AutismKB 2.0

Annotation Detail for PDGFB


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Basic Information Top
Gene Symbol:PDGFB ( FLJ12858,PDGF2,SIS,SSV,c-sis )
Gene Full Name: platelet-derived growth factor beta polypeptide (simian sarcoma viral (v-sis) oncogene homolog)
Band: 22q13.1
Quick LinksEntrez ID:5155; OMIM: 190040; Uniprot ID:PDGFB_HUMAN; ENSEMBL ID: ENSG00000100311; HGNC ID: 8800
Relate to Another Database: SFARIGene; denovo-db
Related Pathway Information Top
No data
Pathway IDPathway Name
hsa04010MAPK signaling pathway
hsa04540Gap junction
hsa05211Renal cell carcinoma
hsa04810Regulation of actin cytoskeleton
hsa05218Melanoma
hsa05214Glioma
hsa05215Prostate cancer
hsa04510Focal adhesion
hsa04060Cytokine-cytokine receptor interaction
hsa05200Pathways in cancer
Pathway IDPathway Name
Hemostasis
Signaling by PDGF
Pathway IDPathway Name
200127PDGFR-beta signaling pathway
Pathway IDPathway Name
P00005Angiogenesis
P00047PDGF signaling pathway
No data
Related Diseases/Disorders Top
Desease IDDesease Name
Cancers
H00015Malignant pleural mesothelioma
Cancers of the lung and pleura
H00042Glioma
Cancers of the nervous system
Desease IDDesease Name
1818Systemic scleroderma
1918Atherosclerosis
1934Cancer
2188Bone marrow disease
No data
No data
Desease Name
Meningioma, SIS-related
Dermatofibrosarcoma protuberans
Giant-cell fibroblastoma
Comparative Toxicogenomics Database Top
Chemical ID Chemical Name Interaction Interaction Action Publication
C085911 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [PDGFB protein results in increased phosphorylation of and results in increased activity of AKT1 protein]decreases reaction|increases activity|increases phosphorylation 15919668
C085911 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [PDGFB protein results in increased phosphorylation of and results in increased activity of MAPK1 protein]decreases reaction|increases activity|increases phosphorylation 15919668
C085911 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [PDGFB protein results in increased phosphorylation of and results in increased activity of MAPK3 protein]decreases reaction|increases activity|increases phosphorylation 15919668
C085911 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [PDGFB protein results in increased phosphorylation of and results in increased activity of RPS6KB1 protein]decreases reaction|increases activity|increases phosphorylation 15919668
C085911 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one U 0126 promotes the reaction [2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [PDGFB protein results in increased phosphorylation of and results in increased activity of RPS6KB1 protein]]decreases reaction|increases activity|increases phosphorylation|increases reaction 15919668
D000643 Ammonium Chloride Ammonium Chloride affects the expression of PDGFB mRNAaffects expression 16483693
D001564 Benzo(a)pyrene Benzo(a)pyrene results in increased expression of PDGFB mRNAincreases expression 20064835
C074619 bivalirudin bivalirudin affects the expression of PDGFB proteinaffects expression 10754393
11316950
D020001 1-Butanol 1-Butanol inhibits the reaction [PDGFB protein results in decreased expression of CCND3 protein]decreases expression|decreases reaction 15919668
D020001 1-Butanol 1-Butanol inhibits the reaction [PDGFB protein results in increased phosphorylation of AKT1 protein]decreases reaction|increases phosphorylation 15919668
D020001 1-Butanol 1-Butanol inhibits the reaction [PDGFB protein results in increased phosphorylation of MAPK1 protein]decreases reaction|increases phosphorylation 15919668
D020001 1-Butanol 1-Butanol inhibits the reaction [PDGFB protein results in increased phosphorylation of MAPK3 protein]decreases reaction|increases phosphorylation 15919668
D020001 1-Butanol 1-Butanol inhibits the reaction [PDGFB protein results in increased phosphorylation of RPS6KB1 protein]decreases reaction|increases phosphorylation 15919668
D020001 1-Butanol 1-Butanol inhibits the reaction [PDGFB protein results in increased expression of FOS mRNA]decreases reaction|increases expression 12782152
D020001 1-Butanol 1-Butanol inhibits the reaction [PDGFB protein results in increased phosphorylation of and results in increased activity of MAPK3 protein]decreases reaction|increases activity|increases phosphorylation 12782152
D002251 Carbon Tetrachloride Carbon Tetrachloride results in increased expression of PDGFB mRNAincreases expression 17341687
D002251 Carbon Tetrachloride S1PR2 protein affects the reaction [Carbon Tetrachloride results in increased expression of PDGFB mRNA]affects reaction|increases expression 17341687
D002251 Carbon Tetrachloride Carbon Tetrachloride results in increased expression of PDGFB proteinincreases expression 14761280
12930639
18006644
D002251 Carbon Tetrachloride Carbon Tetrachloride results in increased expression of [PDGFB protein binds to PDGFB protein]affects binding|increases expression 16097048
D002251 Carbon Tetrachloride Curcumin inhibits the reaction [Carbon Tetrachloride results in increased expression of PDGFB protein]decreases reaction|increases expression 18006644
D002251 Carbon Tetrachloride Losartan inhibits the reaction [Carbon Tetrachloride results in increased expression of PDGFB protein]decreases reaction|increases expression 12930639
D002251 Carbon Tetrachloride Perindopril inhibits the reaction [Carbon Tetrachloride results in increased expression of PDGFB protein]decreases reaction|increases expression 14761280
12930639
D002251 Carbon Tetrachloride Perindopril inhibits the reaction [Carbon Tetrachloride results in increased expression of [PDGFB protein binds to PDGFB protein]]affects binding|decreases reaction|increases expression 16097048
C055162 clopidogrel clopidogrel results in decreased expression of PDGFB mRNAdecreases expression 19155974
C055162 clopidogrel clopidogrel results in decreased expression of PDGFB proteindecreases expression 19155974
C497448 CP-673,451 CP-673,451 inhibits the reaction [PDGFB protein results in increased phosphorylation of PDGFRB protein]decreases reaction|increases phosphorylation 15705896
D003474 Curcumin Curcumin inhibits the reaction [Carbon Tetrachloride results in increased expression of PDGFB protein]decreases reaction|increases expression 18006644
D003474 Curcumin Curcumin inhibits the reaction [PDGFB protein results in increased phosphorylation of MAPK1 protein]decreases reaction|increases phosphorylation 18784349
D003474 Curcumin Curcumin inhibits the reaction [PDGFB protein results in increased phosphorylation of MAPK3 protein]decreases reaction|increases phosphorylation 18784349
D003474 Curcumin tin protoporphyrin IX inhibits the reaction [Curcumin inhibits the reaction [PDGFB protein results in increased phosphorylation of MAPK1 protein]]decreases reaction|increases phosphorylation 18784349
D003474 Curcumin tin protoporphyrin IX inhibits the reaction [Curcumin inhibits the reaction [PDGFB protein results in increased phosphorylation of MAPK3 protein]]decreases reaction|increases phosphorylation 18784349
D016572 Cyclosporine Cyclosporine results in increased expression of PDGFB mRNAincreases expression 8708960
D003545 Cysteine Cysteine inhibits the reaction [PDGFB protein results in increased phosphorylation of AKT1 protein]decreases reaction|increases phosphorylation 15158331
D003545 Cysteine Cysteine inhibits the reaction [PDGFB protein results in increased phosphorylation of PDGFRB protein]decreases reaction|increases phosphorylation 15158331
D003676 Deferoxamine Deferoxamine inhibits the reaction [PDGFB protein results in increased phosphorylation of AKT1 protein]decreases reaction|increases phosphorylation 18032466
D003676 Deferoxamine Deferoxamine inhibits the reaction [PDGFB protein results in increased phosphorylation of MAPK1 protein]decreases reaction|increases phosphorylation 18032466
D003676 Deferoxamine Deferoxamine inhibits the reaction [PDGFB protein results in increased phosphorylation of MAPK3 protein]decreases reaction|increases phosphorylation 18032466
D004128 Dimethylnitrosamine Dimethylnitrosamine results in increased expression of PDGFB mRNAincreases expression 17036385
D004128 Dimethylnitrosamine Drugs, Chinese Herbal inhibits the reaction [Dimethylnitrosamine results in increased expression of PDGFB mRNA]decreases reaction|increases expression 17036385
D004365 Drugs, Chinese Herbal Drugs, Chinese Herbal inhibits the reaction [Dimethylnitrosamine results in increased expression of PDGFB mRNA]decreases reaction|increases expression 17036385
D004642 Emodin Emodin inhibits the reaction [PDGFB protein results in increased phosphorylation of AKT1 protein]decreases reaction|increases phosphorylation 15288473
D004642 Emodin Emodin inhibits the reaction [PDGFB protein results in increased phosphorylation of MAP2K1 protein]decreases reaction|increases phosphorylation 15288473
D004642 Emodin Emodin inhibits the reaction [PDGFB protein results in increased phosphorylation of MAP2K2 protein]decreases reaction|increases phosphorylation 15288473
D004642 Emodin Emodin inhibits the reaction [PDGFB protein results in increased phosphorylation of MAPK1 protein]decreases reaction|increases phosphorylation 15288473
D004642 Emodin Emodin inhibits the reaction [PDGFB protein results in increased phosphorylation of MAPK3 protein]decreases reaction|increases phosphorylation 15288473
D004642 Emodin Emodin inhibits the reaction [PDGFB protein results in increased phosphorylation of PDGFRB protein]decreases reaction|increases phosphorylation 15288473
D004642 Emodin Emodin inhibits the reaction [PDGFB protein results in increased phosphorylation of RAF1 protein]decreases reaction|increases phosphorylation 15288473
D004958 Estradiol [Estradiol co-treated with Medroxyprogesterone Acetate] results in decreased secretion of [PDGFA protein binds to PDGFB protein]affects binding|affects cotreatment|decreases secretion 15866426
D004958 Estradiol [Progesterone co-treated with Estradiol] results in decreased expression of PDGFB mRNAaffects cotreatment|decreases expression 17404688
D004958 Estradiol Estradiol affects the secretion of [PDGFB protein binds to PDGFB protein]affects binding|affects secretion 15653758
D004966 Estrogens, Conjugated (USP) Estrogens, Conjugated (USP) affects the secretion of [PDGFB protein binds to PDGFB protein]affects binding|affects secretion 15653758
C479171 hirulog-like peptide hirulog-like peptide affects the expression of PDGFB proteinaffects expression 11316950
D003900 Desoxycorticosterone [PDGFA protein binds to PDGFB protein] which results in increased susceptibility to Desoxycorticosteroneaffects binding|increases response to substance 11751714
C097613 imatinib imatinib results in decreased expression of PDGFB proteindecreases expression 15786421
C078038 inchinko-to inchinko-to inhibits the reaction [PDGFB protein results in increased phosphorylation of AKT1 protein]decreases reaction|increases phosphorylation 15288473
C078038 inchinko-to inchinko-to inhibits the reaction [PDGFB protein results in increased phosphorylation of MAP2K1 protein]decreases reaction|increases phosphorylation 15288473
C078038 inchinko-to inchinko-to inhibits the reaction [PDGFB protein results in increased phosphorylation of MAP2K2 protein]decreases reaction|increases phosphorylation 15288473
C078038 inchinko-to inchinko-to inhibits the reaction [PDGFB protein results in increased phosphorylation of MAPK1 protein]decreases reaction|increases phosphorylation 15288473
C078038 inchinko-to inchinko-to inhibits the reaction [PDGFB protein results in increased phosphorylation of MAPK3 protein]decreases reaction|increases phosphorylation 15288473
C078038 inchinko-to inchinko-to inhibits the reaction [PDGFB protein results in increased phosphorylation of PDGFRB protein]decreases reaction|increases phosphorylation 15288473
C078038 inchinko-to inchinko-to inhibits the reaction [PDGFB protein results in increased phosphorylation of RAF1 protein]decreases reaction|increases phosphorylation 15288473
C040527 lipoxin A4 lipoxin A4 affects the reaction [PDGFB protein results in increased phosphorylation of PDGFRB protein]affects reaction|increases phosphorylation 12223454
D019808 Losartan Losartan inhibits the reaction [AGT protein results in increased expression of PDGFB mRNA]decreases reaction|increases expression 17043664
D019808 Losartan Losartan inhibits the reaction [Carbon Tetrachloride results in increased expression of PDGFB protein]decreases reaction|increases expression 12930639
D017258 Medroxyprogesterone Acetate [Estradiol co-treated with Medroxyprogesterone Acetate] results in decreased secretion of [PDGFA protein binds to PDGFB protein]affects binding|affects cotreatment|decreases secretion 15866426
D008715 Methionine Methionine inhibits the reaction [PDGFB protein results in increased phosphorylation of AKT1 protein]decreases reaction|increases phosphorylation 15158331
D008715 Methionine Methionine inhibits the reaction [PDGFB protein results in increased phosphorylation of PDGFRB protein]decreases reaction|increases phosphorylation 15158331
D008769 Methylnitronitrosoguanidine Methylnitronitrosoguanidine results in increased expression of PDGFB mRNAincreases expression 12634122
D010269 Paraquat Paraquat results in increased expression of PDGFB mRNAincreases expression 16328009
D020913 Perindopril Perindopril inhibits the reaction [Carbon Tetrachloride results in increased expression of PDGFB protein]decreases reaction|increases expression 14761280
12930639
D020913 Perindopril Perindopril inhibits the reaction [Carbon Tetrachloride results in increased expression of [PDGFB protein binds to PDGFB protein]]affects binding|decreases reaction|increases expression 16097048
D010672 Phenytoin Phenytoin results in increased expression of PDGFB mRNAincreases expression 8463938
9029455
D010672 Phenytoin Phenytoin results in increased expression of PDGFB mRNAincreases expression 8463938
D010672 Phenytoin Phenytoin results in increased expression of PDGFB proteinincreases expression 8463938
C068564 phosphatidylbutanol EWSR1 protein affects the reaction [PLD2 protein promotes the reaction [PDGFB protein results in increased abundance of phosphatidylbutanol]]affects reaction|increases abundance|increases reaction 15919668
C068564 phosphatidylbutanol PLD2 protein promotes the reaction [PDGFB protein results in increased abundance of phosphatidylbutanol]increases abundance|increases reaction 15919668
D011374 Progesterone [Progesterone co-treated with Estradiol] results in decreased expression of PDGFB mRNAaffects cotreatment|decreases expression 17404688
D011374 Progesterone Progesterone results in decreased expression of PDGFB mRNAdecreases expression 17404688
D020849 Raloxifene Raloxifene affects the secretion of [PDGFB protein binds to PDGFB protein]affects binding|affects secretion 15653758
D017382 Reactive Oxygen Species PDGFB protein results in increased abundance of Reactive Oxygen Speciesincreases abundance 11710721
C059514 resveratrol resveratrol inhibits the reaction [PDGFB protein results in increased phosphorylation of and results in increased activity of AKT1 protein]decreases reaction|increases activity|increases phosphorylation 16343977
C059514 resveratrol resveratrol inhibits the reaction [PDGFB protein results in increased phosphorylation of and results in increased activity of MAPK1 protein]decreases reaction|increases activity|increases phosphorylation 16343977
C059514 resveratrol resveratrol inhibits the reaction [PDGFB protein results in increased phosphorylation of and results in increased activity of MAPK3 protein]decreases reaction|increases activity|increases phosphorylation 16343977
C059514 resveratrol resveratrol inhibits the reaction [PDGFB protein results in increased phosphorylation of PDGFRB protein]decreases reaction|increases phosphorylation 16343977
C059514 resveratrol resveratrol results in decreased activity of PDGFB proteindecreases activity 16343977
C059514 resveratrol resveratrol results in increased expression of PDGFB mRNAincreases expression 12002526
C064116 S-(1,1,2,2-tetrafluoroethyl)cysteine S-(1,1,2,2-tetrafluoroethyl)cysteine results in decreased expression of PDGFB mRNAdecreases expression 16678137
D017632 Asbestos, Serpentine Asbestos, Serpentine results in increased expression of PDGFB mRNAincreases expression 18039278
D017632 Asbestos, Serpentine PDGFB protein results in increased susceptibility to Asbestos, Serpentineincreases response to substance 15511213
D020123 Sirolimus Sirolimus inhibits the reaction [PDGFB protein results in increased phosphorylation of and results in increased activity of RPS6KB1 protein]decreases reaction|increases activity|increases phosphorylation 15919668
D020123 Sirolimus [Sirolimus results in decreased activity of MTOR protein] inhibits the reaction [PDGFB protein results in increased phosphorylation of and results in increased activity of RPS6KB1 protein]decreases activity|decreases reaction|increases activity|increases phosphorylation 15919668
C003377 taxifolin taxifolin results in decreased expression of PDGFB mRNAdecreases expression 17541156
D013755 Tetradecanoylphorbol Acetate Tetradecanoylphorbol Acetate results in increased expression of PDGFB mRNAincreases expression 10428506
C032628 tin protoporphyrin IX tin protoporphyrin IX inhibits the reaction [Curcumin inhibits the reaction [PDGFB protein results in increased phosphorylation of MAPK1 protein]]decreases reaction|increases phosphorylation 18784349
C032628 tin protoporphyrin IX tin protoporphyrin IX inhibits the reaction [Curcumin inhibits the reaction [PDGFB protein results in increased phosphorylation of MAPK3 protein]]decreases reaction|increases phosphorylation 18784349
C113580 U 0126 U 0126 inhibits the reaction [PDGFB protein results in increased phosphorylation of and results in increased activity of AKT1 protein]decreases reaction|increases activity|increases phosphorylation 15919668
C113580 U 0126 U 0126 inhibits the reaction [PDGFB protein results in increased phosphorylation of and results in increased activity of MAPK1 protein]decreases reaction|increases activity|increases phosphorylation 15919668
C113580 U 0126 U 0126 inhibits the reaction [PDGFB protein results in increased phosphorylation of and results in increased activity of MAPK3 protein]decreases reaction|increases activity|increases phosphorylation 15919668
C113580 U 0126 U 0126 inhibits the reaction [PDGFB protein results in increased phosphorylation of and results in increased activity of RPS6KB1 protein]decreases reaction|increases activity|increases phosphorylation 15919668
C113580 U 0126 U 0126 promotes the reaction [2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [PDGFB protein results in increased phosphorylation of and results in increased activity of RPS6KB1 protein]]decreases reaction|increases activity|increases phosphorylation|increases reaction 15919668
D014520 Urethane IFNG protein inhibits the reaction [Urethane results in decreased expression of PDGFB mRNA]decreases expression|decreases reaction 12810352
C066075 vanadium pentoxide vanadium pentoxide results in increased expression of PDGFB mRNAincreases expression 17134509
D014859 Warfarin Warfarin results in decreased expression of PDGFB mRNAdecreases expression 11290560
D014859 Warfarin Warfarin results in decreased expression of PDGFB proteindecreases expression 11290560
Disease ID Disease Name Direct Evidence Inference Chemical Name Inference Score Publication
MESH:D000014 Abnormalities, Drug-Induced Phenytoin 4.036195326 8986270 9118846 3425630 10563481 9677735
MESH:D000015 Abnormalities, Multiple imatinib 4.8418322153
MESH:D000022 Abortion, Spontaneous imatinib 5.7418322153
MESH:D000038 Abscess Drugs, Chinese Herbal 5.8415043669
MESH:D000138 Acidosis Ammonium Chloride 3.1018287403
MESH:D000168 Acrocephalosyndactylia U 0126 5.0217694057
MESH:D054058 Acute Coronary Syndrome bivalirudin 11.8419804226 10629409
MESH:D054058 Acute Coronary Syndrome clopidogrel 11.8419106084
MESH:D058186 Acute Kidney Injury Desoxycorticosterone 8.0519564549
MESH:D058186 Acute Kidney Injury resveratrol 8.0516538975
MESH:D000230 Adenocarcinoma Benzo(a)pyrene 9.0920464547 20127859
MESH:D000230 Adenocarcinoma Dimethylnitrosamine 9.0916033868
MESH:D000230 Adenocarcinoma Estradiol 9.0911473722
MESH:D000230 Adenocarcinoma Urethane 9.0918316556
MESH:D002282 Adenocarcinoma, Bronchiolo-Alveolar Urethane 5.2315814487
MESH:D000236 Adenoma Benzo(a)pyrene 13.756695378
MESH:D000236 Adenoma Dimethylnitrosamine 13.7519555203
MESH:D000236 Adenoma resveratrol 13.7515688382
MESH:D000236 Adenoma Urethane 13.7510822126 16926031 11497255 17195641 6695378 10530776 17093202
MESH:D000382 Agricultural Workers' Diseases Paraquat 3.3111874814
MESH:D000419 Albuminuria Losartan 10.4712586211
MESH:D000419 Albuminuria Raloxifene 10.4717451421 17308373
MESH:D019973 Alcohol-Related Disorders Curcumin 4.6117887948
MESH:D000544 Alzheimer Disease Curcumin 5.9915590663
MESH:D000544 Alzheimer Disease Raloxifene 5.9915800139
MESH:D000544 Alzheimer Disease resveratrol 5.9916162502 16183991
MESH:D000740 Anemia Drugs, Chinese Herbal 4.2617963324 15504547
MESH:D000787 Angina Pectoris Drugs, Chinese Herbal 4.9411477813
MESH:D001004 Anus Diseases Drugs, Chinese Herbal 5.4915043669
MESH:D017544 Aortic Aneurysm, Abdominal Benzo(a)pyrene 3.6219183758
MESH:D001169 Arthritis, Experimental resveratrol 3.2117115116
MESH:D015210 Arthritis, Gouty Drugs, Chinese Herbal 5.2919655406
MESH:D001172 Arthritis, Rheumatoid Curcumin 2.6216807698
MESH:D001195 Asbestosis Asbestos, Serpentine 5.2310751356
MESH:D001259 Ataxia 1-Butanol 5.157820390
MESH:D050197 Atherosclerosis Curcumin 13.4318704882
MESH:D050197 Atherosclerosis Losartan 13.4310821809
MESH:D050197 Atherosclerosis Phenytoin 13.4315136057
MESH:D050197 Atherosclerosis resveratrol 13.4317967414 16873680
MESH:D001321 Autistic Disorder Cysteine 2.7119267885 19056591 16917939
MESH:D001321 Autistic Disorder Methionine 2.7116917939 19056591 19267885
MESH:D001321 Autistic Disorder Sirolimus 2.7121115397
MESH:D001327 Autoimmune Diseases Curcumin 4.0419761891
MESH:D001859 Bone Neoplasms imatinib 4.9015867366
MESH:D001862 Bone Resorption Drugs, Chinese Herbal 4.419881647
MESH:D020201 Brain Hemorrhage, Traumatic Progesterone 4.8617868700
MESH:D001930 Brain Injuries Progesterone 9.4615665606 15380490 15845082
MESH:D001930 Brain Injuries Raloxifene 9.4616580743
MESH:D002545 Brain Ischemia Curcumin 8.7816770732
MESH:D002545 Brain Ischemia resveratrol 8.7817600658
MESH:D001932 Brain Neoplasms Curcumin 3.5417596214
MESH:D001943 Breast Neoplasms Benzo(a)pyrene 4.2720146248 17474063
MESH:D001943 Breast Neoplasms Curcumin 4.2716243823 19250217 18462866 18593918
MESH:D001943 Breast Neoplasms Deferoxamine 4.2715993339
MESH:D001943 Breast Neoplasms Estradiol 4.2719861407 17289903 17018787 12948864 17261762 16675129 18497071 14630087
MESH:D001943 Breast Neoplasms imatinib 4.2717614352
MESH:D001943 Breast Neoplasms Progesterone 4.2715562024 17614352 16175315
MESH:D001943 Breast Neoplasms Raloxifene 4.2717595753 17242785 17261762 15572757 17049068 15758505 17893378 16912660 17952589 15775269 16837676 17440819
MESH:D001943 Breast Neoplasms resveratrol 4.2717651959 17534123 16393696
MESH:D001991 Bronchitis vanadium pentoxide 5.7617459161
MESH:D002181 Candidiasis, Vulvovaginal Estradiol 4.0016111702
MESH:D002252 Carbon Tetrachloride Poisoning Carbon Tetrachloride 9.1816050911 15673190 16011737 15700767 18705752 15721981 16124888 16227642 16097048 10355542 3786805 16192424
MESH:D002252 Carbon Tetrachloride Poisoning Perindopril 9.1816097048
MESH:D002277 Carcinoma Curcumin 7.5118593918
MESH:D002277 Carcinoma Dimethylnitrosamine 7.5119555203
MESH:D006528 Carcinoma, Hepatocellular Carbon Tetrachloride 5.9118788625
MESH:D006528 Carcinoma, Hepatocellular Estradiol 5.9116924424
MESH:D006528 Carcinoma, Hepatocellular resveratrol 5.9116227395 19321006
MESH:D006528 Carcinoma, Hepatocellular Sirolimus 5.9119335982
MESH:D018827 Carcinoma, Lewis Lung resveratrol 4.1316675471
MESH:D002289 Carcinoma, Non-Small-Cell Lung Curcumin 2.8018414057
MESH:D002294 Carcinoma, Squamous Cell Benzo(a)pyrene 16.0420419170
MESH:D002294 Carcinoma, Squamous Cell Curcumin 16.0418462866
MESH:D002294 Carcinoma, Squamous Cell Dimethylnitrosamine 16.0416033868
MESH:D002294 Carcinoma, Squamous Cell resveratrol 16.0416227395
MESH:D002294 Carcinoma, Squamous Cell Sirolimus 16.0419435901
MESH:D002294 Carcinoma, Squamous Cell Tetradecanoylphorbol Acetate 16.0418922899
MESH:D002295 Carcinoma, Transitional Cell Raloxifene 3.6717572228
MESH:D006332 Cardiomegaly Desoxycorticosterone 7.3119564549
MESH:D006332 Cardiomegaly Losartan 7.3115969258 12586211
MESH:D002318 Cardiovascular Diseases clopidogrel 10.5320180610
MESH:D002318 Cardiovascular Diseases Raloxifene 10.5315775269
MESH:D002318 Cardiovascular Diseases resveratrol 10.5315458977
MESH:D020212 Carotid Artery Injuries bivalirudin 13.0311316950
MESH:D020212 Carotid Artery Injuries hirulog-like peptide 13.0311316950
MESH:D002471 Cell Transformation, Neoplastic Cyclosporine 9.4212371664
MESH:D002471 Cell Transformation, Neoplastic Estradiol 9.4218566989
MESH:D002471 Cell Transformation, Neoplastic Methylnitronitrosoguanidine 9.422727394
MESH:D002493 Central Nervous System Diseases Phenytoin 4.844080065
MESH:D002543 Cerebral Hemorrhage Warfarin 5.4011061249
MESH:D002659 Child Development Disorders, Pervasive Methionine 4.1419267885
MESH:D002779 Cholestasis Cyclosporine 2.5719486331
OMIM:601042 CHOREOATHETOSIS/SPASTICITY, EPISODIC Phenytoin 5.4011748493
MESH:D002971 Cleft Lip Phenytoin 3.902227380
MESH:D002972 Cleft Palate Phenytoin 6.062227380 3877104 1687470 10789828 6862529 6856622
MESH:D002972 Cleft Palate Urethane 6.0612810352
MESH:D003072 Cognition Disorders Raloxifene 4.1615800139
MESH:D003092 Colitis Curcumin 8.2918200517 16782535 16804969
MESH:D003092 Colitis resveratrol 8.2916474422
MESH:D003103 Coloboma Curcumin 9.9418809619
MESH:D003103 Coloboma Phenytoin 9.949212184
MESH:D003110 Colonic Neoplasms Curcumin 3.6716340194 19359593
MESH:D003110 Colonic Neoplasms resveratrol 3.6716338953
MESH:D015179 Colorectal Neoplasms resveratrol 2.2216550006
MESH:D000013 Congenital Abnormalities Phenytoin 4.3110627286
MESH:D016510 Corneal Neovascularization Curcumin 4.4418497527
MESH:D003327 Coronary Disease resveratrol 3.4516507316
MESH:D023903 Coronary Restenosis Warfarin 5.2412872399
MESH:D003328 Coronary Thrombosis bivalirudin 5.3418036681
OMIM:122700 COUMARIN RESISTANCE Warfarin 5.3920497562 20579077
MESH:D019465 Craniofacial Abnormalities imatinib 3.9818322153
MESH:D019465 Craniofacial Abnormalities Phenytoin 3.9819952982 8986270 9212184
MESH:D019465 Craniofacial Abnormalities Reactive Oxygen Species 3.9815736158
MESH:D003865 Depressive Disorder, Major Raloxifene 3.7717474826
MESH:D048909 Diabetes Complications bivalirudin 5.8818436116
MESH:D003921 Diabetes Mellitus, Experimental resveratrol 3.3916873680
MESH:D003922 Diabetes Mellitus, Type 1 Warfarin 3.9018772604
MESH:D003924 Diabetes Mellitus, Type 2 Curcumin 2.5818403477
MESH:D003928 Diabetic Nephropathies Curcumin 29.8718204486
MESH:D003928 Diabetic Nephropathies Estradiol 29.8719279558
MESH:D003928 Diabetic Nephropathies Perindopril 29.8711427623
MESH:D003928 Diabetic Nephropathies Raloxifene 29.8717308373 17451421 15920148
MESH:D003928 Diabetic Nephropathies resveratrol 29.8716286809
MESH:D003928 Diabetic Nephropathies Warfarin 29.8712644472
MESH:D003929 Diabetic Neuropathies Progesterone 4.0417187935
OMIM:607208 DRAVET SYNDROME Phenytoin 4.9311748493
MESH:D003875 Drug Eruptions Phenytoin 11.4715024534
MESH:D003875 Drug Eruptions Warfarin 11.4714723717
MESH:D056486 Drug-Induced Liver Injury Carbon Tetrachloride 5.5911566570 19336974 15027814 10915739 7179309 7440962 10092053 19085960 3732212 17522070 6623471 3786805 21278145 15968718 15998439 9327722 6884620 16177239 2869522 16227642 4309450 7120509
MESH:D056486 Drug-Induced Liver Injury Dimethylnitrosamine 5.598172417
MESH:D056486 Drug-Induced Liver Injury Drugs, Chinese Herbal 5.5915027814
MESH:D004381 Duodenal Ulcer Curcumin 3.6117351913
MESH:D004487 Edema imatinib 13.2219703484
MESH:D004487 Edema Raloxifene 13.2215860553
MESH:D004487 Edema resveratrol 13.228985016
MESH:D004487 Edema Tetradecanoylphorbol Acetate 13.228273558 7812673 15177302 9599246 16716910 11698051 8113982
MESH:D016769 Embolism and Thrombosis bivalirudin 5.4816084352
MESH:D004681 Encephalomyelitis, Autoimmune, Experimental Phenytoin 18.4117654737
MESH:D004681 Encephalomyelitis, Autoimmune, Experimental Progesterone 18.4117692515
MESH:D004681 Encephalomyelitis, Autoimmune, Experimental Raloxifene 18.4115845917
MESH:D004681 Encephalomyelitis, Autoimmune, Experimental resveratrol 18.4117872969
MESH:D016889 Endometrial Neoplasms Estradiol 2.6711473722 19148513 18566989
MESH:D004715 Endometriosis Progesterone 3.3616134523
MESH:D020345 Enterocolitis, Necrotizing resveratrol 4.3917923197
MESH:D004816 Epidermal Necrolysis, Toxic Phenytoin 4.7620235791
MESH:D004820 Epidermolysis Bullosa Phenytoin 5.761399206 6251365
MESH:D004828 Epilepsies, Partial Phenytoin 4.4511558140 17116037
MESH:D004827 Epilepsy Phenytoin 3.6920417680 821787 11434505
MESH:D017029 Epilepsy, Complex Partial Phenytoin 4.847750514
MESH:D004830 Epilepsy, Tonic-Clonic Phenytoin 4.603659116
MESH:D004938 Esophageal Neoplasms Benzo(a)pyrene 4.1916530937
MESH:D004938 Esophageal Neoplasms Dimethylnitrosamine 4.1917016578
MESH:D005234 Fatty Liver Carbon Tetrachloride 15.4212631006 19224547 15959796 16045604 16239168 61145 12795759 17595544
MESH:D005234 Fatty Liver Curcumin 15.4219297423
MESH:D005234 Fatty Liver Cyclosporine 15.4219224547
MESH:D005234 Fatty Liver Raloxifene 15.4217473493
MESH:D005313 Fetal Death Phenytoin 4.6410627286
MESH:D018222 Fibromatosis, Aggressive imatinib 5.1817453242
MESH:D005355 Fibrosis Carbon Tetrachloride 17.5218705752
MESH:D005355 Fibrosis Curcumin 17.5218705752
MESH:D005355 Fibrosis Cyclosporine 17.5212168785 12639820
MESH:D005355 Fibrosis Emodin 17.5219474275
MESH:D006471 Gastrointestinal Hemorrhage Warfarin 6.2411794436
MESH:D005770 Gastrointestinal Neoplasms Curcumin 4.2418462866
MESH:D005776 Gaucher Disease Warfarin 5.5112359135
MESH:D005885 Gingival Hyperplasia marker/mechanism 8708960
MESH:D005885 Gingival Hyperplasia Cyclosporine 11.368708960
MESH:D005885 Gingival Hyperplasia Phenytoin 11.369029455
MESH:D019214 Gingival Overgrowth Phenytoin 5.7616390469 14659971
MESH:D005909 Glioblastoma Curcumin 3.1717596214
MESH:D005911 Gliosis Paraquat 4.6911124998
MESH:D006258 Head and Neck Neoplasms Curcumin 7.2918829502 18462866
MESH:D006258 Head and Neck Neoplasms Sirolimus 7.2919435901
MESH:D006330 Heart Defects, Congenital Benzo(a)pyrene 2.4020471113
MESH:D006331 Heart Diseases Raloxifene 7.0311110106
MESH:D006331 Heart Diseases Urethane 7.0316046796
MESH:D006333 Heart Failure Losartan 4.3510979640
MESH:D006406 Hematoma Warfarin 6.2417493413
MESH:D006457 Hemoglobinuria, Paroxysmal Cyclosporine 3.9515720958
MESH:D006470 Hemorrhage bivalirudin 10.0618436116 16125490 19147609 16598112 19360860 19281522
MESH:D006470 Hemorrhage Warfarin 10.0618429757
MESH:D006505 Hepatitis Carbon Tetrachloride 8.2419900420 19110552
MESH:D006505 Hepatitis Drugs, Chinese Herbal 8.2418339527
MESH:D015417 Hereditary Sensory and Motor Neuropathy Curcumin 4.5817701891
MESH:D006558 Herpes Genitalis Estradiol 4.5615709030
MESH:D006561 Herpes Simplex resveratrol 3.7216876885
MESH:D019584 Hot Flashes Estradiol 3.2817088409
MESH:D006932 Hyperbilirubinemia Carbon Tetrachloride 4.0716899240
MESH:D006937 Hypercholesterolemia Curcumin 8.0018704882
MESH:D006937 Hypercholesterolemia resveratrol 8.0017188708
MESH:D020138 Hyperhomocysteinemia Phenytoin 4.2810459572
MESH:D006949 Hyperlipidemias resveratrol 3.6016873680
MESH:D006973 Hypertension Cyclosporine 14.3910903974
MESH:D006973 Hypertension Desoxycorticosterone 14.3919564549 11507004
MESH:D006973 Hypertension Losartan 14.3910090350 12512695 12586211 14597852 15969258
MESH:D006973 Hypertension Perindopril 14.3911427623
MESH:D006973 Hypertension Raloxifene 14.3915787275 17577099
MESH:D006975 Hypertension, Portal Carbon Tetrachloride 3.6315338365
MESH:D006976 Hypertension, Pulmonary Warfarin 4.4712359135
MESH:D006984 Hypertrophy Sirolimus 4.8119211884
MESH:D017379 Hypertrophy, Left Ventricular resveratrol 3.9017488730
MESH:D020244 Infarction, Middle Cerebral Artery Progesterone 9.9715869954
MESH:D020244 Infarction, Middle Cerebral Artery resveratrol 9.9717600658
MESH:D007248 Infertility, Male Paraquat 2.944850670
MESH:D007249 Inflammation bivalirudin 16.6516125490
MESH:D007249 Inflammation Curcumin 16.6517151092 16956363 18403477
MESH:D007249 Inflammation Losartan 16.6512586211
MESH:D007249 Inflammation Progesterone 16.6515869954
MESH:D007249 Inflammation resveratrol 16.6516366677
MESH:D007249 Inflammation Tetradecanoylphorbol Acetate 16.6515177302 7812673 8273558 7562506 11698051
MESH:D015212 Inflammatory Bowel Diseases Curcumin 3.0118596194 18200517
MESH:D007251 Influenza, Human resveratrol 4.0716624496
MESH:D007333 Insulin Resistance Estradiol 2.6616627594 16393666
MESH:D007414 Intestinal Neoplasms Curcumin 3.8210783313
MESH:D002532 Intracranial Aneurysm Reactive Oxygen Species 4.5719381132
MESH:D007511 Ischemia bivalirudin 5.5718436116
MESH:D007638 Keratoconjunctivitis Sicca Cyclosporine 3.9715604871
MESH:D007674 Kidney Diseases Cyclosporine 5.0110903974 8314463 18776723
MESH:D007674 Kidney Diseases Estradiol 5.0115618244
MESH:D007680 Kidney Neoplasms Cyclosporine 6.0312371664
MESH:D007680 Kidney Neoplasms Estradiol 6.0315610895
MESH:D007889 Leiomyoma Curcumin 9.7318555241
MESH:D007889 Leiomyoma Raloxifene 9.7316973256
MESH:D007938 Leukemia 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one 6.0512970779
MESH:D007938 Leukemia Curcumin 6.0518462866
MESH:D015451 Leukemia, Lymphocytic, Chronic, B-Cell Drugs, Chinese Herbal 3.7215802533
MESH:D015459 Leukemia-Lymphoma, Adult T-Cell Curcumin 8.8316106398
MESH:D015459 Leukemia-Lymphoma, Adult T-Cell Emodin 8.8317077332
MESH:D007948 Leukemia, Monocytic, Acute U 0126 4.8416972261
MESH:D015464 Leukemia, Myelogenous, Chronic, BCR-ABL Positive imatinib 4.4217301526 15748426 19208803 15107311
MESH:D007951 Leukemia, Myeloid imatinib 4.6917236224
MESH:D015470 Leukemia, Myeloid, Acute Deferoxamine 3.4320368581
MESH:D015473 Leukemia, Promyelocytic, Acute resveratrol 3.2716087638
MESH:D015458 Leukemia, T-Cell Curcumin 4.3216106398
MESH:D054068 Livedo Reticularis Warfarin 6.2418280355
MESH:D008103 Liver Cirrhosis Carbon Tetrachloride 6.1511903743 17174718 16239168 11408273 17334410 16221502 16943688 21278145 17157831
MESH:D008103 Liver Cirrhosis Drugs, Chinese Herbal 6.1517163593
MESH:D008106 Liver Cirrhosis, Experimental Carbon Tetrachloride 24.4618251166 12445418 17631135 17922224 18376398 16015684 17525996 12666154 18412020 17823541 12632512 14512876 16011737 15370692 13678700 17481882 10355542 14716833 18395095 15931870 15362042 16248980 18187930 14716496 18418968 12649538 12445421 14620537 20821823 18472332 18339082 18006644 18166357 18210741 16116963 18263696 17944888 15925388 12958196 17900296 11481614 17698563 15650968 17869086 17640975 12389079 16027843 15818738 12667390 17761835 12741479 15673190 17714472 18472094 18156304 18054572 18420326 17805973 18429990 16097048 17565644 16638106 18705752 12632514 12546737 15730626 17721639 16136751 14724832 17708605 15057751 18277467 12586293 14748882 15893842 15338365 18395914 15052691 18317297 16033810 15996030 15959796 17976157 15123356 18279442 17557913 16192424 18481824 12898905 12609069 18205269 15876570 17766677
MESH:D008106 Liver Cirrhosis, Experimental Curcumin 24.4618006644 18705752 17355460
MESH:D008106 Liver Cirrhosis, Experimental Cysteine 24.4615158331
MESH:D008106 Liver Cirrhosis, Experimental Dimethylnitrosamine 24.4615479170 15298665 17465448 17640959 17719030 15067225 17724770 16544323 15591649 15733078 18629640 14709902 15571005 15842777 15744066 18371158 14568256 18672772 15383259 18095165 17203207 17432682 16169303 14659978 15793283 15081153 14643895 18567088 14726149 17348192 18637143 15763062 15369754 17881167 15099470 16270385 15577212 15161499 15723089 18237412 16627068 15864749 16570917 15942678 17198567 15339415 15504291 16042886 18239293 17666798 16009107 15366600 16603200 15138612 17201889 12918455 15492853 12925901 17036385 17196135 15086199 15798949 18210741 18364076 17534399
MESH:D008106 Liver Cirrhosis, Experimental Drugs, Chinese Herbal 24.4617348192 15744066 15339415 18567088 17629604 15849816 18606216 15763062 17666798 15641146 12632512 15383259 17036385 15754396 18237412 16610055 15818738 17881167 15864749 18371158
MESH:D008106 Liver Cirrhosis, Experimental Emodin 24.4615288473
MESH:D008106 Liver Cirrhosis, Experimental Estradiol 24.4614659978 14716833
MESH:D008106 Liver Cirrhosis, Experimental imatinib 24.4616596278
MESH:D008106 Liver Cirrhosis, Experimental inchinko-to 24.4615288473
MESH:D008106 Liver Cirrhosis, Experimental Losartan 24.4615573910 17900296 12445418
MESH:D008106 Liver Cirrhosis, Experimental Methionine 24.4615158331
MESH:D008106 Liver Cirrhosis, Experimental Perindopril 24.4616097048 15619341 16596278 16872305
MESH:D008106 Liver Cirrhosis, Experimental Sirolimus 24.4617050028
MESH:D008107 Liver Diseases Carbon Tetrachloride 8.3415830285 16964402 16246199 17285989 15720792
MESH:D008107 Liver Diseases Curcumin 8.3416956363
MESH:D008107 Liver Diseases Drugs, Chinese Herbal 8.3417207593
MESH:D008107 Liver Diseases Phenytoin 8.3414986274
MESH:D017093 Liver Failure Carbon Tetrachloride 3.7115123358
MESH:D017114 Liver Failure, Acute Carbon Tetrachloride 8.5014706259 16899240
MESH:D017114 Liver Failure, Acute Dimethylnitrosamine 8.5017457977
MESH:D008113 Liver Neoplasms Benzo(a)pyrene 15.4420195826 21137059
MESH:D008113 Liver Neoplasms Carbon Tetrachloride 15.4419294768
MESH:D008113 Liver Neoplasms Dimethylnitrosamine 15.4415890375 3113478
MESH:D008113 Liver Neoplasms Drugs, Chinese Herbal 15.4418339527
MESH:D008113 Liver Neoplasms resveratrol 15.4419321006 20405173 19073162 19812893
MESH:D008113 Liver Neoplasms Urethane 15.4417559639 16391232 17093202
MESH:D008114 Liver Neoplasms, Experimental Carbon Tetrachloride 5.2215583823 12014681
MESH:D008114 Liver Neoplasms, Experimental Dimethylnitrosamine 5.2215603536 1848544 6150874
MESH:D008171 Lung Diseases Asbestos, Serpentine 4.0317200189
MESH:D008175 Lung Neoplasms Asbestos, Serpentine 11.7111198217
MESH:D008175 Lung Neoplasms Benzo(a)pyrene 11.7118569708 18520028 18816296 6695378 20464547 20064080 17053015 20869020 20135361
MESH:D008175 Lung Neoplasms Curcumin 11.7118462866 19359593 16243823
MESH:D008175 Lung Neoplasms Dimethylnitrosamine 11.7119555203 16061637 11884234
MESH:D008175 Lung Neoplasms Drugs, Chinese Herbal 11.7118339527
MESH:D008175 Lung Neoplasms Tetradecanoylphorbol Acetate 11.7111807781
MESH:D008175 Lung Neoplasms Urethane 11.7112466968 12957351 11893704 15136453 11992545 11074608 6695378 16337739 17255336 16391232 10822126 11497255 11323394 10779650 16289808 17093202 11307925 16788158 16926031 17195641 15902970 15166089 12765245 7750092 11544531 16007126 14587096 11246140 10997738 12117781 11807781 10530776 16204055 11062179 11552296
MESH:D008175 Lung Neoplasms vanadium pentoxide 11.7112376484
MESH:D008223 Lymphoma Curcumin 3.2518462866
MESH:D016393 Lymphoma, B-Cell resveratrol 3.8717088997
MESH:D008228 Lymphoma, Non-Hodgkin resveratrol 3.4914749477
MESH:D016399 Lymphoma, T-Cell Curcumin 4.2416173963
MESH:D015674 Mammary Neoplasms, Animal resveratrol 3.7815688416
MESH:D008325 Mammary Neoplasms, Experimental Drugs, Chinese Herbal 15.5914758024
MESH:D008325 Mammary Neoplasms, Experimental Estradiol 15.5911807958 16891317 11408345 17203775
MESH:D008325 Mammary Neoplasms, Experimental Progesterone 15.5911408345 17203775
MESH:D008325 Mammary Neoplasms, Experimental resveratrol 15.5911606380 8985016
MESH:D008325 Mammary Neoplasms, Experimental Tetradecanoylphorbol Acetate 15.598985016
MESH:D020149 Manganese Poisoning Estradiol 4.0119453300
MESH:D008382 Marfan Syndrome Losartan 5.6119430350
MESH:D008545 Melanoma Curcumin 6.6117885582 18462866
MESH:D008545 Melanoma Reactive Oxygen Species 6.6117992120
MESH:D008545 Melanoma resveratrol 6.6117992120
MESH:D008545 Melanoma Sirolimus 6.6119282848
MESH:D008569 Memory Disorders Curcumin 3.7117263510
MESH:D008607 Mental Retardation Phenytoin 3.509212184
MESH:D008659 Metabolic Diseases resveratrol 3.9617112576
MESH:D008664 Metal Metabolism, Inborn Errors Cyclosporine 4.3116801185
MESH:D053842 Microsatellite Instability Methylnitronitrosoguanidine 5.4217671175
MESH:D018200 Mixed Tumor, Mullerian Raloxifene 5.0815863610
MESH:D009062 Mouth Neoplasms Benzo(a)pyrene 7.7316381670
MESH:D009062 Mouth Neoplasms Sirolimus 7.7319435901
MESH:D009101 Multiple Myeloma Curcumin 10.3019372569
MESH:D009101 Multiple Myeloma Raloxifene 10.3016497877
MESH:D009101 Multiple Myeloma resveratrol 10.3017049120 14749477 17935668 17164350 16490592 16267019
MESH:D009134 Muscular Atrophy, Spinal Curcumin 10.8617962980
MESH:D009134 Muscular Atrophy, Spinal resveratrol 10.8617962980
MESH:D009203 Myocardial Infarction Losartan 5.8112692751
MESH:D009203 Myocardial Infarction resveratrol 5.8116317513 16456233 17125593 16525036 17015251 17188708
MESH:D017202 Myocardial Ischemia bivalirudin 8.7310562259
MESH:D017202 Myocardial Ischemia resveratrol 8.7317015251 17125593
MESH:D015428 Myocardial Reperfusion Injury Estradiol 2.9216810080
MESH:D009205 Myocarditis resveratrol 4.2917322642
MESH:D020191 Myoclonic Epilepsies, Progressive Phenytoin 5.0617484760
MESH:D009224 Myotonia Congenita Phenytoin 4.941896199
MESH:D009232 Myxoma Raloxifene 5.0816343187
MESH:D009336 Necrosis Warfarin 5.0814723717
MESH:D009361 Neoplasm Invasiveness Curcumin 3.9318495463
MESH:D009362 Neoplasm Metastasis clopidogrel 6.1711875746
MESH:D009362 Neoplasm Metastasis imatinib 6.1715867366
MESH:D009369 Neoplasms Benzo(a)pyrene 4.5911141357
MESH:D009369 Neoplasms Urethane 4.5915625555
MESH:D009374 Neoplasms, Experimental Asbestos, Serpentine 12.9711704859
MESH:D009374 Neoplasms, Experimental resveratrol 12.978985016
MESH:D009374 Neoplasms, Experimental Urethane 12.9715582191
MESH:D009376 Neoplasms, Hormone-Dependent Curcumin 9.8012497104
MESH:D009376 Neoplasms, Hormone-Dependent imatinib 9.8017614352
MESH:D009389 Neovascularization, Pathologic Estradiol 3.2717289903
MESH:D009402 Nephrosis, Lipoid Cyclosporine 3.9717954296
MESH:D009404 Nephrotic Syndrome Cyclosporine 2.8918481113 19348381
MESH:D009410 Nerve Degeneration Paraquat 3.3616893418
MESH:D009421 Nervous System Malformations Estradiol 3.2116427766 11399458
MESH:D009423 Nervous System Neoplasms Curcumin 5.1518462866
MESH:D009436 Neural Tube Defects Phenytoin 3.829118846
MESH:D019636 Neurodegenerative Diseases resveratrol 3.4317652729
MESH:D020078 Neurogenic Inflammation resveratrol 3.9717929310
MESH:D009765 Obesity Curcumin 2.6219297423
MESH:D010014 Osteolysis imatinib 5.2715867366
MESH:D010018 Osteomalacia Phenytoin 4.9417016548
MESH:D010024 Osteoporosis Curcumin 6.4318719352
MESH:D010024 Osteoporosis Raloxifene 6.4317882678 19059307 15775268
MESH:D015663 Osteoporosis, Postmenopausal Drugs, Chinese Herbal 14.5416548355
MESH:D015663 Osteoporosis, Postmenopausal Raloxifene 14.5415579764 17823083 17893378 15758505
MESH:D015663 Osteoporosis, Postmenopausal resveratrol 14.5417513867
MESH:D010051 Ovarian Neoplasms 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one 20.3616211241
MESH:D010051 Ovarian Neoplasms Curcumin 20.3618462866 19020741
MESH:D010051 Ovarian Neoplasms Estradiol 20.3619401270
MESH:D010051 Ovarian Neoplasms Medroxyprogesterone Acetate 20.3617393432
MESH:D010051 Ovarian Neoplasms Progesterone 20.3616525653 17393432
MESH:D010051 Ovarian Neoplasms U 0126 20.3616211241
MESH:D010051 Ovarian Neoplasms Urethane 20.3616391232
MESH:D010146 Pain Phenytoin 3.6215215642
MESH:D010190 Pancreatic Neoplasms Curcumin 7.8317440100 19401701 19196508
MESH:D010190 Pancreatic Neoplasms Reactive Oxygen Species 7.8315580305
MESH:D010190 Pancreatic Neoplasms Tetradecanoylphorbol Acetate 7.8315976015
MESH:D010212 Papilloma Tetradecanoylphorbol Acetate 3.8418922899 18404319 8330346 12065085
MESH:D010300 Parkinson Disease Paraquat 5.2216140633 11181820 16510128 15451049 15824117 11445065 11124998 12911755
MESH:D010300 Parkinson Disease Sirolimus 5.2219682553
MESH:D010302 Parkinson Disease, Secondary Paraquat 3.9816190885
MESH:D010911 Pituitary Neoplasms Urethane 4.9616391232
MESH:D010995 Pleural Diseases Asbestos, Serpentine 5.2410923243
MESH:D011014 Pneumonia Paraquat 3.9912504350
MESH:D017689 Polydactyly Phenytoin 4.659212184
MESH:D011230 Precancerous Conditions Cyclosporine 2.8312371664
MESH:D054198 Precursor Cell Lymphoblastic Leukemia-Lymphoma imatinib 4.2112476293
MESH:D011297 Prenatal Exposure Delayed Effects resveratrol 3.7216679765
MESH:D019048 Prostatic Intraepithelial Neoplasia Estradiol 3.4720887781
MESH:D011471 Prostatic Neoplasms Benzo(a)pyrene 1.9217292933
MESH:D011471 Prostatic Neoplasms Curcumin 1.9215129424 12497104 18226269 18156803 10851300 11398177 18769126
MESH:D011471 Prostatic Neoplasms Estradiol 1.9216740699
MESH:D011471 Prostatic Neoplasms Raloxifene 1.9215731164 16536755 16220300
MESH:D011471 Prostatic Neoplasms resveratrol 1.9215767336 17636462 16731767 17804756 17718901 17675339
MESH:D020151 Protein C Deficiency Warfarin 5.8818376272
MESH:D019310 Pseudolymphoma Phenytoin 5.078603615 1419762 12752131
MESH:D011565 Psoriasis Cyclosporine 2.0516882103
MESH:D011655 Pulmonary Embolism Warfarin 5.8819300499
MESH:D011656 Pulmonary Emphysema Curcumin 4.1219168576
MESH:D011658 Pulmonary Fibrosis Asbestos, Serpentine 8.4215511213 18569384
MESH:D011658 Pulmonary Fibrosis Drugs, Chinese Herbal 8.4216987627
MESH:D011658 Pulmonary Fibrosis Paraquat 8.4217997886 16324872
MESH:D011693 Purpura Raloxifene 5.0815770314
MESH:D012003 Rectal Fistula Drugs, Chinese Herbal 5.4915043669
MESH:D051437 Renal Insufficiency Losartan 5.0715728788
MESH:D051436 Renal Insufficiency, Chronic resveratrol 5.1116325855
MESH:D015427 Reperfusion Injury resveratrol 3.0316314181 17520802 17058453 15827377 16317513
MESH:D012128 Respiratory Distress Syndrome, Adult Curcumin 7.8510666014 18379247
MESH:D012128 Respiratory Distress Syndrome, Adult Paraquat 7.8511700416
MESH:D012135 Respiratory Sounds Paraquat 3.6111874814
MESH:D012162 Retinal Degeneration Paraquat 3.5216458197
MESH:D012170 Retinal Vein Occlusion clopidogrel 5.6719371211
MESH:D012221 Rhinitis, Allergic, Perennial Drugs, Chinese Herbal 4.8015015336
MESH:D012468 Salivary Gland Neoplasms Progesterone 2.6818045962
MESH:D012509 Sarcoma Curcumin 3.7118462866
MESH:D012559 Schizophrenia Methionine 3.6115737665
MESH:D012640 Seizures Phenytoin 3.439844417 3691417 3137016 16876388 11044598 19919933 10029267 15946322
MESH:D018805 Sepsis Curcumin 3.6918389075
MESH:D012851 Sinus Thrombosis, Intracranial Warfarin 5.4112269725
MESH:D012878 Skin Neoplasms Benzo(a)pyrene 11.7319755658 10029692
MESH:D012878 Skin Neoplasms resveratrol 11.738985016 15837718
MESH:D012878 Skin Neoplasms Tetradecanoylphorbol Acetate 11.7318404319 11807781 8330346 12065085 8985016
MESH:D012878 Skin Neoplasms Urethane 11.7311807781
MESH:D013119 Spinal Cord Injuries Progesterone 3.8216503802 15862959
MESH:D013158 Splenic Diseases Dimethylnitrosamine 4.7912587719
MESH:D013262 Stevens-Johnson Syndrome Phenytoin 4.7020235791
MESH:D013274 Stomach Neoplasms Benzo(a)pyrene 4.392093021 20155912
MESH:D013274 Stomach Neoplasms Dimethylnitrosamine 4.3916033868
MESH:D013274 Stomach Neoplasms Drugs, Chinese Herbal 4.3918339527
MESH:D013274 Stomach Neoplasms imatinib 4.3915786421
MESH:D013276 Stomach Ulcer Curcumin 3.1016631530 19188055
MESH:D020521 Stroke bivalirudin 12.7314683561
MESH:D020521 Stroke Raloxifene 12.7316837676
MESH:D020521 Stroke Warfarin 12.7319300499
OMIM:601367 STROKE, ISCHEMIC resveratrol 4.0716321402
MESH:D013345 Subarachnoid Hemorrhage Drugs, Chinese Herbal 5.2917634840
MESH:D013921 Thrombocytopenia bivalirudin 5.3116651880 16893407
MESH:D013923 Thromboembolism Warfarin 5.6916960144 18698879
MESH:D019851 Thrombophilia Warfarin 5.1617493413
MESH:D013927 Thrombosis bivalirudin 9.0115979436 8456428 16893407 9125671 14593979
MESH:D013927 Thrombosis Warfarin 9.0111307788 15720958 11518727 17245631 19300499 17672075
MESH:D013964 Thyroid Neoplasms imatinib 4.0816940797
MESH:D013978 Tibial Fractures Estradiol 12.1319048282
MESH:D013978 Tibial Fractures Raloxifene 12.1319048282
MESH:D014062 Tongue Neoplasms resveratrol 3.8116227395
MESH:D014402 Tuberous Sclerosis Sirolimus 5.1221115397 18495876
MESH:D001749 Urinary Bladder Neoplasms Benzo(a)pyrene 7.2417053015
MESH:D001749 Urinary Bladder Neoplasms Curcumin 7.2418593936
MESH:D001749 Urinary Bladder Neoplasms Raloxifene 7.2417572228
MESH:D014565 Urogenital Neoplasms Curcumin 4.8018462866
MESH:D002583 Uterine Cervical Neoplasms resveratrol 3.7017473185
MESH:D014594 Uterine Neoplasms resveratrol 3.7017044934
MESH:D014605 Uveitis Cyclosporine 10.491336536
MESH:D014605 Uveitis Sirolimus 10.491336536
MESH:D019043 Vascular Neoplasms Urethane 5.4410620525
MESH:D014657 Vasculitis Warfarin 5.4120337814
MESH:D054556 Venous Thromboembolism Raloxifene 12.7516837676
MESH:D054556 Venous Thromboembolism Warfarin 12.7518776969
MESH:D020246 Venous Thrombosis Warfarin 5.0914723717 15733061
MESH:D018487 Ventricular Dysfunction, Left resveratrol 3.8517488730
MESH:D014846 Vulvar Neoplasms Raloxifene 5.0816343187
MESH:D014947 Wounds and Injuries Drugs, Chinese Herbal 4.1616313111
MESH:D014985 Xerophthalmia Cyclosporine 3.9717120751
Pathway ID Pathway Name
KEGG:04060 Cytokine-cytokine receptor interaction
KEGG:04510 Focal adhesion
KEGG:04540 Gap junction
KEGG:05214 Glioma
REACT:604 Hemostasis
KEGG:04010 MAPK signaling pathway
KEGG:05218 Melanoma
KEGG:03015 mRNA surveillance pathway
KEGG:04114 Oocyte meiosis
KEGG:05200 Pathways in cancer
KEGG:05215 Prostate cancer
KEGG:04810 Regulation of actin cytoskeleton
KEGG:05211 Renal cell carcinoma
REACT:16888 Signaling by PDGF
KEGG:04350 TGF-beta signaling pathway
KEGG:04530 Tight junction
KEGG:04310 Wnt signaling pathway
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  (e.g. CHD8)

Syndromic Genes

Non-syndromic Genes

AutismKB Statistics

  • Studies: 1,036
  • Genes: 1,379
  • CNVs/SVs: 5,420
  • SNVs/Indels: 11,669
  • de novo Mutations: 5,669
  • Mosaics: 789
  • Linkage Regions: 172
  • Paper Collected: 6/30/2018
  • Last Update: 8/26/2018


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