AutismKB 2.0

Annotation Detail for PDE1B


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Basic Information Top
Gene Symbol:PDE1B ( PDE1B1,PDES1B )
Gene Full Name: phosphodiesterase 1B, calmodulin-dependent
Band: 12q13.2
Quick LinksEntrez ID:5153; OMIM: 171891; Uniprot ID:PDE1B_HUMAN; ENSEMBL ID: ENSG00000123360; HGNC ID: 8775
Relate to Another Database: SFARIGene; denovo-db
Related Pathway Information Top
No data
Pathway IDPathway Name
hsa04020Calcium signaling pathway
hsa00230Purine metabolism
Pathway IDPathway Name
Signaling by GPCR
Signalling by NGF
Hemostasis
Opioid Signalling
No data
No data
No data
Related Diseases/Disorders Top
Comparative Toxicogenomics Database Top
Chemical ID Chemical Name Interaction Interaction Action Publication
C009505 4,4'-diaminodiphenylmethane 4,4'-diaminodiphenylmethane results in decreased expression of PDE1B mRNAdecreases expression 18648102
D000082 Acetaminophen Acetaminophen affects the expression of PDE1B mRNAaffects expression 17562736
D003024 Clozapine Clozapine results in increased expression of PDE1B mRNAincreases expression 14647396
D006220 Haloperidol Haloperidol results in increased expression of PDE1B mRNAincreases expression 14647396
D006220 Haloperidol Haloperidol results in increased expression of PDE1B mRNAincreases expression 18222493
D006220 Haloperidol Haloperidol results in increased expression of PDE1B proteinincreases expression 18222493
C044361 M-VAC protocol PDE1B protein results in increased susceptibility to M-VAC protocolincreases response to substance 15814643
D018038 Sodium Selenite Sodium Selenite results in decreased expression of PDE1B mRNAdecreases expression 16705456
Disease ID Disease Name Direct Evidence Inference Chemical Name Inference Score Publication
MESH:D000236 Adenoma 4,4'-diaminodiphenylmethane 2.923712494
MESH:D000380 Agranulocytosis Clozapine 5.4716160616 14617031 12649775
MESH:D000799 Angioedema Acetaminophen 4.3610982225
MESH:D001321 Autistic Disorder Acetaminophen 2.1318445737
MESH:D001321 Autistic Disorder Haloperidol 2.1319368416 18080171
MESH:D001660 Biliary Tract Diseases 4,4'-diaminodiphenylmethane 5.5411289319 1440618
MESH:D006528 Carcinoma, Hepatocellular 4,4'-diaminodiphenylmethane 2.937296757 3581430
MESH:D006528 Carcinoma, Hepatocellular Acetaminophen 2.933084413
MESH:D002292 Carcinoma, Renal Cell 4,4'-diaminodiphenylmethane 2.807296757
MESH:D002375 Catalepsy Haloperidol 5.3715215559 1977408
MESH:D002386 Cataract Acetaminophen 2.7510977129
MESH:D002471 Cell Transformation, Neoplastic 4,4'-diaminodiphenylmethane 2.967505956
MESH:D002779 Cholestasis 4,4'-diaminodiphenylmethane 3.3819486331 9022650
MESH:D019457 Chromosome Breakage Sodium Selenite 5.1715894690
MESH:D003072 Cognition Disorders Clozapine 5.3817123785
MESH:D016757 Death, Sudden, Cardiac Haloperidol 5.1920210726
MESH:D003704 Dementia Haloperidol 4.9011575062
MESH:D017449 Dermatitis, Allergic Contact 4,4'-diaminodiphenylmethane 3.2112868966 11298694 18759878 11906362 2524372 8970840 14531868 8156756
MESH:D003877 Dermatitis, Contact 4,4'-diaminodiphenylmethane 3.842952479 3621924
MESH:D003920 Diabetes Mellitus Sodium Selenite 4.0616285004
MESH:D003924 Diabetes Mellitus, Type 2 Clozapine 3.0316402076
MESH:D006970 Disorders of Excessive Somnolence Clozapine 6.0715331141
MESH:D056486 Drug-Induced Liver Injury 4,4'-diaminodiphenylmethane 6.6718692083 18289764 8291058 9328219 7440962 1440618 9653073 9022650 16192314 6679447 6482804 11289319 18648102
MESH:D056486 Drug-Induced Liver Injury Acetaminophen 6.6718071297 16177239 17562736 17906064 10774834 11461765 10663392 19420014 2444490 19416960 11529661 19164858 12392966 14725611 11739529 16781746 19923254 19085960 14550746 12958197 16485898 16227642 12153990 12594235 10915739 14986274 11287661 15968718 12540782 11834606 12705907 15619225 18713872 16081117 11743745 11421492 19370779 19739265 16393943 17522070 16109766
MESH:D056486 Drug-Induced Liver Injury Sodium Selenite 6.6715131321
MESH:D056487 Drug-Induced Liver Injury, Chronic Acetaminophen 4.6219426721
MESH:D050171 Dyslipidemias Clozapine 4.4016402076
MESH:D004938 Esophageal Neoplasms 4,4'-diaminodiphenylmethane 2.173581430
MESH:D005350 Fibroma 4,4'-diaminodiphenylmethane 5.546705139
MESH:D005756 Gastritis Acetaminophen 4.1916983495
MESH:D006042 Goiter 4,4'-diaminodiphenylmethane 4.397505956
MESH:D006505 Hepatitis 4,4'-diaminodiphenylmethane 3.896705139
MESH:D006930 Hyperalgesia Acetaminophen 2.9516870215
MESH:D006948 Hyperkinesis Clozapine 5.3716046005
MESH:D006965 Hyperplasia 4,4'-diaminodiphenylmethane 4.3615034207
MESH:D007333 Insulin Resistance Sodium Selenite 3.4714714311
MESH:D007565 Jaundice 4,4'-diaminodiphenylmethane 5.548074119 9022650
MESH:D007674 Kidney Diseases Acetaminophen 2.3615629191 12587719
MESH:D007680 Kidney Neoplasms 4,4'-diaminodiphenylmethane 3.236582329
MESH:D008064 Lipidoses Clozapine 4.1817567588
MESH:D008105 Liver Cirrhosis, Biliary 4,4'-diaminodiphenylmethane 3.3815034207 9327722
MESH:D008107 Liver Diseases Acetaminophen 1.6916610002 19784758 12587719 16611625 11587558 12969438 19460945 19014921
MESH:D017114 Liver Failure, Acute Acetaminophen 3.5416871587 17185352
MESH:D008114 Liver Neoplasms, Experimental 4,4'-diaminodiphenylmethane 2.713712494 598648 6587162 1399818
MESH:D016393 Lymphoma, B-Cell Sodium Selenite 4.4114737004
MESH:D008546 Melanoma, Experimental Acetaminophen 3.9819513568
MESH:D001523 Mental Disorders Clozapine 9.9416856516
MESH:D001523 Mental Disorders Haloperidol 9.9416856516
MESH:D024821 Metabolic Syndrome X Clozapine 4.6819142101
MESH:D009362 Neoplasm Metastasis 4,4'-diaminodiphenylmethane 2.573581430
MESH:D009436 Neural Tube Defects 4,4'-diaminodiphenylmethane 3.106679447
MESH:D019636 Neurodegenerative Diseases Acetaminophen 3.1418514411
MESH:D009765 Obesity Clozapine 3.0719142110 18515891
MESH:D009784 Occupational Diseases 4,4'-diaminodiphenylmethane 3.724026338 6482804
MESH:D009902 Optic Neuritis 4,4'-diaminodiphenylmethane 5.543988306
MESH:D010146 Pain Acetaminophen 2.6516870215
MESH:D010212 Papilloma 4,4'-diaminodiphenylmethane 3.907296757
MESH:D010787 Photosensitivity Disorders 4,4'-diaminodiphenylmethane 4.996228378
MESH:D011471 Prostatic Neoplasms Sodium Selenite 3.3418760546
MESH:D011595 Psychomotor Agitation Haloperidol 5.3711575062
MESH:D011618 Psychotic Disorders Clozapine 9.9015331141
MESH:D011618 Psychotic Disorders Haloperidol 9.9011575062
MESH:D012162 Retinal Degeneration 4,4'-diaminodiphenylmethane 3.613692021
MESH:D012559 Schizophrenia Clozapine 4.2220107430 20521320 20580759 17667964 20452607 17123785 17726453 19369910 11763009 16141801 18855531 11151749 20521326 20168265 18806925
MESH:D012559 Schizophrenia Haloperidol 4.2220107430 18513383 1830565 19369910
MESH:D017180 Tachycardia, Ventricular Haloperidol 5.0920210726
MESH:D013964 Thyroid Neoplasms 4,4'-diaminodiphenylmethane 3.126582329 7505956 3712494 1399818 6587162
MESH:D001749 Urinary Bladder Neoplasms 4,4'-diaminodiphenylmethane 2.378074119
MESH:D014571 Urologic Neoplasms M-VAC protocol 6.5417933135
MESH:D014581 Urticaria Acetaminophen 3.3310982225
MESH:D015430 Weight Gain Clozapine 4.7516402076 16141801 20107430 20564506 17502770 20521320
MESH:D015431 Weight Loss Clozapine 5.5417933447
Pathway ID Pathway Name
KEGG:04020 Calcium signaling pathway
REACT:604 Hemostasis
REACT:15295 Opioid Signalling
KEGG:00230 Purine metabolism
REACT:14797 Signaling by GPCR
REACT:11061 Signalling by NGF
Pharmacogenomics Knowledge Base Top
  • PharmGKB Accession:PA33123
    • No data
    Releated disease ID Related disease Name
    PA447321Depressive Disorder, Major
    Releated drug ID Related drug Name
    PA449233desipramine
    PA449673fluoxetine
    Drug Bank Top
    Drugbank ID Action Drug Name Description
    DB00622 inhibitor Nicardipine Antihypertensive Agents;Vasodilator Agents;Antiarrhythmic Agents;Calcium Channel Blockers;Dihydropyridines
    DB01023 antagonist Lexxel Antihypertensive Agents;Vasodilator Agents;Calcium Channel Blockers;Dihydropyridines
    DB01244 antagonist Bepridil Antihypertensive Agents;Vasodilator Agents;Antiarrhythmic Agents;Calcium Channel Blockers;Anti-Arrhythmia Agents
    DB04530 - S,S-(2-Hydroxyethyl)Thiocysteine
    No data
    No data
    No data

    Simple Query:


      (e.g. CHD8)

    Syndromic Genes

    Non-syndromic Genes

    AutismKB Statistics

    • Studies: 1,036
    • Genes: 1,379
    • CNVs/SVs: 5,420
    • SNVs/Indels: 11,669
    • de novo Mutations: 5,669
    • Mosaics: 789
    • Linkage Regions: 172
    • Paper Collected: 6/30/2018
    • Last Update: 8/26/2018


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