Annotation Detail for SIRT6
Basic Information
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| Chemical ID |
Chemical Name |
Interaction |
Interaction Action |
Publication |
|---|
| C016403 |
2,4-dinitrotoluene |
2,4-dinitrotoluene affects the expression of SIRT6 mRNA | affects expression | 21346803
|
| C023514 |
2,6-dinitrotoluene |
2,6-dinitrotoluene results in increased expression of SIRT6 mRNA | increases expression | 20406850
|
| D001194 |
Asbestos |
Asbestos affects the expression of SIRT6 mRNA | affects expression | 17297452
|
| Disease ID |
Disease Name |
Direct Evidence |
Inference Chemical Name |
Inference Score |
Publication |
|---|
| MESH:D050197 |
Atherosclerosis |
|
Asbestos |
4.45 | 18795166 |
| MESH:D006528 |
Carcinoma, Hepatocellular |
|
2,4-dinitrotoluene |
3.11 | 16705839 |
| MESH:D006528 |
Carcinoma, Hepatocellular |
|
2,6-dinitrotoluene |
3.11 | 16705839 |
| MESH:D002471 |
Cell Transformation, Neoplastic |
|
2,6-dinitrotoluene |
3.06 | 6135515 |
| MESH:D003490 |
Cyanosis |
|
2,4-dinitrotoluene |
13.16 | 18551238 |
| MESH:D003490 |
Cyanosis |
|
2,6-dinitrotoluene |
13.16 | 18551238 |
| MESH:D056486 |
Drug-Induced Liver Injury |
|
2,4-dinitrotoluene |
4.19 | 18551238 21346803 |
| MESH:D056486 |
Drug-Induced Liver Injury |
|
2,6-dinitrotoluene |
4.19 | 21346803 18551238 |
| MESH:D007680 |
Kidney Neoplasms |
|
2,4-dinitrotoluene |
8.67 | 16705839 |
| MESH:D007680 |
Kidney Neoplasms |
|
2,6-dinitrotoluene |
8.67 | 16705839 |
| MESH:D008113 |
Liver Neoplasms |
|
2,6-dinitrotoluene |
2.28 | 7678174 |
| MESH:D008114 |
Liver Neoplasms, Experimental |
|
2,6-dinitrotoluene |
2.79 | 2876784 6135515 2876786 |
| MESH:D008175 |
Lung Neoplasms |
|
Asbestos |
3.18 | 12111688 |
| MESH:D008654 |
Mesothelioma |
|
Asbestos |
4.22 | 16564556 18709470 18310086 16919927 16319530 |
| MESH:D009336 |
Necrosis |
|
2,4-dinitrotoluene |
12.96 | 18551238 |
| MESH:D009336 |
Necrosis |
|
2,6-dinitrotoluene |
12.96 | 7678174 18551238 |
| MESH:D009784 |
Occupational Diseases |
|
2,4-dinitrotoluene |
10.41 | 16049721 12819281 |
| MESH:D009784 |
Occupational Diseases |
|
2,6-dinitrotoluene |
10.41 | 16049721 |
| MESH:D012640 |
Seizures |
|
2,4-dinitrotoluene |
6.84 | 18551238 |
| MESH:D012640 |
Seizures |
|
2,6-dinitrotoluene |
6.84 | 18551238 |
| MESH:D001749 |
Urinary Bladder Neoplasms |
|
2,4-dinitrotoluene |
5.48 | 16049721 |
| MESH:D001749 |
Urinary Bladder Neoplasms |
|
2,6-dinitrotoluene |
5.48 | 16049721 |
| MESH:D014571 |
Urologic Neoplasms |
|
2,4-dinitrotoluene |
14.60 | 10091137 |
| MESH:D014571 |
Urologic Neoplasms |
|
2,6-dinitrotoluene |
14.60 | 10091137 |
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