AutismKB 2.0

Annotation Detail for SCARA3


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Basic Information Top
Gene Symbol:SCARA3 ( APC7,CSR,CSR1,MSLR1,MSRL1 )
Gene Full Name: scavenger receptor class A, member 3
Band: 8p21.1
Quick LinksEntrez ID:51435; OMIM: 602728; Uniprot ID:SCAR3_HUMAN; ENSEMBL ID: ENSG00000168077; HGNC ID: 19000
Relate to Another Database: SFARIGene; denovo-db
Related Pathway Information Top
Related Diseases/Disorders Top
Comparative Toxicogenomics Database Top
Chemical ID Chemical Name Interaction Interaction Action Publication
D000082 Acetaminophen Acetaminophen affects the expression of SCARA3 mRNAaffects expression 17562736
D015123 7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide 7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide results in decreased expression of SCARA3 mRNAdecreases expression 19150397
C014347 decitabine decitabine results in decreased methylation of SCARA3 promoterdecreases methylation 18676679
D004041 Dietary Fats Dietary Fats results in increased expression of SCARA3 mRNAincreases expression 18042831
C041786 palm oil palm oil results in increased expression of SCARA3 mRNAincreases expression 18042831
C006253 pirinixic acid [pirinixic acid binds to and results in increased activity of PPARA protein] which results in decreased expression of SCARA3 mRNAaffects binding|decreases expression|increases activity 19710929
D018038 Sodium Selenite Sodium Selenite results in decreased methylation of SCARA3 promoterdecreases methylation 18676679
D018038 Sodium Selenite Sodium Selenite results in increased expression of SCARA3 mRNAincreases expression 18676679
D015032 Zinc Zinc results in decreased expression of SCARA3 mRNAdecreases expression 16870260
C016837 zinc chloride zinc chloride results in decreased expression of SCARA3 mRNAdecreases expression 16870260
Disease ID Disease Name Direct Evidence Inference Chemical Name Inference Score Publication
MESH:D000169 Acrodermatitis Zinc 5.6917190629 17202136 16889938
MESH:D055371 Acute Lung Injury pirinixic acid 3.3418653653
MESH:D018248 Adenoma, Liver Cell pirinixic acid 3.7616434500
MESH:D000544 Alzheimer Disease Zinc 2.7916325427 16580781 16410023 17119284
MESH:D000755 Anemia, Sickle Cell Zinc 5.1416916123
MESH:D000799 Angioedema Acetaminophen 4.1610982225
MESH:D001161 Arteriosclerosis Dietary Fats 4.1515238619
MESH:D001249 Asthma Zinc 3.0017085522
MESH:D001321 Autistic Disorder Acetaminophen 1.4018445737
MESH:D001778 Blood Coagulation Disorders pirinixic acid 3.3519483382
MESH:D001930 Brain Injuries Zinc 4.9517109824
MESH:D001943 Breast Neoplasms decitabine 2.2919208741 18320071
MESH:D001943 Breast Neoplasms Dietary Fats 2.2920435547
MESH:D006528 Carcinoma, Hepatocellular Acetaminophen 1.393084413
MESH:D002294 Carcinoma, Squamous Cell decitabine 5.1619215824
MESH:D002294 Carcinoma, Squamous Cell Zinc 5.1616543248
MESH:D002318 Cardiovascular Diseases Zinc 3.7916936243
MESH:D002386 Cataract Acetaminophen 2.6910977129
MESH:D002471 Cell Transformation, Neoplastic 7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide 2.8620889678
MESH:D002779 Cholestasis pirinixic acid 2.9719176532
MESH:D019457 Chromosome Breakage Sodium Selenite 5.0115894690
MESH:D003110 Colonic Neoplasms decitabine 2.3617616700
MESH:D015179 Colorectal Neoplasms decitabine 2.1018981723
MESH:D019465 Craniofacial Abnormalities Zinc 2.4419302082
MESH:D003876 Dermatitis, Atopic pirinixic acid 2.5118249437
MESH:D003920 Diabetes Mellitus Sodium Selenite 10.0016285004
MESH:D003920 Diabetes Mellitus Zinc 10.0016479319
MESH:D056486 Drug-Induced Liver Injury Acetaminophen 4.0012392966 14725611 10774834 16781746 19370779 16227642 19164858 11529661 19923254 18071297 11421492 11461765 15968718 19416960 17562736 11287661 2444490 16081117 18713872 11743745 11739529 12540782 12594235 19739265 16393943 10663392 15619225 17906064 19420014 10915739 16485898 14986274 17522070 19085960 12153990 12958197 12705907 16177239 14550746 11834606 16109766
MESH:D056486 Drug-Induced Liver Injury Sodium Selenite 4.0015131321
MESH:D056487 Drug-Induced Liver Injury, Chronic Acetaminophen 4.4219426721
MESH:D050171 Dyslipidemias Dietary Fats 3.6018367378
MESH:D004487 Edema pirinixic acid 2.6812083418
MESH:D004701 Endocrine Gland Neoplasms decitabine 5.4319294695
MESH:D004938 Esophageal Neoplasms 7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide 4.8120426865
MESH:D004938 Esophageal Neoplasms Zinc 4.8116543248
MESH:D005234 Fatty Liver Dietary Fats 8.3918296743 17967931 19004024 19551842
MESH:D005234 Fatty Liver pirinixic acid 8.3920131406 19236843
MESH:D005355 Fibrosis Dietary Fats 3.7818296743
MESH:D005756 Gastritis Acetaminophen 12.2516983495
MESH:D005756 Gastritis Zinc 12.2517241300
MESH:D006130 Growth Disorders Zinc 4.0817217573
MESH:D006258 Head and Neck Neoplasms decitabine 3.6219215824
MESH:D006333 Heart Failure pirinixic acid 7.5420558911
MESH:D006333 Heart Failure Zinc 7.5417162251
MESH:D006335 Heart Injuries Zinc 6.0917074742
MESH:D016481 Helicobacter Infections Zinc 4.7517241300
MESH:D006527 Hepatolenticular Degeneration Zinc 4.9517276780
MESH:D006529 Hepatomegaly pirinixic acid 3.2518467677 16221962 19176532 19772884
MESH:D006930 Hyperalgesia Acetaminophen 2.8616870215
MESH:D006937 Hypercholesterolemia Dietary Fats 3.8021332399
MESH:D006943 Hyperglycemia pirinixic acid 3.3820558911
MESH:D006949 Hyperlipidemias Dietary Fats 3.8321332399
MESH:D007248 Infertility, Male decitabine 3.3317581917
MESH:D007249 Inflammation Dietary Fats 2.5220412841
MESH:D007333 Insulin Resistance Dietary Fats 13.0818457598 11836018
MESH:D007333 Insulin Resistance pirinixic acid 13.0816306350
MESH:D007333 Insulin Resistance Sodium Selenite 13.0814714311
MESH:D007511 Ischemia Zinc 4.8916584753
MESH:D007674 Kidney Diseases Acetaminophen 6.5212587719 15629191
MESH:D007674 Kidney Diseases Zinc 6.5216960431
MESH:D007676 Kidney Failure, Chronic Zinc 4.6316518626
MESH:D007938 Leukemia decitabine 3.1619235587 18980019
MESH:D007951 Leukemia, Myeloid decitabine 4.2119117987 18454857 17236224
MESH:D015470 Leukemia, Myeloid, Acute decitabine 2.4118460780 19010910 18206229 17679729 18704418 19387464
MESH:D015477 Leukemia, Myelomonocytic, Chronic decitabine 5.7818055864
MESH:D008103 Liver Cirrhosis Dietary Fats 2.9818296743
MESH:D008106 Liver Cirrhosis, Experimental pirinixic acid 1.3515474484
MESH:D008107 Liver Diseases Acetaminophen 1.6719014921 12587719 19784758 11587558 12969438 16610002 19460945 16611625
MESH:D017114 Liver Failure, Acute Acetaminophen 3.4317185352 16871587
MESH:D008113 Liver Neoplasms pirinixic acid 1.8816377806 20007298 15890375
MESH:D008223 Lymphoma decitabine 3.5619470736
MESH:D016393 Lymphoma, B-Cell Sodium Selenite 4.2814737004
MESH:D008325 Mammary Neoplasms, Experimental Zinc 3.4212773700
MESH:D008545 Melanoma decitabine 2.2717785578 16505122
MESH:D008546 Melanoma, Experimental Acetaminophen 3.8319513568
MESH:D009101 Multiple Myeloma decitabine 3.4918172295
MESH:D009135 Muscular Diseases pirinixic acid 3.7616239165
MESH:D009190 Myelodysplastic Syndromes decitabine 3.4919010910 18608210 19157545 16882708
MESH:D009203 Myocardial Infarction pirinixic acid 2.2119151258
MESH:D015428 Myocardial Reperfusion Injury pirinixic acid 3.1016411023
MESH:D009369 Neoplasms decitabine 5.3217925555 19470736 19116145
MESH:D009369 Neoplasms pirinixic acid 5.3217405874
MESH:D019636 Neurodegenerative Diseases Acetaminophen 3.0418514411
MESH:D009765 Obesity Dietary Fats 4.5811836018 21332399 20518802 17217161 18674790 19632207 16723640 18457598 20132043
MESH:D009765 Obesity pirinixic acid 4.5820558911
MESH:D010051 Ovarian Neoplasms decitabine 2.7019331143 19259094
MESH:D010146 Pain Acetaminophen 2.5616870215
MESH:D010190 Pancreatic Neoplasms decitabine 2.8319294695
MESH:D011225 Pre-Eclampsia Zinc 4.3317114810
MESH:D055728 Primary Myelofibrosis decitabine 4.9917616702
MESH:D011471 Prostatic Neoplasms Sodium Selenite 3.4918760546
MESH:D011471 Prostatic Neoplasms Zinc 3.4916606632 12429649 16700911 16517595
MESH:D015427 Reperfusion Injury pirinixic acid 2.4719058328
MESH:D012162 Retinal Degeneration Zinc 4.2816584753
MESH:D012208 Rhabdomyosarcoma decitabine 4.6219155313
MESH:D013274 Stomach Neoplasms decitabine 2.1019037991
MESH:D013964 Thyroid Neoplasms decitabine 3.4817967635
MESH:D014062 Tongue Neoplasms Zinc 4.5916543248
MESH:D001749 Urinary Bladder Neoplasms decitabine 2.7919087683 17616700
MESH:D014581 Urticaria Acetaminophen 3.2010982225
MESH:D014604 Uveal Neoplasms decitabine 5.2317785578
MESH:D015430 Weight Gain Dietary Fats 3.9216723640
No data
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Syndromic Genes

Non-syndromic Genes

AutismKB Statistics

  • Studies: 1,036
  • Genes: 1,379
  • CNVs/SVs: 5,420
  • SNVs/Indels: 11,669
  • de novo Mutations: 5,669
  • Mosaics: 789
  • Linkage Regions: 172
  • Paper Collected: 6/30/2018
  • Last Update: 8/26/2018


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