AutismKB 2.0

Annotation Detail for GTSE1


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Basic Information Top
Gene Symbol:GTSE1 ( B99 )
Gene Full Name: G-2 and S-phase expressed 1
Band: 22q13.31
Quick LinksEntrez ID:51512; OMIM: 607477; Uniprot ID:GTSE1_HUMAN; ENSEMBL ID: ENSG00000075218; HGNC ID: 13698
Relate to Another Database: SFARIGene; denovo-db
Related Pathway Information Top
No data
Pathway IDPathway Name
hsa04115p53 signaling pathway
No data
No data
Pathway IDPathway Name
P00059p53 pathway
No data
Related Diseases/Disorders Top
Comparative Toxicogenomics Database Top
Chemical ID Chemical Name Interaction Interaction Action Publication
C010914 2,4-diaminotoluene 2,4-diaminotoluene results in increased expression of GTSE1 mRNAincreases expression 20713471
D000082 Acetaminophen Acetaminophen affects the expression of GTSE1 mRNAaffects expression 17562736
D001151 Arsenic Arsenic results in increased expression of GTSE1 mRNAincreases expression 19945496
D001564 Benzo(a)pyrene Benzo(a)pyrene results in increased expression of GTSE1 mRNAincreases expression 20713471
D015123 7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide 7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide results in decreased expression of GTSE1 mRNAdecreases expression 20382639
20018196
D016572 Cyclosporine Cyclosporine results in decreased expression of GTSE1 mRNAdecreases expression 20106945
C472511 dimethylarsinous acid dimethylarsinous acid results in increased expression of GTSE1 mRNAincreases expression 19945496
C547156 dimethylthioarsinic acid dimethylthioarsinic acid results in increased expression of GTSE1 mRNAincreases expression 19945496
D004317 Doxorubicin GTSE1 protein affects the susceptibility to Doxorubicinaffects response to substance 16217747
D000431 Ethanol [Fish Oils co-treated with Ethanol] results in increased expression of GTSE1 mRNAaffects cotreatment|increases expression 17347304
D004997 Ethinyl Estradiol Ethinyl Estradiol results in increased expression of GTSE1 mRNAincreases expression 17942748
D004997 Ethinyl Estradiol [Tetrachlorodibenzodioxin co-treated with Ethinyl Estradiol] results in increased expression of GTSE1 mRNAaffects cotreatment|increases expression 17942748
D005395 Fish Oils [Fish Oils co-treated with Ethanol] results in increased expression of GTSE1 mRNAaffects cotreatment|increases expression 17347304
D019833 Genistein Genistein affects the expression of GTSE1 mRNAaffects expression 18847459
D008748 Methylcholanthrene Methylcholanthrene results in increased expression of GTSE1 mRNAincreases expression 20713471
D013749 Tetrachlorodibenzodioxin [Tetrachlorodibenzodioxin co-treated with Ethinyl Estradiol] results in increased expression of GTSE1 mRNAaffects cotreatment|increases expression 17942748
C496197 trans-10,cis-12-conjugated linoleic acid trans-10,cis-12-conjugated linoleic acid results in decreased expression of GTSE1 mRNAdecreases expression 17951470
D014212 Tretinoin Tretinoin results in decreased expression of GTSE1 mRNAdecreases expression 16249480
D014747 Vinblastine GTSE1 protein affects the susceptibility to Vinblastineaffects response to substance 16217747
Disease ID Disease Name Direct Evidence Inference Chemical Name Inference Score Publication
MESH:D000014 Abnormalities, Drug-Induced Ethanol 8.3517676605 18926900
MESH:D000014 Abnormalities, Drug-Induced Tetrachlorodibenzodioxin 8.3514514962 15322242 11752688
MESH:D000138 Acidosis Ethanol 4.4611192467
MESH:D000152 Acne Vulgaris Ethinyl Estradiol 3.9117505938
MESH:D000230 Adenocarcinoma Benzo(a)pyrene 10.1020127859 20464547
MESH:D000230 Adenocarcinoma Doxorubicin 10.1017418594
MESH:D000230 Adenocarcinoma Ethinyl Estradiol 10.1014692618
MESH:D000230 Adenocarcinoma Genistein 10.1011473722
MESH:D000236 Adenoma Benzo(a)pyrene 6.786695378
MESH:D000236 Adenoma Methylcholanthrene 6.7810545420 6695378
MESH:D018248 Adenoma, Liver Cell Tetrachlorodibenzodioxin 3.3416835633
MESH:D018246 Adrenocortical Adenoma Arsenic 5.1817306315
MESH:D000419 Albuminuria Doxorubicin 4.5021441931
MESH:D020268 Alcohol-Induced Disorders, Nervous System Ethanol 5.2915451039 15451040
MESH:D000505 Alopecia Tretinoin 3.5815955085
MESH:D000740 Anemia Tetrachlorodibenzodioxin 2.9111748828
MESH:D000799 Angioedema Acetaminophen 3.8110982225
MESH:D000853 Anophthalmos Ethanol 4.7815513904
MESH:D001008 Anxiety Disorders Ethanol 3.9711141031
MESH:D017544 Aortic Aneurysm, Abdominal Benzo(a)pyrene 4.0319183758
MESH:D020261 Arsenic Poisoning Arsenic 2.8516251483 12569548 16835338 18414634
MESH:D001161 Arteriosclerosis Ethinyl Estradiol 3.4211256880
MESH:D001169 Arthritis, Experimental Ethinyl Estradiol 7.1115885639
MESH:D001169 Arthritis, Experimental Tretinoin 7.1116412693
MESH:D001172 Arthritis, Rheumatoid Tretinoin 2.2516292516
MESH:D001249 Asthma Tretinoin 2.3316456186
MESH:D050197 Atherosclerosis Arsenic 6.8719371607 12928151
MESH:D050197 Atherosclerosis Methylcholanthrene 6.8711922910
MESH:D001321 Autistic Disorder Acetaminophen 1.4218445737
MESH:D001471 Barrett Esophagus Tretinoin 4.3616935849
MESH:D001778 Blood Coagulation Disorders Tetrachlorodibenzodioxin 8.8012125929
MESH:D001778 Blood Coagulation Disorders Tretinoin 8.8016206674 16197459
MESH:D001836 Body Weight Changes Tetrachlorodibenzodioxin 3.7615340226
MESH:D001848 Bone Diseases, Developmental Tetrachlorodibenzodioxin 2.7315746008
MESH:D019046 Bone Marrow Neoplasms Doxorubicin 4.6714601052
MESH:D001932 Brain Neoplasms Doxorubicin 3.7717150277
MESH:D001943 Breast Neoplasms 2,4-diaminotoluene 3.7511921183
MESH:D001943 Breast Neoplasms Benzo(a)pyrene 3.7517474063 20146248
MESH:D001943 Breast Neoplasms Doxorubicin 3.7516115903 19526202 18628466 16264153 17983394 16096432 17369602 15136595 11325840 15567936 15994142 18695136 16322301 15939500 15692762 16826403 18234424 15993339 15634643 16935488 18382427 16595493 15668708 17426702
MESH:D001943 Breast Neoplasms Genistein 3.7516873071 17200150 16541309
MESH:D001943 Breast Neoplasms Methylcholanthrene 3.7517474063
MESH:D001943 Breast Neoplasms Tetrachlorodibenzodioxin 3.7520435547
MESH:D001943 Breast Neoplasms Tretinoin 3.7516166294 16443354 16873071
MESH:D001997 Bronchopulmonary Dysplasia Tretinoin 4.5516813970
MESH:D002056 Burns Ethanol 4.6116374292
MESH:D002276 Carcinoid Tumor Doxorubicin 4.7816051944
MESH:D002277 Carcinoma Methylcholanthrene 8.2110545420
MESH:D002277 Carcinoma Tetrachlorodibenzodioxin 8.2116835633
MESH:D002280 Carcinoma, Basal Cell Arsenic 3.5717687452 15504454
MESH:D018236 Carcinoma, Embryonal Tretinoin 5.1316168501
MESH:D006528 Carcinoma, Hepatocellular Acetaminophen 11.323084413
MESH:D006528 Carcinoma, Hepatocellular Arsenic 11.3217306315 16507464
MESH:D006528 Carcinoma, Hepatocellular Doxorubicin 11.3216234567 18059187 16023760 17876044
MESH:D006528 Carcinoma, Hepatocellular Ethanol 11.3218788625 15763234 15289165
MESH:D006528 Carcinoma, Hepatocellular Genistein 11.3216924424
MESH:D006528 Carcinoma, Hepatocellular Tretinoin 11.321917145
MESH:D002292 Carcinoma, Renal Cell Doxorubicin 6.8916201981 1485588
MESH:D002292 Carcinoma, Renal Cell Vinblastine 6.891485588
MESH:D002294 Carcinoma, Squamous Cell Arsenic 10.7215504454 17687452 18922899
MESH:D002294 Carcinoma, Squamous Cell Benzo(a)pyrene 10.7220419170
MESH:D002294 Carcinoma, Squamous Cell Doxorubicin 10.726189445
MESH:D002294 Carcinoma, Squamous Cell Tretinoin 10.7216051514 16096774
MESH:D002295 Carcinoma, Transitional Cell Arsenic 4.0418640142
MESH:D006332 Cardiomegaly Ethanol 6.7619332462
MESH:D006332 Cardiomegaly Tetrachlorodibenzodioxin 6.7618850075 18670907 16120746
MESH:D009202 Cardiomyopathies Doxorubicin 3.5015792986 17308081 17974986 15505089 16455267 16364871 17924179 16109756 17382496 17519947 16242529 18627295 16612575 17329180 17007740 15476868 15811867 17131338 16952015 17351982 16278810 16651473 17928571 16269455 16731534
MESH:D002311 Cardiomyopathy, Dilated Doxorubicin 2.9316243910 17334414
MESH:D002318 Cardiovascular Diseases Arsenic 7.4019152805 15738583 17938729
MESH:D002318 Cardiovascular Diseases Genistein 7.4016332659
MESH:D002340 Carotid Artery Diseases Arsenic 4.2718022660 16973168
MESH:D002386 Cataract Acetaminophen 7.1410977129
MESH:D002386 Cataract Tretinoin 7.1417460283
MESH:D002471 Cell Transformation, Neoplastic 7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide 11.0620889678
MESH:D002471 Cell Transformation, Neoplastic Cyclosporine 11.0612371664
MESH:D002471 Cell Transformation, Neoplastic Methylcholanthrene 11.0616192471
MESH:D018290 Cervical Intraepithelial Neoplasia Tretinoin 4.5516129372
MESH:D018281 Cholangiocarcinoma Tetrachlorodibenzodioxin 3.1216835633
MESH:D002779 Cholestasis Cyclosporine 7.6619486331
MESH:D002779 Cholestasis Ethinyl Estradiol 7.6617681005 17333356 16919318 11677210 16105132 15861022 17110522
MESH:D002822 Choriocarcinoma Tretinoin 5.1316461808
MESH:D002971 Cleft Lip Ethanol 3.5615513904
MESH:D002972 Cleft Palate Ethanol 9.7415513904
MESH:D002972 Cleft Palate Tetrachlorodibenzodioxin 9.7412621046 8697196 15668235 15340226 16354765
MESH:D002972 Cleft Palate Tretinoin 9.749407595
MESH:D003092 Colitis Tretinoin 3.6617035595
MESH:D003110 Colonic Neoplasms Genistein 2.2817182828
MESH:D015179 Colorectal Neoplasms Doxorubicin 2.9218802399 18259882
MESH:D015179 Colorectal Neoplasms Vinblastine 2.9218802399
MESH:D000013 Congenital Abnormalities Tetrachlorodibenzodioxin 3.0217141729 14669216
MESH:D019465 Craniofacial Abnormalities Ethanol 3.7915451039 15451040 19302082 11873399 11198716 10194807 15513904
MESH:D019465 Craniofacial Abnormalities Tetrachlorodibenzodioxin 3.7915322242 10048152 20055451
MESH:D019465 Craniofacial Abnormalities Tretinoin 3.799125849 10589399 9664655 9211117 14991402 16925845 9224671 9142499 8800419 17551590
MESH:D003924 Diabetes Mellitus, Type 2 Genistein 4.2916647724
MESH:D003924 Diabetes Mellitus, Type 2 Tetrachlorodibenzodioxin 4.2917107852
MESH:D056486 Drug-Induced Liver Injury Acetaminophen 8.8911421492 11743745 17522070 19923254 19416960 19420014 16081117 2444490 16227642 16485898 11461765 11739529 18071297 17562736 11834606 19164858 17906064 10663392 16177239 10774834 12705907 15619225 14986274 16393943 19085960 14550746 16109766 12153990 15968718 12392966 12958197 12540782 11287661 12594235 10915739 18713872 11529661 19370779 19739265 16781746 14725611
MESH:D056486 Drug-Induced Liver Injury Doxorubicin 8.8917416283
MESH:D056486 Drug-Induced Liver Injury Ethanol 8.8911566570
MESH:D056486 Drug-Induced Liver Injury Tetrachlorodibenzodioxin 8.8920420201
MESH:D056487 Drug-Induced Liver Injury, Chronic Acetaminophen 4.0719426721
MESH:D004362 Drug Toxicity Doxorubicin 8.0018602426
MESH:D004362 Drug Toxicity Tetrachlorodibenzodioxin 8.0011462148
MESH:D004487 Edema Tetrachlorodibenzodioxin 2.3411000095 12711302
MESH:D004489 Edema, Cardiac Tetrachlorodibenzodioxin 11.8516714409 15322242 18230668
MESH:D004489 Edema, Cardiac Tretinoin 11.8518230668
MESH:D004681 Encephalomyelitis, Autoimmune, Experimental Ethinyl Estradiol 3.1512538720
MESH:D004714 Endometrial Hyperplasia Genistein 4.5516402032
MESH:D016889 Endometrial Neoplasms Doxorubicin 12.3717359293
MESH:D016889 Endometrial Neoplasms Genistein 12.3711473722
MESH:D016889 Endometrial Neoplasms Tretinoin 12.3716569247
MESH:D004715 Endometriosis Tetrachlorodibenzodioxin 2.9810568697 9294722
MESH:D004719 Endomyocardial Fibrosis Doxorubicin 5.1318037988
MESH:D004938 Esophageal Neoplasms 7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide 7.2120426865
MESH:D004938 Esophageal Neoplasms Benzo(a)pyrene 7.2116530937
MESH:D004938 Esophageal Neoplasms Ethanol 7.2116704527
MESH:D005124 Eye Abnormalities Tetrachlorodibenzodioxin 8.7211564622
MESH:D005124 Eye Abnormalities Tretinoin 8.7216938888 9664655
MESH:D005234 Fatty Liver Cyclosporine 18.5119224547
MESH:D005234 Fatty Liver Ethanol 18.5119236843 18620774 16409862
MESH:D005234 Fatty Liver Ethinyl Estradiol 18.5115345470
MESH:D005234 Fatty Liver Fish Oils 18.5118620774
MESH:D005235 Fatty Liver, Alcoholic Ethanol 5.6417920746
MESH:D005310 Fetal Alcohol Syndrome Ethanol 5.2616946407 10194807 15513904 15451040
MESH:D005313 Fetal Death Tetrachlorodibenzodioxin 3.4211858732
MESH:D018222 Fibromatosis, Aggressive Doxorubicin 4.5519069698
MESH:D005354 Fibrosarcoma Methylcholanthrene 4.9010962813 14633661
MESH:D005355 Fibrosis Cyclosporine 14.5012168785 12639820
MESH:D005355 Fibrosis Tetrachlorodibenzodioxin 14.5020067830
MESH:D005355 Fibrosis Tretinoin 14.5017994277
MESH:D005534 Foot Diseases Arsenic 5.536392382
MESH:D005756 Gastritis Acetaminophen 11.0316983495
MESH:D005756 Gastritis Ethanol 11.0315046732
MESH:D005885 Gingival Hyperplasia Cyclosporine 4.188708960
MESH:D005909 Glioblastoma Doxorubicin 11.7617150277
MESH:D005909 Glioblastoma Genistein 11.7616598420
MESH:D005909 Glioblastoma Tretinoin 11.7617312396
MESH:D006058 Gonadal Disorders Tetrachlorodibenzodioxin 4.5710696789
MESH:D006258 Head and Neck Neoplasms Doxorubicin 7.7415692506
MESH:D006258 Head and Neck Neoplasms Tretinoin 7.7416096774
MESH:D006317 Hearing Loss, Noise-Induced Tretinoin 5.1316084493
MESH:D006330 Heart Defects, Congenital Benzo(a)pyrene 10.9620471113
MESH:D006330 Heart Defects, Congenital Tetrachlorodibenzodioxin 10.9611294989 10048152
MESH:D006330 Heart Defects, Congenital Tretinoin 10.969664655 14991402
MESH:D006331 Heart Diseases Doxorubicin 3.4514766674 17888722 16879835 16707910 16244372 16144979 16495754 12587719 18006777 16244371 17875725 18674790 16330681
MESH:D006333 Heart Failure Doxorubicin 3.3117481944
MESH:D006394 Hemangiosarcoma Doxorubicin 3.8615692506
MESH:D006457 Hemoglobinuria, Paroxysmal Cyclosporine 4.3915720958
MESH:D006470 Hemorrhage Tetrachlorodibenzodioxin 3.2911000095
MESH:D006529 Hepatomegaly Tetrachlorodibenzodioxin 2.8515340226 12621046 16120746
MESH:D006689 Hodgkin Disease Doxorubicin 7.6718501091 15147373 17606976
MESH:D006689 Hodgkin Disease Vinblastine 7.6718501091 18180244
MESH:D006869 Hydronephrosis Tetrachlorodibenzodioxin 4.0216354765 8697196 16959395 15340226 18606429
MESH:D006930 Hyperalgesia Acetaminophen 12.8616870215
MESH:D006930 Hyperalgesia Ethanol 12.8618783367
MESH:D006930 Hyperalgesia Tretinoin 12.8616870215
MESH:D017681 Hypereosinophilic Syndrome Tretinoin 4.5316778211
MESH:D017488 Hyperkeratosis, Epidermolytic Arsenic 4.4217050553
MESH:D006949 Hyperlipidemias Fish Oils 4.7115752949
MESH:D006968 Hypersensitivity, Delayed Fish Oils 5.4811484837
MESH:D006973 Hypertension Arsenic 8.4916076760 9931084 11953799
MESH:D006973 Hypertension Cyclosporine 8.4910903974
MESH:D006973 Hypertension Tetrachlorodibenzodioxin 8.4918670907 18850075
MESH:D006987 Hypesthesia Arsenic 5.5316093927
MESH:D007021 Hypospadias Ethinyl Estradiol 3.7716945680 16569931
MESH:D007247 Infertility, Female Ethinyl Estradiol 3.4212013081
MESH:D007248 Infertility, Male Ethinyl Estradiol 2.4617937319
MESH:D007249 Inflammation Tetrachlorodibenzodioxin 1.8312200463 12878042
MESH:D007410 Intestinal Diseases Tretinoin 3.7317994277
MESH:D007569 Jaw Abnormalities Ethanol 16.9515513904
MESH:D007569 Jaw Abnormalities Tetrachlorodibenzodioxin 16.9516580747
MESH:D007569 Jaw Abnormalities Tretinoin 16.9515992940 17551590
MESH:D007638 Keratoconjunctivitis Sicca Cyclosporine 4.4115604871
MESH:D007642 Keratosis Arsenic 4.9512749816 16930632
MESH:D007674 Kidney Diseases Acetaminophen 9.8912587719 15629191
MESH:D007674 Kidney Diseases Cyclosporine 9.898314463 10903974 18776723
MESH:D007674 Kidney Diseases Doxorubicin 9.8915699352 15369732 16775033
MESH:D007676 Kidney Failure, Chronic Doxorubicin 4.1116707910
MESH:D007680 Kidney Neoplasms Cyclosporine 2.7012371664
MESH:D007859 Learning Disorders Ethanol 4.1715451040
MESH:D007938 Leukemia Genistein 6.3417468513 18980019
MESH:D007938 Leukemia Tretinoin 6.3417143497
MESH:D004915 Leukemia, Erythroblastic, Acute Doxorubicin 5.1316085563
MESH:D007951 Leukemia, Myeloid Tretinoin 3.6619285840 16482212 16932348
MESH:D015470 Leukemia, Myeloid, Acute Tretinoin 2.0719850784 16294345 17596541
MESH:D015473 Leukemia, Promyelocytic, Acute Arsenic 7.6617339181
MESH:D015473 Leukemia, Promyelocytic, Acute Tretinoin 7.6616788101 16766008 17712046 19225113 17361223 12679006 17649720 16140955 16823087 17506722 17294898 17217047 17107899 16331271 17339181 17368321 19642359 17301526 19035177 16935935 9834237 15748426 16891316 19029980 19075265
MESH:D017880 Limb Deformities, Congenital Ethanol 8.2117676605
MESH:D017880 Limb Deformities, Congenital Tretinoin 8.219224671
MESH:D008103 Liver Cirrhosis Ethanol 3.3515289165
MESH:D008104 Liver Cirrhosis, Alcoholic Ethanol 5.0618295389
MESH:D008106 Liver Cirrhosis, Experimental Doxorubicin 6.7016439617 16595196
MESH:D008106 Liver Cirrhosis, Experimental Ethanol 6.7018166357
MESH:D008106 Liver Cirrhosis, Experimental Genistein 6.7017823541
MESH:D008106 Liver Cirrhosis, Experimental Tetrachlorodibenzodioxin 6.7012878042
MESH:D008106 Liver Cirrhosis, Experimental Tretinoin 6.7016248980 18397230
MESH:D008107 Liver Diseases Acetaminophen 4.0312969438 12587719 19784758 11587558 19014921 16610002 19460945 16611625
MESH:D008107 Liver Diseases Arsenic 4.0311134558
MESH:D008108 Liver Diseases, Alcoholic Ethanol 4.6117347304 17207112
MESH:D017114 Liver Failure, Acute Acetaminophen 3.2016871587 17185352
MESH:D008113 Liver Neoplasms Arsenic 7.3316368122
MESH:D008113 Liver Neoplasms Benzo(a)pyrene 7.3320195826 21137059
MESH:D008113 Liver Neoplasms Tetrachlorodibenzodioxin 7.3316984957
MESH:D008114 Liver Neoplasms, Experimental Doxorubicin 9.7817085340 16842330
MESH:D008114 Liver Neoplasms, Experimental Methylcholanthrene 9.781399818 598648
MESH:D008114 Liver Neoplasms, Experimental Tetrachlorodibenzodioxin 9.7812151625
MESH:D008175 Lung Neoplasms Arsenic 6.5517306315 19168569 17976673
MESH:D008175 Lung Neoplasms Benzo(a)pyrene 6.5518816296 20135361 18569708 6695378 20869020 20464547 17053015 18520028 20064080
MESH:D008175 Lung Neoplasms Doxorubicin 6.5517418594 6189445
MESH:D008175 Lung Neoplasms Methylcholanthrene 6.5515390079 17909032 1399818 20512841 7750092 21163286 9230183 11893704 16337739 6695378 20970405 10545420 16271038
MESH:D008175 Lung Neoplasms Tetrachlorodibenzodioxin 6.5511884234 19555203
MESH:D008223 Lymphoma Doxorubicin 3.4316098063
MESH:D008228 Lymphoma, Non-Hodgkin Doxorubicin 3.7517654614
MESH:D016399 Lymphoma, T-Cell Doxorubicin 4.5315621674
MESH:D008325 Mammary Neoplasms, Experimental 2,4-diaminotoluene 10.0111921183
MESH:D008325 Mammary Neoplasms, Experimental Doxorubicin 10.0115458769
MESH:D008325 Mammary Neoplasms, Experimental Genistein 10.0114578162 12929590
MESH:D008527 Medulloblastoma Tretinoin 2.7717453147
MESH:D008545 Melanoma Doxorubicin 5.2216827129
MESH:D008545 Melanoma Tretinoin 5.2216752155
MESH:D008545 Melanoma Vinblastine 5.2212374674 18505091 18176117 17761969 15577320 16809738 16248763 15577323 18332650 16432458
MESH:D008546 Melanoma, Experimental Acetaminophen 3.5319513568
MESH:D008569 Memory Disorders Ethanol 4.1518411066 15451040
MESH:D008591 Meningomyelocele Tretinoin 4.3916940565
MESH:D008654 Mesothelioma Doxorubicin 3.0417638057
MESH:D008664 Metal Metabolism, Inborn Errors Cyclosporine 4.7616801185
MESH:D028361 Mitochondrial Diseases Doxorubicin 4.4615792986
MESH:D009062 Mouth Neoplasms Benzo(a)pyrene 3.1516381670
MESH:D052016 Mucositis Doxorubicin 4.7517415656
MESH:D009190 Myelodysplastic Syndromes Tretinoin 3.0517596541
MESH:D009203 Myocardial Infarction Doxorubicin 5.9115857846 19429709
MESH:D009203 Myocardial Infarction Genistein 5.9117141266
MESH:D017202 Myocardial Ischemia Arsenic 8.8815371236
MESH:D017202 Myocardial Ischemia Tetrachlorodibenzodioxin 8.8812213967
MESH:D015428 Myocardial Reperfusion Injury Genistein 3.6317141266
MESH:D009362 Neoplasm Metastasis Doxorubicin 2.9318259882
MESH:D009369 Neoplasms Benzo(a)pyrene 4.9211141357
MESH:D009369 Neoplasms Tretinoin 4.9216594593 16946489
MESH:D009401 Nephrosis Doxorubicin 4.7316899518 16636307
MESH:D009402 Nephrosis, Lipoid Cyclosporine 4.4117954296
MESH:D009404 Nephrotic Syndrome Cyclosporine 9.1719348381 18481113
MESH:D009404 Nephrotic Syndrome Doxorubicin 9.1715640375 16889571
MESH:D009421 Nervous System Malformations Genistein 16.1516427766
MESH:D009421 Nervous System Malformations Tetrachlorodibenzodioxin 16.1514600291
MESH:D009421 Nervous System Malformations Tretinoin 16.159125849
MESH:D009436 Neural Tube Defects Arsenic 7.3316620997
MESH:D009436 Neural Tube Defects Tretinoin 7.339142499
MESH:D009447 Neuroblastoma Doxorubicin 3.2415555623
MESH:D019636 Neurodegenerative Diseases Acetaminophen 2.8318514411
MESH:D020078 Neurogenic Inflammation Arsenic 4.3317056641
MESH:D009503 Neutropenia Vinblastine 4.5317378895
MESH:D010024 Osteoporosis Genistein 3.2219401787
MESH:D015663 Osteoporosis, Postmenopausal Genistein 4.0416169203
MESH:D012516 Osteosarcoma Doxorubicin 4.0815930896
MESH:D010051 Ovarian Neoplasms Arsenic 7.8917306315
MESH:D010051 Ovarian Neoplasms Genistein 7.8919005980
MESH:D010051 Ovarian Neoplasms Tretinoin 7.8916936753
MESH:D010146 Pain Acetaminophen 6.4616870215
MESH:D010146 Pain Tretinoin 6.4616870215
MESH:D010190 Pancreatic Neoplasms Ethanol 5.4012384795
MESH:D010190 Pancreatic Neoplasms Tretinoin 5.4015976015
MESH:D016584 Panic Disorder Ethinyl Estradiol 3.6511578682
MESH:D010382 Peliosis Hepatis Tetrachlorodibenzodioxin 4.2212520081
MESH:D010523 Peripheral Nervous System Diseases Arsenic 4.1416093927
MESH:D016491 Peripheral Vascular Diseases Arsenic 4.956392382 15371236 16905509
MESH:D003557 Phyllodes Tumor Doxorubicin 5.1317983394
MESH:D010997 Pleural Neoplasms Doxorubicin 5.1317638057
MESH:D017119 Porphyria Cutanea Tarda Tetrachlorodibenzodioxin 3.5218163543
MESH:D011230 Precancerous Conditions Cyclosporine 3.1812371664
MESH:D011297 Prenatal Exposure Delayed Effects Tetrachlorodibenzodioxin 3.1611118676 11896295 11222880 11399792
MESH:D011471 Prostatic Neoplasms Arsenic 2.1116140617
MESH:D011471 Prostatic Neoplasms Benzo(a)pyrene 2.1117292933
MESH:D011471 Prostatic Neoplasms Doxorubicin 2.1116888761 18437689 15749863 15897917 16868541 16729912
MESH:D011471 Prostatic Neoplasms Genistein 2.1116925846 15378649 15256057
MESH:D011507 Proteinuria Arsenic 9.1421343184
MESH:D011507 Proteinuria Tretinoin 9.1416636307
MESH:D011537 Pruritus Ethinyl Estradiol 3.2815861022 16919318
MESH:D011565 Psoriasis Cyclosporine 2.2116882103
MESH:D011625 Pterygium Tretinoin 4.7616723453
MESH:D051437 Renal Insufficiency Doxorubicin 4.1817922066
MESH:D015619 Respiratory System Abnormalities Tetrachlorodibenzodioxin 3.8018990726
MESH:D012208 Rhabdomyosarcoma Tretinoin 4.0616116481 16283617
MESH:D012509 Sarcoma Doxorubicin 3.9515625365 17203757 16767912 15675481 17710206 18313854
MESH:D012512 Sarcoma, Ewing's Doxorubicin 4.2014601052 16326096
MESH:D012514 Sarcoma, Kaposi Doxorubicin 4.7517846226
MESH:D012640 Seizures Ethanol 3.149754883
MESH:D012871 Skin Diseases Arsenic 2.7419834688 17938729 16702368 16353154 16759981 17050553 6392382 15952646 17453740 18709164 17548696
MESH:D012878 Skin Neoplasms Arsenic 17.7117976673 16251483 17029826 19538983 15504454 17050553
MESH:D012878 Skin Neoplasms Benzo(a)pyrene 17.7119755658 10029692
MESH:D012878 Skin Neoplasms Doxorubicin 17.7115692506
MESH:D012878 Skin Neoplasms Tetrachlorodibenzodioxin 17.7116192470
MESH:D012878 Skin Neoplasms Tretinoin 17.7116467112
MESH:D012983 Soft Tissue Neoplasms Doxorubicin 4.5317203757 16767912 15625365
MESH:D013088 Spermatocele Ethinyl Estradiol 3.9116709447
MESH:D013274 Stomach Neoplasms Benzo(a)pyrene 3.382093021 20155912
MESH:D013274 Stomach Neoplasms Ethanol 3.3818456281
MESH:D013274 Stomach Neoplasms Tretinoin 3.3817261132
MESH:D013276 Stomach Ulcer Ethanol 3.4916755016 9211565 17918041 9562338 11906479 17189318
MESH:D013375 Substance Withdrawal Syndrome Ethanol 4.219754883
MESH:D019851 Thrombophilia Ethinyl Estradiol 3.5811994571
MESH:D013927 Thrombosis Ethinyl Estradiol 3.1115669648
MESH:D013959 Thyroid Diseases Tetrachlorodibenzodioxin 3.8712697716
MESH:D013964 Thyroid Neoplasms Doxorubicin 7.2017909728 16010429
MESH:D013964 Thyroid Neoplasms Tretinoin 7.2016026305 17045167
MESH:D014062 Tongue Neoplasms Tretinoin 3.7516051514
MESH:D014376 Tuberculosis Tretinoin 3.2016040207
MESH:D001749 Urinary Bladder Neoplasms Arsenic 8.3019429237 17976673 15987713 11144890 18640142 19322015 17306315
MESH:D001749 Urinary Bladder Neoplasms Benzo(a)pyrene 8.3017053015
MESH:D001749 Urinary Bladder Neoplasms Doxorubicin 8.3017653716
MESH:D014581 Urticaria Acetaminophen 2.9410982225
MESH:D002583 Uterine Cervical Neoplasms Tretinoin 3.6416129372
MESH:D014594 Uterine Neoplasms Ethinyl Estradiol 3.2614692618
MESH:D014604 Uveal Neoplasms Tretinoin 4.5816752155
MESH:D014605 Uveitis Cyclosporine 3.961336536
MESH:D014625 Vaginal Neoplasms Vinblastine 5.0115577323
MESH:D014652 Vascular Diseases Arsenic 4.7017056641
MESH:D054079 Vascular Malformations Tetrachlorodibenzodioxin 4.5712125929
MESH:D020246 Venous Thrombosis Ethinyl Estradiol 3.5014671159 15869587
MESH:D018487 Ventricular Dysfunction, Left Doxorubicin 4.1817678736 16364871 17334414 17638931
MESH:D014820 Vitiligo Tretinoin 4.0216761959
MESH:D019282 Wasting Syndrome Tetrachlorodibenzodioxin 4.2215886252
MESH:D009396 Wilms Tumor Tretinoin 3.9316287080
MESH:D014985 Xerophthalmia Cyclosporine 4.4117120751
Pathway ID Pathway Name
KEGG:04115 p53 signaling pathway
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  (e.g. CHD8)

Syndromic Genes

Non-syndromic Genes

AutismKB Statistics

  • Studies: 1,036
  • Genes: 1,379
  • CNVs/SVs: 5,420
  • SNVs/Indels: 11,669
  • de novo Mutations: 5,669
  • Mosaics: 789
  • Linkage Regions: 172
  • Paper Collected: 6/30/2018
  • Last Update: 8/26/2018


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