AutismKB 2.0

Annotation Detail for PDGFRA


View Evidences View Variants View Annotations
Basic Information Top
Gene Symbol:PDGFRA ( CD140A,MGC74795,PDGFR2,RHEPDGFRA )
Gene Full Name: platelet-derived growth factor receptor, alpha polypeptide
Band: 4q12
Quick LinksEntrez ID:5156; OMIM: 173490; Uniprot ID:PGFRA_HUMAN; ENSEMBL ID: ENSG00000134853; HGNC ID: 8803
Relate to Another Database: SFARIGene; denovo-db
Related Pathway Information Top
No data
Pathway IDPathway Name
hsa04010MAPK signaling pathway
hsa04020Calcium signaling pathway
hsa04144Endocytosis
hsa04540Gap junction
hsa04810Regulation of actin cytoskeleton
hsa05218Melanoma
hsa05214Glioma
hsa05215Prostate cancer
hsa04510Focal adhesion
hsa04060Cytokine-cytokine receptor interaction
hsa05200Pathways in cancer
Pathway IDPathway Name
Signaling by PDGF
Pathway IDPathway Name
200140PDGFR-alpha signaling pathway
200116ATF-2 transcription factor network
Pathway IDPathway Name
P00005Angiogenesis
No data
Related Diseases/Disorders Top
Desease IDDesease Name
Cancers
H00042Glioma
Cancers of the nervous system
No data
Desease Name
CARDIOVASCULAR
height
heart transplant complications
Asthma
neural tube defects
IMMUNE
DEVELOPMENTAL
Desease Name
Height
Hematological and biochemical traits
Desease Name
Gastrointestinal stromal tumor, somatic
Hypereosinophilic syndrome, idiopathic, resistant to imatinib
Comparative Toxicogenomics Database Top
Chemical ID Chemical Name Interaction Interaction Action Publication
C054919 2,2-(2-chlorophenyl-4'-chlorophenyl)-1,1-dichloroethene [Dichlorodiphenyldichloroethane co-treated with Dichlorodiphenyl Dichloroethylene co-treated with 2,2-(2-chlorophenyl-4'-chlorophenyl)-1,1-dichloroethene co-treated with Aldrin co-treated with Dieldrin] results in increased expression of PDGFRA mRNAaffects cotreatment|increases expression 19422813
C023514 2,6-dinitrotoluene 2,6-dinitrotoluene results in decreased expression of PDGFRA mRNAdecreases expression 20406850
D000082 Acetaminophen Acetaminophen affects the expression of PDGFRA mRNAaffects expression 17562736
D000452 Aldrin [Dichlorodiphenyldichloroethane co-treated with Dichlorodiphenyl Dichloroethylene co-treated with 2,2-(2-chlorophenyl-4'-chlorophenyl)-1,1-dichloroethene co-treated with Aldrin co-treated with Dieldrin] results in increased expression of PDGFRA mRNAaffects cotreatment|increases expression 19422813
D000643 Ammonium Chloride Ammonium Chloride affects the expression of PDGFRA mRNAaffects expression 16483693
C006780 bisphenol A bisphenol A results in increased expression of PDGFRA mRNAincreases expression 12604637
C006780 bisphenol A bisphenol A results in increased expression of PDGFRA proteinincreases expression 12604637
D002104 Cadmium Cadmium results in increased phosphorylation of PDGFRA proteinincreases phosphorylation 17125913
D002104 Cadmium fulvestrant inhibits the reaction [Cadmium results in increased phosphorylation of PDGFRA protein]decreases reaction|increases phosphorylation 17125913
D019256 Cadmium Chloride Cadmium Chloride results in increased phosphorylation of PDGFRA proteinincreases phosphorylation 17125913
D019256 Cadmium Chloride fulvestrant inhibits the reaction [Cadmium Chloride results in increased phosphorylation of PDGFRA protein]decreases reaction|increases phosphorylation 17125913
D002251 Carbon Tetrachloride Carbon Tetrachloride affects the expression of PDGFRA mRNAaffects expression 17484886
D002251 Carbon Tetrachloride Carbon Tetrachloride results in decreased expression of PDGFRA mRNAdecreases expression 16239168
D003375 Coumestrol Coumestrol results in increased expression of PDGFRA mRNAincreases expression 12604637
D003375 Coumestrol Coumestrol results in increased expression of PDGFRA proteinincreases expression 12604637
C461979 CT52923 CT52923 binds to and results in decreased activity of PDGFRA proteinaffects binding|decreases activity 15994924
C057862 cyanoginosin LR cyanoginosin LR results in increased expression of PDGFRA mRNAincreases expression 17654400
D003632 Dichlorodiphenyldichloroethane [Dichlorodiphenyldichloroethane co-treated with Dichlorodiphenyl Dichloroethylene co-treated with 2,2-(2-chlorophenyl-4'-chlorophenyl)-1,1-dichloroethene co-treated with Aldrin co-treated with Dieldrin] results in increased expression of PDGFRA mRNAaffects cotreatment|increases expression 19422813
D003633 Dichlorodiphenyl Dichloroethylene [Dichlorodiphenyldichloroethane co-treated with Dichlorodiphenyl Dichloroethylene co-treated with 2,2-(2-chlorophenyl-4'-chlorophenyl)-1,1-dichloroethene co-treated with Aldrin co-treated with Dieldrin] results in increased expression of PDGFRA mRNAaffects cotreatment|increases expression 19422813
D004026 Dieldrin [Dichlorodiphenyldichloroethane co-treated with Dichlorodiphenyl Dichloroethylene co-treated with 2,2-(2-chlorophenyl-4'-chlorophenyl)-1,1-dichloroethene co-treated with Aldrin co-treated with Dieldrin] results in increased expression of PDGFRA mRNAaffects cotreatment|increases expression 19422813
D004054 Diethylstilbestrol Diethylstilbestrol results in increased expression of PDGFRA mRNAincreases expression 12604637
D004054 Diethylstilbestrol Diethylstilbestrol results in increased expression of PDGFRA proteinincreases expression 12604637
D004958 Estradiol Estradiol affects the expression of PDGFRA mRNAaffects expression 15598610
D004997 Ethinyl Estradiol Ethinyl Estradiol results in decreased expression of PDGFRA mRNAdecreases expression 17557909
C070081 fulvestrant fulvestrant inhibits the reaction [Cadmium Chloride results in increased phosphorylation of PDGFRA protein]decreases reaction|increases phosphorylation 17125913
C070081 fulvestrant fulvestrant inhibits the reaction [Cadmium results in increased phosphorylation of PDGFRA protein]decreases reaction|increases phosphorylation 17125913
D005665 Furosemide Furosemide affects the expression of PDGFRA mRNAaffects expression 16526316
D019833 Genistein Genistein results in increased expression of PDGFRA mRNAincreases expression 12604637
D019833 Genistein Genistein results in increased expression of PDGFRA proteinincreases expression 12604637
C010176 halofuginone halofuginone results in increased expression of PDGFRA mRNAincreases expression 17180598
D006861 Hydrogen Peroxide Hydrogen Peroxide results in decreased expression of PDGFRA mRNAdecreases expression 17997286
D006861 Hydrogen Peroxide Sodium Selenite inhibits the reaction [Hydrogen Peroxide results in decreased expression of PDGFRA mRNA]decreases expression|decreases reaction 17997286
C097613 imatinib imatinib results in decreased expression of PDGFRA proteindecreases expression 15786421
17614352
C097613 imatinib imatinib results in decreased expression of PDGFRA protein modified formdecreases expression 17614352
C097613 imatinib Progesterone promotes the reaction [imatinib results in decreased expression of PDGFRA protein]decreases expression|increases reaction 17614352
C097613 imatinib Progesterone promotes the reaction [imatinib results in decreased expression of PDGFRA protein modified form]decreases expression|increases reaction 17614352
D007213 Indomethacin Indomethacin results in increased expression of PDGFRA mRNAincreases expression 17440234
D007854 Lead CBL protein affects the reaction [Lead results in decreased expression of PDGFRA protein]affects reaction|decreases expression 17298174
D007854 Lead FYN protein affects the reaction [Lead results in decreased expression of PDGFRA protein]affects reaction|decreases expression 17298174
D007854 Lead Lead results in decreased expression of and results in decreased phosphorylation of and results in decreased activity of PDGFRA proteindecreases activity|decreases expression|decreases phosphorylation 17298174
C008261 lead acetate CBL protein affects the reaction [lead acetate results in decreased expression of PDGFRA protein]affects reaction|decreases expression 17298174
C008261 lead acetate FYN protein affects the reaction [lead acetate results in decreased expression of PDGFRA protein]affects reaction|decreases expression 17298174
C008261 lead acetate lead acetate results in decreased expression of and results in decreased phosphorylation of and results in decreased activity of PDGFRA proteindecreases activity|decreases expression|decreases phosphorylation 17298174
D008767 Methylmercury Compounds Methylmercury Compounds results in decreased expression of PDGFRA proteindecreases expression 17298174
D008767 Methylmercury Compounds CBL protein affects the reaction [Methylmercury Compounds results in increased ubiquitination of and results in increased degradation of PDGFRA protein]affects reaction|increases degradation|increases ubiquitination 17298174
D008767 Methylmercury Compounds FYN protein affects the reaction [Methylmercury Compounds results in increased ubiquitination of and results in increased degradation of PDGFRA protein]affects reaction|increases degradation|increases ubiquitination 17298174
D008767 Methylmercury Compounds Methylmercury Compounds results in decreased expression of and results in decreased phosphorylation of and results in decreased activity of PDGFRA proteindecreases activity|decreases expression|decreases phosphorylation 17298174
D008767 Methylmercury Compounds Methylmercury Compounds results in increased ubiquitination of and results in increased degradation of PDGFRA proteinincreases degradation|increases ubiquitination 17298174
D009151 Mustard Gas Mustard Gas results in increased expression of PDGFRA mRNAincreases expression 18988085
D010269 Paraquat Paraquat results in increased expression of PDGFRA mRNA alternative formincreases expression 17215068
D010269 Paraquat CBL protein affects the reaction [Paraquat results in decreased expression of PDGFRA protein]affects reaction|decreases expression 17298174
D010269 Paraquat FYN protein affects the reaction [Paraquat results in decreased expression of PDGFRA protein]affects reaction|decreases expression 17298174
D010269 Paraquat Paraquat affects the expression of PDGFRA mRNAaffects expression 16854511
D010269 Paraquat Paraquat results in decreased expression of and results in decreased phosphorylation of and results in decreased activity of PDGFRA proteindecreases activity|decreases expression|decreases phosphorylation 17298174
D010671 Phenylurea Compounds Phenylurea Compounds results in decreased activity of PDGFRA proteindecreases activity 18343900
C006253 pirinixic acid [pirinixic acid binds to and results in increased activity of PPARA protein] which results in decreased expression of PDGFRA mRNAaffects binding|decreases expression|increases activity 19710929
C006253 pirinixic acid pirinixic acid results in increased expression of PDGFRA mRNAincreases expression 12832660
D011374 Progesterone Progesterone promotes the reaction [imatinib results in decreased expression of PDGFRA protein]decreases expression|increases reaction 17614352
D011374 Progesterone Progesterone promotes the reaction [imatinib results in decreased expression of PDGFRA protein modified form]decreases expression|increases reaction 17614352
D011374 Progesterone [Progesterone results in increased secretion of [VEGFA protein binds to VEGFA protein]] which results in increased phosphorylation of PDGFRA proteinaffects binding|increases phosphorylation|increases secretion 16888808
D020849 Raloxifene Raloxifene affects the expression of PDGFRA mRNAaffects expression 14699072
D017632 Asbestos, Serpentine Asbestos, Serpentine results in decreased expression of PDGFRA mRNAdecreases expression 16251409
D018038 Sodium Selenite Sodium Selenite inhibits the reaction [Hydrogen Peroxide results in decreased expression of PDGFRA mRNA]decreases expression|decreases reaction 17997286
D018038 Sodium Selenite Sodium Selenite results in decreased expression of PDGFRA mRNAdecreases expression 18209489
D013749 Tetrachlorodibenzodioxin SRC protein promotes the reaction [Tetrachlorodibenzodioxin results in increased expression of PDGFRA mRNA]increases expression|increases reaction 14708085
D013749 Tetrachlorodibenzodioxin Tetrachlorodibenzodioxin results in increased expression of PDGFRA mRNAincreases expression 17586704
14708085
C496197 trans-10,cis-12-conjugated linoleic acid trans-10,cis-12-conjugated linoleic acid results in decreased expression of PDGFRA mRNAdecreases expression 17951470
D014212 Tretinoin Tretinoin results in decreased expression of PDGFRA proteindecreases expression 16956736
D014212 Tretinoin Tretinoin results in increased expression of PDGFRA mRNAincreases expression 16604517
C066075 vanadium pentoxide vanadium pentoxide results in increased expression of PDGFRA mRNAincreases expression 17134509
D014810 Vitamin E Vitamin E results in increased expression of PDGFRA mRNAincreases expression 19244175
Disease ID Disease Name Direct Evidence Inference Chemical Name Inference Score Publication
MESH:D000014 Abnormalities, Drug-Induced Tetrachlorodibenzodioxin 2.4311752688 15322242 14514962
MESH:D000015 Abnormalities, Multiple imatinib 4.8718322153
MESH:D000022 Abortion, Spontaneous imatinib 5.7718322153
MESH:D000138 Acidosis Ammonium Chloride 3.1318287403
MESH:D000152 Acne Vulgaris Ethinyl Estradiol 3.5017505938
MESH:D055371 Acute Lung Injury pirinixic acid 2.7218653653
MESH:D000230 Adenocarcinoma Estradiol 9.1411473722
MESH:D000230 Adenocarcinoma Ethinyl Estradiol 9.1414692618
MESH:D000230 Adenocarcinoma Genistein 9.1411473722
MESH:D000230 Adenocarcinoma Indomethacin 9.1416537180
MESH:D000236 Adenoma Indomethacin 3.2011497255
MESH:D018248 Adenoma, Liver Cell pirinixic acid 8.4716434500
MESH:D018248 Adenoma, Liver Cell Tetrachlorodibenzodioxin 8.4716835633
MESH:D000382 Agricultural Workers' Diseases Dichlorodiphenyl Dichloroethylene 7.7116487989
MESH:D000382 Agricultural Workers' Diseases Paraquat 7.7111874814
MESH:D000419 Albuminuria Raloxifene 4.1917308373 17451421
MESH:D000505 Alopecia Tretinoin 3.2715955085
MESH:D016301 Alveolar Bone Loss Indomethacin 4.9317225004
MESH:D000544 Alzheimer Disease Indomethacin 4.0915579461 17627676
MESH:D000544 Alzheimer Disease Raloxifene 4.0915800139
MESH:D000686 Amyloidosis Diethylstilbestrol 4.0715469931
MESH:D000740 Anemia Tetrachlorodibenzodioxin 2.5811748828
MESH:D000799 Angioedema Acetaminophen 3.4010982225
MESH:D001014 Aortic Aneurysm Indomethacin 4.4410231640
MESH:D017544 Aortic Aneurysm, Abdominal Indomethacin 4.4510388637
MESH:D001161 Arteriosclerosis Ethinyl Estradiol 3.0511256880
MESH:D018771 Arthralgia Indomethacin 4.732160914
MESH:D001169 Arthritis, Experimental Ethinyl Estradiol 6.3015885639
MESH:D001169 Arthritis, Experimental Tretinoin 6.3016412693
MESH:D001172 Arthritis, Rheumatoid Indomethacin 4.3711248219
MESH:D001172 Arthritis, Rheumatoid Tretinoin 4.3716292516
MESH:D001195 Asbestosis Asbestos, Serpentine 5.2610751356
MESH:D001249 Asthma Mustard Gas 4.4810378619
MESH:D001249 Asthma Tretinoin 4.4816456186
MESH:D050197 Atherosclerosis Cadmium 3.3815687053
MESH:D001284 Atrophy fulvestrant 4.4411514358
MESH:D001321 Autistic Disorder Acetaminophen 1.4718445737
MESH:D001471 Barrett Esophagus Tretinoin 3.9916935849
MESH:D001477 Bartter Syndrome Indomethacin 4.5610684365
MESH:D001768 Blister Mustard Gas 4.7319167455
MESH:D001778 Blood Coagulation Disorders pirinixic acid 13.0419483382
MESH:D001778 Blood Coagulation Disorders Tetrachlorodibenzodioxin 13.0412125929
MESH:D001778 Blood Coagulation Disorders Tretinoin 13.0416206674 16197459
MESH:D001836 Body Weight Changes Tetrachlorodibenzodioxin 3.3515340226
MESH:D001848 Bone Diseases, Developmental Tetrachlorodibenzodioxin 2.4815746008
MESH:D001859 Bone Neoplasms imatinib 4.9315867366
MESH:D001862 Bone Resorption bisphenol A 3.4811985600
MESH:D001929 Brain Edema Indomethacin 4.5911481608
MESH:D020201 Brain Hemorrhage, Traumatic Progesterone 4.9017868700
MESH:D001930 Brain Injuries Progesterone 9.5715665606 15380490 15845082
MESH:D001930 Brain Injuries Raloxifene 9.5716580743
MESH:D002545 Brain Ischemia Indomethacin 3.9912524144
MESH:D001943 Breast Neoplasms bisphenol A 10.3817123778
MESH:D001943 Breast Neoplasms Dichlorodiphenyl Dichloroethylene 10.3815061365
MESH:D001943 Breast Neoplasms Dieldrin 10.3811859874 15770527
MESH:D001943 Breast Neoplasms Diethylstilbestrol 10.3817129689 15324884
MESH:D001943 Breast Neoplasms Estradiol 10.3817261762 12948864 19861407 17289903 18497071 14630087 17018787 16675129
MESH:D001943 Breast Neoplasms fulvestrant 10.3818984771
MESH:D001943 Breast Neoplasms Genistein 10.3816541309 17200150 16873071
MESH:D001943 Breast Neoplasms imatinib 10.3817614352
MESH:D001943 Breast Neoplasms Indomethacin 10.3817401462
MESH:D001943 Breast Neoplasms Progesterone 10.3816175315 15562024 17614352
MESH:D001943 Breast Neoplasms Raloxifene 10.3816912660 17242785 15572757 17440819 17893378 17049068 17261762 17952589 16837676 17595753 15758505 15775269
MESH:D001943 Breast Neoplasms Tetrachlorodibenzodioxin 10.3820435547
MESH:D001943 Breast Neoplasms Tretinoin 10.3816166294 16443354 16873071
MESH:D001989 Bronchiolitis Obliterans Mustard Gas 4.7315286001
MESH:D001991 Bronchitis vanadium pentoxide 5.8017459161
MESH:D029481 Bronchitis, Chronic Mustard Gas 4.5417687719 10378619
MESH:D001997 Bronchopulmonary Dysplasia Tretinoin 4.1616813970
MESH:D002056 Burns Indomethacin 4.2810459503
MESH:D002100 Cachexia Indomethacin 4.5715625704 16537180 15141370 11239499
MESH:D002181 Candidiasis, Vulvovaginal Estradiol 4.0316111702
MESH:D002252 Carbon Tetrachloride Poisoning Carbon Tetrachloride 8.5416227642 10355542 16192424 16124888 15700767 16011737 15721981 18705752 16050911 16097048 15673190 3786805
MESH:D002252 Carbon Tetrachloride Poisoning Vitamin E 8.5416050911
MESH:D002277 Carcinoma Tetrachlorodibenzodioxin 2.4616835633
MESH:D018236 Carcinoma, Embryonal Tretinoin 4.7216168501
MESH:D006528 Carcinoma, Hepatocellular 2,6-dinitrotoluene 15.4316705839
MESH:D006528 Carcinoma, Hepatocellular Acetaminophen 15.433084413
MESH:D006528 Carcinoma, Hepatocellular Carbon Tetrachloride 15.4318788625
MESH:D006528 Carcinoma, Hepatocellular Diethylstilbestrol 15.4316924424 15948411
MESH:D006528 Carcinoma, Hepatocellular Estradiol 15.4316924424
MESH:D006528 Carcinoma, Hepatocellular Genistein 15.4316924424
MESH:D006528 Carcinoma, Hepatocellular Indomethacin 15.4316391822
MESH:D006528 Carcinoma, Hepatocellular Tretinoin 15.431917145
MESH:D002278 Carcinoma in Situ bisphenol A 4.5617123778
MESH:D018827 Carcinoma, Lewis Lung Indomethacin 4.3011053908
MESH:D018276 Carcinoma, Medullary Indomethacin 4.9218791128 14736730 11352223
MESH:D002292 Carcinoma, Renal Cell Indomethacin 3.1617341418
MESH:D002294 Carcinoma, Squamous Cell Indomethacin 4.3915482327 12636206
MESH:D002294 Carcinoma, Squamous Cell Tretinoin 4.3916096774 16051514
MESH:D002295 Carcinoma, Transitional Cell Raloxifene 3.7017572228
MESH:D006332 Cardiomegaly Tetrachlorodibenzodioxin 2.1218850075 18670907 16120746
MESH:D002318 Cardiovascular Diseases Genistein 10.5116332659
MESH:D002318 Cardiovascular Diseases Hydrogen Peroxide 10.5116936243
MESH:D002318 Cardiovascular Diseases Raloxifene 10.5115775269
MESH:D002386 Cataract Acetaminophen 6.3610977129
MESH:D002386 Cataract Tretinoin 6.3617460283
MESH:D002471 Cell Transformation, Neoplastic 2,6-dinitrotoluene 9.566135515
MESH:D002471 Cell Transformation, Neoplastic Cadmium 9.5617332340
MESH:D002471 Cell Transformation, Neoplastic Estradiol 9.5618566989
MESH:D018290 Cervical Intraepithelial Neoplasia Tretinoin 4.1616129372
MESH:D018281 Cholangiocarcinoma Tetrachlorodibenzodioxin 2.8016835633
MESH:D002764 Cholecystitis Indomethacin 4.7311181007
MESH:D002779 Cholestasis Ethinyl Estradiol 6.6816919318 11677210 17681005 17333356 16105132 15861022 17110522
MESH:D002779 Cholestasis pirinixic acid 6.6819176532
MESH:D018211 Chondrosarcoma, Mesenchymal marker/mechanism 12817616
MESH:D002822 Choriocarcinoma Tretinoin 4.7216461808
MESH:D019457 Chromosome Breakage Sodium Selenite 4.3315894690
MESH:D002972 Cleft Palate marker/mechanism 18264099
MESH:D002972 Cleft Palate Tetrachlorodibenzodioxin 5.128697196 15668235 16354765 15340226 12621046
MESH:D002972 Cleft Palate Tretinoin 5.129407595
MESH:D003072 Cognition Disorders Raloxifene 4.2015800139
MESH:D003092 Colitis Tretinoin 3.2917035595
MESH:D003110 Colonic Neoplasms Genistein 3.6717182828
MESH:D003110 Colonic Neoplasms Indomethacin 3.6715625704 15637740 15786552 15936596 15963497 11260862
MESH:D015179 Colorectal Neoplasms Indomethacin 2.3518059344 12606626 17054584 11197048
MESH:D000013 Congenital Abnormalities Dichlorodiphenyldichloroethane 8.6115095906
MESH:D000013 Congenital Abnormalities Tetrachlorodibenzodioxin 8.6117141729 14669216
MESH:D018352 Coronavirus Infections Indomethacin 5.2817302372
MESH:D019465 Craniofacial Abnormalities marker/mechanism 11023856
MESH:D019465 Craniofacial Abnormalities imatinib 8.7218322153
MESH:D019465 Craniofacial Abnormalities Lead 8.7219769572
MESH:D019465 Craniofacial Abnormalities lead acetate 8.7219769572
MESH:D019465 Craniofacial Abnormalities Tetrachlorodibenzodioxin 8.7210048152 15322242 20055451
MESH:D019465 Craniofacial Abnormalities Tretinoin 8.7217551590 16925845 9125849 9211117 10589399 9142499 8800419 9224671 9664655 14991402
MESH:D019465 Craniofacial Abnormalities Vitamin E 8.7219769572
MESH:D003456 Cryptorchidism Diethylstilbestrol 4.1512952375 16002989
MESH:D003490 Cyanosis 2,6-dinitrotoluene 3.6018551238
MESH:D003704 Dementia Lead 9.4116140633
MESH:D003704 Dementia Methylmercury Compounds 9.4116140633
MESH:D003865 Depressive Disorder, Major Raloxifene 3.8017474826
MESH:D003876 Dermatitis, Atopic pirinixic acid 2.2218249437
MESH:D003920 Diabetes Mellitus Sodium Selenite 3.4216285004
MESH:D003924 Diabetes Mellitus, Type 2 Genistein 3.9216647724
MESH:D003924 Diabetes Mellitus, Type 2 Tetrachlorodibenzodioxin 3.9217107852
MESH:D003928 Diabetic Nephropathies Estradiol 7.8119279558
MESH:D003928 Diabetic Nephropathies Raloxifene 7.8115920148 17451421 17308373
MESH:D003929 Diabetic Neuropathies Progesterone 4.0717187935
MESH:D003967 Diarrhea Indomethacin 3.407907874 7237001
MESH:D056486 Drug-Induced Liver Injury 2,6-dinitrotoluene 13.3521346803 18551238
MESH:D056486 Drug-Induced Liver Injury Acetaminophen 13.3516177239 17906064 12594235 16109766 12540782 12958197 19420014 14725611 11739529 10915739 19085960 17522070 10774834 11421492 11743745 19739265 17562736 11834606 16393943 11287661 16485898 19416960 19370779 12153990 16081117 10663392 14550746 16781746 15619225 14986274 15968718 11461765 18713872 12705907 2444490 18071297 19923254 16227642 12392966 11529661 19164858
MESH:D056486 Drug-Induced Liver Injury Carbon Tetrachloride 13.3515998439 10092053 2869522 7179309 10915739 15027814 9327722 3786805 15968718 19336974 4309450 3732212 7440962 11566570 6623471 7120509 16227642 6884620 21278145 17522070 19085960 16177239
MESH:D056486 Drug-Induced Liver Injury cyanoginosin LR 13.3517654400
MESH:D056486 Drug-Induced Liver Injury Sodium Selenite 13.3515131321
MESH:D056486 Drug-Induced Liver Injury Tetrachlorodibenzodioxin 13.3520420201
MESH:D056487 Drug-Induced Liver Injury, Chronic Acetaminophen 3.6619426721
MESH:D004362 Drug Toxicity Tetrachlorodibenzodioxin 2.4411462148
MESH:D004374 Ductus Arteriosus, Patent Indomethacin 4.7212774134 18446180 16133044 16326151 18043480 17190690
MESH:D004381 Duodenal Ulcer Indomethacin 3.7317202747 10671773 17045617 11595415 11595431 17351913 11535926 11991626 17329845 16699067 17151854
MESH:D004417 Dyspnea Dichlorodiphenyl Dichloroethylene 9.5016487989
MESH:D004417 Dyspnea Furosemide 9.5016935035
MESH:C538011 Eales disease Vitamin E 4.269068938
MESH:D004487 Edema Furosemide 26.7611834646
MESH:D004487 Edema imatinib 26.7619703484
MESH:D004487 Edema Indomethacin 26.768273558 8985016 7907874 7990266 16100529 10653021 19703484
MESH:D004487 Edema Mustard Gas 26.7611428631 9260866 11402378 11428647
MESH:D004487 Edema pirinixic acid 26.7612083418
MESH:D004487 Edema Raloxifene 26.7615860553
MESH:D004487 Edema Tetrachlorodibenzodioxin 26.7612711302 11000095
MESH:D004489 Edema, Cardiac Tetrachlorodibenzodioxin 10.4818230668 15322242 16714409
MESH:D004489 Edema, Cardiac Tretinoin 10.4818230668
MESH:D004681 Encephalomyelitis, Autoimmune, Experimental Ethinyl Estradiol 13.0212538720
MESH:D004681 Encephalomyelitis, Autoimmune, Experimental Progesterone 13.0217692515
MESH:D004681 Encephalomyelitis, Autoimmune, Experimental Raloxifene 13.0215845917
MESH:D004714 Endometrial Hyperplasia Diethylstilbestrol 10.4616402032
MESH:D004714 Endometrial Hyperplasia Genistein 10.4616402032
MESH:D016889 Endometrial Neoplasms Diethylstilbestrol 15.4416804899 15700306
MESH:D016889 Endometrial Neoplasms Estradiol 15.4418566989 11473722 19148513
MESH:D016889 Endometrial Neoplasms Genistein 15.4411473722
MESH:D016889 Endometrial Neoplasms Tretinoin 15.4416569247
MESH:D004715 Endometriosis Indomethacin 13.1415652904
MESH:D004715 Endometriosis Progesterone 13.1416134523
MESH:D004715 Endometriosis Tetrachlorodibenzodioxin 13.149294722 10568697
MESH:D019446 Endotoxemia Indomethacin 4.0718509659
MESH:D004751 Enteritis Indomethacin 4.3110567023 17763956 16328016
MESH:D020345 Enterocolitis, Necrotizing Indomethacin 4.5617980183
MESH:D004802 Eosinophilia Indomethacin 3.6411298111
MESH:D004890 Erythema Mustard Gas 4.739357497
MESH:D004938 Esophageal Neoplasms Indomethacin 2.6911005569
MESH:D020329 Essential Tremor Lead 5.5018007985 14594619
MESH:D005124 Eye Abnormalities Tetrachlorodibenzodioxin 7.7611564622
MESH:D005124 Eye Abnormalities Tretinoin 7.7616938888 9664655
MESH:D005234 Fatty Liver Carbon Tetrachloride 15.6216045604 12795759 17595544 15959796 19224547 16239168 12631006 61145
MESH:D005234 Fatty Liver Ethinyl Estradiol 15.6215345470
MESH:D005234 Fatty Liver pirinixic acid 15.6220131406 19236843
MESH:D005234 Fatty Liver Raloxifene 15.6217473493
MESH:D052776 Female Urogenital Diseases Diethylstilbestrol 3.3916513791 16534752 16611131 15751030 16002989
MESH:D005313 Fetal Death marker/mechanism 11023856
MESH:D005313 Fetal Death Tetrachlorodibenzodioxin 3.0411858732
MESH:D005317 Fetal Growth Retardation Lead 10.3519769572
MESH:D005317 Fetal Growth Retardation lead acetate 10.3519769572
MESH:D005334 Fever Indomethacin 3.7510431976 17627676 11852909
MESH:D018222 Fibromatosis, Aggressive imatinib 5.2217453242
MESH:D005354 Fibrosarcoma Indomethacin 4.4610962813
MESH:D005355 Fibrosis Carbon Tetrachloride 17.7318705752
MESH:D005355 Fibrosis Indomethacin 17.7317994277
MESH:D005355 Fibrosis Tetrachlorodibenzodioxin 17.7320067830
MESH:D005355 Fibrosis Tretinoin 17.7317994277
MESH:D005499 Folliculitis Indomethacin 4.7311298111
MESH:D005756 Gastritis Acetaminophen 9.6816983495
MESH:D005756 Gastritis Indomethacin 9.6815046732
MESH:D046152 Gastrointestinal Stromal Tumors marker/mechanism
MESH:D005833 Genital Neoplasms, Female Diethylstilbestrol 4.5216452187
MESH:D005909 Glioblastoma Genistein 10.3016598420
MESH:D005909 Glioblastoma Indomethacin 10.3012870263
MESH:D005909 Glioblastoma Tretinoin 10.3017312396
MESH:D005910 Glioma Indomethacin 3.0518371953 16487511
MESH:D005911 Gliosis Paraquat 4.7211124998
MESH:D005923 Glomerulosclerosis, Focal Segmental Indomethacin 3.9411849393
MESH:D006058 Gonadal Disorders Tetrachlorodibenzodioxin 4.1510696789
MESH:D006073 Gout Indomethacin 4.9211248219
MESH:D006258 Head and Neck Neoplasms Indomethacin 6.9415482327
MESH:D006258 Head and Neck Neoplasms Tretinoin 6.9416096774
MESH:D034381 Hearing Loss Furosemide 4.4717868369
MESH:D006317 Hearing Loss, Noise-Induced Tretinoin 4.7216084493
MESH:D006330 Heart Defects, Congenital Tetrachlorodibenzodioxin 9.7510048152 11294989
MESH:D006330 Heart Defects, Congenital Tretinoin 9.759664655 14991402
MESH:D006330 Heart Defects, Congenital Vitamin E 9.7516080930
MESH:D006331 Heart Diseases Raloxifene 3.2411110106
MESH:D006333 Heart Failure Furosemide 6.4112660669 16845234 16011733
MESH:D006333 Heart Failure pirinixic acid 6.4120558911
MESH:D006470 Hemorrhage Tetrachlorodibenzodioxin 2.9511000095
MESH:D006501 Hepatic Encephalopathy Indomethacin 4.1815633222
MESH:D006505 Hepatitis Carbon Tetrachloride 8.4319900420 19110552
MESH:D006505 Hepatitis Dichlorodiphenyl Dichloroethylene 8.4316487989
MESH:D019698 Hepatitis C, Chronic Indomethacin 4.2715135802
MESH:D006529 Hepatomegaly pirinixic acid 6.8716221962 19772884 19176532 18467677
MESH:D006529 Hepatomegaly Tetrachlorodibenzodioxin 6.8712621046 16120746 15340226
MESH:D006548 Hernia, Diaphragmatic Vitamin E 2.5416863852 16490937
MESH:D006558 Herpes Genitalis Estradiol 4.5915709030
MESH:D019584 Hot Flashes Estradiol 8.5917088409
MESH:D019584 Hot Flashes Vitamin E 8.5914716179
MESH:D006869 Hydronephrosis Tetrachlorodibenzodioxin 3.6116354765 15340226 18606429 16959395 8697196
MESH:D006930 Hyperalgesia Acetaminophen 11.1116870215
MESH:D006930 Hyperalgesia Indomethacin 11.1112727271
MESH:D006930 Hyperalgesia Tretinoin 11.1116870215
MESH:D034321 Hyperamylasemia Indomethacin 5.2817883296
MESH:D006932 Hyperbilirubinemia Carbon Tetrachloride 4.1016899240
MESH:D006934 Hypercalcemia Furosemide 4.6917652376
MESH:D053565 Hypercalciuria Furosemide 5.2217652376
MESH:D006940 Hyperemia Indomethacin 4.5712524144
MESH:D017681 Hypereosinophilic Syndrome marker/mechanism 16778211
MESH:D017681 Hypereosinophilic Syndrome Tretinoin 4.1516778211
OMIM:607685 HYPEREOSINOPHILIC SYNDROME, IDIOPATHIC marker/mechanism
MESH:D006943 Hyperglycemia pirinixic acid 2.8120558911
MESH:D006949 Hyperlipidemias Indomethacin 3.7717546600
MESH:D006962 Hyperparathyroidism, Secondary Furosemide 5.4315086907
MESH:D006965 Hyperplasia Diethylstilbestrol 9.9212960047 14722030
MESH:D006965 Hyperplasia halofuginone 9.9211874485
MESH:D006973 Hypertension Raloxifene 4.6317577099 15787275
MESH:D006973 Hypertension Tetrachlorodibenzodioxin 4.6318670907 18850075
MESH:D006975 Hypertension, Portal Carbon Tetrachloride 3.6715338365
MESH:D046110 Hypertension, Pregnancy-Induced Furosemide 4.8616612254
MESH:C537153 Hypomagnesemia primary Furosemide 5.2211041285
MESH:D007019 Hypoproteinemia Furosemide 5.4316096441
MESH:D007021 Hypospadias Diethylstilbestrol 9.8416002989
MESH:D007021 Hypospadias Ethinyl Estradiol 9.8416945680 16569931
MESH:D007022 Hypotension Furosemide 4.2211041285
MESH:D007024 Hypotension, Orthostatic Furosemide 4.9815811171
MESH:D007077 Ileal Diseases Indomethacin 4.5910574470 18306037
MESH:D007079 Ileitis Indomethacin 4.9210647630 10651667 16133968
MESH:D007235 Infant, Premature, Diseases Indomethacin 4.9316133044
MESH:D020244 Infarction, Middle Cerebral Artery Progesterone 3.9815869954
MESH:D007246 Infertility Diethylstilbestrol 3.9515036965
MESH:D007247 Infertility, Female 2,2-(2-chlorophenyl-4'-chlorophenyl)-1,1-dichloroethene 15.1112515675
MESH:D007247 Infertility, Female Dieldrin 15.1110630421
MESH:D007247 Infertility, Female Ethinyl Estradiol 15.1112013081
MESH:D007248 Infertility, Male 2,2-(2-chlorophenyl-4'-chlorophenyl)-1,1-dichloroethene 27.3412515675
MESH:D007248 Infertility, Male Coumestrol 27.3416892005
MESH:D007248 Infertility, Male Dichlorodiphenyl Dichloroethylene 27.3417192596 12948891
MESH:D007248 Infertility, Male Ethinyl Estradiol 27.3417937319
MESH:D007248 Infertility, Male fulvestrant 27.3411514358
MESH:D007248 Infertility, Male Lead 27.3416780224
MESH:D007248 Infertility, Male Paraquat 27.344850670
MESH:D007249 Inflammation Indomethacin 10.063291741 12568917 7812673
MESH:D007249 Inflammation Mustard Gas 10.068975870 11402378 11428620 11428647 9260866 16001271 17524151 9357497 11428631
MESH:D007249 Inflammation Progesterone 10.0615869954
MESH:D007249 Inflammation Tetrachlorodibenzodioxin 10.0612878042 12200463
MESH:D007251 Influenza, Human Vitamin E 3.7816624496
MESH:D007333 Insulin Resistance bisphenol A 15.2916393666
MESH:D007333 Insulin Resistance Estradiol 15.2916393666 16627594
MESH:D007333 Insulin Resistance pirinixic acid 15.2916306350
MESH:D007333 Insulin Resistance Sodium Selenite 15.2914714311
MESH:D007410 Intestinal Diseases Indomethacin 8.4918236018 15831440 17994277 17329856 11686837 15610444 11855677 11713966 10210152
MESH:D007410 Intestinal Diseases Tretinoin 8.4917994277
MESH:D019586 Intracranial Hypertension Indomethacin 4.9315241188
MESH:D007569 Jaw Abnormalities Tetrachlorodibenzodioxin 8.6516580747
MESH:D007569 Jaw Abnormalities Tretinoin 8.6515992940 17551590
MESH:D007579 Jejunal Diseases Indomethacin 4.5910574470 16133968 18306037
MESH:D007674 Kidney Diseases Acetaminophen 24.9115629191 12587719
MESH:D007674 Kidney Diseases Cadmium 24.9116322080 16962696 16226777
MESH:D007674 Kidney Diseases Cadmium Chloride 24.9116962696
MESH:D007674 Kidney Diseases Estradiol 24.9115618244
MESH:D007674 Kidney Diseases Furosemide 24.9111041285
MESH:D007674 Kidney Diseases Indomethacin 24.9117190690
MESH:D007674 Kidney Diseases Vitamin E 24.9112488133
MESH:D007676 Kidney Failure, Chronic Hydrogen Peroxide 3.8916518626
MESH:D007680 Kidney Neoplasms 2,6-dinitrotoluene 10.4516705839
MESH:D007680 Kidney Neoplasms Diethylstilbestrol 10.4516762066 15003126 14681315
MESH:D007680 Kidney Neoplasms Estradiol 10.4515610895
MESH:D007855 Lead Poisoning Lead 5.5016700817
MESH:D007859 Learning Disorders Diethylstilbestrol 8.7517184923
MESH:D007859 Learning Disorders Lead 8.7516384672
MESH:D007889 Leiomyoma Raloxifene 4.1016973256
MESH:D016773 Leishmaniasis, Cutaneous Indomethacin 3.5610320625 12228301 11703811
MESH:D007938 Leukemia Genistein 5.6617468513 18980019
MESH:D007938 Leukemia Tretinoin 5.6617143497
MESH:D015464 Leukemia, Myelogenous, Chronic, BCR-ABL Positive imatinib 7.9817301526 15107311 19208803 15748426
MESH:D015464 Leukemia, Myelogenous, Chronic, BCR-ABL Positive Indomethacin 7.9816572323 10785260 15631656
MESH:D007951 Leukemia, Myeloid imatinib 8.6917236224
MESH:D007951 Leukemia, Myeloid Tretinoin 8.6916932348 16482212 19285840
MESH:D015470 Leukemia, Myeloid, Acute Indomethacin 3.7518360721
MESH:D015470 Leukemia, Myeloid, Acute Tretinoin 3.7516294345 17596541 19850784
MESH:D015473 Leukemia, Promyelocytic, Acute Tretinoin 2.8712679006 9834237 19225113 16788101 16935935 16823087 15748426 16891316 17506722 17294898 16331271 17712046 17301526 19075265 19029980 17361223 16766008 17107899 19642359 17339181 16140955 17649720 19035177 17217047 17368321
MESH:D007964 Leukocytosis Indomethacin 4.9316537180
MESH:D007969 Leukomalacia, Periventricular Indomethacin 5.2817980183
MESH:D017880 Limb Deformities, Congenital Dichlorodiphenyl Dichloroethylene 7.6012745335
MESH:D017880 Limb Deformities, Congenital Tretinoin 7.609224671
MESH:D008101 Liver Abscess, Amebic Indomethacin 5.2811479899
MESH:D008103 Liver Cirrhosis Carbon Tetrachloride 6.2317157831 16943688 11903743 17334410 21278145 11408273 17174718 16239168 16221502
MESH:D008103 Liver Cirrhosis halofuginone 6.2317180598
MESH:D008106 Liver Cirrhosis, Experimental Carbon Tetrachloride 16.8112546737 16033810 15931870 15959796 12445418 12609069 18277467 17766677 17557913 17721639 18006644 18420326 15673190 10355542 18472094 12586293 18705752 18481824 14748882 18418968 14716496 15876570 12649538 17761835 18412020 17708605 12389079 18166357 14620537 15052691 18472332 18279442 17869086 16011737 11481614 17900296 17565644 18205269 17944888 13678700 18317297 12667390 17698563 18339082 15893842 17805973 12632514 17631135 12898905 16192424 16015684 15996030 14724832 18263696 15818738 17976157 15925388 15362042 15370692 14716833 12666154 17640975 17922224 16097048 15650968 16248980 16136751 18395095 17481882 18187930 14512876 12445421 16638106 12741479 18395914 15338365 20821823 12958196 16116963 12632512 15057751 16027843 15730626 17525996 18376398 18429990 17823541 18156304 18251166 18210741 18054572 15123356 17714472
MESH:D008106 Liver Cirrhosis, Experimental Estradiol 16.8114716833 14659978
MESH:D008106 Liver Cirrhosis, Experimental Genistein 16.8117823541
MESH:D008106 Liver Cirrhosis, Experimental halofuginone 16.8111172339 16489207 18458672 12175628 14739098
MESH:D008106 Liver Cirrhosis, Experimental imatinib 16.8116596278
MESH:D008106 Liver Cirrhosis, Experimental Indomethacin 16.8118194892
MESH:D008106 Liver Cirrhosis, Experimental pirinixic acid 16.8115474484
MESH:D008106 Liver Cirrhosis, Experimental Tetrachlorodibenzodioxin 16.8112878042
MESH:D008106 Liver Cirrhosis, Experimental Tretinoin 16.8118397230 16248980
MESH:D008106 Liver Cirrhosis, Experimental Vitamin E 16.8116169303
MESH:D008107 Liver Diseases Acetaminophen 3.4819784758 16611625 11587558 16610002 12969438 19014921 19460945 12587719
MESH:D008107 Liver Diseases Carbon Tetrachloride 3.4815830285 15720792 17285989 16246199 16964402
MESH:D017093 Liver Failure Carbon Tetrachloride 3.7415123358
MESH:D017114 Liver Failure, Acute Acetaminophen 8.1717185352 16871587
MESH:D017114 Liver Failure, Acute Carbon Tetrachloride 8.1716899240 14706259
MESH:D008113 Liver Neoplasms 2,6-dinitrotoluene 15.647678174
MESH:D008113 Liver Neoplasms Carbon Tetrachloride 15.6419294768
MESH:D008113 Liver Neoplasms Dieldrin 15.648742319 9539021
MESH:D008113 Liver Neoplasms Diethylstilbestrol 15.6416712894 15890375
MESH:D008113 Liver Neoplasms pirinixic acid 15.6420007298 16377806 15890375
MESH:D008113 Liver Neoplasms Tetrachlorodibenzodioxin 15.6416984957
MESH:D008114 Liver Neoplasms, Experimental 2,6-dinitrotoluene 8.196135515 2876786 2876784
MESH:D008114 Liver Neoplasms, Experimental Carbon Tetrachloride 8.1915583823 12014681
MESH:D008114 Liver Neoplasms, Experimental Tetrachlorodibenzodioxin 8.1912151625
MESH:D008171 Lung Diseases Asbestos, Serpentine 10.8317200189
MESH:D008171 Lung Diseases Mustard Gas 10.8318702808 18161513
MESH:D008171 Lung Diseases Vitamin E 10.8316863852
MESH:D008175 Lung Neoplasms Asbestos, Serpentine 7.7311198217
MESH:D008175 Lung Neoplasms Indomethacin 7.7311053908 16537180 11497255
MESH:D008175 Lung Neoplasms Mustard Gas 7.733148597 8781369
MESH:D008175 Lung Neoplasms Tetrachlorodibenzodioxin 7.7311884234 19555203
MESH:D008175 Lung Neoplasms vanadium pentoxide 7.7312376484
MESH:D008175 Lung Neoplasms Vitamin E 7.7311062179
MESH:D008181 Lupus Nephritis Diethylstilbestrol 4.7215166399
MESH:D008223 Lymphoma Diethylstilbestrol 3.1715700306
MESH:D016393 Lymphoma, B-Cell Sodium Selenite 3.6614737004
MESH:D052801 Male Urogenital Diseases Diethylstilbestrol 5.0816002989
MESH:D008325 Mammary Neoplasms, Experimental Estradiol 8.3811408345 16891317 17203775 11807958
MESH:D008325 Mammary Neoplasms, Experimental Genistein 8.3814578162 12929590
MESH:D008325 Mammary Neoplasms, Experimental Progesterone 8.3811408345 17203775
MESH:D020149 Manganese Poisoning Estradiol 4.0419453300
MESH:D008527 Medulloblastoma marker/mechanism 19270706
MESH:D008527 Medulloblastoma Tretinoin 2.6017453147
MESH:D008545 Melanoma Tretinoin 1.8816752155
MESH:D008546 Melanoma, Experimental Acetaminophen 3.1519513568
MESH:D008569 Memory Disorders Lead 9.0316384672 17263510
MESH:D008569 Memory Disorders Methylmercury Compounds 9.0318436314
MESH:D008591 Meningomyelocele Tretinoin 4.0016940565
MESH:D008881 Migraine Disorders Indomethacin 3.3711903285
MESH:D018200 Mixed Tumor, Mullerian Raloxifene 5.1115863610
MESH:D009062 Mouth Neoplasms Indomethacin 3.6612636206
MESH:D009069 Movement Disorders Methylmercury Compounds 4.9318436314
MESH:D009101 Multiple Myeloma Raloxifene 3.1316497877
MESH:D009135 Muscular Diseases pirinixic acid 3.0916239165
MESH:D009190 Myelodysplastic Syndromes Tretinoin 2.8317596541
MESH:D009203 Myocardial Infarction Genistein 5.0317141266
MESH:D009203 Myocardial Infarction pirinixic acid 5.0319151258
MESH:D017202 Myocardial Ischemia Tetrachlorodibenzodioxin 2.6812213967
MESH:D015428 Myocardial Reperfusion Injury Estradiol 12.2616810080
MESH:D015428 Myocardial Reperfusion Injury Genistein 12.2617141266
MESH:D015428 Myocardial Reperfusion Injury pirinixic acid 12.2616411023
MESH:D009232 Myxoma Raloxifene 5.1116343187
MESH:D009336 Necrosis 2,6-dinitrotoluene 3.4318551238 7678174
MESH:D009362 Neoplasm Metastasis imatinib 5.8715867366
MESH:D009362 Neoplasm Metastasis Indomethacin 5.8716537180 11239499 11053908
MESH:D009369 Neoplasms Dieldrin 10.068820588
MESH:D009369 Neoplasms Diethylstilbestrol 10.0615313581
MESH:D009369 Neoplasms pirinixic acid 10.0617405874
MESH:D009369 Neoplasms Tretinoin 10.0616594593 16946489
MESH:D009374 Neoplasms, Experimental Asbestos, Serpentine 8.3211704859
MESH:D009374 Neoplasms, Experimental Indomethacin 8.3210663608 15625704
MESH:D009376 Neoplasms, Hormone-Dependent imatinib 5.0317614352
MESH:D009389 Neovascularization, Pathologic Estradiol 3.3017289903
MESH:D009397 Nephrocalcinosis Furosemide 5.4315086907
MESH:D009410 Nerve Degeneration Paraquat 3.3916893418
MESH:D009421 Nervous System Malformations bisphenol A 32.9616427766 11399458
MESH:D009421 Nervous System Malformations Diethylstilbestrol 32.9611399458
MESH:D009421 Nervous System Malformations Estradiol 32.9616427766 11399458
MESH:D009421 Nervous System Malformations Genistein 32.9616427766
MESH:D009421 Nervous System Malformations Tetrachlorodibenzodioxin 32.9614600291
MESH:D009421 Nervous System Malformations Tretinoin 32.969125849
MESH:D009436 Neural Tube Defects Tretinoin 2.779142499
MESH:D019636 Neurodegenerative Diseases Acetaminophen 7.2418514411
MESH:D019636 Neurodegenerative Diseases Indomethacin 7.2412349958
MESH:D009503 Neutropenia Mustard Gas 3.587688884 16761898
MESH:D053206 Nocturnal Enuresis Furosemide 5.4317945291
MESH:D009765 Obesity pirinixic acid 1.7020558911
MESH:D007752 Obstetric Labor, Premature Indomethacin 4.736374098
MESH:D009784 Occupational Diseases 2,6-dinitrotoluene 3.0616049721
MESH:D010003 Osteoarthritis Indomethacin 3.407009135
MESH:D010014 Osteolysis imatinib 5.3115867366
MESH:D010024 Osteoporosis Genistein 6.4319401787
MESH:D010024 Osteoporosis Raloxifene 6.4317882678 15775268 19059307
MESH:D015663 Osteoporosis, Postmenopausal Genistein 8.8216169203
MESH:D015663 Osteoporosis, Postmenopausal Raloxifene 8.8217893378 17823083 15579764 15758505
MESH:D010049 Ovarian Diseases bisphenol A 4.5611985600
MESH:D010051 Ovarian Neoplasms Estradiol 10.0419401270
MESH:D010051 Ovarian Neoplasms Genistein 10.0419005980
MESH:D010051 Ovarian Neoplasms Progesterone 10.0416525653 17393432
MESH:D010051 Ovarian Neoplasms Tretinoin 10.0416936753
MESH:D010146 Pain Acetaminophen 9.2716870215
MESH:D010146 Pain Indomethacin 9.273291741 17440234 13679232 17627676
MESH:D010146 Pain Tretinoin 9.2716870215
MESH:D010149 Pain, Postoperative Indomethacin 4.2418702446 12538197
MESH:D010190 Pancreatic Neoplasms Tretinoin 2.3015976015
MESH:D010195 Pancreatitis Indomethacin 3.5317883296 15028970
MESH:D016584 Panic Disorder Ethinyl Estradiol 3.2911578682
MESH:D010212 Papilloma Hydrogen Peroxide 3.6712065085
MESH:D010257 Paraneoplastic Syndromes Indomethacin 5.2816537180
MESH:D010300 Parkinson Disease Dieldrin 5.2011445065 11181820 16112328 17291500 16809432
MESH:D010300 Parkinson Disease Paraquat 5.2011124998 11445065 15451049 12911755 16140633 16510128 15824117 11181820
MESH:D010302 Parkinson Disease, Secondary Paraquat 4.0116190885
MESH:D020734 Parkinsonian Disorders Indomethacin 3.7512349958
MESH:D051302 Paroxysmal Hemicrania Indomethacin 5.2811903285
MESH:D010382 Peliosis Hepatis Tetrachlorodibenzodioxin 3.8112520081
MESH:D010437 Peptic Ulcer Indomethacin 4.7211148446
MESH:D010518 Periodontitis Indomethacin 4.4717225004
MESH:D016491 Peripheral Vascular Diseases Cadmium 4.9515687053
MESH:D010900 Pituitary Diseases Diethylstilbestrol 4.7314722030
MESH:D010911 Pituitary Neoplasms Diethylstilbestrol 4.2515687265 16977796
MESH:D010995 Pleural Diseases Asbestos, Serpentine 5.2710923243
MESH:D011014 Pneumonia Paraquat 4.0212504350
MESH:D011041 Poisoning Mustard Gas 3.4115727166
MESH:D011141 Polyuria Furosemide 5.2217945291
MESH:D017119 Porphyria Cutanea Tarda Tetrachlorodibenzodioxin 3.1518163543
MESH:D054198 Precursor Cell Lymphoblastic Leukemia-Lymphoma imatinib 4.2412476293
MESH:D047928 Premature Birth Indomethacin 4.7117000239
MESH:D011297 Prenatal Exposure Delayed Effects bisphenol A 25.9210548101
MESH:D011297 Prenatal Exposure Delayed Effects Diethylstilbestrol 25.9217184923
MESH:D011297 Prenatal Exposure Delayed Effects Lead 25.9216384672
MESH:D011297 Prenatal Exposure Delayed Effects Methylmercury Compounds 25.9218436314
MESH:D011297 Prenatal Exposure Delayed Effects Tetrachlorodibenzodioxin 25.9211222880 11896295 11118676 11399792
MESH:D019048 Prostatic Intraepithelial Neoplasia bisphenol A 9.2720887781
MESH:D019048 Prostatic Intraepithelial Neoplasia Estradiol 9.2720887781
MESH:D011471 Prostatic Neoplasms bisphenol A 2.7716740699
MESH:D011471 Prostatic Neoplasms Cadmium 2.7717075824
MESH:D011471 Prostatic Neoplasms Coumestrol 2.7716921512
MESH:D011471 Prostatic Neoplasms Diethylstilbestrol 2.7715046698 15846301 17136230
MESH:D011471 Prostatic Neoplasms Estradiol 2.7716740699
MESH:D011471 Prostatic Neoplasms Genistein 2.7715378649 16925846 15256057
MESH:D011471 Prostatic Neoplasms Raloxifene 2.7716536755 15731164 16220300
MESH:D011471 Prostatic Neoplasms Sodium Selenite 2.7718760546
MESH:D011471 Prostatic Neoplasms Vitamin E 2.7715084515
MESH:D011507 Proteinuria Indomethacin 8.0211849393
MESH:D011507 Proteinuria Tretinoin 8.0216636307
MESH:D011537 Pruritus Ethinyl Estradiol 8.1015861022 16919318
MESH:D011537 Pruritus Mustard Gas 8.1018058305
MESH:D011625 Pterygium Tretinoin 4.3616723453
MESH:D011629 Puberty, Precocious bisphenol A 4.3510548101
MESH:D011658 Pulmonary Fibrosis Asbestos, Serpentine 8.4218569384 15511213
MESH:D011658 Pulmonary Fibrosis Mustard Gas 8.4217620002 10334151 17720292 17894541 17266442
MESH:D011658 Pulmonary Fibrosis Paraquat 8.4217997886 16324872
MESH:D011693 Purpura Raloxifene 5.1115770314
MESH:D015427 Reperfusion Injury Furosemide 6.0616526316
MESH:D015427 Reperfusion Injury pirinixic acid 6.0619058328
MESH:D012128 Respiratory Distress Syndrome, Adult Furosemide 8.1715912074 16096441 12394941
MESH:D012128 Respiratory Distress Syndrome, Adult Paraquat 8.1711700416
MESH:D012135 Respiratory Sounds Paraquat 3.6411874814
MESH:D015619 Respiratory System Abnormalities marker/mechanism 11023856
MESH:D015619 Respiratory System Abnormalities Tetrachlorodibenzodioxin 3.4318990726
MESH:D012162 Retinal Degeneration Paraquat 3.5516458197
MESH:D012208 Rhabdomyosarcoma Tretinoin 3.7016283617 16116481
MESH:D012468 Salivary Gland Neoplasms Progesterone 2.6918045962
MESH:D012640 Seizures 2,6-dinitrotoluene 2.2518551238
MESH:D012871 Skin Diseases halofuginone 7.3511874485
MESH:D012871 Skin Diseases Mustard Gas 7.3512880345 15451306 16961503
MESH:D012871 Skin Diseases Vitamin E 7.3518709164
MESH:D012878 Skin Neoplasms Hydrogen Peroxide 8.2212065085
MESH:D012878 Skin Neoplasms Tetrachlorodibenzodioxin 8.2216192470
MESH:D012878 Skin Neoplasms Tretinoin 8.2216467112
MESH:D013088 Spermatocele Diethylstilbestrol 10.2516709447 16002989
MESH:D013088 Spermatocele Ethinyl Estradiol 10.2516709447
MESH:D013119 Spinal Cord Injuries Progesterone 3.8515862959 16503802
MESH:D016135 Spinal Dysraphism marker/mechanism 11023856
MESH:D013272 Stomach Diseases Indomethacin 3.9915472012 15038085 10215738 17638125 10486359 18209964 10192188 16280098 17207306 16184426 17160473 16113693 18545984
MESH:D013274 Stomach Neoplasms Furosemide 4.4417052386
MESH:D013274 Stomach Neoplasms imatinib 4.4415786421
MESH:D013274 Stomach Neoplasms Indomethacin 4.4415609394
MESH:D013274 Stomach Neoplasms Tretinoin 4.4417261132
MESH:D013276 Stomach Ulcer Indomethacin 3.2118299717 12500499 17657623 1323529 11523592 15104355 12787963 10750652 14567935 16150113 18193104 12077510 16169175 16397915 18237397 17627676 15255614 10878458 11729361 16252198 11595431 17895592 18181030 16755016 11595415 11145282 18087811 17977527 17918041 15138204 18209962 17135157 17654042 10423059 11906479 18431645 12467913 18543354 12498302 16631530 18726076 16934674
MESH:D020521 Stroke Raloxifene 7.5816837676
MESH:D020521 Stroke Vitamin E 7.5816517955
MESH:D019966 Substance-Related Disorders bisphenol A 3.5616684133 16045194
MESH:D019851 Thrombophilia Ethinyl Estradiol 3.2211994571
MESH:D013927 Thrombosis Ethinyl Estradiol 2.7915669648
MESH:D013959 Thyroid Diseases Tetrachlorodibenzodioxin 3.4612697716
MESH:D013964 Thyroid Neoplasms imatinib 10.3416940797
MESH:D013964 Thyroid Neoplasms Indomethacin 10.3418791128 14736730 11352223
MESH:D013964 Thyroid Neoplasms Tretinoin 10.3417045167 16026305
MESH:D013978 Tibial Fractures Estradiol 12.2519048282
MESH:D013978 Tibial Fractures Raloxifene 12.2519048282
MESH:D014062 Tongue Neoplasms Tretinoin 3.4116051514
MESH:D014202 Tremor Lead 5.0521145352
MESH:D014376 Tuberculosis Tretinoin 2.9516040207
MESH:D014456 Ulcer Indomethacin 4.4617380554 10574470
MESH:D001749 Urinary Bladder Neoplasms 2,6-dinitrotoluene 7.3416049721
MESH:D001749 Urinary Bladder Neoplasms Diethylstilbestrol 7.3416452187 16712894 17306315
MESH:D001749 Urinary Bladder Neoplasms Raloxifene 7.3417572228
MESH:D014570 Urologic Diseases Dichlorodiphenyl Dichloroethylene 5.3016487989
MESH:D014571 Urologic Neoplasms 2,6-dinitrotoluene 3.8910091137
MESH:D014581 Urticaria Acetaminophen 2.5810982225
MESH:D002583 Uterine Cervical Neoplasms Diethylstilbestrol 8.2716175088
MESH:D002583 Uterine Cervical Neoplasms Tretinoin 8.2716129372
MESH:D014591 Uterine Diseases bisphenol A 12.3514652134
MESH:D014591 Uterine Diseases Diethylstilbestrol 12.3514652134
MESH:D014594 Uterine Neoplasms Diethylstilbestrol 8.1216690809 15809267
MESH:D014594 Uterine Neoplasms Ethinyl Estradiol 8.1214692618
MESH:D014604 Uveal Neoplasms Tretinoin 4.1716752155
MESH:D014625 Vaginal Neoplasms Diethylstilbestrol 4.0216002989 16513791
MESH:D054079 Vascular Malformations Tetrachlorodibenzodioxin 4.1512125929
MESH:D054556 Venous Thromboembolism Raloxifene 4.7716837676
MESH:D020246 Venous Thrombosis Ethinyl Estradiol 3.1514671159 15869587
MESH:D014820 Vitiligo Tretinoin 3.6516761959
MESH:D014839 Vomiting Indomethacin 4.3111897121
MESH:D014846 Vulvar Neoplasms Raloxifene 5.1116343187
MESH:D019282 Wasting Syndrome Tetrachlorodibenzodioxin 3.8115886252
MESH:D009396 Wilms Tumor Tretinoin 3.6016287080
Pathway ID Pathway Name
KEGG:04020 Calcium signaling pathway
KEGG:04060 Cytokine-cytokine receptor interaction
KEGG:04144 Endocytosis
KEGG:04510 Focal adhesion
KEGG:04540 Gap junction
KEGG:05214 Glioma
KEGG:04010 MAPK signaling pathway
KEGG:05218 Melanoma
KEGG:05200 Pathways in cancer
KEGG:05215 Prostate cancer
KEGG:04810 Regulation of actin cytoskeleton
REACT:16888 Signaling by PDGF
Pharmacogenomics Knowledge Base Top
  • PharmGKB Accession:PA33147
    • No data
    Releated disease ID Related disease Name
    PA443836Cytomegalovirus Infections
    PA151958383Gastrointestinal Stromal Tumors
    PA446155Precursor Cell Lymphoblastic Leukemia-Lymphoma
    Releated drug ID Related drug Name
    PA162372840sunitinib
    PA10804imatinib
    Drug Bank Top
    Drugbank ID Action Drug Name Description
    DB00102 - Becaplermin Anti-Ulcer Agents;Topical
    DB00619 inhibitor Imatinib Antineoplastic Agents;Protein Kinase Inhibitors
    DB01268 inhibitor Sunitinib Antineoplastic Agents;Angiogenesis Inhibitors
    No data
    No data
    No data

    Simple Query:


      (e.g. CHD8)

    Syndromic Genes

    Non-syndromic Genes

    AutismKB Statistics

    • Studies: 1,036
    • Genes: 1,379
    • CNVs/SVs: 5,420
    • SNVs/Indels: 11,669
    • de novo Mutations: 5,669
    • Mosaics: 789
    • Linkage Regions: 172
    • Paper Collected: 6/30/2018
    • Last Update: 8/26/2018


    Copyright © 2017, Center for Bioinformatics , Peking University | All Rights Reserved