AutismKB 2.0

Annotation Detail for DTL


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Basic Information Top
Gene Symbol:DTL ( CDT2,DCAF2,L2DTL,RAMP )
Gene Full Name: denticleless homolog (Drosophila)
Band: 1q32.3
Quick LinksEntrez ID:51514; OMIM: 610617; Uniprot ID:DTL_HUMAN; ENSEMBL ID: ENSG00000143476; HGNC ID: 30288
Relate to Another Database: SFARIGene; denovo-db
Related Pathway Information Top
Related Diseases/Disorders Top
Comparative Toxicogenomics Database Top
Chemical ID Chemical Name Interaction Interaction Action Publication
D016604 Aflatoxin B1 Aflatoxin B1 affects the expression of DTL proteinaffects expression 20106945
C447119 bazedoxifene acetate bazedoxifene acetate results in decreased expression of DTL mRNAdecreases expression 19914376
D001564 Benzo(a)pyrene Benzo(a)pyrene results in decreased expression of DTL mRNAdecreases expression 20064835
D001564 Benzo(a)pyrene Benzo(a)pyrene results in increased expression of DTL mRNAincreases expression 20713471
D015123 7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide 7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide results in decreased expression of DTL mRNAdecreases expression 20382639
C006780 bisphenol A bisphenol A results in increased expression of DTL mRNAincreases expression 16474171
D002251 Carbon Tetrachloride Carbon Tetrachloride results in increased expression of DTL mRNAincreases expression 17484886
D016572 Cyclosporine Cyclosporine results in decreased expression of DTL mRNAdecreases expression 20106945
D004958 Estradiol Estradiol results in increased expression of DTL mRNAincreases expression 16474171
20106945
D019833 Genistein Genistein results in increased expression of DTL mRNAincreases expression 16474171
D008748 Methylcholanthrene Methylcholanthrene results in increased expression of DTL mRNAincreases expression 20713471
D011078 Polychlorinated Biphenyls Polychlorinated Biphenyls analog results in increased expression of DTL mRNAincreases expression 16474171
Disease ID Disease Name Direct Evidence Inference Chemical Name Inference Score Publication
MESH:D000230 Adenocarcinoma Benzo(a)pyrene 7.2820127859 20464547
MESH:D000230 Adenocarcinoma Estradiol 7.2811473722
MESH:D000230 Adenocarcinoma Genistein 7.2811473722
MESH:D000236 Adenoma Benzo(a)pyrene 7.136695378
MESH:D000236 Adenoma Methylcholanthrene 7.136695378 10545420
MESH:D017544 Aortic Aneurysm, Abdominal Benzo(a)pyrene 4.2519183758
MESH:D050197 Atherosclerosis Methylcholanthrene 3.5311922910
MESH:D001862 Bone Resorption bisphenol A 4.0011985600
MESH:D001943 Breast Neoplasms Benzo(a)pyrene 2.3920146248 17474063
MESH:D001943 Breast Neoplasms bisphenol A 2.3917123778
MESH:D001943 Breast Neoplasms Estradiol 2.3917261762 12948864 18497071 17289903 14630087 16675129 19861407 17018787
MESH:D001943 Breast Neoplasms Genistein 2.3916873071 16541309 17200150
MESH:D001943 Breast Neoplasms Methylcholanthrene 2.3917474063
MESH:D002181 Candidiasis, Vulvovaginal Estradiol 4.6616111702
MESH:D002252 Carbon Tetrachloride Poisoning Carbon Tetrachloride 3.9515721981 16124888 15700767 16011737 10355542 16097048 15673190 16050911 3786805 16192424 16227642 18705752
MESH:D002277 Carcinoma Methylcholanthrene 4.0810545420
MESH:D003528 Carcinoma, Adenoid Cystic marker/mechanism 16762588
MESH:D006528 Carcinoma, Hepatocellular Aflatoxin B1 6.7621507988 12619106 12907637
MESH:D006528 Carcinoma, Hepatocellular Carbon Tetrachloride 6.7618788625
MESH:D006528 Carcinoma, Hepatocellular Estradiol 6.7616924424
MESH:D006528 Carcinoma, Hepatocellular Genistein 6.7616924424
MESH:D002278 Carcinoma in Situ bisphenol A 5.1817123778
MESH:D002294 Carcinoma, Squamous Cell Benzo(a)pyrene 2.0820419170
MESH:D002318 Cardiovascular Diseases Genistein 3.4016332659
MESH:D002471 Cell Transformation, Neoplastic 7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide 16.8420889678
MESH:D002471 Cell Transformation, Neoplastic Cyclosporine 16.8412371664
MESH:D002471 Cell Transformation, Neoplastic Estradiol 16.8418566989
MESH:D002471 Cell Transformation, Neoplastic Methylcholanthrene 16.8416192471
MESH:D002779 Cholestasis Cyclosporine 3.0219486331
MESH:D003110 Colonic Neoplasms Genistein 2.3017182828
MESH:D015179 Colorectal Neoplasms Polychlorinated Biphenyls 2.7315531428
MESH:D003704 Dementia Polychlorinated Biphenyls 4.8416140633
MESH:D003924 Diabetes Mellitus, Type 2 Genistein 2.5116647724
MESH:D003928 Diabetic Nephropathies Estradiol 3.5419279558
MESH:D056486 Drug-Induced Liver Injury Carbon Tetrachloride 2.0715998439 2869522 6623471 16177239 10092053 16227642 11566570 3732212 7179309 21278145 3786805 15968718 19336974 4309450 6884620 7120509 15027814 7440962 17522070 19085960 10915739 9327722
MESH:D004714 Endometrial Hyperplasia Genistein 4.7816402032
MESH:D016889 Endometrial Neoplasms Estradiol 7.8011473722 18566989 19148513
MESH:D016889 Endometrial Neoplasms Genistein 7.8011473722
MESH:D004938 Esophageal Neoplasms 7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide 4.4620426865
MESH:D004938 Esophageal Neoplasms Benzo(a)pyrene 4.4616530937
MESH:D005234 Fatty Liver Carbon Tetrachloride 8.1812795759 61145 15959796 16239168 12631006 19224547 17595544 16045604
MESH:D005234 Fatty Liver Cyclosporine 8.1819224547
MESH:D005354 Fibrosarcoma Methylcholanthrene 5.1310962813 14633661
MESH:D005355 Fibrosis Carbon Tetrachloride 9.2618705752
MESH:D005355 Fibrosis Cyclosporine 9.2612639820 12168785
MESH:D005885 Gingival Hyperplasia Cyclosporine 4.418708960
MESH:D005909 Glioblastoma Genistein 3.3416598420
MESH:D006330 Heart Defects, Congenital Benzo(a)pyrene 2.7220471113
MESH:D006457 Hemoglobinuria, Paroxysmal Cyclosporine 4.6215720958
MESH:D006505 Hepatitis Carbon Tetrachloride 3.7619900420 19110552
MESH:D006558 Herpes Genitalis Estradiol 5.2515709030
MESH:D019584 Hot Flashes Estradiol 3.9717088409
MESH:D006932 Hyperbilirubinemia Carbon Tetrachloride 4.7316899240
MESH:D006973 Hypertension Cyclosporine 2.1410903974
MESH:D006975 Hypertension, Portal Carbon Tetrachloride 4.2615338365
MESH:D007333 Insulin Resistance bisphenol A 7.7316393666
MESH:D007333 Insulin Resistance Estradiol 7.7316627594 16393666
MESH:D007638 Keratoconjunctivitis Sicca Cyclosporine 4.6615604871
MESH:D007674 Kidney Diseases Cyclosporine 6.198314463 10903974 18776723
MESH:D007674 Kidney Diseases Estradiol 6.1915618244
MESH:D007680 Kidney Neoplasms Cyclosporine 7.6712371664
MESH:D007680 Kidney Neoplasms Estradiol 7.6715610895
MESH:D007938 Leukemia Genistein 3.0917468513 18980019
MESH:D008103 Liver Cirrhosis Carbon Tetrachloride 2.8817157831 16239168 16221502 11408273 17334410 16943688 17174718 11903743 21278145
MESH:D008106 Liver Cirrhosis, Experimental Carbon Tetrachloride 3.6218263696 16015684 18429990 14716496 13678700 16248980 17766677 17823541 18420326 12666154 10355542 18210741 18705752 18395914 15876570 15931870 18166357 17805973 15959796 18472332 12667390 18412020 16192424 15338365 16027843 18251166 12445421 17922224 18481824 14748882 12741479 18376398 17525996 16638106 15123356 18277467 17631135 17557913 16033810 17714472 16116963 12898905 17761835 12632514 18317297 15730626 18187930 12546737 17900296 15673190 12958196 15893842 16097048 17869086 17640975 16136751 18418968 12649538 16011737 15370692 15818738 14620537 14716833 11481614 18205269 17481882 17721639 12445418 17944888 14724832 12586293 17698563 18279442 12389079 18156304 18472094 18395095 18054572 17708605 15925388 12632512 17565644 18339082 15650968 15996030 18006644 15052691 20821823 15362042 14512876 12609069 17976157 15057751
MESH:D008106 Liver Cirrhosis, Experimental Estradiol 3.6214659978 14716833
MESH:D008106 Liver Cirrhosis, Experimental Genistein 3.6217823541
MESH:D008107 Liver Diseases Carbon Tetrachloride 2.1116246199 15720792 16964402 17285989 15830285
MESH:D017093 Liver Failure Carbon Tetrachloride 4.3415123358
MESH:D017114 Liver Failure, Acute Carbon Tetrachloride 3.8216899240 14706259
MESH:D008113 Liver Neoplasms Aflatoxin B1 7.7315890375 18177683 2125692 9163691
MESH:D008113 Liver Neoplasms Benzo(a)pyrene 7.7320195826 21137059
MESH:D008113 Liver Neoplasms Carbon Tetrachloride 7.7319294768
MESH:D008114 Liver Neoplasms, Experimental Aflatoxin B1 14.938603461
MESH:D008114 Liver Neoplasms, Experimental Carbon Tetrachloride 14.9315583823 12014681
MESH:D008114 Liver Neoplasms, Experimental Methylcholanthrene 14.93598648 1399818
MESH:D008114 Liver Neoplasms, Experimental Polychlorinated Biphenyls 14.931423854
MESH:D008175 Lung Neoplasms Aflatoxin B1 3.5914755239
MESH:D008175 Lung Neoplasms Benzo(a)pyrene 3.5918816296 17053015 18569708 18520028 20064080 6695378 20464547 20135361 20869020
MESH:D008175 Lung Neoplasms Methylcholanthrene 3.5920970405 6695378 16337739 11893704 9230183 17909032 7750092 20512841 16271038 21163286 1399818 10545420 15390079
MESH:D008325 Mammary Neoplasms, Experimental Estradiol 6.3711807958 11408345 16891317 17203775
MESH:D008325 Mammary Neoplasms, Experimental Genistein 6.3712929590 14578162
MESH:D020149 Manganese Poisoning Estradiol 4.7019453300
MESH:D008664 Metal Metabolism, Inborn Errors Cyclosporine 5.0116801185
MESH:D009062 Mouth Neoplasms Benzo(a)pyrene 3.3016381670
MESH:D009203 Myocardial Infarction Genistein 2.9117141266
MESH:D015428 Myocardial Reperfusion Injury Estradiol 8.8716810080
MESH:D015428 Myocardial Reperfusion Injury Genistein 8.8717141266
MESH:D009369 Neoplasms Benzo(a)pyrene 2.2311141357
MESH:D009389 Neovascularization, Pathologic Estradiol 3.9317289903
MESH:D009402 Nephrosis, Lipoid Cyclosporine 4.6617954296
MESH:D009404 Nephrotic Syndrome Cyclosporine 3.4118481113 19348381
MESH:D009421 Nervous System Malformations bisphenol A 17.4416427766 11399458
MESH:D009421 Nervous System Malformations Estradiol 17.4411399458 16427766
MESH:D009421 Nervous System Malformations Genistein 17.4416427766
MESH:D010024 Osteoporosis Genistein 3.3319401787
MESH:D015663 Osteoporosis, Postmenopausal Genistein 4.2316169203
MESH:D010049 Ovarian Diseases bisphenol A 5.1811985600
MESH:D010051 Ovarian Neoplasms Estradiol 5.0319401270
MESH:D010051 Ovarian Neoplasms Genistein 5.0319005980
MESH:D010300 Parkinson Disease Polychlorinated Biphenyls 3.4416702228
MESH:D011230 Precancerous Conditions Cyclosporine 3.3512371664
MESH:D011297 Prenatal Exposure Delayed Effects bisphenol A 4.1410548101
MESH:D019048 Prostatic Intraepithelial Neoplasia bisphenol A 11.0220887781
MESH:D019048 Prostatic Intraepithelial Neoplasia Estradiol 11.0220887781
MESH:D011471 Prostatic Neoplasms Benzo(a)pyrene 1.8717292933
MESH:D011471 Prostatic Neoplasms bisphenol A 1.8716740699
MESH:D011471 Prostatic Neoplasms Estradiol 1.8716740699
MESH:D011471 Prostatic Neoplasms Genistein 1.8715256057 15378649 16925846
MESH:D011471 Prostatic Neoplasms Polychlorinated Biphenyls 1.8715721890
MESH:D011565 Psoriasis Cyclosporine 2.2716882103
MESH:D011629 Puberty, Precocious bisphenol A 4.9810548101
MESH:D012468 Salivary Gland Neoplasms marker/mechanism 16762588
MESH:D012878 Skin Neoplasms Benzo(a)pyrene 2.4310029692 19755658
MESH:D013274 Stomach Neoplasms Benzo(a)pyrene 1.5620155912 2093021
MESH:D019966 Substance-Related Disorders bisphenol A 4.1816045194 16684133
MESH:D013978 Tibial Fractures Estradiol 4.9019048282
MESH:D001749 Urinary Bladder Neoplasms Benzo(a)pyrene 2.2217053015
MESH:D014591 Uterine Diseases bisphenol A 5.2314652134
MESH:D014605 Uveitis Cyclosporine 4.201336536
MESH:D014985 Xerophthalmia Cyclosporine 4.6617120751
No data
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Syndromic Genes

Non-syndromic Genes

AutismKB Statistics

  • Studies: 1,036
  • Genes: 1,379
  • CNVs/SVs: 5,420
  • SNVs/Indels: 11,669
  • de novo Mutations: 5,669
  • Mosaics: 789
  • Linkage Regions: 172
  • Paper Collected: 6/30/2018
  • Last Update: 8/26/2018


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