AutismKB 2.0

Annotation Detail for EVL


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Basic Information Top
Gene Symbol:EVL ( RNB6 )
Gene Full Name: Enah/Vasp-like
Band: 14q32.2
Quick LinksEntrez ID:51466; OMIM: NA; Uniprot ID:EVL_HUMAN; ENSEMBL ID: ENSG00000196405; HGNC ID: 20234
Relate to Another Database: SFARIGene; denovo-db
Related Pathway Information Top
No data
No data
Pathway IDPathway Name
Axon guidance
Signaling in Immune system
No data
No data
No data
Related Diseases/Disorders Top
Comparative Toxicogenomics Database Top
Chemical ID Chemical Name Interaction Interaction Action Publication
C023514 2,6-dinitrotoluene 2,6-dinitrotoluene affects the expression of EVL mRNAaffects expression 21346803
C035208 2-amino-4,6-dinitrotoluene 2-amino-4,6-dinitrotoluene affects the expression of EVL mRNAaffects expression 21346803
D000082 Acetaminophen Acetaminophen affects the expression of EVL mRNAaffects expression 17562736
D016604 Aflatoxin B1 Aflatoxin B1 affects the expression of EVL proteinaffects expression 20106945
C058317 arsenic disulfide arsenic disulfide results in decreased expression of EVL mRNAdecreases expression 12890387
C006632 arsenic trioxide arsenic trioxide results in decreased expression of EVL mRNAdecreases expression 15725085
D001564 Benzo(a)pyrene Benzo(a)pyrene results in decreased expression of EVL mRNAdecreases expression 20064835
C006780 bisphenol A bisphenol A results in increased expression of EVL mRNAincreases expression 20678512
C006780 bisphenol A bisphenol A results in increased expression of EVL mRNAincreases expression 18180321
C009160 cyclonite cyclonite results in increased expression of EVL mRNAincreases expression 19417177
D016572 Cyclosporine Cyclosporine results in decreased expression of EVL mRNAdecreases expression 20106945
D004997 Ethinyl Estradiol Ethinyl Estradiol results in decreased expression of EVL mRNAdecreases expression 17557909
D005419 Flavonoids Flavonoids results in decreased expression of EVL mRNAdecreases expression 18035473
D007657 Ketone Bodies Ketone Bodies results in increased expression of EVL mRNAincreases expression 16807920
D008727 Methotrexate EVL protein affects the susceptibility to Methotrexateaffects response to substance 16217747
D010126 Ozone Ozone results in decreased expression of EVL mRNAdecreases expression 12763052
C006253 pirinixic acid [pirinixic acid binds to and results in increased activity of PPARA protein] which results in decreased expression of EVL mRNAaffects binding|decreases expression|increases activity 19710929
C006253 pirinixic acid pirinixic acid results in decreased expression of EVL mRNAdecreases expression 18445702
C017947 sodium arsenite sodium arsenite results in increased expression of EVL mRNAincreases expression 17879257
D014501 Uranium Uranium affects the expression of EVL mRNAaffects expression 15672453
C005460 uranyl acetate uranyl acetate affects the expression of EVL mRNAaffects expression 15672453
D014810 Vitamin E Vitamin E results in increased expression of EVL mRNAincreases expression 19244175
Disease ID Disease Name Direct Evidence Inference Chemical Name Inference Score Publication
MESH:D000014 Abnormalities, Drug-Induced 2-amino-4,6-dinitrotoluene 9.097525203
MESH:D000014 Abnormalities, Drug-Induced Methotrexate 9.0912039119
MESH:D000152 Acne Vulgaris Ethinyl Estradiol 3.8617505938
MESH:D055371 Acute Lung Injury pirinixic acid 3.0318653653
MESH:D000230 Adenocarcinoma arsenic trioxide 6.9011798837 19825857
MESH:D000230 Adenocarcinoma Benzo(a)pyrene 6.9020127859 20464547
MESH:D000230 Adenocarcinoma Ethinyl Estradiol 6.9014692618
MESH:D000236 Adenoma Benzo(a)pyrene 2.606695378
MESH:D018248 Adenoma, Liver Cell pirinixic acid 3.4016434500
MESH:D000310 Adrenal Gland Neoplasms sodium arsenite 4.6215276417
MESH:D018246 Adrenocortical Adenoma sodium arsenite 4.8216712894 17306315
MESH:D000544 Alzheimer Disease Ozone 2.4215513908
MESH:D000799 Angioedema Acetaminophen 3.7610982225
MESH:D017544 Aortic Aneurysm, Abdominal Benzo(a)pyrene 3.9919183758
MESH:D001161 Arteriosclerosis Ethinyl Estradiol 3.3811256880
MESH:D001169 Arthritis, Experimental Ethinyl Estradiol 2.6115885639
MESH:D001172 Arthritis, Rheumatoid Methotrexate 4.9117286800
MESH:D001172 Arthritis, Rheumatoid Ozone 4.9115570426
MESH:D001249 Asthma Ozone 2.6117854713 16373670
MESH:D001321 Autistic Disorder Acetaminophen 1.4318445737
MESH:D001778 Blood Coagulation Disorders arsenic trioxide 8.7216206674
MESH:D001778 Blood Coagulation Disorders pirinixic acid 8.7219483382
MESH:D001862 Bone Resorption bisphenol A 3.7811985600
MESH:D001943 Breast Neoplasms marker/mechanism 18507500
MESH:D001943 Breast Neoplasms Benzo(a)pyrene 2.0217474063 20146248
MESH:D001943 Breast Neoplasms bisphenol A 2.0217123778
MESH:D001943 Breast Neoplasms Methotrexate 2.0216978400
MESH:D016535 Bronchial Hyperreactivity Ozone 3.6015516495 16777450 18417511 17626835 14754758 18315731 19059883
MESH:D002051 Burkitt Lymphoma arsenic trioxide 4.2411589617
MESH:D002100 Cachexia Ozone 4.6516183385
MESH:D002252 Carbon Tetrachloride Poisoning Vitamin E 3.8416050911
MESH:D006528 Carcinoma, Hepatocellular 2,6-dinitrotoluene 8.7216705839
MESH:D006528 Carcinoma, Hepatocellular Acetaminophen 8.723084413
MESH:D006528 Carcinoma, Hepatocellular Aflatoxin B1 8.7221507988 12619106 12907637
MESH:D006528 Carcinoma, Hepatocellular arsenic trioxide 8.7216217749 14691202 15073043 15553829 11135700
MESH:D006528 Carcinoma, Hepatocellular sodium arsenite 8.7216507464 17306315 15276417
MESH:D002278 Carcinoma in Situ bisphenol A 4.9017123778
MESH:D002291 Carcinoma, Papillary arsenic trioxide 4.7919014326
MESH:D018288 Carcinoma, Small Cell arsenic trioxide 4.0412490120
MESH:D002294 Carcinoma, Squamous Cell Benzo(a)pyrene 4.5120419170
MESH:D002294 Carcinoma, Squamous Cell sodium arsenite 4.5118572023
MESH:D002386 Cataract Acetaminophen 2.5310977129
MESH:D002471 Cell Transformation, Neoplastic 2,6-dinitrotoluene 10.826135515
MESH:D002471 Cell Transformation, Neoplastic Cyclosporine 10.8212371664
MESH:D002471 Cell Transformation, Neoplastic sodium arsenite 10.8220056578 19524636
MESH:D002779 Cholestasis Cyclosporine 12.9619486331
MESH:D002779 Cholestasis Ethinyl Estradiol 12.9617681005 17333356 15861022 11677210 16919318 17110522 16105132
MESH:D002779 Cholestasis pirinixic acid 12.9619176532
MESH:D015179 Colorectal Neoplasms marker/mechanism 21278247 18507500
MESH:D015179 Colorectal Neoplasms arsenic trioxide 1.8620501625
MESH:D000013 Congenital Abnormalities 2-amino-4,6-dinitrotoluene 5.1015095906
MESH:D023903 Coronary Restenosis arsenic trioxide 4.1012609071
MESH:D019465 Craniofacial Abnormalities arsenic trioxide 3.9110525206
MESH:D019465 Craniofacial Abnormalities Methotrexate 3.9112039119 9562676
MESH:D019465 Craniofacial Abnormalities Vitamin E 3.9119769572
MESH:D003490 Cyanosis 2,6-dinitrotoluene 3.9318551238
MESH:D003550 Cystic Fibrosis Methotrexate 4.1619747007
MESH:D016757 Death, Sudden, Cardiac arsenic trioxide 4.0115213294
MESH:D003876 Dermatitis, Atopic pirinixic acid 2.3818249437
MESH:D003882 Dermatomyositis Methotrexate 5.0420191521
MESH:D056486 Drug-Induced Liver Injury 2,6-dinitrotoluene 6.2521346803 18551238
MESH:D056486 Drug-Induced Liver Injury 2-amino-4,6-dinitrotoluene 6.2521346803
MESH:D056486 Drug-Induced Liver Injury Acetaminophen 6.2516177239 19416960 2444490 14550746 11421492 11739529 10915739 11461765 14986274 11529661 14725611 11743745 16109766 12540782 19085960 18071297 19739265 18713872 15619225 19420014 16781746 12392966 15968718 19164858 12705907 16393943 16227642 17562736 19923254 19370779 17522070 12594235 12958197 10663392 16081117 16485898 11287661 12153990 11834606 10774834 17906064
MESH:D056487 Drug-Induced Liver Injury, Chronic Acetaminophen 4.0219426721
MESH:C538011 Eales disease Vitamin E 4.629068938
MESH:D004487 Edema pirinixic acid 2.4012083418
MESH:D004681 Encephalomyelitis, Autoimmune, Experimental Ethinyl Estradiol 3.1012538720
MESH:D004938 Esophageal Neoplasms arsenic trioxide 4.3612903497
MESH:D004938 Esophageal Neoplasms Benzo(a)pyrene 4.3616530937
MESH:D005234 Fatty Liver arsenic trioxide 18.0615073043
MESH:D005234 Fatty Liver Cyclosporine 18.0619224547
MESH:D005234 Fatty Liver Ethinyl Estradiol 18.0615345470
MESH:D005234 Fatty Liver pirinixic acid 18.0620131406 19236843
MESH:D005355 Fibrosis Cyclosporine 3.0612168785 12639820
MESH:D005706 Gallbladder Neoplasms arsenic trioxide 4.1816904648
MESH:D005756 Gastritis Acetaminophen 3.5916983495
MESH:D005833 Genital Neoplasms, Female sodium arsenite 4.5916452187
MESH:D005885 Gingival Hyperplasia Cyclosporine 4.138708960
MESH:D006086 Graft vs Host Disease Methotrexate 5.0616518429
MESH:D006330 Heart Defects, Congenital Benzo(a)pyrene 6.5420471113
MESH:D006330 Heart Defects, Congenital Vitamin E 6.5416080930
MESH:D006333 Heart Failure pirinixic acid 2.4820558911
MESH:D006457 Hemoglobinuria, Paroxysmal Cyclosporine 4.3415720958
MESH:D006529 Hepatomegaly pirinixic acid 2.9116221962 19772884 19176532 18467677
MESH:D006548 Hernia, Diaphragmatic Vitamin E 2.6716490937 16863852
MESH:D006689 Hodgkin Disease sodium arsenite 3.0812676792
MESH:D019584 Hot Flashes Vitamin E 3.8914716179
MESH:D006930 Hyperalgesia Acetaminophen 2.6316870215
MESH:D006943 Hyperglycemia pirinixic acid 3.1020558911
MESH:D006973 Hypertension Cyclosporine 2.0710903974
MESH:D007021 Hypospadias Ethinyl Estradiol 3.7216945680 16569931
MESH:D007247 Infertility, Female Ethinyl Estradiol 3.3812013081
MESH:D007248 Infertility, Male Ethinyl Estradiol 6.4417937319
MESH:D007248 Infertility, Male sodium arsenite 6.4412646999 15346721
MESH:D007249 Inflammation Flavonoids 2.6017296493
MESH:D007251 Influenza, Human Vitamin E 4.1316624496
MESH:D007333 Insulin Resistance bisphenol A 7.1216393666
MESH:D007333 Insulin Resistance pirinixic acid 7.1216306350
MESH:D007638 Keratoconjunctivitis Sicca Cyclosporine 4.3615604871
MESH:D007674 Kidney Diseases Acetaminophen 14.0112587719 15629191
MESH:D007674 Kidney Diseases Cyclosporine 14.018314463 18776723 10903974
MESH:D007674 Kidney Diseases sodium arsenite 14.0120008137
MESH:D007674 Kidney Diseases Vitamin E 14.0112488133
MESH:D007680 Kidney Neoplasms 2,6-dinitrotoluene 7.0316705839
MESH:D007680 Kidney Neoplasms Cyclosporine 7.0312371664
MESH:D007805 Language Development Disorders Methotrexate 5.029562676
MESH:D007938 Leukemia arsenic trioxide 2.7915070760
MESH:D015459 Leukemia-Lymphoma, Adult T-Cell arsenic trioxide 3.7112560223 17077332
MESH:D007948 Leukemia, Monocytic, Acute arsenic trioxide 4.2216972261
MESH:D015464 Leukemia, Myelogenous, Chronic, BCR-ABL Positive arsenic disulfide 8.7012421474
MESH:D015464 Leukemia, Myelogenous, Chronic, BCR-ABL Positive arsenic trioxide 8.7014633726
MESH:D007951 Leukemia, Myeloid arsenic trioxide 3.6819077051
MESH:D015470 Leukemia, Myeloid, Acute arsenic trioxide 2.1219850784 20471514 16467208 16968895 17050201
MESH:D015473 Leukemia, Promyelocytic, Acute arsenic trioxide 3.1619642359 15622746 11468182 17217047 17107899 16330433 19035177 15336539 9834237 11161223 16112521 16331271 16891316 15748426 12018890 12679006 17649720 16966277 12712474 17869043 17712046 19225113 16823087 15213294 19075265
MESH:D015458 Leukemia, T-Cell arsenic trioxide 4.2716882451
MESH:D008103 Liver Cirrhosis Methotrexate 3.6514986274
MESH:D008106 Liver Cirrhosis, Experimental pirinixic acid 2.3515474484
MESH:D008106 Liver Cirrhosis, Experimental Vitamin E 2.3516169303
MESH:D008107 Liver Diseases Acetaminophen 1.6112969438 16610002 16611625 11587558 19784758 12587719 19460945 19014921
MESH:D017114 Liver Failure, Acute Acetaminophen 3.1617185352 16871587
MESH:D008113 Liver Neoplasms 2,6-dinitrotoluene 17.567678174
MESH:D008113 Liver Neoplasms Aflatoxin B1 17.562125692 18177683 9163691 15890375
MESH:D008113 Liver Neoplasms arsenic trioxide 17.5614682389
MESH:D008113 Liver Neoplasms Benzo(a)pyrene 17.5621137059 20195826
MESH:D008113 Liver Neoplasms pirinixic acid 17.5620007298 16377806 15890375
MESH:D008113 Liver Neoplasms sodium arsenite 17.5616712894 15276417
MESH:D008114 Liver Neoplasms, Experimental 2,6-dinitrotoluene 9.562876786 2876784 6135515
MESH:D008114 Liver Neoplasms, Experimental Aflatoxin B1 9.568603461
MESH:D008114 Liver Neoplasms, Experimental arsenic trioxide 9.5620377131
MESH:D008133 Long QT Syndrome arsenic trioxide 3.2815213294
MESH:D008171 Lung Diseases Ozone 12.0219066396 8266340
MESH:D008171 Lung Diseases sodium arsenite 12.0219095001
MESH:D008171 Lung Diseases Vitamin E 12.0216863852
MESH:D017563 Lung Diseases, Interstitial Methotrexate 4.9418516814
MESH:D055370 Lung Injury Ozone 3.7620417186
MESH:D008175 Lung Neoplasms Aflatoxin B1 8.4214755239
MESH:D008175 Lung Neoplasms arsenic trioxide 8.4219825857 11798837
MESH:D008175 Lung Neoplasms Benzo(a)pyrene 8.4218569708 17053015 18816296 20464547 6695378 20064080 18520028 20869020 20135361
MESH:D008175 Lung Neoplasms Ozone 8.427614698 8597069
MESH:D008175 Lung Neoplasms sodium arsenite 8.4217306315 19931552 16712894 15276417 17077188
MESH:D008175 Lung Neoplasms Vitamin E 8.4211062179
MESH:D008223 Lymphoma Methotrexate 3.8917352296
MESH:D008545 Melanoma sodium arsenite 2.0216487513 19082730
MESH:D008546 Melanoma, Experimental Acetaminophen 3.4819513568
MESH:D008664 Metal Metabolism, Inborn Errors Cyclosporine 4.7116801185
MESH:D008679 Metaplasia Ozone 5.0210496685
MESH:D009062 Mouth Neoplasms Benzo(a)pyrene 3.1216381670
MESH:D052016 Mucositis Methotrexate 5.1917488658
MESH:D009101 Multiple Myeloma arsenic trioxide 3.0414977855 19417148 11468182 19549372 15949261
MESH:D009135 Muscular Diseases pirinixic acid 3.4216239165
MESH:D009182 Mycosis Fungoides arsenic trioxide 4.5918349030
MESH:D009190 Myelodysplastic Syndromes arsenic trioxide 3.0916105982 16882451
MESH:D009203 Myocardial Infarction pirinixic acid 2.1119151258
MESH:D015428 Myocardial Reperfusion Injury pirinixic acid 2.8816411023
MESH:D009336 Necrosis 2,6-dinitrotoluene 3.7818551238 7678174
MESH:D009361 Neoplasm Invasiveness arsenic trioxide 3.8716624393
MESH:D009369 Neoplasms Benzo(a)pyrene 7.9511141357
MESH:D009369 Neoplasms pirinixic acid 7.9517405874
MESH:D009369 Neoplasms sodium arsenite 7.9511559025
MESH:D009374 Neoplasms, Experimental sodium arsenite 3.5820056578
MESH:D009402 Nephrosis, Lipoid Cyclosporine 4.3617954296
MESH:D009404 Nephrotic Syndrome Cyclosporine 3.2119348381 18481113
MESH:D009421 Nervous System Malformations bisphenol A 3.8911399458 16427766
MESH:D009436 Neural Tube Defects arsenic trioxide 7.1410525206
MESH:D009436 Neural Tube Defects sodium arsenite 7.1412854658
MESH:D019636 Neurodegenerative Diseases Acetaminophen 2.8018514411
MESH:D009765 Obesity pirinixic acid 1.7920558911
MESH:D009784 Occupational Diseases 2,6-dinitrotoluene 3.3516049721
MESH:D010049 Ovarian Diseases bisphenol A 4.9011985600
MESH:D010051 Ovarian Neoplasms arsenic trioxide 4.8216624393 12452020 19769630
MESH:D010051 Ovarian Neoplasms sodium arsenite 4.8215276417 17306315
MESH:D010146 Pain Acetaminophen 2.3216870215
MESH:D010190 Pancreatic Neoplasms arsenic trioxide 2.4915580305
MESH:D016584 Panic Disorder Ethinyl Estradiol 3.6011578682
MESH:D010235 Paraganglioma arsenic trioxide 4.0819927285
MESH:D010538 Peritonitis Ozone 4.0416369182
MESH:D011014 Pneumonia Ozone 4.3118381685 18929643 18007984
MESH:D011230 Precancerous Conditions Cyclosporine 3.1412371664
MESH:D011297 Prenatal Exposure Delayed Effects bisphenol A 3.8710548101
MESH:D019048 Prostatic Intraepithelial Neoplasia bisphenol A 4.1220887781
MESH:D011471 Prostatic Neoplasms arsenic trioxide 1.8619131511
MESH:D011471 Prostatic Neoplasms Benzo(a)pyrene 1.8617292933
MESH:D011471 Prostatic Neoplasms bisphenol A 1.8616740699
MESH:D011471 Prostatic Neoplasms sodium arsenite 1.8616039940
MESH:D011471 Prostatic Neoplasms Vitamin E 1.8615084515
MESH:D011537 Pruritus Ethinyl Estradiol 3.2316919318 15861022
MESH:D011565 Psoriasis Cyclosporine 5.8116882103
MESH:D011565 Psoriasis Methotrexate 5.8117410198
MESH:D011629 Puberty, Precocious bisphenol A 4.7010548101
MESH:D051437 Renal Insufficiency Methotrexate 4.6217352296
MESH:D015427 Reperfusion Injury pirinixic acid 2.3419058328
MESH:D012512 Sarcoma, Ewing's arsenic trioxide 3.8716646077
MESH:D012640 Seizures 2,6-dinitrotoluene 6.4018551238
MESH:D012640 Seizures cyclonite 6.4019417177
MESH:D012871 Skin Diseases Vitamin E 2.4218709164
MESH:D012878 Skin Neoplasms Benzo(a)pyrene 5.5819755658 10029692
MESH:D012878 Skin Neoplasms sodium arsenite 5.5818572023 19524636
MESH:D013088 Spermatocele Ethinyl Estradiol 3.8616709447
MESH:D016135 Spinal Dysraphism sodium arsenite 3.7312854658
MESH:D013274 Stomach Neoplasms arsenic trioxide 2.3517007042
MESH:D013274 Stomach Neoplasms Benzo(a)pyrene 2.3520155912 2093021
MESH:D020521 Stroke Vitamin E 3.4516517955
MESH:D019966 Substance-Related Disorders bisphenol A 3.9016684133 16045194
MESH:D013576 Syndactyly Methotrexate 4.959562676
MESH:D019851 Thrombophilia Ethinyl Estradiol 3.5411994571
MESH:D013927 Thrombosis Ethinyl Estradiol 3.0715669648
MESH:D013964 Thyroid Neoplasms arsenic trioxide 3.0219014326
MESH:D016171 Torsades de Pointes arsenic trioxide 3.8815213294
MESH:D001749 Urinary Bladder Neoplasms 2,6-dinitrotoluene 11.6416049721
MESH:D001749 Urinary Bladder Neoplasms arsenic trioxide 11.6412845720 20435036 11780464 12973940
MESH:D001749 Urinary Bladder Neoplasms Benzo(a)pyrene 11.6417053015
MESH:D001749 Urinary Bladder Neoplasms sodium arsenite 11.6416712894 16452187 17306315 11723127
MESH:D014571 Urologic Neoplasms 2,6-dinitrotoluene 4.2310091137
MESH:D014581 Urticaria Acetaminophen 2.8910982225
MESH:D002583 Uterine Cervical Neoplasms sodium arsenite 3.6911813266
MESH:D014591 Uterine Diseases bisphenol A 4.9314652134
MESH:D014594 Uterine Neoplasms Ethinyl Estradiol 3.2114692618
MESH:D014605 Uveitis Cyclosporine 3.901336536
MESH:D014652 Vascular Diseases sodium arsenite 4.3417056641
MESH:D020246 Venous Thrombosis Ethinyl Estradiol 3.4615869587 14671159
MESH:D014985 Xerophthalmia Cyclosporine 4.3617120751
Pathway ID Pathway Name
REACT:18266 Axon guidance
REACT:6900 Signaling in Immune system
Pharmacogenomics Knowledge Base Top
  • PharmGKB Accession:PA134890866
    • No data
    Releated disease ID Related disease Name
    PA443756Colonic Neoplasms
    No data
    Drug Bank Top

    Simple Query:


      (e.g. CHD8)

    Syndromic Genes

    Non-syndromic Genes

    AutismKB Statistics

    • Studies: 1,036
    • Genes: 1,379
    • CNVs/SVs: 5,420
    • SNVs/Indels: 11,669
    • de novo Mutations: 5,669
    • Mosaics: 789
    • Linkage Regions: 172
    • Paper Collected: 6/30/2018
    • Last Update: 8/26/2018


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