AutismKB 2.0

Annotation Detail for CXXC5


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Basic Information Top
Gene Symbol:CXXC5 ( CF5,RINF,WID )
Gene Full Name: CXXC finger protein 5
Band: 5q31.2
Quick LinksEntrez ID:51523; OMIM: 612752; Uniprot ID:CXXC5_HUMAN; ENSEMBL ID: ENSG00000171604; HGNC ID: 26943
Relate to Another Database: SFARIGene; denovo-db
Related Pathway Information Top
Related Diseases/Disorders Top
Comparative Toxicogenomics Database Top
Chemical ID Chemical Name Interaction Interaction Action Publication
D000082 Acetaminophen Acetaminophen affects the expression of CXXC5 mRNAaffects expression 17562736
D015123 7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide 7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide results in decreased expression of CXXC5 mRNAdecreases expression 19150397
D004041 Dietary Fats Dietary Fats results in increased expression of CXXC5 mRNAincreases expression 18042831
D004997 Ethinyl Estradiol Ethinyl Estradiol affects the expression of CXXC5 mRNAaffects expression 17555576
D004997 Ethinyl Estradiol Ethinyl Estradiol results in increased expression of CXXC5 mRNAincreases expression 17942748
D004997 Ethinyl Estradiol [Tetrachlorodibenzodioxin co-treated with Ethinyl Estradiol] results in increased expression of CXXC5 mRNAaffects cotreatment|increases expression 17942748
C041786 palm oil palm oil results in increased expression of CXXC5 mRNAincreases expression 18042831
D011374 Progesterone Progesterone affects the expression of CXXC5 mRNAaffects expression 17251523
D012402 Rotenone Rotenone results in increased expression of CXXC5 mRNAincreases expression 19013527
D018038 Sodium Selenite Sodium Selenite results in increased expression of CXXC5 mRNAincreases expression 18175754
D013629 Tamoxifen Tamoxifen affects the expression of CXXC5 mRNAaffects expression 17555576
D013749 Tetrachlorodibenzodioxin [Tetrachlorodibenzodioxin co-treated with Ethinyl Estradiol] results in increased expression of CXXC5 mRNAaffects cotreatment|increases expression 17942748
C025643 vinclozolin vinclozolin affects the expression of CXXC5 mRNAaffects expression 19015723
Disease ID Disease Name Direct Evidence Inference Chemical Name Inference Score Publication
MESH:D000008 Abdominal Neoplasms Tamoxifen 4.7614745880
MESH:D000014 Abnormalities, Drug-Induced Tetrachlorodibenzodioxin 3.0411752688 14514962 15322242
MESH:D000152 Acne Vulgaris Ethinyl Estradiol 4.1617505938
MESH:D000230 Adenocarcinoma Ethinyl Estradiol 1.8414692618
MESH:D018248 Adenoma, Liver Cell Tetrachlorodibenzodioxin 3.5716835633
MESH:D000740 Anemia Tetrachlorodibenzodioxin 3.0811748828
MESH:D000799 Angioedema Acetaminophen 4.0610982225
MESH:D001008 Anxiety Disorders vinclozolin 3.7519015723
MESH:D001161 Arteriosclerosis Dietary Fats 10.5015238619
MESH:D001161 Arteriosclerosis Ethinyl Estradiol 10.5011256880
MESH:D001169 Arthritis, Experimental Ethinyl Estradiol 2.7415885639
MESH:D001321 Autistic Disorder Acetaminophen 1.4118445737
MESH:D001778 Blood Coagulation Disorders Tetrachlorodibenzodioxin 3.1812125929
MESH:D001836 Body Weight Changes Tetrachlorodibenzodioxin 4.0115340226
MESH:D001848 Bone Diseases, Developmental Tetrachlorodibenzodioxin 2.8515746008
MESH:D020201 Brain Hemorrhage, Traumatic Progesterone 5.5617868700
MESH:D001930 Brain Injuries Progesterone 4.4315845082 15380490 15665606
MESH:D001943 Breast Neoplasms Dietary Fats 1.9620435547
MESH:D001943 Breast Neoplasms Progesterone 1.9615562024 17614352 16175315
MESH:D001943 Breast Neoplasms Tamoxifen 1.9615668708 18997820 18351453 17242785 19142967 17261762 19189212 19288272 18629630 19244106 19155303 20135344 19084267 20859285 16202921 19059307 19011961 16818667 18855134 20005174 19189210 18821012 20544844 20390343 19487384 18425577 19115204 19066611 15565566 19103187 17440819 16273361 21138602 19289846 16873071 18984771 19410462 20065188 17049068 21152245 18815881 19200415 17893378 11161223 19221464
MESH:D001943 Breast Neoplasms Tetrachlorodibenzodioxin 1.9620435547
MESH:D002277 Carcinoma Tetrachlorodibenzodioxin 2.9116835633
MESH:D018270 Carcinoma, Ductal, Breast Tamoxifen 4.6819066611
MESH:D006528 Carcinoma, Hepatocellular Acetaminophen 2.903084413
MESH:D006528 Carcinoma, Hepatocellular Tamoxifen 2.9016924424
MESH:D002295 Carcinoma, Transitional Cell Tamoxifen 3.7517572228
MESH:D006332 Cardiomegaly Tetrachlorodibenzodioxin 2.4418850075 18670907 16120746
MESH:D002386 Cataract Acetaminophen 2.6610977129
MESH:D002471 Cell Transformation, Neoplastic 7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide 2.8220889678
MESH:D018281 Cholangiocarcinoma Tetrachlorodibenzodioxin 3.2916835633
MESH:D002779 Cholestasis Ethinyl Estradiol 2.9815861022 17681005 17333356 16919318 17110522 16105132 11677210
MESH:D019457 Chromosome Breakage Sodium Selenite 4.9315894690
MESH:D002972 Cleft Palate Tetrachlorodibenzodioxin 2.1515668235 15340226 12621046 8697196 16354765
MESH:D000013 Congenital Abnormalities Tetrachlorodibenzodioxin 3.1814669216 17141729
MESH:D019465 Craniofacial Abnormalities Tetrachlorodibenzodioxin 1.2610048152 20055451 15322242
MESH:D003456 Cryptorchidism vinclozolin 4.5014966744
MESH:D003711 Demyelinating Diseases Tamoxifen 4.5419031437
MESH:D003920 Diabetes Mellitus Sodium Selenite 3.9016285004
MESH:D003924 Diabetes Mellitus, Type 2 Tetrachlorodibenzodioxin 1.6917107852
MESH:D003928 Diabetic Nephropathies Tamoxifen 3.6019279558
MESH:D003929 Diabetic Neuropathies Progesterone 4.6717187935
MESH:D056486 Drug-Induced Liver Injury Acetaminophen 6.3712705907 12958197 11739529 12594235 17906064 19923254 18713872 11529661 11743745 14550746 18071297 12153990 16781746 12392966 16109766 12540782 14725611 19420014 16227642 10663392 11287661 17562736 16081117 14986274 19739265 10774834 11834606 19370779 19416960 2444490 10915739 16393943 16177239 19164858 19085960 17522070 15968718 15619225 11461765 16485898 11421492
MESH:D056486 Drug-Induced Liver Injury Sodium Selenite 6.3715131321
MESH:D056486 Drug-Induced Liver Injury Tetrachlorodibenzodioxin 6.3720420201
MESH:D056487 Drug-Induced Liver Injury, Chronic Acetaminophen 4.3219426721
MESH:D004362 Drug Toxicity Tetrachlorodibenzodioxin 2.8611462148
MESH:D050171 Dyslipidemias Dietary Fats 3.5518367378
MESH:D004487 Edema Tetrachlorodibenzodioxin 2.5111000095 12711302
MESH:D004489 Edema, Cardiac Tetrachlorodibenzodioxin 4.1216714409 15322242 18230668
MESH:D004681 Encephalomyelitis, Autoimmune, Experimental Ethinyl Estradiol 16.3012538720
MESH:D004681 Encephalomyelitis, Autoimmune, Experimental Progesterone 16.3017692515
MESH:D004681 Encephalomyelitis, Autoimmune, Experimental Tamoxifen 16.3019031437
MESH:D016889 Endometrial Neoplasms Tamoxifen 3.1319155303 20544844 16202921 17893378
MESH:D004715 Endometriosis Progesterone 9.3716134523
MESH:D004715 Endometriosis Tetrachlorodibenzodioxin 9.3710568697 9294722
MESH:D004938 Esophageal Neoplasms 7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide 2.1020426865
MESH:D005124 Eye Abnormalities Tetrachlorodibenzodioxin 3.1211564622
MESH:D005234 Fatty Liver Dietary Fats 13.9418296743 17967931 19004024 19551842
MESH:D005234 Fatty Liver Ethinyl Estradiol 13.9415345470
MESH:D005234 Fatty Liver Tamoxifen 13.9419224547 14986274
MESH:D052776 Female Urogenital Diseases Tamoxifen 3.3116709447
MESH:D005313 Fetal Death Tetrachlorodibenzodioxin 3.6311858732
MESH:D018221 Fibromatosis, Abdominal Tamoxifen 4.7214745880
MESH:D018222 Fibromatosis, Aggressive Tamoxifen 4.3819069698
MESH:D005355 Fibrosis Dietary Fats 9.2218296743
MESH:D005355 Fibrosis Tetrachlorodibenzodioxin 9.2220067830
MESH:D005756 Gastritis Acetaminophen 3.8916983495
MESH:D030342 Genetic Diseases, Inborn vinclozolin 5.1316973722
MESH:D005832 Genital Diseases, Male vinclozolin 5.5216417039
MESH:D006058 Gonadal Disorders Tetrachlorodibenzodioxin 4.8110696789
MESH:D006330 Heart Defects, Congenital Tetrachlorodibenzodioxin 2.4010048152 11294989
MESH:D006470 Hemorrhage Tetrachlorodibenzodioxin 3.4811000095
MESH:D006529 Hepatomegaly Tetrachlorodibenzodioxin 3.0715340226 12621046 16120746
MESH:D006869 Hydronephrosis Tetrachlorodibenzodioxin 4.268697196 18606429 15340226 16959395 16354765
MESH:D006930 Hyperalgesia Acetaminophen 2.8116870215
MESH:D006937 Hypercholesterolemia Dietary Fats 3.7321332399
MESH:D006949 Hyperlipidemias Dietary Fats 3.7621332399
MESH:D006973 Hypertension Tetrachlorodibenzodioxin 1.9518850075 18670907
MESH:D007021 Hypospadias Ethinyl Estradiol 3.9816945680 16569931
MESH:D020244 Infarction, Middle Cerebral Artery Progesterone 4.5815869954
MESH:D007247 Infertility, Female Ethinyl Estradiol 3.6112013081
MESH:D007248 Infertility, Male Ethinyl Estradiol 6.9617937319
MESH:D007248 Infertility, Male vinclozolin 6.9616467254
MESH:D007249 Inflammation Dietary Fats 12.5320412841
MESH:D007249 Inflammation Progesterone 12.5315869954
MESH:D007249 Inflammation Tamoxifen 12.5319457130
MESH:D007249 Inflammation Tetrachlorodibenzodioxin 12.5312200463 12878042
MESH:D007333 Insulin Resistance Dietary Fats 7.7811836018 18457598
MESH:D007333 Insulin Resistance Sodium Selenite 7.7814714311
MESH:D007569 Jaw Abnormalities Tetrachlorodibenzodioxin 3.4816580747
MESH:D007674 Kidney Diseases Acetaminophen 2.2715629191 12587719
MESH:D007680 Kidney Neoplasms Tamoxifen 3.1618625569
MESH:D007984 Leydig Cell Tumor vinclozolin 4.9316417039
MESH:D008064 Lipidoses Tamoxifen 3.2517567588 15342952
MESH:D008103 Liver Cirrhosis Dietary Fats 2.9518296743
MESH:D008106 Liver Cirrhosis, Experimental Tamoxifen 2.3218564211
MESH:D008106 Liver Cirrhosis, Experimental Tetrachlorodibenzodioxin 2.3212878042
MESH:D008107 Liver Diseases Acetaminophen 1.6611587558 16611625 12587719 12969438 19784758 19014921 16610002 19460945
MESH:D017114 Liver Failure, Acute Acetaminophen 3.3716871587 17185352
MESH:D008113 Liver Neoplasms Tamoxifen 4.5516684651
MESH:D008113 Liver Neoplasms Tetrachlorodibenzodioxin 4.5516984957
MESH:D008114 Liver Neoplasms, Experimental Tetrachlorodibenzodioxin 2.1912151625
MESH:D008175 Lung Neoplasms Tamoxifen 2.2818625569
MESH:D008175 Lung Neoplasms Tetrachlorodibenzodioxin 2.2819555203 11884234
MESH:D016393 Lymphoma, B-Cell Sodium Selenite 4.2114737004
MESH:D015674 Mammary Neoplasms, Animal Tamoxifen 3.9519428831
MESH:D008325 Mammary Neoplasms, Experimental Progesterone 6.3711408345 17203775
MESH:D008325 Mammary Neoplasms, Experimental Tamoxifen 6.3714580682 11731420 16827153 19196723 19196722
MESH:D020149 Manganese Poisoning Tamoxifen 4.7619453300
MESH:D008545 Melanoma Tamoxifen 1.9019393235 12393984
MESH:D018328 Melanoma, Amelanotic Tamoxifen 4.3815990972
MESH:D008546 Melanoma, Experimental Acetaminophen 3.7419513568
MESH:D017202 Myocardial Ischemia Tetrachlorodibenzodioxin 3.1312213967
MESH:D009362 Neoplasm Metastasis Tamoxifen 2.5919393235
MESH:D009364 Neoplasm Recurrence, Local Tamoxifen 2.5519410462
MESH:D009376 Neoplasms, Hormone-Dependent Tamoxifen 4.2219189210 19200415 19196722
MESH:D009410 Nerve Degeneration Rotenone 3.9915790535 18619942 17356569
MESH:D009421 Nervous System Malformations Tetrachlorodibenzodioxin 3.3714600291
MESH:D019636 Neurodegenerative Diseases Acetaminophen 2.9918514411
MESH:D009765 Obesity Dietary Fats 2.3111836018 21332399 20132043 20518802 17217161 19632207 16723640 18457598 18674790
MESH:D010051 Ovarian Neoplasms Progesterone 2.5617393432 16525653
MESH:D010146 Pain Acetaminophen 2.5016870215
MESH:D016584 Panic Disorder Ethinyl Estradiol 3.8411578682
MESH:D010300 Parkinson Disease Rotenone 3.0211445065 19232380 11535288 16412576 15451049 18619942 19114014 18191903 16140633
MESH:D020734 Parkinsonian Disorders Rotenone 4.2115795934 18197244 15927086 15574749
MESH:D010382 Peliosis Hepatis Tetrachlorodibenzodioxin 4.4712520081
MESH:D017119 Porphyria Cutanea Tarda Tetrachlorodibenzodioxin 3.7218163543
MESH:D011297 Prenatal Exposure Delayed Effects Tetrachlorodibenzodioxin 10.1411896295 11118676 11222880 11399792
MESH:D011297 Prenatal Exposure Delayed Effects vinclozolin 10.1418042343 18220299 19015723
MESH:D011469 Prostatic Diseases vinclozolin 5.1318220299
MESH:D011471 Prostatic Neoplasms Sodium Selenite 3.2518760546
MESH:D011471 Prostatic Neoplasms Tamoxifen 3.2515067354
MESH:D011472 Prostatitis vinclozolin 5.1318629315
MESH:D011537 Pruritus Ethinyl Estradiol 3.5116919318 15861022
MESH:D015619 Respiratory System Abnormalities Tetrachlorodibenzodioxin 4.0018990726
MESH:D012468 Salivary Gland Neoplasms Progesterone 2.9018045962
MESH:D012878 Skin Neoplasms Tetrachlorodibenzodioxin 2.1016192470
MESH:D013088 Spermatocele Ethinyl Estradiol 12.3016709447
MESH:D013088 Spermatocele Tamoxifen 12.3016709447
MESH:D013119 Spinal Cord Injuries Progesterone 11.5315862959 16503802
MESH:D013119 Spinal Cord Injuries Tamoxifen 11.5319457130
MESH:D019851 Thrombophilia Ethinyl Estradiol 3.7711994571
MESH:D013927 Thrombosis Ethinyl Estradiol 3.2815669648
MESH:D013959 Thyroid Diseases Tetrachlorodibenzodioxin 4.1212697716
MESH:D001749 Urinary Bladder Neoplasms Tamoxifen 2.4016712894 8653321 17572228
MESH:D014581 Urticaria Acetaminophen 3.1210982225
MESH:D014594 Uterine Neoplasms Ethinyl Estradiol 3.4614692618
MESH:D054079 Vascular Malformations Tetrachlorodibenzodioxin 4.8112125929
MESH:D020246 Venous Thrombosis Ethinyl Estradiol 3.6814671159 15869587
MESH:D019282 Wasting Syndrome Tetrachlorodibenzodioxin 4.4715886252
MESH:D015430 Weight Gain Dietary Fats 3.8616723640
No data
Pharmacogenomics Knowledge Base Top
  • PharmGKB Accession:PA128394661
    • No data
    Releated disease ID Related disease Name
    PA446155Precursor Cell Lymphoblastic Leukemia-Lymphoma
    No data
    Drug Bank Top

    Simple Query:


      (e.g. CHD8)

    Syndromic Genes

    Non-syndromic Genes

    AutismKB Statistics

    • Studies: 1,036
    • Genes: 1,379
    • CNVs/SVs: 5,420
    • SNVs/Indels: 11,669
    • de novo Mutations: 5,669
    • Mosaics: 789
    • Linkage Regions: 172
    • Paper Collected: 6/30/2018
    • Last Update: 8/26/2018


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