AutismKB 2.0

Annotation Detail for PDE8A


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Basic Information Top
Gene Symbol:PDE8A ( FLJ16150,HsT19550 )
Gene Full Name: phosphodiesterase 8A
Band: 15q25.3
Quick LinksEntrez ID:5151; OMIM: 602972; Uniprot ID:PDE8A_HUMAN; ENSEMBL ID: ENSG00000073417; HGNC ID: 8793
Relate to Another Database: SFARIGene; denovo-db
Related Pathway Information Top
No data
Pathway IDPathway Name
hsa00230Purine metabolism
Pathway IDPathway Name
Signaling by GPCR
No data
No data
No data
Related Diseases/Disorders Top
Comparative Toxicogenomics Database Top
Chemical ID Chemical Name Interaction Interaction Action Publication
C548651 2-(1'H-indolo-3'-carbonyl)thiazole-4-carboxylic acid methyl ester 2-(1'H-indolo-3'-carbonyl)thiazole-4-carboxylic acid methyl ester results in decreased expression of PDE8A mRNAdecreases expression 19933214
D000082 Acetaminophen Acetaminophen affects the expression of PDE8A mRNAaffects expression 17562736
D015123 7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide 7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide results in decreased expression of PDE8A mRNAdecreases expression 19150397
D004390 Chlorpyrifos Chlorpyrifos results in increased expression of PDE8A mRNAincreases expression 17452286
D003976 Diazinon Diazinon results in increased expression of PDE8A mRNAincreases expression 17452286
D004997 Ethinyl Estradiol Ethinyl Estradiol results in decreased expression of PDE8A mRNAdecreases expression 17942748
D005419 Flavonoids Flavonoids results in decreased expression of PDE8A mRNAdecreases expression 18035473
D008942 Mitoxantrone PDE8A protein affects the susceptibility to Mitoxantroneaffects response to substance 16217747
C010327 salinomycin salinomycin results in decreased expression of PDE8A mRNAdecreases expression 19682730
D012643 Selenium [Selenium co-treated with Vitamin E] results in decreased expression of PDE8A mRNAaffects cotreatment|decreases expression 19244175
D012643 Selenium Selenium results in decreased expression of PDE8A mRNAdecreases expression 19244175
D013749 Tetrachlorodibenzodioxin Tetrachlorodibenzodioxin results in decreased expression of PDE8A mRNAdecreases expression 19933214
D019772 Topotecan PDE8A protein affects the susceptibility to Topotecanaffects response to substance 16217747
D014810 Vitamin E [Selenium co-treated with Vitamin E] results in decreased expression of PDE8A mRNAaffects cotreatment|decreases expression 19244175
D014810 Vitamin E Vitamin E results in decreased expression of PDE8A mRNAdecreases expression 19244175
Disease ID Disease Name Direct Evidence Inference Chemical Name Inference Score Publication
MESH:D000014 Abnormalities, Drug-Induced Tetrachlorodibenzodioxin 2.9614514962 15322242 11752688
MESH:D000152 Acne Vulgaris Ethinyl Estradiol 4.0817505938
MESH:D000230 Adenocarcinoma Ethinyl Estradiol 1.8314692618
MESH:D018248 Adenoma, Liver Cell Tetrachlorodibenzodioxin 3.4916835633
MESH:D000382 Agricultural Workers' Diseases Chlorpyrifos 9.5711874814 16611668 17119214
MESH:D000382 Agricultural Workers' Diseases Diazinon 9.5716487989
MESH:D000740 Anemia Tetrachlorodibenzodioxin 3.0211748828
MESH:D000799 Angioedema Acetaminophen 3.9810982225
MESH:D001161 Arteriosclerosis Ethinyl Estradiol 3.5711256880
MESH:D001169 Arthritis, Experimental Ethinyl Estradiol 2.7115885639
MESH:D001321 Autistic Disorder Acetaminophen 1.4118445737
MESH:D001778 Blood Coagulation Disorders Tetrachlorodibenzodioxin 3.1212125929
MESH:D001836 Body Weight Changes Tetrachlorodibenzodioxin 3.9215340226
MESH:D001848 Bone Diseases, Developmental Tetrachlorodibenzodioxin 2.8115746008
MESH:D001943 Breast Neoplasms salinomycin 2.3719682730
MESH:D001943 Breast Neoplasms Tetrachlorodibenzodioxin 2.3720435547
MESH:D002252 Carbon Tetrachloride Poisoning Vitamin E 4.0316050911
MESH:D002277 Carcinoma Tetrachlorodibenzodioxin 2.8616835633
MESH:D006528 Carcinoma, Hepatocellular Acetaminophen 1.383084413
MESH:D006332 Cardiomegaly Tetrachlorodibenzodioxin 2.4118850075 18670907 16120746
MESH:D002386 Cataract Acetaminophen 2.6310977129
MESH:D002471 Cell Transformation, Neoplastic 7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide 2.7820889678
MESH:D018281 Cholangiocarcinoma Tetrachlorodibenzodioxin 3.2316835633
MESH:D002779 Cholestasis Ethinyl Estradiol 2.9311677210 16105132 17333356 15861022 17110522 17681005 16919318
MESH:D002972 Cleft Palate Tetrachlorodibenzodioxin 2.1316354765 8697196 15340226 15668235 12621046
MESH:D003092 Colitis Selenium 3.8817936198
MESH:D000013 Congenital Abnormalities Tetrachlorodibenzodioxin 3.1314669216 17141729
MESH:D019465 Craniofacial Abnormalities Tetrachlorodibenzodioxin 2.5015322242 10048152 20055451
MESH:D019465 Craniofacial Abnormalities Vitamin E 2.5019769572
MESH:D003924 Diabetes Mellitus, Type 2 Tetrachlorodibenzodioxin 1.6817107852
MESH:D056486 Drug-Induced Liver Injury Acetaminophen 6.2716177239 12153990 19420014 16485898 16109766 19164858 17906064 12392966 15968718 11529661 16081117 12705907 19085960 10663392 14986274 18713872 12958197 14725611 15619225 19370779 16227642 11739529 11287661 17562736 10915739 16781746 18071297 12594235 11421492 14550746 11461765 12540782 19739265 16393943 19416960 11743745 17522070 2444490 11834606 19923254 10774834
MESH:D056486 Drug-Induced Liver Injury Selenium 6.2715131321
MESH:D056486 Drug-Induced Liver Injury Tetrachlorodibenzodioxin 6.2720420201
MESH:D056487 Drug-Induced Liver Injury, Chronic Acetaminophen 4.2319426721
MESH:D004362 Drug Toxicity Tetrachlorodibenzodioxin 2.8211462148
MESH:D004417 Dyspnea Diazinon 4.9316487989
MESH:C538011 Eales disease Vitamin E 4.849068938
MESH:D004487 Edema Tetrachlorodibenzodioxin 2.4611000095 12711302
MESH:D004489 Edema, Cardiac Tetrachlorodibenzodioxin 4.0418230668 15322242 16714409
MESH:D004681 Encephalomyelitis, Autoimmune, Experimental Ethinyl Estradiol 3.2812538720
MESH:D004715 Endometriosis Tetrachlorodibenzodioxin 3.109294722 10568697
MESH:D004938 Esophageal Neoplasms 7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide 2.0920426865
MESH:D005124 Eye Abnormalities Tetrachlorodibenzodioxin 3.0711564622
MESH:D005234 Fatty Liver Ethinyl Estradiol 2.8915345470
MESH:D005313 Fetal Death Tetrachlorodibenzodioxin 3.5611858732
MESH:D005355 Fibrosis Tetrachlorodibenzodioxin 3.0520067830
MESH:D005756 Gastritis Acetaminophen 3.8116983495
MESH:D006058 Gonadal Disorders Tetrachlorodibenzodioxin 4.7310696789
MESH:D006330 Heart Defects, Congenital Tetrachlorodibenzodioxin 6.7010048152 11294989
MESH:D006330 Heart Defects, Congenital Vitamin E 6.7016080930
MESH:D006331 Heart Diseases Mitoxantrone 4.2116019553
MESH:D006333 Heart Failure Selenium 3.1217162251
MESH:D006470 Hemorrhage Tetrachlorodibenzodioxin 3.4211000095
MESH:D006505 Hepatitis Diazinon 4.6716487989
MESH:D006529 Hepatomegaly Tetrachlorodibenzodioxin 3.0016120746 15340226 12621046
MESH:D006548 Hernia, Diaphragmatic Vitamin E 2.7316863852 16490937
MESH:D019584 Hot Flashes Vitamin E 4.1114716179
MESH:D006869 Hydronephrosis Tetrachlorodibenzodioxin 4.188697196 18606429 15340226 16959395 16354765
MESH:D006930 Hyperalgesia Acetaminophen 2.7616870215
MESH:D006973 Hypertension Tetrachlorodibenzodioxin 1.9318850075 18670907
MESH:D007021 Hypospadias Ethinyl Estradiol 3.9116945680 16569931
MESH:D007247 Infertility, Female Ethinyl Estradiol 3.5512013081
MESH:D007248 Infertility, Male Diazinon 7.1312948887 16466525
MESH:D007248 Infertility, Male Ethinyl Estradiol 7.1317937319
MESH:D007249 Inflammation Flavonoids 5.1317296493
MESH:D007249 Inflammation Tetrachlorodibenzodioxin 5.1312200463 12878042
MESH:D007251 Influenza, Human Selenium 11.4116624496
MESH:D007251 Influenza, Human Vitamin E 11.4116624496
MESH:D007569 Jaw Abnormalities Tetrachlorodibenzodioxin 3.4216580747
MESH:D007674 Kidney Diseases Acetaminophen 6.1115629191 12587719
MESH:D007674 Kidney Diseases Vitamin E 6.1112488133
MESH:D007676 Kidney Failure, Chronic Selenium 3.9716518626
MESH:D015451 Leukemia, Lymphocytic, Chronic, B-Cell Mitoxantrone 3.8218172266
MESH:D008106 Liver Cirrhosis, Experimental Tetrachlorodibenzodioxin 2.3612878042
MESH:D008106 Liver Cirrhosis, Experimental Vitamin E 2.3616169303
MESH:D008107 Liver Diseases Acetaminophen 4.3312969438 19014921 19784758 12587719 16611625 19460945 11587558 16610002
MESH:D008107 Liver Diseases Chlorpyrifos 4.3315991261
MESH:D017114 Liver Failure, Acute Acetaminophen 3.3116871587 17185352
MESH:D008113 Liver Neoplasms Tetrachlorodibenzodioxin 1.7416984957
MESH:D008114 Liver Neoplasms, Experimental Tetrachlorodibenzodioxin 2.1512151625
MESH:D008171 Lung Diseases Vitamin E 3.2316863852
MESH:D008175 Lung Neoplasms Tetrachlorodibenzodioxin 2.3319555203 11884234
MESH:D008175 Lung Neoplasms Vitamin E 2.3311062179
MESH:D008325 Mammary Neoplasms, Experimental salinomycin 6.6319682730
MESH:D008325 Mammary Neoplasms, Experimental Selenium 6.6315318939
MESH:D008546 Melanoma, Experimental Acetaminophen 3.6719513568
MESH:D008654 Mesothelioma Selenium 2.8215107826
MESH:D017202 Myocardial Ischemia Tetrachlorodibenzodioxin 3.0812213967
MESH:D009369 Neoplasms Mitoxantrone 3.4516640825
MESH:D009421 Nervous System Malformations Tetrachlorodibenzodioxin 3.3114600291
MESH:D009447 Neuroblastoma Topotecan 3.8915176712
MESH:D019636 Neurodegenerative Diseases Acetaminophen 2.9418514411
MESH:D020258 Neurotoxicity Syndromes Chlorpyrifos 4.2215081274
MESH:D010146 Pain Acetaminophen 2.4616870215
MESH:D016584 Panic Disorder Ethinyl Estradiol 3.7711578682
MESH:D010382 Peliosis Hepatis Tetrachlorodibenzodioxin 4.3812520081
MESH:D010954 Plasmacytoma Selenium 5.0215087411
MESH:D011041 Poisoning Diazinon 4.4417603234
MESH:D017119 Porphyria Cutanea Tarda Tetrachlorodibenzodioxin 3.6518163543
MESH:D011297 Prenatal Exposure Delayed Effects Tetrachlorodibenzodioxin 3.3111399792 11118676 11222880 11896295
MESH:D011471 Prostatic Neoplasms Vitamin E 3.2915084515
MESH:D011537 Pruritus Ethinyl Estradiol 3.4316919318 15861022
MESH:D012135 Respiratory Sounds Chlorpyrifos 4.7417119214 11874814 16611668
MESH:D015619 Respiratory System Abnormalities Tetrachlorodibenzodioxin 3.9318990726
MESH:D012140 Respiratory Tract Diseases Chlorpyrifos 5.0316611668 17119214
MESH:D012729 Sex Chromosome Aberrations Chlorpyrifos 6.226418539
MESH:D012871 Skin Diseases Vitamin E 2.4618709164
MESH:D012878 Skin Neoplasms Tetrachlorodibenzodioxin 2.0816192470
MESH:D013088 Spermatocele Ethinyl Estradiol 4.0816709447
MESH:D020521 Stroke Vitamin E 3.5816517955
MESH:D019851 Thrombophilia Ethinyl Estradiol 3.7111994571
MESH:D013927 Thrombosis Ethinyl Estradiol 3.2215669648
MESH:D013959 Thyroid Diseases Tetrachlorodibenzodioxin 4.0412697716
MESH:D014570 Urologic Diseases Diazinon 5.4116487989
MESH:D014581 Urticaria Acetaminophen 3.0610982225
MESH:D014594 Uterine Neoplasms Ethinyl Estradiol 3.3914692618
MESH:D054079 Vascular Malformations Tetrachlorodibenzodioxin 4.7312125929
MESH:D020246 Venous Thrombosis Ethinyl Estradiol 3.6214671159 15869587
MESH:D019282 Wasting Syndrome Tetrachlorodibenzodioxin 4.3815886252
Pathway ID Pathway Name
KEGG:00230 Purine metabolism
REACT:14797 Signaling by GPCR
Pharmacogenomics Knowledge Base Top
  • PharmGKB Accession:PA33141
    • No data
    Releated disease ID Related disease Name
    PA447321Depressive Disorder, Major
    PA446155Precursor Cell Lymphoblastic Leukemia-Lymphoma
    Releated drug ID Related drug Name
    PA449233desipramine
    PA449673fluoxetine
    Drug Bank Top
    Drugbank ID Action Drug Name Description
    DB00920 antagonist Ketotifen Antipruritics;Anti-Allergic Agents;Histamine H1 Antagonists
    DB07954 - 3-ISOBUTYL-1-METHYLXANTHINE
    No data
    No data
    No data

    Simple Query:


      (e.g. CHD8)

    Syndromic Genes

    Non-syndromic Genes

    AutismKB Statistics

    • Studies: 1,036
    • Genes: 1,379
    • CNVs/SVs: 5,420
    • SNVs/Indels: 11,669
    • de novo Mutations: 5,669
    • Mosaics: 789
    • Linkage Regions: 172
    • Paper Collected: 6/30/2018
    • Last Update: 8/26/2018


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