MESH:D006505 Hepatitis 4,4'-diaminodiphenylmethane 3.556705139
MESH:D006849 Hydrocephalus Valproic Acid 4.9217688650
MESH:D006930 Hyperalgesia Acetaminophen 2.7216870215
MESH:D006948 Hyperkinesis Clozapine 4.9616046005
MESH:D006965 Hyperplasia 4,4'-diaminodiphenylmethane 3.9815034207
MESH:D007077 Ileal Diseases Rolipram 6.4718306037
MESH:D007565 Jaundice 4,4'-diaminodiphenylmethane 5.088074119 9022650
MESH:D007579 Jejunal Diseases Rolipram 6.4718306037
MESH:D007674 Kidney Diseases Acetaminophen 2.2115629191 12587719
MESH:D007680 Kidney Neoplasms 4,4'-diaminodiphenylmethane 2.996582329
MESH:D007938 Leukemia arsenic trioxide 2.8415070760
MESH:D015459 Leukemia-Lymphoma, Adult T-Cell arsenic trioxide 3.8212560223 17077332
MESH:D007948 Leukemia, Monocytic, Acute arsenic trioxide 4.3616972261
MESH:D015464 Leukemia, Myelogenous, Chronic, BCR-ABL Positive arsenic trioxide 3.4514633726
MESH:D007951 Leukemia, Myeloid arsenic trioxide 3.7919077051
MESH:D015470 Leukemia, Myeloid, Acute arsenic trioxide 3.9216968895 17050201 19850784 20471514 16467208
MESH:D015470 Leukemia, Myeloid, Acute Valproic Acid 3.9217596541 16294345
MESH:D015473 Leukemia, Promyelocytic, Acute arsenic trioxide 3.2316966277 16891316 15748426 15213294 15622746 17649720 19225113 9834237 16823087 17712046 12679006 17107899 16331271 12712474 17869043 17217047 15336539 11468182 16330433 16112521 11161223 12018890 19075265 19035177 19642359
MESH:D015458 Leukemia, T-Cell arsenic trioxide 4.3916882451
MESH:D008064 Lipidoses Clozapine 3.9817567588
MESH:D008105 Liver Cirrhosis, Biliary 4,4'-diaminodiphenylmethane 3.219327722 15034207
MESH:D008107 Liver Diseases Acetaminophen 1.6319784758 19014921 16610002 19460945 12587719 12969438 11587558 16611625
MESH:D017114 Liver Failure, Acute Acetaminophen 3.2616871587 17185352
MESH:D008113 Liver Neoplasms arsenic trioxide 2.3514682389
MESH:D008114 Liver Neoplasms, Experimental 4,4'-diaminodiphenylmethane 6.013712494 1399818 598648 6587162
MESH:D008114 Liver Neoplasms, Experimental arsenic trioxide 6.0120377131
MESH:D008133 Long QT Syndrome arsenic trioxide 3.3715213294
MESH:D008171 Lung Diseases Ozone 3.3919066396 8266340
MESH:D017563 Lung Diseases, Interstitial Valproic Acid 4.3217228818
MESH:D055370 Lung Injury Ozone 3.8920417186
MESH:D008175 Lung Neoplasms arsenic trioxide 2.6211798837 19825857
MESH:D008175 Lung Neoplasms Ozone 2.627614698 8597069
MESH:D008546 Melanoma, Experimental Acetaminophen 3.6119513568
MESH:D001523 Mental Disorders Clozapine 8.5316856516
MESH:D001523 Mental Disorders Haloperidol 8.5316856516
MESH:D024821 Metabolic Syndrome X Clozapine 4.4319142101
MESH:D008679 Metaplasia Ozone 5.1710496685
MESH:D008881 Migraine Disorders Valproic Acid 3.2118803445 18765137
MESH:D009101 Multiple Myeloma arsenic trioxide 3.1211468182 15949261 19417148 14977855 19549372
MESH:D009139 Musculoskeletal Abnormalities Valproic Acid 4.068888407
MESH:D009182 Mycosis Fungoides arsenic trioxide 4.7318349030
MESH:D009190 Myelodysplastic Syndromes arsenic trioxide 7.4716105982 16882451
MESH:D009190 Myelodysplastic Syndromes Valproic Acid 7.4717596541
MESH:D009203 Myocardial Infarction Lithium 3.9316288908
MESH:D009361 Neoplasm Invasiveness arsenic trioxide 4.0016624393
MESH:D009362 Neoplasm Metastasis 4,4'-diaminodiphenylmethane 2.483581430
MESH:D009436 Neural Tube Defects 4,4'-diaminodiphenylmethane 12.246679447
MESH:D009436 Neural Tube Defects arsenic trioxide 12.2410525206
MESH:D009436 Neural Tube Defects Valproic Acid 12.2416359493 8888407
MESH:D019636 Neurodegenerative Diseases Acetaminophen 2.8918514411
MESH:D009765 Obesity Clozapine 3.0219142110 18515891
MESH:D009784 Occupational Diseases 4,4'-diaminodiphenylmethane 3.454026338 6482804
MESH:D009902 Optic Neuritis 4,4'-diaminodiphenylmethane 5.083988306
MESH:D010051 Ovarian Neoplasms arsenic trioxide 2.4116624393 19769630 12452020
MESH:D010146 Pain Acetaminophen 2.4116870215
MESH:D010190 Pancreatic Neoplasms arsenic trioxide 2.5315580305
MESH:D010212 Papilloma 4,4'-diaminodiphenylmethane 3.527296757
MESH:D010235 Paraganglioma arsenic trioxide 4.1919927285
MESH:D010538 Peritonitis Ozone 4.1716369182
MESH:D010787 Photosensitivity Disorders 4,4'-diaminodiphenylmethane 4.536228378
MESH:D011014 Pneumonia Ozone 4.4418929643 18007984 18381685
MESH:D011297 Prenatal Exposure Delayed Effects Valproic Acid 3.8820603192
MESH:D011471 Prostatic Neoplasms arsenic trioxide 3.2719131511
MESH:D019310 Pseudolymphoma Valproic Acid 4.6011422049 12752131
MESH:D011595 Psychomotor Agitation Haloperidol 5.0011575062
MESH:D011618 Psychotic Disorders Clozapine 9.2215331141
MESH:D011618 Psychotic Disorders Haloperidol 9.2211575062
MESH:D012162 Retinal Degeneration 4,4'-diaminodiphenylmethane 3.393692021
MESH:D012208 Rhabdomyosarcoma Valproic Acid 4.2119155313
MESH:D012512 Sarcoma, Ewing's arsenic trioxide 4.0016646077
MESH:D012559 Schizophrenia Clozapine 5.7420580759 18806925 20107430 20168265 11763009 17123785 17726453 17667964 18855531 16141801 20521326 20521320 20452607 11151749 19369910
MESH:D012559 Schizophrenia Haloperidol 5.7420107430 18513383 1830565 19369910
MESH:D012559 Schizophrenia Valproic Acid 5.7415737665 19110320
MESH:D012640 Seizures Lithium 6.5419660546
MESH:D012640 Seizures Valproic Acid 6.5416876388 14763951 17978042 11044598 11738929 3137016 15475178 1511512
MESH:D016135 Spinal Dysraphism Valproic Acid 3.8019490988
MESH:D013226 Status Epilepticus Lithium 12.8819951488 19430551 19570321
MESH:D013226 Status Epilepticus Valproic Acid 12.8812833885
MESH:D013272 Stomach Diseases Rolipram 5.8515038085
MESH:D013274 Stomach Neoplasms arsenic trioxide 1.8617007042
MESH:D013276 Stomach Ulcer Rolipram 4.9914567935
MESH:D017180 Tachycardia, Ventricular Haloperidol 4.7420210726
MESH:D013964 Thyroid Neoplasms 4,4'-diaminodiphenylmethane 7.233712494 6582329 6587162 1399818 7505956
MESH:D013964 Thyroid Neoplasms arsenic trioxide 7.2319014326
MESH:D016171 Torsades de Pointes arsenic trioxide 4.0115213294
MESH:D014178 Translocation, Genetic Valproic Acid 5.3017262798
MESH:D020194 Unverricht-Lundborg Syndrome Valproic Acid 4.573119515
MESH:D001749 Urinary Bladder Neoplasms 4,4'-diaminodiphenylmethane 5.118074119
MESH:D001749 Urinary Bladder Neoplasms arsenic trioxide 5.1112845720 20435036 11780464 12973940
MESH:D014564 Urogenital Abnormalities Valproic Acid 4.688888407
MESH:D014581 Urticaria Acetaminophen 3.0110982225
MESH:D015430 Weight Gain Clozapine 4.4920107430 16141801 16402076 20521320 17502770 20564506
MESH:D015431 Weight Loss Clozapine 5.1317933447
Pathway ID Pathway Name
REACT:15295 Opioid Signalling
KEGG:00230 Purine metabolism
REACT:14797 Signaling by GPCR
Pharmacogenomics Knowledge Base Top
  • PharmGKB Accession:PA33128
    • No data
    Releated disease ID Related disease Name
    PA447321Depressive Disorder, Major
    Releated drug ID Related drug Name
    PA452229antidepressants
    PA449233desipramine
    PA449673fluoxetine
    Drug Bank Top
    Drugbank ID Action Drug Name Description
    DB00277 antagonist Theophylline rougier elixir Vasodilator Agents;Phosphodiesterase Inhibitors;Bronchodilator Agents;Respiratory Smooth Muscle Relaxants
    DB00651 inhibitor Dyphylline Vasodilator Agents;Phosphodiesterase Inhibitors;Bronchodilator Agents;Respiratory Smooth Muscle Relaxants
    DB00806 antagonist Pentoxifylline Free Radical Scavengers;Vasodilator Agents;Platelet Aggregation Inhibitors;Phosphodiesterase Inhibitors;Radiation-Protective Agents;Hematologic Agents;Hemorrheologic Agents
    DB00824 antagonist Enprofylline Anti-Asthmatic Agents;Antiarrhythmic Agents;Bronchodilator Agents
    DB00920 antagonist Ketotifen Antipruritics;Anti-Allergic Agents;Histamine H1 Antagonists
    DB00975 antagonist Dipyridamole Vasodilator Agents;Platelet Aggregation Inhibitors;Phosphodiesterase Inhibitors
    DB01088 agonist Iloprost Antihypertensive Agents
    DB01303 antagonist Oxtriphylline Bronchodilator Agents
    DB01791 - Piclamilast Phosphodiesterase Inhibitors
    DB05266 antagonist Ibudilast Vasodilator Agents;Platelet Aggregation Inhibitors;Phosphodiesterase Inhibitors;Bronchodilator Agents
    DB06751 antagonist Drotaverine
    DB06842 - (4R)-4-(3-butoxy-4-methoxybenzyl)imidazolidin-2-one
    DB08299 - 4-[8-(3-nitrophenyl)-1,7-naphthyridin-6-yl]benzoic acid
    DB08811 inhibitor Tofisopam Benzodiazepines
    No data
    No data
    No data

    Simple Query:


      (e.g. CHD8)

    Syndromic Genes

    Non-syndromic Genes

    AutismKB Statistics

    • Studies: 1,036
    • Genes: 1,379
    • CNVs/SVs: 5,420
    • SNVs/Indels: 11,669
    • de novo Mutations: 5,669
    • Mosaics: 789
    • Linkage Regions: 172
    • Paper Collected: 6/30/2018
    • Last Update: 8/26/2018


    Copyright © 2017, Center for Bioinformatics , Peking University | All Rights Reserved