AutismKB 2.0

Annotation Detail for PDE9A


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Basic Information Top
Gene Symbol:PDE9A ( FLJ90181,HSPDE9A2 )
Gene Full Name: phosphodiesterase 9A
Band: 21q22.3
Quick LinksEntrez ID:5152; OMIM: 602973; Uniprot ID:PDE9A_HUMAN; ENSEMBL ID: ENSG00000160191; HGNC ID: 8795
Relate to Another Database: SFARIGene; denovo-db
Related Pathway Information Top
No data
Pathway IDPathway Name
hsa00230Purine metabolism
Pathway IDPathway Name
Hemostasis
Pathway IDPathway Name
200102Regulation of Androgen receptor activity
No data
No data
Related Diseases/Disorders Top
Comparative Toxicogenomics Database Top
Chemical ID Chemical Name Interaction Interaction Action Publication
D000082 Acetaminophen Acetaminophen affects the expression of PDE9A mRNAaffects expression 17562736
D016604 Aflatoxin B1 Aflatoxin B1 affects the expression of PDE9A proteinaffects expression 20106945
D000643 Ammonium Chloride Ammonium Chloride affects the expression of PDE9A mRNAaffects expression 16483693
D001564 Benzo(a)pyrene Benzo(a)pyrene results in decreased expression of PDE9A mRNAdecreases expression 20106945
D004997 Ethinyl Estradiol Ethinyl Estradiol affects the expression of PDE9A mRNAaffects expression 17555576
D004997 Ethinyl Estradiol Ethinyl Estradiol results in increased expression of PDE9A mRNAincreases expression 17942748
C106014 gedunin gedunin results in decreased expression of PDE9A mRNAdecreases expression 17010675
D010634 Phenobarbital Phenobarbital results in decreased expression of PDE9A mRNAdecreases expression 19270015
D013629 Tamoxifen Tamoxifen affects the expression of PDE9A mRNAaffects expression 17555576
D013749 Tetrachlorodibenzodioxin Tetrachlorodibenzodioxin results in decreased expression of PDE9A mRNAdecreases expression 20106945
C050414 tripterine tripterine results in decreased expression of PDE9A mRNAdecreases expression 17010675
Disease ID Disease Name Direct Evidence Inference Chemical Name Inference Score Publication
MESH:D000008 Abdominal Neoplasms Tamoxifen 4.8114745880
MESH:D000014 Abnormalities, Drug-Induced Phenobarbital 9.106195326
MESH:D000014 Abnormalities, Drug-Induced Tetrachlorodibenzodioxin 9.1015322242 14514962 11752688
MESH:D000138 Acidosis Ammonium Chloride 3.8018287403
MESH:D000152 Acne Vulgaris Ethinyl Estradiol 4.2117505938
MESH:D000230 Adenocarcinoma Benzo(a)pyrene 4.3020127859 20464547
MESH:D000230 Adenocarcinoma Ethinyl Estradiol 4.3014692618
MESH:D000236 Adenoma Benzo(a)pyrene 2.746695378
MESH:D018248 Adenoma, Liver Cell Phenobarbital 10.8917620307
MESH:D018248 Adenoma, Liver Cell Tetrachlorodibenzodioxin 10.8916835633
MESH:D000740 Anemia Tetrachlorodibenzodioxin 3.1111748828
MESH:D000799 Angioedema Acetaminophen 4.1110982225
MESH:D017544 Aortic Aneurysm, Abdominal Benzo(a)pyrene 4.2919183758
MESH:D001161 Arteriosclerosis Ethinyl Estradiol 3.6811256880
MESH:D001169 Arthritis, Experimental Ethinyl Estradiol 2.7615885639
MESH:D001321 Autistic Disorder Acetaminophen 1.4118445737
MESH:D001778 Blood Coagulation Disorders Tetrachlorodibenzodioxin 3.2112125929
MESH:D001836 Body Weight Changes Tetrachlorodibenzodioxin 4.0615340226
MESH:D001848 Bone Diseases, Developmental Tetrachlorodibenzodioxin 2.8715746008
MESH:D001943 Breast Neoplasms Benzo(a)pyrene 1.7920146248 17474063
MESH:D001943 Breast Neoplasms Tamoxifen 1.7919221464 16873071 19244106 19410462 19142967 19200415 20135344 20005174 16818667 17440819 18855134 19059307 18815881 17261762 18351453 20390343 15565566 18425577 17893378 19487384 18629630 15668708 19011961 19103187 19066611 17242785 19155303 20859285 16273361 19084267 18997820 19289846 11161223 17049068 18821012 21138602 19189210 19288272 16202921 18984771 20065188 21152245 19189212 19115204 20544844
MESH:D001943 Breast Neoplasms Tetrachlorodibenzodioxin 1.7920435547
MESH:D002277 Carcinoma Tetrachlorodibenzodioxin 2.9316835633
MESH:D018270 Carcinoma, Ductal, Breast Tamoxifen 4.7219066611
MESH:D006528 Carcinoma, Hepatocellular Acetaminophen 6.763084413
MESH:D006528 Carcinoma, Hepatocellular Aflatoxin B1 6.7612907637 12619106 21507988
MESH:D006528 Carcinoma, Hepatocellular Phenobarbital 6.761701930 6705139 20935162 17173139 20007298
MESH:D006528 Carcinoma, Hepatocellular Tamoxifen 6.7616924424
MESH:D002294 Carcinoma, Squamous Cell Benzo(a)pyrene 2.0920419170
MESH:D002295 Carcinoma, Transitional Cell Tamoxifen 3.7817572228
MESH:D006332 Cardiomegaly Tetrachlorodibenzodioxin 2.4518670907 18850075 16120746
MESH:D002386 Cataract Acetaminophen 2.6710977129
MESH:D002493 Central Nervous System Diseases Phenobarbital 4.474080065
MESH:D018281 Cholangiocarcinoma Tetrachlorodibenzodioxin 3.3116835633
MESH:D002779 Cholestasis Ethinyl Estradiol 3.0017681005 16105132 11677210 16919318 17110522 15861022 17333356
MESH:D002972 Cleft Palate Tetrachlorodibenzodioxin 2.1615668235 12621046 15340226 16354765 8697196
MESH:D000013 Congenital Abnormalities Tetrachlorodibenzodioxin 3.2117141729 14669216
MESH:D019465 Craniofacial Abnormalities Tetrachlorodibenzodioxin 1.2620055451 15322242 10048152
MESH:D003711 Demyelinating Diseases Tamoxifen 4.5819031437
MESH:D003924 Diabetes Mellitus, Type 2 Tetrachlorodibenzodioxin 1.7017107852
MESH:D003928 Diabetic Nephropathies Tamoxifen 3.6319279558
MESH:D056486 Drug-Induced Liver Injury Acetaminophen 3.7019416960 14986274 12392966 16227642 11739529 17522070 12540782 19164858 18713872 17906064 19739265 11421492 11529661 16177239 16485898 18071297 19370779 15968718 11743745 19420014 10663392 11287661 17562736 12958197 10774834 12705907 14550746 19085960 16781746 10915739 16393943 16081117 12153990 12594235 14725611 15619225 2444490 11834606 11461765 16109766 19923254
MESH:D056486 Drug-Induced Liver Injury Tetrachlorodibenzodioxin 3.7020420201
MESH:D056487 Drug-Induced Liver Injury, Chronic Acetaminophen 4.3619426721
MESH:D004362 Drug Toxicity Tetrachlorodibenzodioxin 2.8911462148
MESH:D004421 Dystonia Phenobarbital 4.191851702
MESH:D004487 Edema Tetrachlorodibenzodioxin 2.5511000095 12711302
MESH:D004489 Edema, Cardiac Tetrachlorodibenzodioxin 4.1718230668 15322242 16714409
MESH:D004681 Encephalomyelitis, Autoimmune, Experimental Ethinyl Estradiol 9.6212538720
MESH:D004681 Encephalomyelitis, Autoimmune, Experimental Tamoxifen 9.6219031437
MESH:D016889 Endometrial Neoplasms Tamoxifen 3.1520544844 19155303 16202921 17893378
MESH:D004715 Endometriosis Tetrachlorodibenzodioxin 3.189294722 10568697
MESH:D004831 Epilepsies, Myoclonic Phenobarbital 4.323659116
MESH:D004828 Epilepsies, Partial Phenobarbital 4.1411558140 3922381
MESH:D004827 Epilepsy Phenobarbital 2.9720417680
MESH:D004832 Epilepsy, Absence Phenobarbital 3.696401628
MESH:D017029 Epilepsy, Complex Partial Phenobarbital 4.477750514
MESH:D004830 Epilepsy, Tonic-Clonic Phenobarbital 4.263659116
MESH:D004938 Esophageal Neoplasms Benzo(a)pyrene 2.0416530937
MESH:D005124 Eye Abnormalities Tetrachlorodibenzodioxin 3.1411564622
MESH:D005234 Fatty Liver Ethinyl Estradiol 8.2715345470
MESH:D005234 Fatty Liver Tamoxifen 8.2719224547 14986274
MESH:D052776 Female Urogenital Diseases Tamoxifen 3.3316709447
MESH:D005313 Fetal Death Tetrachlorodibenzodioxin 3.6711858732
MESH:D018221 Fibromatosis, Abdominal Tamoxifen 4.7614745880
MESH:D018222 Fibromatosis, Aggressive Tamoxifen 4.4219069698
MESH:D005355 Fibrosis Tetrachlorodibenzodioxin 3.1620067830
MESH:D005756 Gastritis Acetaminophen 3.9416983495
MESH:D006058 Gonadal Disorders Tetrachlorodibenzodioxin 4.8610696789
MESH:D006330 Heart Defects, Congenital Benzo(a)pyrene 6.7220471113
MESH:D006330 Heart Defects, Congenital Tetrachlorodibenzodioxin 6.7210048152 11294989
MESH:D006470 Hemorrhage Tetrachlorodibenzodioxin 3.5111000095
MESH:D006529 Hepatomegaly Phenobarbital 9.1716109766
MESH:D006529 Hepatomegaly Tetrachlorodibenzodioxin 9.1712621046 16120746 15340226
MESH:D006869 Hydronephrosis Tetrachlorodibenzodioxin 4.3116354765 16959395 8697196 18606429 15340226
MESH:D006930 Hyperalgesia Acetaminophen 2.8416870215
MESH:D006973 Hypertension Tetrachlorodibenzodioxin 1.9618850075 18670907
MESH:D007021 Hypospadias Ethinyl Estradiol 4.0216569931 16945680
MESH:D007247 Infertility, Female Ethinyl Estradiol 3.6512013081
MESH:D007248 Infertility, Male Ethinyl Estradiol 2.5917937319
MESH:D007249 Inflammation Tamoxifen 5.1619457130
MESH:D007249 Inflammation Tetrachlorodibenzodioxin 5.1612878042 12200463
MESH:D007569 Jaw Abnormalities Tetrachlorodibenzodioxin 3.5116580747
MESH:D007674 Kidney Diseases Acetaminophen 2.2915629191 12587719
MESH:D007680 Kidney Neoplasms Tamoxifen 3.1918625569
MESH:D008064 Lipidoses Tamoxifen 3.2715342952 17567588
MESH:D008103 Liver Cirrhosis Phenobarbital 2.9821047994
MESH:D008106 Liver Cirrhosis, Experimental Tamoxifen 2.3318564211
MESH:D008106 Liver Cirrhosis, Experimental Tetrachlorodibenzodioxin 2.3312878042
MESH:D008107 Liver Diseases Acetaminophen 4.0619784758 19014921 12969438 19460945 16611625 11587558 12587719 16610002
MESH:D008107 Liver Diseases Phenobarbital 4.0619363144
MESH:D017114 Liver Failure, Acute Acetaminophen 3.4016871587 17185352
MESH:D008113 Liver Neoplasms Aflatoxin B1 14.8715890375 2125692 18177683 9163691
MESH:D008113 Liver Neoplasms Benzo(a)pyrene 14.8720195826 21137059
MESH:D008113 Liver Neoplasms Phenobarbital 14.8719482888 19812893 15975961 8742319 19073162 21047994
MESH:D008113 Liver Neoplasms Tamoxifen 14.8716684651
MESH:D008113 Liver Neoplasms Tetrachlorodibenzodioxin 14.8716984957
MESH:D008114 Liver Neoplasms, Experimental Aflatoxin B1 10.428603461
MESH:D008114 Liver Neoplasms, Experimental Phenobarbital 10.426150874 1399818 2563599 18308698 17172636
MESH:D008114 Liver Neoplasms, Experimental Tetrachlorodibenzodioxin 10.4212151625
MESH:D008175 Lung Neoplasms Aflatoxin B1 4.9614755239
MESH:D008175 Lung Neoplasms Benzo(a)pyrene 4.9620464547 18816296 18520028 6695378 18569708 17053015 20135361 20869020 20064080
MESH:D008175 Lung Neoplasms Tamoxifen 4.9618625569
MESH:D008175 Lung Neoplasms Tetrachlorodibenzodioxin 4.9619555203 11884234
MESH:D015674 Mammary Neoplasms, Animal Tamoxifen 4.0019428831
MESH:D008325 Mammary Neoplasms, Experimental Tamoxifen 2.7316827153 11731420 19196723 19196722 14580682
MESH:D020149 Manganese Poisoning Tamoxifen 4.8119453300
MESH:D008545 Melanoma Tamoxifen 1.9019393235 12393984
MESH:D018328 Melanoma, Amelanotic Tamoxifen 4.4215990972
MESH:D008546 Melanoma, Experimental Acetaminophen 3.7819513568
MESH:D009062 Mouth Neoplasms Benzo(a)pyrene 3.3216381670
MESH:D017202 Myocardial Ischemia Tetrachlorodibenzodioxin 3.1612213967
MESH:D020191 Myoclonic Epilepsies, Progressive Phenobarbital 4.7117484760
MESH:D009362 Neoplasm Metastasis Tamoxifen 2.6019393235
MESH:D009364 Neoplasm Recurrence, Local Tamoxifen 2.5619410462
MESH:D009369 Neoplasms Benzo(a)pyrene 2.2411141357
MESH:D009376 Neoplasms, Hormone-Dependent Tamoxifen 4.2619189210 19200415 19196722
MESH:D009421 Nervous System Malformations Tetrachlorodibenzodioxin 3.4114600291
MESH:D019636 Neurodegenerative Diseases Acetaminophen 3.0118514411
MESH:D010018 Osteomalacia Phenobarbital 4.6017016548
MESH:D010146 Pain Acetaminophen 2.5316870215
MESH:D010190 Pancreatic Neoplasms Phenobarbital 2.5416965848
MESH:D016584 Panic Disorder Ethinyl Estradiol 3.8711578682
MESH:D010382 Peliosis Hepatis Tetrachlorodibenzodioxin 4.5112520081
MESH:D017119 Porphyria Cutanea Tarda Tetrachlorodibenzodioxin 3.7618163543
MESH:D011230 Precancerous Conditions Phenobarbital 3.772563599
MESH:D011297 Prenatal Exposure Delayed Effects Tetrachlorodibenzodioxin 3.4311118676 11896295 11399792 11222880
MESH:D011471 Prostatic Neoplasms Benzo(a)pyrene 3.0917292933
MESH:D011471 Prostatic Neoplasms Tamoxifen 3.0915067354
MESH:D011537 Pruritus Ethinyl Estradiol 3.5515861022 16919318
MESH:D019310 Pseudolymphoma Phenobarbital 4.7612752131
MESH:D015619 Respiratory System Abnormalities Tetrachlorodibenzodioxin 4.0418990726
MESH:D012640 Seizures Phenobarbital 2.8016876388 3137016 11442880 4039156
MESH:D003294 Seizures, Febrile Phenobarbital 5.066407741
MESH:D012878 Skin Neoplasms Benzo(a)pyrene 5.7219755658 10029692
MESH:D012878 Skin Neoplasms Tetrachlorodibenzodioxin 5.7216192470
MESH:D013088 Spermatocele Ethinyl Estradiol 12.4616709447
MESH:D013088 Spermatocele Tamoxifen 12.4616709447
MESH:D013119 Spinal Cord Injuries Tamoxifen 4.2819457130
MESH:D013274 Stomach Neoplasms Benzo(a)pyrene 1.5620155912 2093021
MESH:D019851 Thrombophilia Ethinyl Estradiol 3.8011994571
MESH:D013927 Thrombosis Ethinyl Estradiol 3.3015669648
MESH:D013959 Thyroid Diseases Tetrachlorodibenzodioxin 4.1712697716
MESH:D013964 Thyroid Neoplasms Phenobarbital 3.181399818
MESH:D001749 Urinary Bladder Neoplasms Benzo(a)pyrene 5.1917053015
MESH:D001749 Urinary Bladder Neoplasms Tamoxifen 5.1916712894 17572228 8653321
MESH:D014581 Urticaria Acetaminophen 3.1610982225
MESH:D014594 Uterine Neoplasms Ethinyl Estradiol 3.5014692618
MESH:D054079 Vascular Malformations Tetrachlorodibenzodioxin 4.8612125929
MESH:D020246 Venous Thrombosis Ethinyl Estradiol 3.7114671159 15869587
MESH:D019282 Wasting Syndrome Tetrachlorodibenzodioxin 4.5115886252
Pathway ID Pathway Name
REACT:604 Hemostasis
KEGG:00230 Purine metabolism
Pharmacogenomics Knowledge Base Top
  • PharmGKB Accession:PA33143
    • No data
    Releated disease ID Related disease Name
    PA447321Depressive Disorder, Major
    No data
    Drug Bank Top
    Drugbank ID Action Drug Name Description
    DB03597 - Gamma-Glutamyl[S-(2-Iodobenzyl)Cysteinyl]Glycine
    DB07954 - 3-ISOBUTYL-1-METHYLXANTHINE
    No data
    No data
    No data

    Simple Query:


      (e.g. CHD8)

    Syndromic Genes

    Non-syndromic Genes

    AutismKB Statistics

    • Studies: 1,036
    • Genes: 1,379
    • CNVs/SVs: 5,420
    • SNVs/Indels: 11,669
    • de novo Mutations: 5,669
    • Mosaics: 789
    • Linkage Regions: 172
    • Paper Collected: 6/30/2018
    • Last Update: 8/26/2018


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