AutismKB 2.0

Annotation Detail for ANAPC7


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Basic Information Top
Gene Symbol:ANAPC7 ( APC7 )
Gene Full Name: anaphase promoting complex subunit 7
Band: 12q24.11
Quick LinksEntrez ID:51434; OMIM: 606949; Uniprot ID:APC7_HUMAN; ENSEMBL ID: ENSG00000196510; HGNC ID: 17380
Relate to Another Database: SFARIGene; denovo-db
Related Pathway Information Top
No data
Pathway IDPathway Name
hsa04914Progesterone-mediated oocyte maturation
hsa04120Ubiquitin mediated proteolysis
hsa04110Cell cycle
hsa04114Oocyte meiosis
Pathway IDPathway Name
APC-Cdc20 mediated degradation of Nek2A
Cell Cycle, Mitotic
Cdc20:Phospho-APC/C mediated degradation of Cyclin A
Cell Cycle Checkpoints
No data
No data
Pathway IDPathway Name
500391Regulation of APC/C activators between G1/S and early anaphase
500395Phosphorylation of the APC/C
500390APC/C-mediated degradation of cell cycle proteins
500401Autodegradation of Cdh1 by Cdh1:APC/C
Related Diseases/Disorders Top
Comparative Toxicogenomics Database Top
Chemical ID Chemical Name Interaction Interaction Action Publication
C016403 2,4-dinitrotoluene 2,4-dinitrotoluene affects the expression of ANAPC7 mRNAaffects expression 21346803
C023514 2,6-dinitrotoluene 2,6-dinitrotoluene affects the expression of ANAPC7 mRNAaffects expression 21346803
D000082 Acetaminophen Acetaminophen affects the expression of ANAPC7 mRNAaffects expression 17562736
D004997 Ethinyl Estradiol Ethinyl Estradiol affects the expression of ANAPC7 mRNAaffects expression 17555576
D004997 Ethinyl Estradiol Ethinyl Estradiol results in increased expression of ANAPC7 mRNAincreases expression 17942748
C044361 M-VAC protocol ANAPC7 protein results in decreased susceptibility to M-VAC protocoldecreases response to substance 15814643
C006253 pirinixic acid pirinixic acid results in increased expression of ANAPC7 mRNAincreases expression 18301758
D013629 Tamoxifen Tamoxifen affects the expression of ANAPC7 mRNAaffects expression 17555576
Disease ID Disease Name Direct Evidence Inference Chemical Name Inference Score Publication
MESH:D000008 Abdominal Neoplasms Tamoxifen 4.9914745880
MESH:D000152 Acne Vulgaris Ethinyl Estradiol 4.3817505938
MESH:D055371 Acute Lung Injury pirinixic acid 3.4218653653
MESH:D000230 Adenocarcinoma Ethinyl Estradiol 1.8614692618
MESH:D018248 Adenoma, Liver Cell pirinixic acid 3.8816434500
MESH:D000799 Angioedema Acetaminophen 4.2910982225
MESH:D001161 Arteriosclerosis Ethinyl Estradiol 3.8211256880
MESH:D001169 Arthritis, Experimental Ethinyl Estradiol 2.8215885639
MESH:D001321 Autistic Disorder Acetaminophen 1.4018445737
MESH:D001778 Blood Coagulation Disorders pirinixic acid 3.4319483382
MESH:D001943 Breast Neoplasms Tamoxifen 2.1816873071 18351453 21138602 20135344 17893378 19155303 19410462 19115204 21152245 15668708 19221464 15565566 19189212 11161223 18815881 20544844 19189210 20065188 16273361 18855134 19288272 19142967 19011961 18425577 17440819 19289846 17049068 19244106 19200415 19066611 17261762 18984771 19487384 19103187 19084267 16818667 19059307 20005174 20390343 18997820 20859285 18821012 17242785 18629630 16202921
MESH:D018270 Carcinoma, Ductal, Breast Tamoxifen 4.8719066611
MESH:D006528 Carcinoma, Hepatocellular 2,4-dinitrotoluene 6.8416705839
MESH:D006528 Carcinoma, Hepatocellular 2,6-dinitrotoluene 6.8416705839
MESH:D006528 Carcinoma, Hepatocellular Acetaminophen 6.843084413
MESH:D006528 Carcinoma, Hepatocellular Tamoxifen 6.8416924424
MESH:D002295 Carcinoma, Transitional Cell Tamoxifen 3.8817572228
MESH:D002386 Cataract Acetaminophen 2.7310977129
MESH:D002471 Cell Transformation, Neoplastic 2,6-dinitrotoluene 2.956135515
MESH:D002779 Cholestasis Ethinyl Estradiol 8.4216105132 17681005 15861022 17110522 16919318 17333356 11677210
MESH:D002779 Cholestasis pirinixic acid 8.4219176532
MESH:D003490 Cyanosis 2,4-dinitrotoluene 12.1218551238
MESH:D003490 Cyanosis 2,6-dinitrotoluene 12.1218551238
MESH:D003711 Demyelinating Diseases Tamoxifen 4.7219031437
MESH:D003876 Dermatitis, Atopic pirinixic acid 2.5318249437
MESH:D003928 Diabetic Nephropathies Tamoxifen 3.7219279558
MESH:D056486 Drug-Induced Liver Injury 2,4-dinitrotoluene 6.5818551238 21346803
MESH:D056486 Drug-Induced Liver Injury 2,6-dinitrotoluene 6.5818551238 21346803
MESH:D056486 Drug-Induced Liver Injury Acetaminophen 6.5816081117 17906064 12958197 19923254 12705907 18713872 16781746 15619225 14725611 19739265 19085960 12540782 16177239 11529661 16109766 11743745 11421492 10915739 17522070 11287661 16227642 11739529 11834606 14550746 11461765 10663392 18071297 2444490 14986274 12153990 19416960 12594235 19370779 19420014 16485898 19164858 16393943 15968718 17562736 12392966 10774834
MESH:D056487 Drug-Induced Liver Injury, Chronic Acetaminophen 4.5419426721
MESH:D004487 Edema pirinixic acid 2.7612083418
MESH:D004681 Encephalomyelitis, Autoimmune, Experimental Ethinyl Estradiol 10.0612538720
MESH:D004681 Encephalomyelitis, Autoimmune, Experimental Tamoxifen 10.0619031437
MESH:D016889 Endometrial Neoplasms Tamoxifen 3.2119155303 17893378 16202921 20544844
MESH:D005234 Fatty Liver Ethinyl Estradiol 14.7415345470
MESH:D005234 Fatty Liver pirinixic acid 14.7419236843 20131406
MESH:D005234 Fatty Liver Tamoxifen 14.7414986274 19224547
MESH:D052776 Female Urogenital Diseases Tamoxifen 3.3916709447
MESH:D018221 Fibromatosis, Abdominal Tamoxifen 4.9214745880
MESH:D018222 Fibromatosis, Aggressive Tamoxifen 4.5819069698
MESH:D005756 Gastritis Acetaminophen 4.1216983495
MESH:D006333 Heart Failure pirinixic acid 2.6920558911
MESH:D006529 Hepatomegaly pirinixic acid 3.3518467677 16221962 19772884 19176532
MESH:D006930 Hyperalgesia Acetaminophen 2.9216870215
MESH:D006943 Hyperglycemia pirinixic acid 3.4520558911
MESH:D007021 Hypospadias Ethinyl Estradiol 4.1716569931 16945680
MESH:D007247 Infertility, Female Ethinyl Estradiol 3.7712013081
MESH:D007248 Infertility, Male Ethinyl Estradiol 2.6617937319
MESH:D007249 Inflammation Tamoxifen 2.4819457130
MESH:D007333 Insulin Resistance pirinixic acid 2.8016306350
MESH:D007674 Kidney Diseases Acetaminophen 2.3415629191 12587719
MESH:D007680 Kidney Neoplasms 2,4-dinitrotoluene 13.8116705839
MESH:D007680 Kidney Neoplasms 2,6-dinitrotoluene 13.8116705839
MESH:D007680 Kidney Neoplasms Tamoxifen 13.8118625569
MESH:D008064 Lipidoses Tamoxifen 3.3515342952 17567588
MESH:D008106 Liver Cirrhosis, Experimental pirinixic acid 2.3915474484
MESH:D008106 Liver Cirrhosis, Experimental Tamoxifen 2.3918564211
MESH:D008107 Liver Diseases Acetaminophen 1.6816611625 19014921 19784758 19460945 16610002 12969438 12587719 11587558
MESH:D017114 Liver Failure, Acute Acetaminophen 3.5017185352 16871587
MESH:D008113 Liver Neoplasms 2,6-dinitrotoluene 7.927678174
MESH:D008113 Liver Neoplasms pirinixic acid 7.9215890375 20007298 16377806
MESH:D008113 Liver Neoplasms Tamoxifen 7.9216684651
MESH:D008114 Liver Neoplasms, Experimental 2,6-dinitrotoluene 2.706135515 2876786 2876784
MESH:D008175 Lung Neoplasms Tamoxifen 1.7418625569
MESH:D015674 Mammary Neoplasms, Animal Tamoxifen 4.1519428831
MESH:D008325 Mammary Neoplasms, Experimental Tamoxifen 2.7919196723 11731420 16827153 19196722 14580682
MESH:D020149 Manganese Poisoning Tamoxifen 4.9919453300
MESH:D008545 Melanoma Tamoxifen 1.9119393235 12393984
MESH:D018328 Melanoma, Amelanotic Tamoxifen 4.5815990972
MESH:D008546 Melanoma, Experimental Acetaminophen 3.9319513568
MESH:D009135 Muscular Diseases pirinixic acid 3.8616239165
MESH:D009203 Myocardial Infarction pirinixic acid 2.2419151258
MESH:D015428 Myocardial Reperfusion Injury pirinixic acid 3.1616411023
MESH:D009336 Necrosis 2,4-dinitrotoluene 11.7018551238
MESH:D009336 Necrosis 2,6-dinitrotoluene 11.7018551238 7678174
MESH:D009362 Neoplasm Metastasis Tamoxifen 2.6419393235
MESH:D009364 Neoplasm Recurrence, Local Tamoxifen 2.5919410462
MESH:D009369 Neoplasms pirinixic acid 2.0617405874
MESH:D009376 Neoplasms, Hormone-Dependent Tamoxifen 4.4419196722 19200415 19189210
MESH:D019636 Neurodegenerative Diseases Acetaminophen 3.1018514411
MESH:D009765 Obesity pirinixic acid 1.8620558911
MESH:D009784 Occupational Diseases 2,4-dinitrotoluene 9.7816049721 12819281
MESH:D009784 Occupational Diseases 2,6-dinitrotoluene 9.7816049721
MESH:D010146 Pain Acetaminophen 2.6216870215
MESH:D016584 Panic Disorder Ethinyl Estradiol 3.9911578682
MESH:D011471 Prostatic Neoplasms Tamoxifen 3.1015067354
MESH:D011537 Pruritus Ethinyl Estradiol 3.7116919318 15861022
MESH:D015427 Reperfusion Injury pirinixic acid 2.5019058328
MESH:D012640 Seizures 2,4-dinitrotoluene 6.4718551238
MESH:D012640 Seizures 2,6-dinitrotoluene 6.4718551238
MESH:D013088 Spermatocele Ethinyl Estradiol 13.0916709447
MESH:D013088 Spermatocele Tamoxifen 13.0916709447
MESH:D013119 Spinal Cord Injuries Tamoxifen 4.4319457130
MESH:D019851 Thrombophilia Ethinyl Estradiol 3.9211994571
MESH:D013927 Thrombosis Ethinyl Estradiol 3.4015669648
MESH:D001749 Urinary Bladder Neoplasms 2,4-dinitrotoluene 8.8316049721
MESH:D001749 Urinary Bladder Neoplasms 2,6-dinitrotoluene 8.8316049721
MESH:D001749 Urinary Bladder Neoplasms Tamoxifen 8.838653321 16712894 17572228
MESH:D014571 Urologic Neoplasms 2,4-dinitrotoluene 23.5310091137
MESH:D014571 Urologic Neoplasms 2,6-dinitrotoluene 23.5310091137
MESH:D014571 Urologic Neoplasms M-VAC protocol 23.5317933135
MESH:D014581 Urticaria Acetaminophen 3.2810982225
MESH:D014594 Uterine Neoplasms Ethinyl Estradiol 3.6314692618
MESH:D020246 Venous Thrombosis Ethinyl Estradiol 3.8215869587 14671159
Pathway ID Pathway Name
REACT:8017 APC-Cdc20 mediated degradation of Nek2A
REACT:6850 Cdc20:Phospho-APC/C mediated degradation of Cyclin A
KEGG:04110 Cell cycle
REACT:1538 Cell Cycle Checkpoints
REACT:152 Cell Cycle, Mitotic
KEGG:04114 Oocyte meiosis
KEGG:04914 Progesterone-mediated oocyte maturation
KEGG:04120 Ubiquitin mediated proteolysis
Pharmacogenomics Knowledge Base Top
Drug Bank Top

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  (e.g. CHD8)

Syndromic Genes

Non-syndromic Genes

AutismKB Statistics

  • Studies: 1,036
  • Genes: 1,379
  • CNVs/SVs: 5,420
  • SNVs/Indels: 11,669
  • de novo Mutations: 5,669
  • Mosaics: 789
  • Linkage Regions: 172
  • Paper Collected: 6/30/2018
  • Last Update: 8/26/2018


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