AutismKB 2.0

Annotation Detail for PCYOX1


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Basic Information Top
Gene Symbol:PCYOX1 ( KIAA0908,PCL1 )
Gene Full Name: prenylcysteine oxidase 1
Band: 2p13.3
Quick LinksEntrez ID:51449; OMIM: 610995; Uniprot ID:PCYOX_HUMAN; ENSEMBL ID: ENSG00000116005; HGNC ID: 20588
Relate to Another Database: SFARIGene; denovo-db
Related Pathway Information Top
Related Diseases/Disorders Top
Comparative Toxicogenomics Database Top
Chemical ID Chemical Name Interaction Interaction Action Publication
C023514 2,6-dinitrotoluene 2,6-dinitrotoluene affects the expression of PCYOX1 mRNAaffects expression 21346803
C009505 4,4'-diaminodiphenylmethane 4,4'-diaminodiphenylmethane results in increased expression of PCYOX1 mRNAincreases expression 18648102
D000082 Acetaminophen Acetaminophen affects the expression of PCYOX1 mRNAaffects expression 17562736
D016604 Aflatoxin B1 Aflatoxin B1 affects the expression of PCYOX1 proteinaffects expression 20106945
D000643 Ammonium Chloride Ammonium Chloride affects the expression of PCYOX1 mRNAaffects expression 16483693
D017638 Asbestos, Crocidolite Asbestos, Crocidolite affects the expression of PCYOX1 mRNAaffects expression 17331233
D001554 Benzene Benzene affects the expression of PCYOX1 mRNAaffects expression 15878777
D015123 7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide 7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide results in decreased expression of PCYOX1 mRNAdecreases expression 20018196
D015123 7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide 7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide results in increased expression of PCYOX1 mRNAincreases expression 20382639
D020122 tert-Butylhydroperoxide tert-Butylhydroperoxide results in decreased expression of PCYOX1 mRNAdecreases expression 15336504
D016572 Cyclosporine Cyclosporine results in decreased expression of PCYOX1 mRNAdecreases expression 20106945
C475919 hydroxytamoxifen hydroxytamoxifen results in increased expression of PCYOX1 mRNAincreases expression 16849584
D010269 Paraquat Paraquat affects the expression of PCYOX1 mRNAaffects expression 16854511
C006253 pirinixic acid pirinixic acid results in decreased expression of PCYOX1 mRNAdecreases expression 18445702
C006253 pirinixic acid pirinixic acid results in increased expression of PCYOX1 mRNAincreases expression 18301758
17426115
C004648 testosterone enanthate testosterone enanthate affects the expression of PCYOX1 mRNAaffects expression 17440010
D014635 Valproic Acid Valproic Acid results in increased expression of PCYOX1 mRNAincreases expression 19101580
Disease ID Disease Name Direct Evidence Inference Chemical Name Inference Score Publication
MESH:D000014 Abnormalities, Drug-Induced Valproic Acid 3.548875741
MESH:D000015 Abnormalities, Multiple Valproic Acid 3.9619490988
MESH:D000138 Acidosis Ammonium Chloride 3.6118287403
MESH:D055371 Acute Lung Injury pirinixic acid 3.1518653653
MESH:D000236 Adenoma 4,4'-diaminodiphenylmethane 2.773712494
MESH:D018248 Adenoma, Liver Cell pirinixic acid 3.5316434500
MESH:D000382 Agricultural Workers' Diseases Paraquat 3.8111874814
MESH:D000550 Amblyopia Valproic Acid 5.3017688650
MESH:D000741 Anemia, Aplastic Benzene 4.3911369114 14761424 17661222
MESH:D000799 Angioedema Acetaminophen 3.9110982225
MESH:D001008 Anxiety Disorders Valproic Acid 3.5917497229
MESH:D001321 Autistic Disorder Acetaminophen 1.8518445737
MESH:D001321 Autistic Disorder Valproic Acid 1.8519232924 20603192 18177632 18558336 18316065 18940202 17688650 18396377 16609825 15238991 19460635 18985861 17157402 17507914 18775368
MESH:D001660 Biliary Tract Diseases 4,4'-diaminodiphenylmethane 5.0811289319 1440618
MESH:D001714 Bipolar Disorder Valproic Acid 3.0917594078 20046352
MESH:D001778 Blood Coagulation Disorders pirinixic acid 3.1719483382
MESH:D001848 Bone Diseases, Developmental Valproic Acid 3.428888407
MESH:D001855 Bone Marrow Diseases Benzene 5.2916183116
MESH:D001943 Breast Neoplasms Benzene 2.8911921183 17162533
MESH:D006528 Carcinoma, Hepatocellular 2,6-dinitrotoluene 6.5916705839
MESH:D006528 Carcinoma, Hepatocellular 4,4'-diaminodiphenylmethane 6.593581430 7296757
MESH:D006528 Carcinoma, Hepatocellular Acetaminophen 6.593084413
MESH:D006528 Carcinoma, Hepatocellular Aflatoxin B1 6.5912907637 21507988 12619106
MESH:D002292 Carcinoma, Renal Cell 4,4'-diaminodiphenylmethane 2.697296757
MESH:D002386 Cataract Acetaminophen 2.6010977129
MESH:D002471 Cell Transformation, Neoplastic 2,6-dinitrotoluene 16.176135515
MESH:D002471 Cell Transformation, Neoplastic 4,4'-diaminodiphenylmethane 16.177505956
MESH:D002471 Cell Transformation, Neoplastic 7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide 16.1720889678
MESH:D002471 Cell Transformation, Neoplastic Cyclosporine 16.1712371664
MESH:D002659 Child Development Disorders, Pervasive Valproic Acid 2.7220734317
MESH:D002779 Cholestasis 4,4'-diaminodiphenylmethane 13.5019486331 9022650
MESH:D002779 Cholestasis Cyclosporine 13.5019486331
MESH:D002779 Cholestasis pirinixic acid 13.5019176532
MESH:D019465 Craniofacial Abnormalities Benzene 2.9215643154
MESH:D019465 Craniofacial Abnormalities Valproic Acid 2.9216575769 17688650 8888407
MESH:D003490 Cyanosis 2,6-dinitrotoluene 4.0618551238
MESH:D003872 Dermatitis Benzene 4.8115902427
MESH:D017449 Dermatitis, Allergic Contact 4,4'-diaminodiphenylmethane 2.8411298694 11906362 18759878 14531868 8970840 8156756 12868966 2524372
MESH:D003876 Dermatitis, Atopic pirinixic acid 2.4418249437
MESH:D003877 Dermatitis, Contact 4,4'-diaminodiphenylmethane 3.523621924 2952479
MESH:D056486 Drug-Induced Liver Injury 2,6-dinitrotoluene 9.0421346803 18551238
MESH:D056486 Drug-Induced Liver Injury 4,4'-diaminodiphenylmethane 9.048291058 9328219 18692083 11289319 9653073 18648102 18289764 6482804 7440962 9022650 16192314 6679447 1440618
MESH:D056486 Drug-Induced Liver Injury Acetaminophen 9.0410663392 12958197 16393943 16081117 19370779 10915739 12392966 12705907 15968718 11287661 11421492 11743745 17562736 19739265 12540782 11739529 19164858 18071297 12594235 19416960 12153990 14725611 16485898 16109766 10774834 16227642 19923254 16781746 2444490 14986274 17522070 11834606 14550746 17906064 19420014 19085960 15619225 16177239 11529661 11461765 18713872
MESH:D056486 Drug-Induced Liver Injury Valproic Acid 9.0419641884 1733752
MESH:D056487 Drug-Induced Liver Injury, Chronic Acetaminophen 4.1619426721
MESH:D004421 Dystonia Valproic Acid 4.081851702
MESH:D004487 Edema pirinixic acid 2.5112083418
MESH:D004831 Epilepsies, Myoclonic Valproic Acid 4.193659116 17275665
MESH:D004828 Epilepsies, Partial Valproic Acid 3.9816628512 3922381
MESH:D004827 Epilepsy Valproic Acid 2.9518234410 20417680
MESH:D004832 Epilepsy, Absence Valproic Acid 3.617562514 6254150 6426943
MESH:D017029 Epilepsy, Complex Partial Valproic Acid 4.347750514
MESH:D004830 Epilepsy, Tonic-Clonic Valproic Acid 4.113659116
MESH:D004938 Esophageal Neoplasms 4,4'-diaminodiphenylmethane 4.413581430
MESH:D004938 Esophageal Neoplasms 7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide 4.4120426865
MESH:D005234 Fatty Liver Cyclosporine 13.2419224547
MESH:D005234 Fatty Liver pirinixic acid 13.2420131406 19236843
MESH:D005234 Fatty Liver Valproic Acid 13.2414986274 19224547
MESH:D005315 Fetal Diseases Valproic Acid 4.9516575769
MESH:D005317 Fetal Growth Retardation Valproic Acid 4.1718558336 8888407
MESH:D005350 Fibroma 4,4'-diaminodiphenylmethane 5.086705139
MESH:D005355 Fibrosis Cyclosporine 3.1812639820 12168785
MESH:D005756 Gastritis Acetaminophen 3.7416983495
MESH:D005885 Gingival Hyperplasia Cyclosporine 4.278708960
MESH:D005911 Gliosis Paraquat 5.2311124998
MESH:D006042 Goiter 4,4'-diaminodiphenylmethane 4.077505956
MESH:D006333 Heart Failure pirinixic acid 2.5520558911
MESH:D006402 Hematologic Diseases Benzene 4.6916183116
MESH:D006457 Hemoglobinuria, Paroxysmal Cyclosporine 4.4715720958
MESH:D006505 Hepatitis 4,4'-diaminodiphenylmethane 3.556705139
MESH:D006529 Hepatomegaly pirinixic acid 3.0416221962 18467677 19176532 19772884
MESH:D019247 HIV Wasting Syndrome testosterone enanthate 5.8117440010
MESH:D006849 Hydrocephalus Valproic Acid 4.9217688650
MESH:D006930 Hyperalgesia Acetaminophen 2.7216870215
MESH:D006943 Hyperglycemia pirinixic acid 3.2120558911
MESH:D006965 Hyperplasia 4,4'-diaminodiphenylmethane 3.9815034207
MESH:D006973 Hypertension Benzene 5.4117940673
MESH:D006973 Hypertension Cyclosporine 5.4110903974
MESH:D007248 Infertility, Male Paraquat 3.274850670
MESH:D007333 Insulin Resistance pirinixic acid 2.6516306350
MESH:D007565 Jaundice 4,4'-diaminodiphenylmethane 5.089022650 8074119
MESH:D007638 Keratoconjunctivitis Sicca Cyclosporine 4.5015604871
MESH:D007674 Kidney Diseases Acetaminophen 5.8512587719 15629191
MESH:D007674 Kidney Diseases Cyclosporine 5.8518776723 8314463 10903974
MESH:D007680 Kidney Neoplasms 2,6-dinitrotoluene 12.5016705839
MESH:D007680 Kidney Neoplasms 4,4'-diaminodiphenylmethane 12.506582329
MESH:D007680 Kidney Neoplasms Cyclosporine 12.5012371664
MESH:D007938 Leukemia Benzene 3.4018335105 14694614 15935818 17119257
MESH:D007951 Leukemia, Myeloid Benzene 4.3517506065
MESH:D015470 Leukemia, Myeloid, Acute Benzene 4.1319478238
MESH:D015470 Leukemia, Myeloid, Acute Valproic Acid 4.1317596541 16294345
MESH:D008105 Liver Cirrhosis, Biliary 4,4'-diaminodiphenylmethane 3.2115034207 9327722
MESH:D008106 Liver Cirrhosis, Experimental pirinixic acid 1.3415474484
MESH:D008107 Liver Diseases Acetaminophen 1.6319014921 16611625 11587558 12587719 19460945 16610002 12969438 19784758
MESH:D017114 Liver Failure, Acute Acetaminophen 3.2616871587 17185352
MESH:D008113 Liver Neoplasms 2,6-dinitrotoluene 7.477678174
MESH:D008113 Liver Neoplasms Aflatoxin B1 7.479163691 15890375 2125692 18177683
MESH:D008113 Liver Neoplasms pirinixic acid 7.4716377806 20007298 15890375
MESH:D008114 Liver Neoplasms, Experimental 2,6-dinitrotoluene 14.312876784 6135515 2876786
MESH:D008114 Liver Neoplasms, Experimental 4,4'-diaminodiphenylmethane 14.31598648 1399818 6587162 3712494
MESH:D008114 Liver Neoplasms, Experimental Aflatoxin B1 14.318603461
MESH:D008114 Liver Neoplasms, Experimental Benzene 14.3112562636
MESH:D017563 Lung Diseases, Interstitial Benzene 11.6014698565
MESH:D017563 Lung Diseases, Interstitial Valproic Acid 11.6017228818
MESH:D055370 Lung Injury Asbestos, Crocidolite 4.0617365036
MESH:D008175 Lung Neoplasms Aflatoxin B1 2.7414755239
MESH:D008175 Lung Neoplasms Benzene 2.7412562636
MESH:D008223 Lymphoma Benzene 3.7517119257 17584886
MESH:D015674 Mammary Neoplasms, Animal Benzene 4.4912562636
MESH:D008325 Mammary Neoplasms, Experimental Benzene 3.3211921183
MESH:D008546 Melanoma, Experimental Acetaminophen 3.6119513568
MESH:D008654 Mesothelioma Asbestos, Crocidolite 3.1916166281 18303189 16966607
MESH:D008664 Metal Metabolism, Inborn Errors Cyclosporine 4.8516801185
MESH:D008881 Migraine Disorders Valproic Acid 3.2118803445 18765137
MESH:D009101 Multiple Myeloma Benzene 3.6817119195
MESH:D009135 Muscular Diseases pirinixic acid 3.5516239165
MESH:D009139 Musculoskeletal Abnormalities Valproic Acid 4.068888407
MESH:D009190 Myelodysplastic Syndromes Valproic Acid 3.1717596541
MESH:D009203 Myocardial Infarction pirinixic acid 2.1519151258
MESH:D015428 Myocardial Reperfusion Injury pirinixic acid 2.9716411023
MESH:D009336 Necrosis 2,6-dinitrotoluene 3.9118551238 7678174
MESH:D009362 Neoplasm Metastasis 4,4'-diaminodiphenylmethane 2.483581430
MESH:D009369 Neoplasms pirinixic acid 1.9617405874
MESH:D009402 Nephrosis, Lipoid Cyclosporine 4.5017954296
MESH:D009404 Nephrotic Syndrome Cyclosporine 3.3119348381 18481113
MESH:D009410 Nerve Degeneration Paraquat 3.7416893418
MESH:D009436 Neural Tube Defects 4,4'-diaminodiphenylmethane 12.326679447
MESH:D009436 Neural Tube Defects Benzene 12.3215643154
MESH:D009436 Neural Tube Defects Valproic Acid 12.328888407 16359493
MESH:D019636 Neurodegenerative Diseases Acetaminophen 2.8918514411
MESH:D009765 Obesity pirinixic acid 1.8220558911
MESH:D009784 Occupational Diseases 2,6-dinitrotoluene 15.3316049721
MESH:D009784 Occupational Diseases 4,4'-diaminodiphenylmethane 15.336482804 4026338
MESH:D009784 Occupational Diseases Benzene 15.3315935809 17119257 15727169 15576619 15913788 15612468 16737584 17479406 17178637
MESH:D009902 Optic Neuritis 4,4'-diaminodiphenylmethane 5.083988306
MESH:D010051 Ovarian Neoplasms Benzene 2.9712562636
MESH:D010146 Pain Acetaminophen 2.4116870215
MESH:D010212 Papilloma 4,4'-diaminodiphenylmethane 3.527296757
MESH:D010300 Parkinson Disease Paraquat 2.8216510128 11445065 15824117 12911755 16140633 15451049 11124998 11181820
MESH:D010302 Parkinson Disease, Secondary Paraquat 4.4716190885
MESH:D010787 Photosensitivity Disorders 4,4'-diaminodiphenylmethane 4.536228378
MESH:D010995 Pleural Diseases Asbestos, Crocidolite 4.9310923243
MESH:D011014 Pneumonia Paraquat 4.5012504350
MESH:D011230 Precancerous Conditions Cyclosporine 3.2512371664
MESH:D011297 Prenatal Exposure Delayed Effects Valproic Acid 3.8820603192
MESH:D019310 Pseudolymphoma Valproic Acid 4.6012752131 11422049
MESH:D011565 Psoriasis Cyclosporine 2.2416882103
MESH:D011658 Pulmonary Fibrosis Asbestos, Crocidolite 5.9417365031 15814490 17975199 17322281
MESH:D011658 Pulmonary Fibrosis Paraquat 5.9417997886 16324872
MESH:D015427 Reperfusion Injury pirinixic acid 2.4019058328
MESH:D012128 Respiratory Distress Syndrome, Adult Paraquat 3.9411700416
MESH:D012135 Respiratory Sounds Paraquat 4.1011874814
MESH:D012162 Retinal Degeneration 4,4'-diaminodiphenylmethane 8.983692021
MESH:D012162 Retinal Degeneration Paraquat 8.9816458197
MESH:D012208 Rhabdomyosarcoma Valproic Acid 4.2119155313
MESH:D012559 Schizophrenia Valproic Acid 2.0719110320 15737665
MESH:D012640 Seizures 2,6-dinitrotoluene 6.0018551238
MESH:D012640 Seizures Valproic Acid 6.0011738929 11044598 17978042 14763951 15475178 1511512 16876388 3137016
MESH:D012878 Skin Neoplasms tert-Butylhydroperoxide 2.708532709
MESH:D016135 Spinal Dysraphism Valproic Acid 3.8019490988
MESH:D013226 Status Epilepticus Valproic Acid 4.6012833885
MESH:D013274 Stomach Neoplasms Benzene 2.4212562636
MESH:D013953 Thymus Neoplasms Benzene 5.0110850423
MESH:D013964 Thyroid Neoplasms 4,4'-diaminodiphenylmethane 2.906587162 3712494 6582329 7505956 1399818
MESH:D014178 Translocation, Genetic Valproic Acid 5.3017262798
MESH:D020194 Unverricht-Lundborg Syndrome Valproic Acid 4.573119515
MESH:D001749 Urinary Bladder Neoplasms 2,6-dinitrotoluene 5.0416049721
MESH:D001749 Urinary Bladder Neoplasms 4,4'-diaminodiphenylmethane 5.048074119
MESH:D014564 Urogenital Abnormalities Valproic Acid 4.688888407
MESH:D014571 Urologic Neoplasms 2,6-dinitrotoluene 4.3710091137
MESH:D014581 Urticaria Acetaminophen 3.0110982225
MESH:D014594 Uterine Neoplasms Benzene 4.3712562636
MESH:D014605 Uveitis Cyclosporine 4.051336536
MESH:D014985 Xerophthalmia Cyclosporine 4.5017120751
No data
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Syndromic Genes

Non-syndromic Genes

AutismKB Statistics

  • Studies: 1,036
  • Genes: 1,379
  • CNVs/SVs: 5,420
  • SNVs/Indels: 11,669
  • de novo Mutations: 5,669
  • Mosaics: 789
  • Linkage Regions: 172
  • Paper Collected: 6/30/2018
  • Last Update: 8/26/2018


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