AutismKB 2.0

Annotation Detail for GULP1


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Basic Information Top
Gene Symbol:GULP1 ( CED-6,CED6,FLJ31156,GULP )
Gene Full Name: GULP, engulfment adaptor PTB domain containing 1
Band: 2q32.1-q32.2
Quick LinksEntrez ID:51454; OMIM: 608165; Uniprot ID:GULP1_HUMAN; ENSEMBL ID: ENSG00000144366; HGNC ID: 18649
Relate to Another Database: SFARIGene; denovo-db
Related Pathway Information Top
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Pathway IDPathway Name
200060Arf6 signaling events
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Related Diseases/Disorders Top
Comparative Toxicogenomics Database Top
Chemical ID Chemical Name Interaction Interaction Action Publication
C548651 2-(1'H-indolo-3'-carbonyl)thiazole-4-carboxylic acid methyl ester 2-(1'H-indolo-3'-carbonyl)thiazole-4-carboxylic acid methyl ester results in increased expression of GULP1 mRNAincreases expression 19933214
D000111 Acetylcysteine Acetylcysteine results in decreased expression of GULP1 mRNAdecreases expression 16084531
D016604 Aflatoxin B1 Aflatoxin B1 affects the expression of GULP1 proteinaffects expression 20106945
D001564 Benzo(a)pyrene Benzo(a)pyrene results in decreased expression of GULP1 mRNAdecreases expression 20713471
D015123 7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide 7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide results in decreased expression of GULP1 mRNAdecreases expression 20018196
D020122 tert-Butylhydroperoxide tert-Butylhydroperoxide results in decreased expression of GULP1 mRNAdecreases expression 15336504
D002251 Carbon Tetrachloride Carbon Tetrachloride affects the expression of GULP1 mRNAaffects expression 17484886
D016572 Cyclosporine Cyclosporine results in increased expression of GULP1 mRNAincreases expression 20106945
D004317 Doxorubicin Doxorubicin results in decreased expression of GULP1 mRNAdecreases expression 16001973
C045651 epigallocatechin gallate epigallocatechin gallate results in decreased expression of GULP1 mRNAdecreases expression 16084531
C006253 pirinixic acid [pirinixic acid binds to and results in increased activity of PPARA protein] which results in decreased expression of GULP1 mRNAaffects binding|decreases expression|increases activity 19710929
D012643 Selenium Selenium results in decreased expression of GULP1 mRNAdecreases expression 19244175
D018038 Sodium Selenite Sodium Selenite results in decreased expression of GULP1 mRNAdecreases expression 18175754
D013749 Tetrachlorodibenzodioxin Tetrachlorodibenzodioxin results in increased expression of GULP1 mRNAincreases expression 19933214
Disease ID Disease Name Direct Evidence Inference Chemical Name Inference Score Publication
MESH:D000014 Abnormalities, Drug-Induced Tetrachlorodibenzodioxin 2.9315322242 11752688 14514962
MESH:D055371 Acute Lung Injury pirinixic acid 3.1718653653
MESH:D000230 Adenocarcinoma Benzo(a)pyrene 4.5020127859 20464547
MESH:D000230 Adenocarcinoma Doxorubicin 4.5017418594
MESH:D000236 Adenoma Benzo(a)pyrene 2.686695378
MESH:D018248 Adenoma, Liver Cell pirinixic acid 10.1816434500
MESH:D018248 Adenoma, Liver Cell Tetrachlorodibenzodioxin 10.1816835633
MESH:D000419 Albuminuria Doxorubicin 4.6121441931
MESH:D000740 Anemia Tetrachlorodibenzodioxin 3.0011748828
MESH:D017544 Aortic Aneurysm, Abdominal Benzo(a)pyrene 4.1519183758
MESH:D001249 Asthma epigallocatechin gallate 3.4016516891
MESH:D001327 Autoimmune Diseases epigallocatechin gallate 5.1419761891
MESH:D001778 Blood Coagulation Disorders pirinixic acid 8.9519483382
MESH:D001778 Blood Coagulation Disorders Tetrachlorodibenzodioxin 8.9512125929
MESH:D001836 Body Weight Changes Tetrachlorodibenzodioxin 3.8915340226
MESH:D001848 Bone Diseases, Developmental Tetrachlorodibenzodioxin 2.8015746008
MESH:D019046 Bone Marrow Neoplasms Doxorubicin 4.8014601052
MESH:D001932 Brain Neoplasms Doxorubicin 3.8617150277
MESH:D001943 Breast Neoplasms Benzo(a)pyrene 1.8517474063 20146248
MESH:D001943 Breast Neoplasms Doxorubicin 1.8516115903 18695136 17369602 16096432 15692762 18628466 16595493 16264153 15993339 19526202 18234424 15136595 17983394 15939500 16826403 15567936 16935488 18382427 15634643 17426702 15668708 11325840 16322301 15994142
MESH:D001943 Breast Neoplasms Tetrachlorodibenzodioxin 1.8520435547
MESH:D002252 Carbon Tetrachloride Poisoning Carbon Tetrachloride 3.8510355542 15721981 16124888 15700767 3786805 16227642 16050911 15673190 16192424 18705752 16097048 16011737
MESH:D002276 Carcinoid Tumor Doxorubicin 4.9116051944
MESH:D002277 Carcinoma Tetrachlorodibenzodioxin 2.8416835633
MESH:D006528 Carcinoma, Hepatocellular Aflatoxin B1 4.7012907637 21507988 12619106
MESH:D006528 Carcinoma, Hepatocellular Carbon Tetrachloride 4.7018788625
MESH:D006528 Carcinoma, Hepatocellular Doxorubicin 4.7017876044 18059187 16234567 16023760
MESH:D002292 Carcinoma, Renal Cell Doxorubicin 3.1816201981 1485588
MESH:D002294 Carcinoma, Squamous Cell Acetylcysteine 7.7617015178
MESH:D002294 Carcinoma, Squamous Cell Benzo(a)pyrene 7.7620419170
MESH:D002294 Carcinoma, Squamous Cell Doxorubicin 7.766189445
MESH:D006332 Cardiomegaly Tetrachlorodibenzodioxin 2.3918850075 18670907 16120746
MESH:D009202 Cardiomyopathies Doxorubicin 3.5616242529 17519947 17928571 18627295 16612575 16109756 16952015 17308081 17974986 15505089 15792986 16651473 16455267 16731534 15811867 16269455 16278810 17329180 17007740 17351982 17924179 15476868 17382496 16364871 17131338
MESH:D002311 Cardiomyopathy, Dilated Doxorubicin 2.9617334414 16243910
MESH:D002471 Cell Transformation, Neoplastic 7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide 11.5020889678
MESH:D002471 Cell Transformation, Neoplastic Acetylcysteine 11.5018226522
MESH:D002471 Cell Transformation, Neoplastic Cyclosporine 11.5012371664
MESH:D018281 Cholangiocarcinoma Tetrachlorodibenzodioxin 3.2116835633
MESH:D002779 Cholestasis Cyclosporine 7.8919486331
MESH:D002779 Cholestasis pirinixic acid 7.8919176532
MESH:D019457 Chromosome Breakage Sodium Selenite 4.8215894690
MESH:D002972 Cleft Palate Tetrachlorodibenzodioxin 2.1212621046 8697196 15668235 15340226 16354765
MESH:D003092 Colitis Selenium 3.8517936198
MESH:D015179 Colorectal Neoplasms Doxorubicin 2.1418802399 18259882
MESH:D000013 Congenital Abnormalities Tetrachlorodibenzodioxin 3.1117141729 14669216
MESH:D019465 Craniofacial Abnormalities Tetrachlorodibenzodioxin 1.2615322242 10048152 20055451
MESH:D003550 Cystic Fibrosis Acetylcysteine 4.4219747007
MESH:D003876 Dermatitis, Atopic pirinixic acid 2.4518249437
MESH:D003920 Diabetes Mellitus Sodium Selenite 3.8216285004
MESH:D003924 Diabetes Mellitus, Type 2 epigallocatechin gallate 4.6616988119
MESH:D003924 Diabetes Mellitus, Type 2 Tetrachlorodibenzodioxin 4.6617107852
MESH:D056486 Drug-Induced Liver Injury Acetylcysteine 15.4911287661
MESH:D056486 Drug-Induced Liver Injury Carbon Tetrachloride 15.493732212 17522070 7179309 16227642 11566570 7440962 19336974 15968718 3786805 2869522 10092053 9327722 6884620 19085960 7120509 16177239 15027814 4309450 6623471 21278145 15998439 10915739
MESH:D056486 Drug-Induced Liver Injury Doxorubicin 15.4917416283
MESH:D056486 Drug-Induced Liver Injury Selenium 15.4915131321
MESH:D056486 Drug-Induced Liver Injury Sodium Selenite 15.4915131321
MESH:D056486 Drug-Induced Liver Injury Tetrachlorodibenzodioxin 15.4920420201
MESH:D004362 Drug Toxicity Doxorubicin 8.2418602426
MESH:D004362 Drug Toxicity Tetrachlorodibenzodioxin 8.2411462148
MESH:D004487 Edema pirinixic acid 6.7212083418
MESH:D004487 Edema Tetrachlorodibenzodioxin 6.7212711302 11000095
MESH:D004489 Edema, Cardiac Tetrachlorodibenzodioxin 4.0015322242 16714409 18230668
MESH:D016889 Endometrial Neoplasms Doxorubicin 3.4817359293
MESH:D004715 Endometriosis Tetrachlorodibenzodioxin 3.079294722 10568697
MESH:D004719 Endomyocardial Fibrosis Doxorubicin 5.2518037988
MESH:D004938 Esophageal Neoplasms 7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide 4.3920426865
MESH:D004938 Esophageal Neoplasms Benzo(a)pyrene 4.3916530937
MESH:D005124 Eye Abnormalities Tetrachlorodibenzodioxin 3.0511564622
MESH:D005234 Fatty Liver Carbon Tetrachloride 13.3715959796 16239168 12631006 16045604 12795759 19224547 61145 17595544
MESH:D005234 Fatty Liver Cyclosporine 13.3719224547
MESH:D005234 Fatty Liver pirinixic acid 13.3719236843 20131406
MESH:D005313 Fetal Death Tetrachlorodibenzodioxin 3.5311858732
MESH:D018222 Fibromatosis, Aggressive Doxorubicin 4.6719069698
MESH:D005355 Fibrosis Carbon Tetrachloride 15.1518705752
MESH:D005355 Fibrosis Cyclosporine 15.1512639820 12168785
MESH:D005355 Fibrosis Tetrachlorodibenzodioxin 15.1520067830
MESH:D005885 Gingival Hyperplasia Cyclosporine 4.308708960
MESH:D005909 Glioblastoma Doxorubicin 3.3817150277
MESH:D006058 Gonadal Disorders Tetrachlorodibenzodioxin 4.6910696789
MESH:D006258 Head and Neck Neoplasms Doxorubicin 3.5615692506
MESH:D006330 Heart Defects, Congenital Benzo(a)pyrene 6.5420471113
MESH:D006330 Heart Defects, Congenital Tetrachlorodibenzodioxin 6.5410048152 11294989
MESH:D006331 Heart Diseases Doxorubicin 3.5216330681 16244372 12587719 16495754 16144979 17875725 18674790 18006777 16244371 16879835 17888722 14766674 16707910
MESH:D006333 Heart Failure Doxorubicin 12.0017481944
MESH:D006333 Heart Failure pirinixic acid 12.0020558911
MESH:D006333 Heart Failure Selenium 12.0017162251
MESH:D006394 Hemangiosarcoma Doxorubicin 3.9515692506
MESH:D006457 Hemoglobinuria, Paroxysmal Cyclosporine 4.5015720958
MESH:D006470 Hemorrhage Tetrachlorodibenzodioxin 3.3911000095
MESH:D006505 Hepatitis Carbon Tetrachloride 3.6619110552 19900420
MESH:D006529 Hepatomegaly pirinixic acid 8.5016221962 19176532 19772884 18467677
MESH:D006529 Hepatomegaly Tetrachlorodibenzodioxin 8.5015340226 12621046 16120746
MESH:D006689 Hodgkin Disease Doxorubicin 3.4518501091 17606976 15147373
MESH:D006869 Hydronephrosis Tetrachlorodibenzodioxin 4.148697196 15340226 16959395 18606429 16354765
MESH:D006932 Hyperbilirubinemia Carbon Tetrachloride 4.6116899240
MESH:D006943 Hyperglycemia pirinixic acid 3.2320558911
MESH:D006973 Hypertension Cyclosporine 5.0110903974
MESH:D006973 Hypertension Tetrachlorodibenzodioxin 5.0118670907 18850075
MESH:D006975 Hypertension, Portal Carbon Tetrachloride 4.1615338365
MESH:D007249 Inflammation Tetrachlorodibenzodioxin 1.8812200463 12878042
MESH:D007251 Influenza, Human Selenium 4.2916624496
MESH:D007333 Insulin Resistance pirinixic acid 7.4216306350
MESH:D007333 Insulin Resistance Sodium Selenite 7.4214714311
MESH:D007569 Jaw Abnormalities Tetrachlorodibenzodioxin 3.3916580747
MESH:D007638 Keratoconjunctivitis Sicca Cyclosporine 4.5415604871
MESH:D007674 Kidney Diseases Cyclosporine 6.218314463 10903974 18776723
MESH:D007674 Kidney Diseases Doxorubicin 6.2116775033 15369732 15699352
MESH:D007676 Kidney Failure, Chronic Doxorubicin 10.1716707910
MESH:D007676 Kidney Failure, Chronic Selenium 10.1716518626
MESH:D007680 Kidney Neoplasms Cyclosporine 2.7812371664
MESH:D004915 Leukemia, Erythroblastic, Acute Doxorubicin 5.2516085563
MESH:D008103 Liver Cirrhosis Carbon Tetrachloride 2.8311408273 16943688 17157831 11903743 17174718 16239168 16221502 21278145 17334410
MESH:D008106 Liver Cirrhosis, Experimental Carbon Tetrachloride 6.8218395095 17698563 14724832 12649538 14716833 17805973 18705752 18210741 11481614 17557913 16136751 12898905 16033810 17721639 16097048 15730626 14748882 17823541 18420326 18472094 17900296 18472332 20821823 17708605 12609069 12389079 15057751 12546737 17944888 17481882 18263696 18395914 15052691 16015684 17640975 18251166 17565644 17869086 17631135 15338365 12632512 14512876 16192424 14620537 17525996 15931870 17766677 14716496 15123356 18376398 16027843 15673190 15362042 15818738 18339082 17922224 18156304 17761835 12445421 18054572 18187930 10355542 16011737 18006644 15650968 12445418 15893842 12666154 12586293 15370692 12667390 16248980 12741479 16638106 18481824 18277467 18429990 18279442 13678700 17714472 18166357 15925388 15959796 18412020 18205269 12632514 15876570 17976157 18418968 16116963 15996030 12958196 18317297
MESH:D008106 Liver Cirrhosis, Experimental Doxorubicin 6.8216439617 16595196
MESH:D008106 Liver Cirrhosis, Experimental epigallocatechin gallate 6.8217481882
MESH:D008106 Liver Cirrhosis, Experimental pirinixic acid 6.8215474484
MESH:D008106 Liver Cirrhosis, Experimental Tetrachlorodibenzodioxin 6.8212878042
MESH:D008107 Liver Diseases Carbon Tetrachloride 2.0917285989 15830285 16964402 16246199 15720792
MESH:D017093 Liver Failure Carbon Tetrachloride 4.2415123358
MESH:D017114 Liver Failure, Acute Carbon Tetrachloride 3.7416899240 14706259
MESH:D008113 Liver Neoplasms Aflatoxin B1 14.442125692 15890375 9163691 18177683
MESH:D008113 Liver Neoplasms Benzo(a)pyrene 14.4421137059 20195826
MESH:D008113 Liver Neoplasms Carbon Tetrachloride 14.4419294768
MESH:D008113 Liver Neoplasms pirinixic acid 14.4416377806 20007298 15890375
MESH:D008113 Liver Neoplasms Tetrachlorodibenzodioxin 14.4416984957
MESH:D008114 Liver Neoplasms, Experimental Aflatoxin B1 14.418603461
MESH:D008114 Liver Neoplasms, Experimental Carbon Tetrachloride 14.4112014681 15583823
MESH:D008114 Liver Neoplasms, Experimental Doxorubicin 14.4117085340 16842330
MESH:D008114 Liver Neoplasms, Experimental Tetrachlorodibenzodioxin 14.4112151625
MESH:D008171 Lung Diseases Acetylcysteine 4.0912815614
MESH:D008175 Lung Neoplasms Aflatoxin B1 4.8914755239
MESH:D008175 Lung Neoplasms Benzo(a)pyrene 4.8918816296 17053015 18569708 6695378 18520028 20064080 20464547 20135361 20869020
MESH:D008175 Lung Neoplasms Doxorubicin 4.8917418594 6189445
MESH:D008175 Lung Neoplasms Tetrachlorodibenzodioxin 4.8911884234 19555203
MESH:D008223 Lymphoma Doxorubicin 3.5016098063
MESH:D016393 Lymphoma, B-Cell Sodium Selenite 4.1214737004
MESH:D008228 Lymphoma, Non-Hodgkin Doxorubicin 3.8317654614
MESH:D016399 Lymphoma, T-Cell Doxorubicin 4.6415621674
MESH:D008325 Mammary Neoplasms, Experimental Doxorubicin 6.3115458769
MESH:D008325 Mammary Neoplasms, Experimental Selenium 6.3115318939
MESH:D008545 Melanoma Doxorubicin 3.8516827129
MESH:D008545 Melanoma epigallocatechin gallate 3.8511746506 17992120
MESH:D008654 Mesothelioma Doxorubicin 6.3517638057
MESH:D008654 Mesothelioma Selenium 6.3515107826
MESH:D008664 Metal Metabolism, Inborn Errors Cyclosporine 4.8816801185
MESH:D028361 Mitochondrial Diseases Doxorubicin 4.5515792986
MESH:D009062 Mouth Neoplasms Benzo(a)pyrene 3.2316381670
MESH:D052016 Mucositis Doxorubicin 4.8717415656
MESH:D009134 Muscular Atrophy, Spinal epigallocatechin gallate 5.5717962980
MESH:D009135 Muscular Diseases pirinixic acid 3.5816239165
MESH:D009203 Myocardial Infarction Doxorubicin 5.7819429709 15857846
MESH:D009203 Myocardial Infarction pirinixic acid 5.7819151258
MESH:D017202 Myocardial Ischemia Tetrachlorodibenzodioxin 3.0612213967
MESH:D015428 Myocardial Reperfusion Injury pirinixic acid 2.9916411023
MESH:D009362 Neoplasm Metastasis Acetylcysteine 6.3214720322
MESH:D009362 Neoplasm Metastasis Doxorubicin 6.3218259882
MESH:D009369 Neoplasms Benzo(a)pyrene 4.9011141357
MESH:D009369 Neoplasms pirinixic acid 4.9017405874
MESH:D009401 Nephrosis Doxorubicin 4.8416899518 16636307
MESH:D009402 Nephrosis, Lipoid Cyclosporine 4.5417954296
MESH:D009404 Nephrotic Syndrome Cyclosporine 9.4619348381 18481113
MESH:D009404 Nephrotic Syndrome Doxorubicin 9.4615640375 16889571
MESH:D009421 Nervous System Malformations Tetrachlorodibenzodioxin 3.2814600291
MESH:D009436 Neural Tube Defects Acetylcysteine 4.0619446573
MESH:D009447 Neuroblastoma Doxorubicin 3.2915555623
MESH:D009765 Obesity pirinixic acid 1.8220558911
MESH:D012516 Osteosarcoma Doxorubicin 4.1615930896
MESH:D010382 Peliosis Hepatis Tetrachlorodibenzodioxin 4.3512520081
MESH:D003557 Phyllodes Tumor Doxorubicin 5.2517983394
MESH:D010954 Plasmacytoma Selenium 4.9915087411
MESH:D010997 Pleural Neoplasms Doxorubicin 5.2517638057
MESH:D017119 Porphyria Cutanea Tarda Tetrachlorodibenzodioxin 3.6218163543
MESH:D011230 Precancerous Conditions Cyclosporine 3.2712371664
MESH:D011297 Prenatal Exposure Delayed Effects Tetrachlorodibenzodioxin 3.2711896295 11118676 11399792 11222880
MESH:D011471 Prostatic Neoplasms Benzo(a)pyrene 2.5917292933
MESH:D011471 Prostatic Neoplasms Doxorubicin 2.5915897917 16888761 18437689 15749863 16729912 16868541
MESH:D011471 Prostatic Neoplasms Sodium Selenite 2.5918760546
MESH:D011565 Psoriasis Cyclosporine 2.2416882103
MESH:D051437 Renal Insufficiency Doxorubicin 4.2917922066
MESH:D015427 Reperfusion Injury pirinixic acid 2.4119058328
MESH:D012128 Respiratory Distress Syndrome, Adult Acetylcysteine 4.5812210543
MESH:D015619 Respiratory System Abnormalities Tetrachlorodibenzodioxin 3.9018990726
MESH:D012509 Sarcoma Doxorubicin 4.0418313854 16767912 17710206 15625365 17203757 15675481
MESH:D012512 Sarcoma, Ewing's Doxorubicin 4.3114601052 16326096
MESH:D012514 Sarcoma, Kaposi Doxorubicin 4.8717846226
MESH:D012878 Skin Neoplasms Benzo(a)pyrene 13.7719755658 10029692
MESH:D012878 Skin Neoplasms Doxorubicin 13.7715692506
MESH:D012878 Skin Neoplasms tert-Butylhydroperoxide 13.778532709
MESH:D012878 Skin Neoplasms Tetrachlorodibenzodioxin 13.7716192470
MESH:D012983 Soft Tissue Neoplasms Doxorubicin 4.6415625365 17203757 16767912
MESH:D013274 Stomach Neoplasms Benzo(a)pyrene 1.5620155912 2093021
MESH:D013276 Stomach Ulcer Acetylcysteine 4.0517918041
MESH:D013959 Thyroid Diseases Tetrachlorodibenzodioxin 4.0012697716
MESH:D013964 Thyroid Neoplasms Doxorubicin 3.4117909728 16010429
MESH:D001749 Urinary Bladder Neoplasms Benzo(a)pyrene 5.2117053015
MESH:D001749 Urinary Bladder Neoplasms Doxorubicin 5.2117653716
MESH:D014605 Uveitis Cyclosporine 4.081336536
MESH:D054079 Vascular Malformations Tetrachlorodibenzodioxin 4.6912125929
MESH:D018487 Ventricular Dysfunction, Left Doxorubicin 4.2917678736 17334414 17638931 16364871
MESH:D019282 Wasting Syndrome Tetrachlorodibenzodioxin 4.3515886252
MESH:D014985 Xerophthalmia Cyclosporine 4.5417120751
No data
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Syndromic Genes

Non-syndromic Genes

AutismKB Statistics

  • Studies: 1,036
  • Genes: 1,379
  • CNVs/SVs: 5,420
  • SNVs/Indels: 11,669
  • de novo Mutations: 5,669
  • Mosaics: 789
  • Linkage Regions: 172
  • Paper Collected: 6/30/2018
  • Last Update: 8/26/2018


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