Annotation Detail for ZC3HC1
Basic Information
Top
| Gene Symbol: | ZC3HC1 ( 1110054L24Rik,FBXO50,NIPA ) |
|---|
| Gene Full Name: | zinc finger, C3HC-type containing 1 |
|---|
| Band: | 7q32.2 |
|---|
| Quick Links | Entrez ID:51530; OMIM: NA; Uniprot ID:NIPA_HUMAN; ENSEMBL ID: ENSG00000091732; HGNC ID: 29913 |
|---|
| Relate to Another Database: |
SFARIGene;
denovo-db |
| Chemical ID |
Chemical Name |
Interaction |
Interaction Action |
Publication |
|---|
| C016403 |
2,4-dinitrotoluene |
2,4-dinitrotoluene affects the expression of ZC3HC1 mRNA | affects expression | 21346803
|
| C023514 |
2,6-dinitrotoluene |
2,6-dinitrotoluene affects the expression of ZC3HC1 mRNA | affects expression | 21346803
|
| D000082 |
Acetaminophen |
Acetaminophen affects the expression of ZC3HC1 mRNA | affects expression | 17562736
|
| C006253 |
pirinixic acid |
[pirinixic acid binds to and results in increased activity of PPARA protein] which results in increased expression of ZC3HC1 mRNA | affects binding|increases activity|increases expression | 19710929
|
| Disease ID |
Disease Name |
Direct Evidence |
Inference Chemical Name |
Inference Score |
Publication |
|---|
| MESH:D055371 |
Acute Lung Injury |
|
pirinixic acid |
3.58 | 18653653 |
| MESH:D018248 |
Adenoma, Liver Cell |
|
pirinixic acid |
4.11 | 16434500 |
| MESH:D000799 |
Angioedema |
|
Acetaminophen |
4.57 | 10982225 |
| MESH:D001321 |
Autistic Disorder |
|
Acetaminophen |
1.40 | 18445737 |
| MESH:D001778 |
Blood Coagulation Disorders |
|
pirinixic acid |
3.57 | 19483382 |
| MESH:D006528 |
Carcinoma, Hepatocellular |
|
2,4-dinitrotoluene |
4.78 | 16705839 |
| MESH:D006528 |
Carcinoma, Hepatocellular |
|
2,6-dinitrotoluene |
4.78 | 16705839 |
| MESH:D006528 |
Carcinoma, Hepatocellular |
|
Acetaminophen |
4.78 | 3084413 |
| MESH:D002386 |
Cataract |
|
Acetaminophen |
2.79 | 10977129 |
| MESH:D002471 |
Cell Transformation, Neoplastic |
|
2,6-dinitrotoluene |
3.03 | 6135515 |
| MESH:D002779 |
Cholestasis |
|
pirinixic acid |
3.12 | 19176532 |
| MESH:D003324 |
Coronary Artery Disease |
marker/mechanism |
|
| 21378990 |
| MESH:D003490 |
Cyanosis |
|
2,4-dinitrotoluene |
12.83 | 18551238 |
| MESH:D003490 |
Cyanosis |
|
2,6-dinitrotoluene |
12.83 | 18551238 |
| MESH:D003876 |
Dermatitis, Atopic |
|
pirinixic acid |
2.57 | 18249437 |
| MESH:D056486 |
Drug-Induced Liver Injury |
|
2,4-dinitrotoluene |
6.72 | 18551238 21346803 |
| MESH:D056486 |
Drug-Induced Liver Injury |
|
2,6-dinitrotoluene |
6.72 | 18551238 21346803 |
| MESH:D056486 |
Drug-Induced Liver Injury |
|
Acetaminophen |
6.72 | 16227642 19739265 15619225 10663392 12540782 12153990 2444490 19416960 16781746 10915739 16081117 11461765 19923254 12705907 11739529 18071297 15968718 18713872 14725611 17906064 16109766 11287661 12392966 11529661 19085960 10774834 11421492 16485898 11834606 19420014 19370779 14550746 11743745 12958197 14986274 19164858 16393943 17522070 16177239 17562736 12594235 |
| MESH:D056487 |
Drug-Induced Liver Injury, Chronic |
|
Acetaminophen |
4.82 | 19426721 |
| MESH:D004487 |
Edema |
|
pirinixic acid |
2.90 | 12083418 |
| MESH:D005234 |
Fatty Liver |
|
pirinixic acid |
3.19 | 19236843 20131406 |
| MESH:D005756 |
Gastritis |
|
Acetaminophen |
4.40 | 16983495 |
| MESH:D006333 |
Heart Failure |
|
pirinixic acid |
2.76 | 20558911 |
| MESH:D006529 |
Hepatomegaly |
|
pirinixic acid |
3.55 | 16221962 19772884 19176532 18467677 |
| MESH:D006930 |
Hyperalgesia |
|
Acetaminophen |
3.02 | 16870215 |
| MESH:D006943 |
Hyperglycemia |
|
pirinixic acid |
3.58 | 20558911 |
| MESH:D007333 |
Insulin Resistance |
|
pirinixic acid |
2.87 | 16306350 |
| MESH:D007674 |
Kidney Diseases |
|
Acetaminophen |
2.40 | 15629191 12587719 |
| MESH:D007680 |
Kidney Neoplasms |
|
2,4-dinitrotoluene |
8.53 | 16705839 |
| MESH:D007680 |
Kidney Neoplasms |
|
2,6-dinitrotoluene |
8.53 | 16705839 |
| MESH:D008106 |
Liver Cirrhosis, Experimental |
|
pirinixic acid |
1.35 | 15474484 |
| MESH:D008107 |
Liver Diseases |
|
Acetaminophen |
1.70 | 19014921 12587719 16610002 11587558 19784758 16611625 19460945 12969438 |
| MESH:D017114 |
Liver Failure, Acute |
|
Acetaminophen |
3.63 | 16871587 17185352 |
| MESH:D008113 |
Liver Neoplasms |
|
2,6-dinitrotoluene |
4.81 | 7678174 |
| MESH:D008113 |
Liver Neoplasms |
|
pirinixic acid |
4.81 | 20007298 16377806 15890375 |
| MESH:D008114 |
Liver Neoplasms, Experimental |
|
2,6-dinitrotoluene |
2.77 | 2876786 6135515 2876784 |
| MESH:D008546 |
Melanoma, Experimental |
|
Acetaminophen |
4.13 | 19513568 |
| MESH:D009135 |
Muscular Diseases |
|
pirinixic acid |
4.07 | 16239165 |
| MESH:D009203 |
Myocardial Infarction |
|
pirinixic acid |
2.27 | 19151258 |
| MESH:D015428 |
Myocardial Reperfusion Injury |
|
pirinixic acid |
3.25 | 16411023 |
| MESH:D009336 |
Necrosis |
|
2,4-dinitrotoluene |
12.54 | 18551238 |
| MESH:D009336 |
Necrosis |
|
2,6-dinitrotoluene |
12.54 | 18551238 7678174 |
| MESH:D009369 |
Neoplasms |
|
pirinixic acid |
2.11 | 17405874 |
| MESH:D019636 |
Neurodegenerative Diseases |
|
Acetaminophen |
3.21 | 18514411 |
| MESH:D009765 |
Obesity |
|
pirinixic acid |
1.88 | 20558911 |
| MESH:D009784 |
Occupational Diseases |
|
2,4-dinitrotoluene |
10.23 | 16049721 12819281 |
| MESH:D009784 |
Occupational Diseases |
|
2,6-dinitrotoluene |
10.23 | 16049721 |
| MESH:D010146 |
Pain |
|
Acetaminophen |
2.73 | 16870215 |
| MESH:D015427 |
Reperfusion Injury |
|
pirinixic acid |
2.55 | 19058328 |
| MESH:D012640 |
Seizures |
|
2,4-dinitrotoluene |
6.74 | 18551238 |
| MESH:D012640 |
Seizures |
|
2,6-dinitrotoluene |
6.74 | 18551238 |
| MESH:D001749 |
Urinary Bladder Neoplasms |
|
2,4-dinitrotoluene |
5.43 | 16049721 |
| MESH:D001749 |
Urinary Bladder Neoplasms |
|
2,6-dinitrotoluene |
5.43 | 16049721 |
| MESH:D014571 |
Urologic Neoplasms |
|
2,4-dinitrotoluene |
14.19 | 10091137 |
| MESH:D014571 |
Urologic Neoplasms |
|
2,6-dinitrotoluene |
14.19 | 10091137 |
| MESH:D014581 |
Urticaria |
|
Acetaminophen |
3.44 | 10982225 |
Related Pathway Information