AutismKB 2.0

Annotation Detail for POLK


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Basic Information Top
Gene Symbol:POLK ( DINB1,DINP,POLQ )
Gene Full Name: polymerase (DNA directed) kappa
Band: 5q13.3
Quick LinksEntrez ID:51426; OMIM: 605650; Uniprot ID:POLK_HUMAN; ENSEMBL ID: ENSG00000122008; HGNC ID: 9183
Relate to Another Database: SFARIGene; denovo-db
Related Pathway Information Top
Related Diseases/Disorders Top
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Desease Name
CANCER
head and neck cancer lung cancer
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Comparative Toxicogenomics Database Top
Chemical ID Chemical Name Interaction Interaction Action Publication
C023514 2,6-dinitrotoluene 2,6-dinitrotoluene results in increased expression of POLK mRNAincreases expression 20406850
C472791 3-(4'-hydroxy-3'-adamantylbiphenyl-4-yl)acrylic acid 3-(4'-hydroxy-3'-adamantylbiphenyl-4-yl)acrylic acid results in increased expression of POLK mRNAincreases expression 16788091
D000643 Ammonium Chloride Ammonium Chloride affects the expression of POLK mRNAaffects expression 16483693
D003010 Clorgyline Clorgyline results in increased expression of POLK mRNAincreases expression 19691856
D004041 Dietary Fats Dietary Fats results in decreased expression of POLK mRNAdecreases expression 18042831
C051890 irinotecan irinotecan analog results in decreased expression of POLK mRNAdecreases expression 18927307
C041786 palm oil palm oil results in decreased expression of POLK mRNAdecreases expression 18042831
Disease ID Disease Name Direct Evidence Inference Chemical Name Inference Score Publication
MESH:D000138 Acidosis Ammonium Chloride 3.9518287403
MESH:D001161 Arteriosclerosis Dietary Fats 4.2515238619
MESH:D001943 Breast Neoplasms Dietary Fats 2.2520435547
MESH:D006528 Carcinoma, Hepatocellular 2,6-dinitrotoluene 1.7816705839
MESH:D002471 Cell Transformation, Neoplastic 2,6-dinitrotoluene 2.956135515
MESH:D003110 Colonic Neoplasms irinotecan 2.6317725105 17287894
MESH:D015179 Colorectal Neoplasms irinotecan 2.3615273666 18509181 16391804 17454858 17159606 18259882 16303861
MESH:D003490 Cyanosis 2,6-dinitrotoluene 4.3818551238
MESH:D056486 Drug-Induced Liver Injury 2,6-dinitrotoluene 2.0318551238 21346803
MESH:D050171 Dyslipidemias Dietary Fats 3.6518367378
MESH:D005234 Fatty Liver Dietary Fats 3.5217967931 18296743 19551842 19004024
MESH:D005355 Fibrosis Dietary Fats 3.8818296743
MESH:D006937 Hypercholesterolemia Dietary Fats 3.8721332399
MESH:D006949 Hyperlipidemias Dietary Fats 3.9221332399
MESH:D007249 Inflammation Dietary Fats 2.5520412841
MESH:D007333 Insulin Resistance Dietary Fats 3.2711836018 18457598
MESH:D007680 Kidney Neoplasms 2,6-dinitrotoluene 3.2116705839
MESH:D008103 Liver Cirrhosis Dietary Fats 3.0118296743
MESH:D008113 Liver Neoplasms 2,6-dinitrotoluene 2.237678174
MESH:D008114 Liver Neoplasms, Experimental 2,6-dinitrotoluene 2.702876784 6135515 2876786
MESH:D052016 Mucositis irinotecan 5.4017159606
MESH:D009336 Necrosis 2,6-dinitrotoluene 4.2618551238 7678174
MESH:D009362 Neoplasm Metastasis irinotecan 3.2618259882
MESH:D009447 Neuroblastoma irinotecan 3.608761367
MESH:D017599 Neuroectodermal Tumors irinotecan 5.128761367
MESH:D009765 Obesity Dietary Fats 2.3418674790 21332399 11836018 20518802 17217161 20132043 16723640 18457598 19632207
MESH:D009784 Occupational Diseases 2,6-dinitrotoluene 3.7016049721
MESH:D011471 Prostatic Neoplasms Clorgyline 4.2419691856
MESH:D012640 Seizures 2,6-dinitrotoluene 2.7118551238
MESH:D013274 Stomach Neoplasms irinotecan 2.3615723263
MESH:D001749 Urinary Bladder Neoplasms 2,6-dinitrotoluene 2.3816049721
MESH:D014571 Urologic Neoplasms 2,6-dinitrotoluene 4.7110091137
MESH:D015430 Weight Gain Dietary Fats 3.9916723640
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Pharmacogenomics Knowledge Base Top
Drug Bank Top
Drugbank ID Action Drug Name Description
DB07435 - 1,2,3-TRIHYDROXY-1,2,3,4-TETRAHYDROBENZO[A]PYRENE
DB07652 - 1-[2-DEOXYRIBOFURANOSYL]-2,4-DIFLUORO-5-METHYL-BENZENE-5'MONOPHOSPHATE
DB08237 - 2'-deoxy-N-(naphthalen-1-ylmethyl)guanosine 5'-(dihydrogen phosphate)
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  (e.g. CHD8)

Syndromic Genes

Non-syndromic Genes

AutismKB Statistics

  • Studies: 1,036
  • Genes: 1,379
  • CNVs/SVs: 5,420
  • SNVs/Indels: 11,669
  • de novo Mutations: 5,669
  • Mosaics: 789
  • Linkage Regions: 172
  • Paper Collected: 6/30/2018
  • Last Update: 8/26/2018


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