AutismKB 2.0

Annotation Detail for LCMT1


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Basic Information Top
Gene Symbol:LCMT1 ( LCMT,PPMT1 )
Gene Full Name: leucine carboxyl methyltransferase 1
Band: 16p12.1
Quick LinksEntrez ID:51451; OMIM: 610286; Uniprot ID:LCMT1_HUMAN; ENSEMBL ID: ENSG00000205629; HGNC ID: 17557
Relate to Another Database: SFARIGene; denovo-db
Related Pathway Information Top
No data
Pathway IDPathway Name
hsa00350Tyrosine metabolism
hsa00450Selenoamino acid metabolism
hsa00340Histidine metabolism
No data
No data
No data
No data
Related Diseases/Disorders Top
Comparative Toxicogenomics Database Top
Chemical ID Chemical Name Interaction Interaction Action Publication
C023514 2,6-dinitrotoluene 2,6-dinitrotoluene results in increased expression of LCMT1 mRNAincreases expression 20406850
C023514 2,6-dinitrotoluene 2,6-dinitrotoluene affects the expression of LCMT1 mRNAaffects expression 21346803
D000082 Acetaminophen Acetaminophen affects the expression of LCMT1 mRNAaffects expression 17562736
D000638 Amiodarone Amiodarone affects the expression of LCMT1 mRNAaffects expression 19483382
D001553 Benzbromarone Benzbromarone affects the expression of LCMT1 mRNAaffects expression 19483382
D002994 Clofibrate Clofibrate affects the expression of LCMT1 mRNAaffects expression 19483382
D016572 Cyclosporine Cyclosporine results in increased expression of LCMT1 mRNAincreases expression 20106945
D005001 Ethionine Ethionine affects the expression of LCMT1 mRNAaffects expression 19483382
D009853 Omeprazole Omeprazole affects the expression of LCMT1 mRNAaffects expression 19483382
C006253 pirinixic acid pirinixic acid affects the expression of LCMT1 mRNAaffects expression 19483382
D011441 Propylthiouracil Propylthiouracil affects the expression of LCMT1 mRNAaffects expression 19483382
D018038 Sodium Selenite Sodium Selenite results in increased expression of LCMT1 mRNAincreases expression 18175754
D013853 Thioacetamide Thioacetamide affects the expression of LCMT1 mRNAaffects expression 19483382
D014415 Tunicamycin Tunicamycin results in decreased expression of LCMT1 mRNAdecreases expression 17127020
Disease ID Disease Name Direct Evidence Inference Chemical Name Inference Score Publication
MESH:D055371 Acute Lung Injury pirinixic acid 3.2018653653
MESH:D018248 Adenoma, Liver Cell pirinixic acid 3.6016434500
MESH:D000799 Angioedema Acetaminophen 3.9810982225
MESH:D001145 Arrhythmias, Cardiac Amiodarone 3.8818218290 20041841 18057881
MESH:D001281 Atrial Fibrillation Amiodarone 3.9618651412 19698954
MESH:D001321 Autistic Disorder Acetaminophen 1.4118445737
MESH:D001778 Blood Coagulation Disorders Amiodarone 52.5019483382
MESH:D001778 Blood Coagulation Disorders Benzbromarone 52.5019483382
MESH:D001778 Blood Coagulation Disorders Clofibrate 52.5019483382
MESH:D001778 Blood Coagulation Disorders Ethionine 52.5019483382
MESH:D001778 Blood Coagulation Disorders Omeprazole 52.5019483382
MESH:D001778 Blood Coagulation Disorders pirinixic acid 52.5019483382
MESH:D001778 Blood Coagulation Disorders Propylthiouracil 52.5019483382
MESH:D001778 Blood Coagulation Disorders Thioacetamide 52.5019483382
MESH:D006528 Carcinoma, Hepatocellular 2,6-dinitrotoluene 6.7216705839
MESH:D006528 Carcinoma, Hepatocellular Acetaminophen 6.723084413
MESH:D006528 Carcinoma, Hepatocellular Benzbromarone 6.721701930
MESH:D006528 Carcinoma, Hepatocellular Thioacetamide 6.7217997003
MESH:D002311 Cardiomyopathy, Dilated Amiodarone 2.9219225199 15710769
MESH:D002341 Carotid Artery Thrombosis Amiodarone 5.2018974383
MESH:D002386 Cataract Acetaminophen 2.6310977129
MESH:D002471 Cell Transformation, Neoplastic 2,6-dinitrotoluene 11.576135515
MESH:D002471 Cell Transformation, Neoplastic Clofibrate 11.571399818
MESH:D002471 Cell Transformation, Neoplastic Cyclosporine 11.5712371664
MESH:D002637 Chest Pain Omeprazole 5.2415447763
MESH:D018281 Cholangiocarcinoma Thioacetamide 4.3618291259
MESH:D002779 Cholestasis Cyclosporine 7.9619486331
MESH:D002779 Cholestasis pirinixic acid 7.9619176532
MESH:D019457 Chromosome Breakage Sodium Selenite 4.8615894690
MESH:D003490 Cyanosis 2,6-dinitrotoluene 4.1218551238
MESH:D003876 Dermatitis, Atopic pirinixic acid 2.4618249437
MESH:D003920 Diabetes Mellitus Sodium Selenite 3.8516285004
MESH:D056486 Drug-Induced Liver Injury 2,6-dinitrotoluene 12.2821346803 18551238
MESH:D056486 Drug-Induced Liver Injury Acetaminophen 12.2819370779 14725611 12705907 18071297 10663392 10915739 16485898 11421492 12594235 16081117 19164858 17522070 11529661 11461765 11743745 17906064 11739529 11834606 12392966 16109766 16393943 16177239 12153990 16781746 18713872 16227642 12540782 15968718 19923254 19420014 2444490 19416960 17562736 19739265 14550746 14986274 15619225 12958197 10774834 11287661 19085960
MESH:D056486 Drug-Induced Liver Injury Amiodarone 12.2818218290 15265979
MESH:D056486 Drug-Induced Liver Injury Sodium Selenite 12.2815131321
MESH:D056486 Drug-Induced Liver Injury Thioacetamide 12.2812963478
MESH:D056487 Drug-Induced Liver Injury, Chronic Acetaminophen 4.2319426721
MESH:D004381 Duodenal Ulcer Omeprazole 4.4217151854 16613094 15991576 21218061
MESH:D050171 Dyslipidemias Clofibrate 4.1216707586
MESH:D004487 Edema pirinixic acid 2.5612083418
MESH:D005218 Fat Necrosis Thioacetamide 5.8516456712
MESH:D005234 Fatty Liver Amiodarone 19.5014986274
MESH:D005234 Fatty Liver Clofibrate 19.5019224547
MESH:D005234 Fatty Liver Cyclosporine 19.5019224547
MESH:D005234 Fatty Liver pirinixic acid 19.5019236843 20131406
MESH:D005355 Fibrosis Cyclosporine 3.2412639820 12168785
MESH:D005756 Gastritis Acetaminophen 3.8116983495
MESH:D005885 Gingival Hyperplasia Cyclosporine 4.348708960
MESH:D006333 Heart Failure pirinixic acid 2.5820558911
MESH:D006457 Hemoglobinuria, Paroxysmal Cyclosporine 4.5415720958
MESH:D006501 Hepatic Encephalopathy Thioacetamide 4.6518665440 17276928 15929193
MESH:D006505 Hepatitis Thioacetamide 4.3116456712
MESH:D006529 Hepatomegaly Amiodarone 8.9315265979
MESH:D006529 Hepatomegaly pirinixic acid 8.9319772884 18467677 19176532 16221962
MESH:D006930 Hyperalgesia Acetaminophen 2.7616870215
MESH:D006937 Hypercholesterolemia Amiodarone 3.958137927 9751232
MESH:D006943 Hyperglycemia pirinixic acid 3.2620558911
MESH:D006973 Hypertension Cyclosporine 2.1210903974
MESH:D007037 Hypothyroidism Amiodarone 11.9618020914 17991464
MESH:D007037 Hypothyroidism Propylthiouracil 11.968137927 18031379
MESH:D007333 Insulin Resistance pirinixic acid 7.4816306350
MESH:D007333 Insulin Resistance Sodium Selenite 7.4814714311
MESH:D007638 Keratoconjunctivitis Sicca Cyclosporine 4.5815604871
MESH:D007674 Kidney Diseases Acetaminophen 5.9412587719 15629191
MESH:D007674 Kidney Diseases Cyclosporine 5.9418776723 10903974 8314463
MESH:D007680 Kidney Neoplasms 2,6-dinitrotoluene 7.5016705839
MESH:D007680 Kidney Neoplasms Cyclosporine 7.5012371664
MESH:D016773 Leishmaniasis, Cutaneous Omeprazole 4.1619248655
MESH:D008064 Lipidoses Amiodarone 3.5715342952 17567588
MESH:D008106 Liver Cirrhosis, Experimental pirinixic acid 2.5715474484
MESH:D008106 Liver Cirrhosis, Experimental Thioacetamide 2.5715288472 17127702 16343077 18615449 18295389 11682029 17292413 16489207 15095483 15288473 17629604 16511523 11172339 18606216 18032466 11481614 15078482 12175628 15316131 14739098 18031379 18263696 18458672 12531686 15474484 18416461 16248980 15334695 17355460 18395095 18380797 16098781 15716488 12557150 15158331 15075984 10677585 12085344 16126171 15465738 17050028 12891558 16097051 12679928 15362042
MESH:D008107 Liver Diseases Acetaminophen 4.1916610002 19784758 12587719 12969438 11587558 19460945 16611625 19014921
MESH:D008107 Liver Diseases Thioacetamide 4.1918374380 16337175 15158337
MESH:D017114 Liver Failure, Acute Acetaminophen 9.8917185352 16871587
MESH:D017114 Liver Failure, Acute Thioacetamide 9.8917276928 15313186 12479984 15633222
MESH:D008113 Liver Neoplasms 2,6-dinitrotoluene 4.507678174
MESH:D008113 Liver Neoplasms pirinixic acid 4.5015890375 20007298 16377806
MESH:D008114 Liver Neoplasms, Experimental 2,6-dinitrotoluene 2.592876786 2876784 6135515
MESH:D008133 Long QT Syndrome Amiodarone 3.6417391786 15350150 11989578
MESH:D008171 Lung Diseases Amiodarone 3.4312587719
MESH:D017563 Lung Diseases, Interstitial Amiodarone 4.6118516814
MESH:D016393 Lymphoma, B-Cell Sodium Selenite 4.1514737004
MESH:D008546 Melanoma, Experimental Acetaminophen 3.6719513568
MESH:D008664 Metal Metabolism, Inborn Errors Cyclosporine 4.9216801185
MESH:D009135 Muscular Diseases pirinixic acid 3.6116239165
MESH:D009181 Mycoses Amiodarone 5.0417974566 12754197
MESH:D009203 Myocardial Infarction pirinixic acid 2.1719151258
MESH:D015428 Myocardial Reperfusion Injury pirinixic acid 3.0116411023
MESH:D009336 Necrosis 2,6-dinitrotoluene 3.9818551238 7678174
MESH:D009369 Neoplasms pirinixic acid 1.9817405874
MESH:D009402 Nephrosis, Lipoid Cyclosporine 4.5817954296
MESH:D009404 Nephrotic Syndrome Cyclosporine 3.3619348381 18481113
MESH:D019636 Neurodegenerative Diseases Acetaminophen 2.9418514411
MESH:D052556 Niemann-Pick Disease, Type C Clofibrate 5.049802331
MESH:D009765 Obesity pirinixic acid 1.8320558911
MESH:D009784 Occupational Diseases 2,6-dinitrotoluene 3.5116049721
MESH:D010146 Pain Acetaminophen 2.4616870215
MESH:D011230 Precancerous Conditions Cyclosporine 3.2912371664
MESH:D011471 Prostatic Neoplasms Sodium Selenite 3.3818760546
MESH:D011565 Psoriasis Cyclosporine 2.2516882103
MESH:D011658 Pulmonary Fibrosis Amiodarone 2.8811597910 12832656 12490602
MESH:D015427 Reperfusion Injury pirinixic acid 2.4219058328
MESH:D012640 Seizures 2,6-dinitrotoluene 2.5918551238
OMIM:609620 SHORT QT SYNDROME 1 Amiodarone 5.2018724381
MESH:D013272 Stomach Diseases Omeprazole 4.7318545984
MESH:D013276 Stomach Ulcer Amiodarone 7.8518087811
MESH:D013276 Stomach Ulcer Omeprazole 7.8510750652 17977527 18237397 15991576 11906479 16755016
MESH:D013610 Tachycardia Amiodarone 4.3811238279
MESH:D017180 Tachycardia, Ventricular Amiodarone 4.2819225199
MESH:D013959 Thyroid Diseases Amiodarone 4.8919731979
MESH:D013964 Thyroid Neoplasms Propylthiouracil 3.7415710170
MESH:D013971 Thyrotoxicosis Amiodarone 4.9618020914 19584973
MESH:D016171 Torsades de Pointes Amiodarone 4.3117467628 11989578
MESH:D001749 Urinary Bladder Neoplasms 2,6-dinitrotoluene 2.3216049721
MESH:D014571 Urologic Neoplasms 2,6-dinitrotoluene 4.4310091137
MESH:D014581 Urticaria Acetaminophen 3.0610982225
MESH:D014605 Uveitis Cyclosporine 4.121336536
MESH:D014985 Xerophthalmia Cyclosporine 4.5817120751
Pathway ID Pathway Name
KEGG:00340 Histidine metabolism
KEGG:00350 Tyrosine metabolism
Pharmacogenomics Knowledge Base Top
Drug Bank Top
Drugbank ID Action Drug Name Description
DB00149 - Hi-Test Muscle Octane BCAA's (Anabol Naturals) Dietary supplement;Micronutrient;Essential Amino Acids
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Syndromic Genes

Non-syndromic Genes

AutismKB Statistics

  • Studies: 1,036
  • Genes: 1,379
  • CNVs/SVs: 5,420
  • SNVs/Indels: 11,669
  • de novo Mutations: 5,669
  • Mosaics: 789
  • Linkage Regions: 172
  • Paper Collected: 6/30/2018
  • Last Update: 8/26/2018


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