AutismKB 2.0

Annotation Detail for RHCG


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Basic Information Top
Gene Symbol:RHCG ( C15orf6,PDRC2,RHGK,SLC42A3 )
Gene Full Name: Rh family, C glycoprotein
Band: 15q26.1
Quick LinksEntrez ID:51458; OMIM: 605381; Uniprot ID:RHCG_HUMAN; ENSEMBL ID: ENSG00000140519; HGNC ID: 18140
Relate to Another Database: SFARIGene; denovo-db
Related Pathway Information Top
No data
No data
Pathway IDPathway Name
Amine compound SLC transporters
Transmembrane transport of small molecules
No data
No data
Pathway IDPathway Name
500358Rhesus glycoproteins mediate ammonium transport.
Related Diseases/Disorders Top
Comparative Toxicogenomics Database Top
Chemical ID Chemical Name Interaction Interaction Action Publication
D000641 Ammonia RHCG protein affects the metabolism of Ammoniaaffects metabolic processing 16928804
D000641 Ammonia RHCG protein affects the secretion of Ammoniaaffects secretion 16928804
D000641 Ammonia RHCG protein affects the metabolism of Ammoniaaffects metabolic processing 20462967
D000641 Ammonia RHCG protein affects the reaction [Hydrochloric Acid results in increased secretion of Ammonia]affects reaction|increases secretion 20462967
D000641 Ammonia RHCG protein affects the secretion of Ammoniaaffects secretion 20462967
D000641 Ammonia RHCG protein results in increased secretion of Ammoniaincreases secretion 19321595
D000641 Ammonia [Hydrochloric Acid results in increased expression of RHCG protein] which results in increased secretion of Ammoniaincreases expression|increases secretion 16144966
D016572 Cyclosporine Cyclosporine results in decreased expression of RHCG proteindecreases expression 18776723
D004317 Doxorubicin Doxorubicin results in increased expression of RHCG mRNAincreases expression 16404146
D004997 Ethinyl Estradiol [Tetrachlorodibenzodioxin co-treated with Ethinyl Estradiol] results in increased expression of RHCG mRNAaffects cotreatment|increases expression 17942748
D006851 Hydrochloric Acid Hydrochloric Acid results in increased expression of RHCG proteinincreases expression 20462967
D006851 Hydrochloric Acid RHCG protein affects the reaction [Hydrochloric Acid results in increased secretion of Ammonia]affects reaction|increases secretion 20462967
D006851 Hydrochloric Acid RHCG protein affects the susceptibility to Hydrochloric Acidaffects response to substance 19321595
D006851 Hydrochloric Acid Hydrochloric Acid results in increased expression of RHCG proteinincreases expression 16144966
D006851 Hydrochloric Acid [Hydrochloric Acid results in increased expression of RHCG protein] which results in increased secretion of Ammoniaincreases expression|increases secretion 16144966
D013749 Tetrachlorodibenzodioxin [Tetrachlorodibenzodioxin co-treated with Ethinyl Estradiol] results in increased expression of RHCG mRNAaffects cotreatment|increases expression 17942748
Disease ID Disease Name Direct Evidence Inference Chemical Name Inference Score Publication
MESH:D000014 Abnormalities, Drug-Induced Tetrachlorodibenzodioxin 3.3111752688 14514962 15322242
MESH:D000138 Acidosis Hydrochloric Acid 5.6620872349 16144966 19262391 15920416 12771618 11574821
MESH:D000141 Acidosis, Renal Tubular Hydrochloric Acid 6.1917183249
MESH:D000142 Acidosis, Respiratory Hydrochloric Acid 6.3320597076
MESH:D000152 Acne Vulgaris Ethinyl Estradiol 4.4617505938
MESH:D055371 Acute Lung Injury Hydrochloric Acid 5.1311953099 19760209 15970105 16759491 19094174 11850527 19060228
MESH:D000230 Adenocarcinoma Doxorubicin 4.6117418594
MESH:D000230 Adenocarcinoma Ethinyl Estradiol 4.6114692618
MESH:D018248 Adenoma, Liver Cell Tetrachlorodibenzodioxin 3.8416835633
MESH:D000419 Albuminuria Doxorubicin 4.9321441931
MESH:D000740 Anemia Tetrachlorodibenzodioxin 3.2511748828
MESH:D000860 Anoxia Hydrochloric Acid 5.7715090967
MESH:D001161 Arteriosclerosis Ethinyl Estradiol 3.8811256880
MESH:D001169 Arthritis, Experimental Ethinyl Estradiol 2.8415885639
MESH:D001778 Blood Coagulation Disorders Hydrochloric Acid 10.4915920416
MESH:D001778 Blood Coagulation Disorders Tetrachlorodibenzodioxin 10.4912125929
MESH:D001836 Body Weight Changes Tetrachlorodibenzodioxin 4.3115340226
MESH:D001848 Bone Diseases, Developmental Tetrachlorodibenzodioxin 2.9515746008
MESH:D019046 Bone Marrow Neoplasms Doxorubicin 5.2214601052
MESH:D001929 Brain Edema Ammonia 6.7920217200 11481608 19393034
MESH:D001932 Brain Neoplasms Doxorubicin 4.1117150277
MESH:D001943 Breast Neoplasms Doxorubicin 2.0817983394 18382427 15939500 11325840 15136595 15567936 18628466 16595493 18234424 16322301 16096432 15993339 16264153 15634643 18695136 17426702 19526202 16935488 15994142 15668708 16115903 16826403 17369602 15692762
MESH:D001943 Breast Neoplasms Tetrachlorodibenzodioxin 2.0820435547
MESH:D016535 Bronchial Hyperreactivity Hydrochloric Acid 4.8412378975
MESH:D001986 Bronchial Spasm Hydrochloric Acid 5.9915578804
MESH:D002276 Carcinoid Tumor Doxorubicin 5.3316051944
MESH:D002277 Carcinoma Tetrachlorodibenzodioxin 3.0516835633
MESH:D006528 Carcinoma, Hepatocellular Doxorubicin 2.2616023760 16234567 17876044 18059187
MESH:D002292 Carcinoma, Renal Cell Doxorubicin 3.2816201981 1485588
MESH:D002294 Carcinoma, Squamous Cell Doxorubicin 2.706189445
MESH:D006332 Cardiomegaly Tetrachlorodibenzodioxin 2.5216120746 18670907 18850075
MESH:D009202 Cardiomyopathies Doxorubicin 3.7216242529 17308081 16109756 17519947 17351982 17329180 17974986 16651473 17928571 15476868 16269455 16731534 16455267 17131338 18627295 16364871 15792986 17007740 15505089 16612575 17382496 17924179 15811867 16278810 16952015
MESH:D002311 Cardiomyopathy, Dilated Doxorubicin 3.0317334414 16243910
MESH:D002471 Cell Transformation, Neoplastic Cyclosporine 2.7312371664
MESH:D018281 Cholangiocarcinoma Tetrachlorodibenzodioxin 3.4516835633
MESH:D002779 Cholestasis Cyclosporine 8.5519486331
MESH:D002779 Cholestasis Ethinyl Estradiol 8.5516919318 17333356 16105132 11677210 15861022 17681005 17110522
MESH:D002972 Cleft Palate Tetrachlorodibenzodioxin 2.218697196 16354765 15340226 15668235 12621046
MESH:D015179 Colorectal Neoplasms Doxorubicin 2.1518259882 18802399
MESH:D000013 Congenital Abnormalities Tetrachlorodibenzodioxin 3.3417141729 14669216
MESH:D019465 Craniofacial Abnormalities Tetrachlorodibenzodioxin 1.2610048152 20055451 15322242
MESH:D003556 Cystitis Hydrochloric Acid 5.9912599022 20719367 12853844 19279288
MESH:D018856 Cystitis, Interstitial Hydrochloric Acid 6.3317714534
MESH:D017449 Dermatitis, Allergic Contact Ammonia 5.1616823706
MESH:D003924 Diabetes Mellitus, Type 2 Tetrachlorodibenzodioxin 1.7217107852
MESH:D056486 Drug-Induced Liver Injury Doxorubicin 4.1217416283
MESH:D056486 Drug-Induced Liver Injury Tetrachlorodibenzodioxin 4.1220420201
MESH:D004362 Drug Toxicity Doxorubicin 8.8918602426
MESH:D004362 Drug Toxicity Tetrachlorodibenzodioxin 8.8911462148
MESH:D004487 Edema Tetrachlorodibenzodioxin 2.7012711302 11000095
MESH:D004489 Edema, Cardiac Tetrachlorodibenzodioxin 4.4215322242 18230668 16714409
MESH:D004681 Encephalomyelitis, Autoimmune, Experimental Ethinyl Estradiol 3.5712538720
MESH:D016889 Endometrial Neoplasms Doxorubicin 3.6417359293
MESH:D004715 Endometriosis Tetrachlorodibenzodioxin 3.339294722 10568697
MESH:D004719 Endomyocardial Fibrosis Doxorubicin 5.6818037988
MESH:D004935 Esophageal Diseases Hydrochloric Acid 6.2619566590
MESH:D004941 Esophagitis Hydrochloric Acid 6.4612928072
MESH:D004942 Esophagitis, Peptic Hydrochloric Acid 6.5414621274 11346197 20516732
MESH:D005124 Eye Abnormalities Tetrachlorodibenzodioxin 3.2411564622
MESH:D005234 Fatty Liver Cyclosporine 8.6819224547
MESH:D005234 Fatty Liver Ethinyl Estradiol 8.6815345470
MESH:D005313 Fetal Death Tetrachlorodibenzodioxin 3.8711858732
MESH:D018222 Fibromatosis, Aggressive Doxorubicin 5.0519069698
MESH:D005355 Fibrosis Cyclosporine 17.4612168785 12639820
MESH:D005355 Fibrosis Hydrochloric Acid 17.4618497604
MESH:D005355 Fibrosis Tetrachlorodibenzodioxin 17.4620067830
MESH:D005739 Gas Poisoning Hydrochloric Acid 5.9912378975
MESH:D005764 Gastroesophageal Reflux Hydrochloric Acid 5.7119951613 20616304 12212954 20545468 19957777 20516732
MESH:D005885 Gingival Hyperplasia Cyclosporine 4.688708960
MESH:D005909 Glioblastoma Doxorubicin 3.5417150277
MESH:D006058 Gonadal Disorders Tetrachlorodibenzodioxin 5.1210696789
MESH:D006258 Head and Neck Neoplasms Doxorubicin 3.7315692506
MESH:D006356 Heartburn Hydrochloric Acid 6.2619566590
MESH:D006330 Heart Defects, Congenital Tetrachlorodibenzodioxin 2.4710048152 11294989
MESH:D006331 Heart Diseases Doxorubicin 3.6912587719 16244371 16330681 17875725 16707910 16495754 14766674 18006777 16244372 18674790 16879835 16144979 17888722
MESH:D006333 Heart Failure Doxorubicin 3.5217481944
MESH:D006394 Hemangiosarcoma Doxorubicin 4.2315692506
MESH:D006457 Hemoglobinuria, Paroxysmal Cyclosporine 4.8815720958
MESH:D006470 Hemorrhage Tetrachlorodibenzodioxin 3.6611000095
MESH:D006501 Hepatic Encephalopathy Ammonia 6.1412420312 16338762 20549931
MESH:D006529 Hepatomegaly Tetrachlorodibenzodioxin 3.3115340226 16120746 12621046
MESH:D006689 Hodgkin Disease Doxorubicin 3.6915147373 18501091 17606976
MESH:D006869 Hydronephrosis Tetrachlorodibenzodioxin 4.5718606429 16959395 8697196 16354765 15340226
MESH:D006940 Hyperemia Hydrochloric Acid 6.1112646421
MESH:D006973 Hypertension Cyclosporine 5.2810903974
MESH:D006973 Hypertension Tetrachlorodibenzodioxin 5.2818850075 18670907
MESH:D006975 Hypertension, Portal Hydrochloric Acid 5.7716984587
MESH:D006976 Hypertension, Pulmonary Hydrochloric Acid 4.6719262391
MESH:D007021 Hypospadias Ethinyl Estradiol 4.2316945680 16569931
MESH:D007022 Hypotension Hydrochloric Acid 5.1111574821
MESH:D007247 Infertility, Female Ethinyl Estradiol 3.8112013081
MESH:D007248 Infertility, Male Ethinyl Estradiol 2.6817937319
MESH:D007249 Inflammation Hydrochloric Acid 5.8411574821
MESH:D007249 Inflammation Tetrachlorodibenzodioxin 5.8412878042 12200463
MESH:D007410 Intestinal Diseases Hydrochloric Acid 5.3911574821
MESH:D007569 Jaw Abnormalities Tetrachlorodibenzodioxin 3.6616580747
MESH:D007638 Keratoconjunctivitis Sicca Cyclosporine 4.9615604871
MESH:D007674 Kidney Diseases Cyclosporine 6.668314463 10903974 18776723
MESH:D007674 Kidney Diseases Doxorubicin 6.6615699352 16775033 15369732
MESH:D007676 Kidney Failure, Chronic Doxorubicin 4.4816707910
MESH:D007680 Kidney Neoplasms Cyclosporine 3.0012371664
MESH:D007818 Laryngeal Diseases Hydrochloric Acid 6.8816498863
MESH:D007826 Laryngismus Hydrochloric Acid 6.8811510729
MESH:D004915 Leukemia, Erythroblastic, Acute Doxorubicin 5.6816085563
MESH:D008103 Liver Cirrhosis Hydrochloric Acid 4.2216984587
MESH:D008106 Liver Cirrhosis, Experimental Doxorubicin 2.5116439617 16595196
MESH:D008106 Liver Cirrhosis, Experimental Tetrachlorodibenzodioxin 2.5112878042
MESH:D008113 Liver Neoplasms Tetrachlorodibenzodioxin 1.8116984957
MESH:D008114 Liver Neoplasms, Experimental Doxorubicin 6.5217085340 16842330
MESH:D008114 Liver Neoplasms, Experimental Tetrachlorodibenzodioxin 6.5212151625
MESH:D008171 Lung Diseases Hydrochloric Acid 4.4816784557
MESH:D055370 Lung Injury Hydrochloric Acid 5.1717627322 15044056 21114838 18573544 15090967 18497604 19644408 16129981 20597076 11395602 21311175 18339021 15607125 19262391
MESH:D008175 Lung Neoplasms Doxorubicin 2.4717418594 6189445
MESH:D008175 Lung Neoplasms Tetrachlorodibenzodioxin 2.4719555203 11884234
MESH:D008223 Lymphoma Doxorubicin 3.6816098063
MESH:D008228 Lymphoma, Non-Hodgkin Doxorubicin 4.0617654614
MESH:D016399 Lymphoma, T-Cell Doxorubicin 4.9815621674
MESH:D008325 Mammary Neoplasms, Experimental Doxorubicin 3.2115458769
MESH:D008545 Melanoma Doxorubicin 2.3216827129
MESH:D008654 Mesothelioma Doxorubicin 3.1617638057
MESH:D008664 Metal Metabolism, Inborn Errors Cyclosporine 5.3116801185
MESH:D028361 Mitochondrial Diseases Doxorubicin 4.8315792986
MESH:D052016 Mucositis Doxorubicin 5.2517415656
MESH:D009203 Myocardial Infarction Doxorubicin 6.6919429709 15857846
MESH:D009203 Myocardial Infarction Hydrochloric Acid 6.6918534312
MESH:D017202 Myocardial Ischemia Tetrachlorodibenzodioxin 3.2712213967
MESH:D009362 Neoplasm Metastasis Doxorubicin 3.0518259882
MESH:D009401 Nephrosis Doxorubicin 5.1916899518 16636307
MESH:D009402 Nephrosis, Lipoid Cyclosporine 4.9617954296
MESH:D009404 Nephrotic Syndrome Cyclosporine 10.2619348381 18481113
MESH:D009404 Nephrotic Syndrome Doxorubicin 10.2616889571 15640375
MESH:D009421 Nervous System Malformations Tetrachlorodibenzodioxin 3.5914600291
MESH:D009447 Neuroblastoma Doxorubicin 3.4015555623
MESH:D009784 Occupational Diseases Hydrochloric Acid 5.0712378975
MESH:D012516 Osteosarcoma Doxorubicin 4.3715930896
MESH:D016584 Panic Disorder Ethinyl Estradiol 4.0411578682
MESH:D010382 Peliosis Hepatis Tetrachlorodibenzodioxin 4.7712520081
MESH:D003557 Phyllodes Tumor Doxorubicin 5.6817983394
MESH:D010997 Pleural Neoplasms Doxorubicin 5.6817638057
MESH:D011015 Pneumonia, Aspiration Hydrochloric Acid 5.8315970105 18497604 15607125 18573544
MESH:D017119 Porphyria Cutanea Tarda Tetrachlorodibenzodioxin 3.9418163543
MESH:D011230 Precancerous Conditions Cyclosporine 3.5112371664
MESH:D011297 Prenatal Exposure Delayed Effects Tetrachlorodibenzodioxin 3.6511222880 11399792 11896295 11118676
MESH:D011471 Prostatic Neoplasms Doxorubicin 3.5018437689 15897917 16729912 16888761 15749863 16868541
MESH:D011537 Pruritus Ethinyl Estradiol 3.7716919318 15861022
MESH:D011565 Psoriasis Cyclosporine 2.3116882103
MESH:D001261 Pulmonary Atelectasis Hydrochloric Acid 6.5420597076
MESH:D011654 Pulmonary Edema Hydrochloric Acid 5.7315090967
MESH:D051437 Renal Insufficiency Doxorubicin 4.6417922066
MESH:D012128 Respiratory Distress Syndrome, Adult Hydrochloric Acid 5.1116129981 18339021 17627322 16784557 18549715
MESH:D012133 Respiratory Paralysis Hydrochloric Acid 6.8811510729
MESH:D015619 Respiratory System Abnormalities Tetrachlorodibenzodioxin 4.2218990726
MESH:D012140 Respiratory Tract Diseases Hydrochloric Acid 5.6820516732
MESH:D012509 Sarcoma Doxorubicin 4.2917710206 15675481 15625365 17203757 16767912 18313854
MESH:D012512 Sarcoma, Ewing's Doxorubicin 4.6214601052 16326096
MESH:D012514 Sarcoma, Kaposi Doxorubicin 5.2517846226
MESH:D012878 Skin Neoplasms Doxorubicin 6.1115692506
MESH:D012878 Skin Neoplasms Tetrachlorodibenzodioxin 6.1116192470
MESH:D012983 Soft Tissue Neoplasms Doxorubicin 4.9816767912 17203757 15625365
MESH:D013088 Spermatocele Ethinyl Estradiol 4.4616709447
MESH:D013276 Stomach Ulcer Hydrochloric Acid 4.5515309881 16755016 17189318
MESH:D019851 Thrombophilia Ethinyl Estradiol 3.9711994571
MESH:D013927 Thrombosis Ethinyl Estradiol 3.4415669648
MESH:D013959 Thyroid Diseases Tetrachlorodibenzodioxin 4.4212697716
MESH:D013964 Thyroid Neoplasms Doxorubicin 3.6116010429 17909728
MESH:D001749 Urinary Bladder Neoplasms Doxorubicin 2.8617653716
MESH:D014594 Uterine Neoplasms Ethinyl Estradiol 3.6814692618
MESH:D014605 Uveitis Cyclosporine 4.501336536
MESH:D054079 Vascular Malformations Tetrachlorodibenzodioxin 5.1212125929
MESH:D020246 Venous Thrombosis Ethinyl Estradiol 3.8714671159 15869587
MESH:D018487 Ventricular Dysfunction, Left Doxorubicin 4.6417638931 16364871 17678736 17334414
MESH:D019282 Wasting Syndrome Tetrachlorodibenzodioxin 4.7715886252
MESH:D014985 Xerophthalmia Cyclosporine 4.9617120751
Pathway ID Pathway Name
REACT:20679 Amine compound SLC transporters
REACT:15518 Transmembrane transport of small molecules
Pharmacogenomics Knowledge Base Top
Drug Bank Top
Drugbank ID Action Drug Name Description
DB03122 - B-Octylglucoside Detergents
No data
No data
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Syndromic Genes

Non-syndromic Genes

AutismKB Statistics

  • Studies: 1,036
  • Genes: 1,379
  • CNVs/SVs: 5,420
  • SNVs/Indels: 11,669
  • de novo Mutations: 5,669
  • Mosaics: 789
  • Linkage Regions: 172
  • Paper Collected: 6/30/2018
  • Last Update: 8/26/2018


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