AutismKB 2.0

Annotation Detail for LIMA1


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Basic Information Top
Gene Symbol:LIMA1 ( EPLIN,FLJ38853,MGC131726,SREBP3 )
Gene Full Name: LIM domain and actin binding 1
Band: 12q13.12
Quick LinksEntrez ID:51474; OMIM: 608364; Uniprot ID:LIMA1_HUMAN; ENSEMBL ID: ENSG00000050405; HGNC ID: 24636
Relate to Another Database: SFARIGene; denovo-db
Related Pathway Information Top
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Pathway IDPathway Name
200155Stabilization and expansion of the E-cadherin adherens junction
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Related Diseases/Disorders Top
Comparative Toxicogenomics Database Top
Chemical ID Chemical Name Interaction Interaction Action Publication
D000082 Acetaminophen Acetaminophen affects the expression of LIMA1 mRNAaffects expression 17562736
D017638 Asbestos, Crocidolite Asbestos, Crocidolite results in increased expression of LIMA1 mRNAincreases expression 18687144
D001564 Benzo(a)pyrene Benzo(a)pyrene results in decreased expression of LIMA1 mRNAdecreases expression 20064835
D001564 Benzo(a)pyrene Benzo(a)pyrene results in increased expression of LIMA1 mRNAincreases expression 20106945
17879257
D016572 Cyclosporine Cyclosporine results in decreased expression of LIMA1 mRNAdecreases expression 20106945
D004317 Doxorubicin LIMA1 mRNA affects the susceptibility to Doxorubicinaffects response to substance 16044152
C533894 LG 100815 LG 100815 results in increased expression of LIMA1 mRNAincreases expression 16951191
C062198 octa-2,4,6-trienoic acid octa-2,4,6-trienoic acid results in increased expression of LIMA1 mRNAincreases expression 16951191
C058305 phenethyl isothiocyanate phenethyl isothiocyanate results in decreased expression of LIMA1 mRNAdecreases expression 17616710
C006253 pirinixic acid pirinixic acid results in increased expression of LIMA1 mRNAincreases expression 18301758
D011374 Progesterone Progesterone results in decreased expression of LIMA1 mRNAdecreases expression 18037150
D014212 Tretinoin Tretinoin results in increased expression of LIMA1 mRNAincreases expression 16951191
Disease ID Disease Name Direct Evidence Inference Chemical Name Inference Score Publication
MESH:D055371 Acute Lung Injury pirinixic acid 3.2718653653
MESH:D000230 Adenocarcinoma Benzo(a)pyrene 4.5620127859 20464547
MESH:D000230 Adenocarcinoma Doxorubicin 4.5617418594
MESH:D000236 Adenoma Benzo(a)pyrene 2.736695378
MESH:D018248 Adenoma, Liver Cell pirinixic acid 3.6716434500
MESH:D000419 Albuminuria Doxorubicin 4.7021441931
MESH:D000505 Alopecia Tretinoin 3.7315955085
MESH:D000799 Angioedema Acetaminophen 4.0610982225
MESH:D017544 Aortic Aneurysm, Abdominal Benzo(a)pyrene 4.2519183758
MESH:D001169 Arthritis, Experimental Tretinoin 3.1616412693
MESH:D001172 Arthritis, Rheumatoid Tretinoin 2.2916292516
MESH:D001249 Asthma Tretinoin 2.3816456186
MESH:D001321 Autistic Disorder Acetaminophen 1.4118445737
MESH:D001471 Barrett Esophagus Tretinoin 4.5616935849
MESH:D001778 Blood Coagulation Disorders pirinixic acid 9.4519483382
MESH:D001778 Blood Coagulation Disorders Tretinoin 9.4516197459 16206674
MESH:D019046 Bone Marrow Neoplasms Doxorubicin 4.9214601052
MESH:D020201 Brain Hemorrhage, Traumatic Progesterone 5.5617868700
MESH:D001930 Brain Injuries Progesterone 4.4315380490 15665606 15845082
MESH:D001932 Brain Neoplasms Doxorubicin 3.9417150277
MESH:D001943 Breast Neoplasms Benzo(a)pyrene 2.0020146248 17474063
MESH:D001943 Breast Neoplasms Doxorubicin 2.0017426702 18382427 15939500 11325840 16096432 17983394 16264153 18628466 19526202 15993339 15567936 17369602 18695136 16826403 15136595 15692762 16935488 15668708 16595493 18234424 16322301 16115903 15634643 15994142
MESH:D001943 Breast Neoplasms Progesterone 2.0017614352 15562024 16175315
MESH:D001943 Breast Neoplasms Tretinoin 2.0016443354 16873071 16166294
MESH:D001997 Bronchopulmonary Dysplasia Tretinoin 4.7816813970
MESH:D002276 Carcinoid Tumor Doxorubicin 5.0316051944
MESH:D018236 Carcinoma, Embryonal Tretinoin 5.3816168501
MESH:D006528 Carcinoma, Hepatocellular Acetaminophen 4.703084413
MESH:D006528 Carcinoma, Hepatocellular Doxorubicin 4.7017876044 18059187 16023760 16234567
MESH:D006528 Carcinoma, Hepatocellular Tretinoin 4.701917145
MESH:D002292 Carcinoma, Renal Cell Doxorubicin 3.2216201981 1485588
MESH:D002294 Carcinoma, Squamous Cell Benzo(a)pyrene 7.7620419170
MESH:D002294 Carcinoma, Squamous Cell Doxorubicin 7.766189445
MESH:D002294 Carcinoma, Squamous Cell Tretinoin 7.7616096774 16051514
MESH:D009202 Cardiomyopathies Doxorubicin 3.6217131338 17974986 17519947 15811867 16364871 16278810 16269455 17382496 17308081 16242529 17351982 15792986 18627295 16455267 17928571 16952015 15476868 17924179 16731534 16612575 15505089 17007740 16109756 17329180 16651473
MESH:D002311 Cardiomyopathy, Dilated Doxorubicin 2.9817334414 16243910
MESH:D002386 Cataract Acetaminophen 7.4810977129
MESH:D002386 Cataract Tretinoin 7.4817460283
MESH:D002471 Cell Transformation, Neoplastic Cyclosporine 2.6212371664
MESH:D018290 Cervical Intraepithelial Neoplasia Tretinoin 4.7816129372
MESH:D002779 Cholestasis Cyclosporine 8.1019486331
MESH:D002779 Cholestasis pirinixic acid 8.1019176532
MESH:D002822 Choriocarcinoma Tretinoin 5.3816461808
MESH:D002972 Cleft Palate Tretinoin 2.729407595
MESH:D003092 Colitis Tretinoin 3.8817035595
MESH:D003093 Colitis, Ulcerative phenethyl isothiocyanate 3.6920423518
MESH:D015179 Colorectal Neoplasms Doxorubicin 2.1418802399 18259882
MESH:D019465 Craniofacial Abnormalities Tretinoin 1.8217551590 9211117 10589399 9224671 16925845 8800419 9142499 14991402 9664655 9125849
MESH:D003876 Dermatitis, Atopic pirinixic acid 2.4818249437
MESH:D003929 Diabetic Neuropathies Progesterone 4.6717187935
MESH:D056486 Drug-Induced Liver Injury Acetaminophen 4.0111529661 11739529 17522070 19923254 17906064 19085960 16781746 19370779 14725611 10663392 12705907 15619225 10915739 10774834 12958197 16485898 11287661 12540782 15968718 12153990 19739265 17562736 19416960 12594235 11461765 16177239 18071297 11743745 11421492 14550746 14986274 12392966 16227642 16393943 16081117 2444490 16109766 18713872 11834606 19164858 19420014
MESH:D056486 Drug-Induced Liver Injury Doxorubicin 4.0117416283
MESH:D056487 Drug-Induced Liver Injury, Chronic Acetaminophen 4.3219426721
MESH:D004362 Drug Toxicity Doxorubicin 3.7718602426
MESH:D004487 Edema pirinixic acid 2.6212083418
MESH:D004489 Edema, Cardiac Tretinoin 4.6818230668
MESH:D004681 Encephalomyelitis, Autoimmune, Experimental Progesterone 3.9417692515
MESH:D016889 Endometrial Neoplasms Doxorubicin 7.8817359293
MESH:D016889 Endometrial Neoplasms Tretinoin 7.8816569247
MESH:D004715 Endometriosis Progesterone 3.9016134523
MESH:D004719 Endomyocardial Fibrosis Doxorubicin 5.3718037988
MESH:D004938 Esophageal Neoplasms Benzo(a)pyrene 2.0416530937
MESH:D005124 Eye Abnormalities Tretinoin 3.689664655 16938888
MESH:D005234 Fatty Liver Cyclosporine 8.0319224547
MESH:D005234 Fatty Liver pirinixic acid 8.0319236843 20131406
MESH:D018222 Fibromatosis, Aggressive Doxorubicin 4.7819069698
MESH:D005355 Fibrosis Cyclosporine 9.2812168785 12639820
MESH:D005355 Fibrosis Tretinoin 9.2817994277
MESH:D005756 Gastritis Acetaminophen 3.8916983495
MESH:D005885 Gingival Hyperplasia Cyclosporine 4.418708960
MESH:D005909 Glioblastoma Doxorubicin 7.5417150277
MESH:D005909 Glioblastoma Tretinoin 7.5417312396
MESH:D006258 Head and Neck Neoplasms Doxorubicin 8.1515692506
MESH:D006258 Head and Neck Neoplasms Tretinoin 8.1516096774
MESH:D006317 Hearing Loss, Noise-Induced Tretinoin 5.3816084493
MESH:D006330 Heart Defects, Congenital Benzo(a)pyrene 6.8820471113
MESH:D006330 Heart Defects, Congenital Tretinoin 6.889664655 14991402
MESH:D006331 Heart Diseases Doxorubicin 3.5816495754 18674790 18006777 16244371 16879835 16144979 16244372 16707910 17875725 16330681 14766674 17888722 12587719
MESH:D006333 Heart Failure Doxorubicin 7.3217481944
MESH:D006333 Heart Failure pirinixic acid 7.3220558911
MESH:D006394 Hemangiosarcoma Doxorubicin 4.0415692506
MESH:D006457 Hemoglobinuria, Paroxysmal Cyclosporine 4.6215720958
MESH:D006529 Hepatomegaly pirinixic acid 3.1716221962 19176532 18467677 19772884
MESH:D006689 Hodgkin Disease Doxorubicin 3.5317606976 15147373 18501091
MESH:D006930 Hyperalgesia Acetaminophen 8.0016870215
MESH:D006930 Hyperalgesia Tretinoin 8.0016870215
MESH:D017681 Hypereosinophilic Syndrome Tretinoin 4.7416778211
MESH:D006943 Hyperglycemia pirinixic acid 3.3120558911
MESH:D006973 Hypertension Cyclosporine 2.1410903974
MESH:D020244 Infarction, Middle Cerebral Artery Progesterone 4.5815869954
MESH:D007249 Inflammation Progesterone 2.6615869954
MESH:D007333 Insulin Resistance pirinixic acid 2.7216306350
MESH:D007410 Intestinal Diseases Tretinoin 3.9417994277
MESH:D007569 Jaw Abnormalities Tretinoin 4.0415992940 17551590
MESH:D007638 Keratoconjunctivitis Sicca Cyclosporine 4.6615604871
MESH:D007674 Kidney Diseases Acetaminophen 10.4912587719 15629191
MESH:D007674 Kidney Diseases Cyclosporine 10.4918776723 10903974 8314463
MESH:D007674 Kidney Diseases Doxorubicin 10.4916775033 15369732 15699352
MESH:D007676 Kidney Failure, Chronic Doxorubicin 4.2916707910
MESH:D007680 Kidney Neoplasms Cyclosporine 2.8512371664
MESH:D007938 Leukemia Tretinoin 2.8317143497
MESH:D004915 Leukemia, Erythroblastic, Acute Doxorubicin 5.3716085563
MESH:D007951 Leukemia, Myeloid Tretinoin 3.8419285840 16482212 16932348
MESH:D015470 Leukemia, Myeloid, Acute Tretinoin 2.1017596541 16294345 19850784
MESH:D015473 Leukemia, Promyelocytic, Acute Tretinoin 3.2415748426 17712046 16766008 19642359 17301526 9834237 17217047 16788101 12679006 16891316 19225113 17649720 17368321 16823087 16140955 19075265 17506722 17294898 19035177 17339181 16935935 17107899 16331271 17361223 19029980
MESH:D017880 Limb Deformities, Congenital Tretinoin 3.419224671
MESH:D008106 Liver Cirrhosis, Experimental Doxorubicin 3.6016595196 16439617
MESH:D008106 Liver Cirrhosis, Experimental pirinixic acid 3.6015474484
MESH:D008106 Liver Cirrhosis, Experimental Tretinoin 3.6018397230 16248980
MESH:D008107 Liver Diseases Acetaminophen 1.6619784758 16611625 19460945 16610002 19014921 11587558 12969438 12587719
MESH:D017114 Liver Failure, Acute Acetaminophen 3.3717185352 16871587
MESH:D008113 Liver Neoplasms Benzo(a)pyrene 4.5220195826 21137059
MESH:D008113 Liver Neoplasms pirinixic acid 4.5220007298 15890375 16377806
MESH:D008114 Liver Neoplasms, Experimental Doxorubicin 3.1016842330 17085340
MESH:D055370 Lung Injury Asbestos, Crocidolite 4.2017365036
MESH:D008175 Lung Neoplasms Benzo(a)pyrene 2.5518816296 20064080 18569708 6695378 20135361 20464547 17053015 18520028 20869020
MESH:D008175 Lung Neoplasms Doxorubicin 2.5517418594 6189445
MESH:D008223 Lymphoma Doxorubicin 3.5616098063
MESH:D008228 Lymphoma, Non-Hodgkin Doxorubicin 3.9117654614
MESH:D016399 Lymphoma, T-Cell Doxorubicin 4.7415621674
MESH:D008325 Mammary Neoplasms, Experimental Doxorubicin 6.5215458769
MESH:D008325 Mammary Neoplasms, Experimental Progesterone 6.5217203775 11408345
MESH:D008527 Medulloblastoma Tretinoin 2.8317453147
MESH:D008545 Melanoma Doxorubicin 3.5016827129
MESH:D008545 Melanoma Tretinoin 3.5016752155
MESH:D008546 Melanoma, Experimental Acetaminophen 3.7419513568
MESH:D008591 Meningomyelocele Tretinoin 4.6016940565
MESH:D008654 Mesothelioma Asbestos, Crocidolite 6.6018303189 16966607 16166281
MESH:D008654 Mesothelioma Doxorubicin 6.6017638057
MESH:D008664 Metal Metabolism, Inborn Errors Cyclosporine 5.0116801185
MESH:D028361 Mitochondrial Diseases Doxorubicin 4.6415792986
MESH:D009062 Mouth Neoplasms Benzo(a)pyrene 3.3016381670
MESH:D052016 Mucositis Doxorubicin 4.9817415656
MESH:D009135 Muscular Diseases pirinixic acid 3.6816239165
MESH:D009190 Myelodysplastic Syndromes Tretinoin 3.1517596541
MESH:D009203 Myocardial Infarction Doxorubicin 5.8819429709 15857846
MESH:D009203 Myocardial Infarction pirinixic acid 5.8819151258
MESH:D015428 Myocardial Reperfusion Injury pirinixic acid 3.0516411023
MESH:D009362 Neoplasm Metastasis Doxorubicin 3.0018259882
MESH:D009369 Neoplasms Benzo(a)pyrene 8.5711141357
MESH:D009369 Neoplasms pirinixic acid 8.5717405874
MESH:D009369 Neoplasms Tretinoin 8.5716594593 16946489
MESH:D009401 Nephrosis Doxorubicin 4.9416636307 16899518
MESH:D009402 Nephrosis, Lipoid Cyclosporine 4.6617954296
MESH:D009404 Nephrotic Syndrome Cyclosporine 9.7119348381 18481113
MESH:D009404 Nephrotic Syndrome Doxorubicin 9.7116889571 15640375
MESH:D009421 Nervous System Malformations Tretinoin 3.949125849
MESH:D009436 Neural Tube Defects Tretinoin 3.149142499
MESH:D009447 Neuroblastoma Doxorubicin 3.3315555623
MESH:D019636 Neurodegenerative Diseases Acetaminophen 2.9918514411
MESH:D009765 Obesity pirinixic acid 1.8420558911
MESH:D012516 Osteosarcoma Doxorubicin 4.2315930896
MESH:D010051 Ovarian Neoplasms Progesterone 5.0517393432 16525653
MESH:D010051 Ovarian Neoplasms Tretinoin 5.0516936753
MESH:D010146 Pain Acetaminophen 6.9816870215
MESH:D010146 Pain Tretinoin 6.9816870215
MESH:D010190 Pancreatic Neoplasms Tretinoin 2.5015976015
MESH:D003557 Phyllodes Tumor Doxorubicin 5.3717983394
MESH:D010995 Pleural Diseases Asbestos, Crocidolite 5.0710923243
MESH:D010997 Pleural Neoplasms Doxorubicin 5.3717638057
MESH:D011230 Precancerous Conditions Cyclosporine 3.3512371664
MESH:D011471 Prostatic Neoplasms Benzo(a)pyrene 3.2517292933
MESH:D011471 Prostatic Neoplasms Doxorubicin 3.2516868541 16729912 15749863 16888761 15897917 18437689
MESH:D011507 Proteinuria Tretinoin 3.7516636307
MESH:D011565 Psoriasis Cyclosporine 2.2716882103
MESH:D011625 Pterygium Tretinoin 4.9916723453
MESH:D011658 Pulmonary Fibrosis Asbestos, Crocidolite 3.0717322281 17365031 15814490 17975199
MESH:D051437 Renal Insufficiency Doxorubicin 4.4017922066
MESH:D015427 Reperfusion Injury pirinixic acid 2.4519058328
MESH:D012208 Rhabdomyosarcoma Tretinoin 4.2516283617 16116481
MESH:D012468 Salivary Gland Neoplasms Progesterone 2.9018045962
MESH:D012509 Sarcoma Doxorubicin 4.1215625365 15675481 16767912 17710206 17203757 18313854
MESH:D012512 Sarcoma, Ewing's Doxorubicin 4.4014601052 16326096
MESH:D012514 Sarcoma, Kaposi Doxorubicin 4.9817846226
MESH:D012878 Skin Neoplasms Benzo(a)pyrene 9.8619755658 10029692
MESH:D012878 Skin Neoplasms Doxorubicin 9.8615692506
MESH:D012878 Skin Neoplasms Tretinoin 9.8616467112
MESH:D012983 Soft Tissue Neoplasms Doxorubicin 4.7417203757 16767912 15625365
MESH:D013119 Spinal Cord Injuries Progesterone 4.4715862959 16503802
MESH:D013274 Stomach Neoplasms Benzo(a)pyrene 2.3820155912 2093021
MESH:D013274 Stomach Neoplasms Tretinoin 2.3817261132
MESH:D013733 Testicular Diseases phenethyl isothiocyanate 5.1415864552
MESH:D013964 Thyroid Neoplasms Doxorubicin 7.6716010429 17909728
MESH:D013964 Thyroid Neoplasms Tretinoin 7.6717045167 16026305
MESH:D014062 Tongue Neoplasms Tretinoin 3.9216051514
MESH:D014376 Tuberculosis Tretinoin 3.3116040207
MESH:D001749 Urinary Bladder Neoplasms Benzo(a)pyrene 5.3117053015
MESH:D001749 Urinary Bladder Neoplasms Doxorubicin 5.3117653716
MESH:D014581 Urticaria Acetaminophen 3.1210982225
MESH:D002583 Uterine Cervical Neoplasms Tretinoin 3.8116129372
MESH:D014604 Uveal Neoplasms Tretinoin 4.8316752155
MESH:D014605 Uveitis Cyclosporine 4.201336536
MESH:D018487 Ventricular Dysfunction, Left Doxorubicin 4.4017638931 17678736 16364871 17334414
MESH:D014820 Vitiligo Tretinoin 4.2216761959
MESH:D009396 Wilms Tumor Tretinoin 4.0916287080
MESH:D014985 Xerophthalmia Cyclosporine 4.6617120751
No data
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Syndromic Genes

Non-syndromic Genes

AutismKB Statistics

  • Studies: 1,036
  • Genes: 1,379
  • CNVs/SVs: 5,420
  • SNVs/Indels: 11,669
  • de novo Mutations: 5,669
  • Mosaics: 789
  • Linkage Regions: 172
  • Paper Collected: 6/30/2018
  • Last Update: 8/26/2018


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