AutismKB 2.0

Annotation Detail for RAB6B


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Basic Information Top
Gene Symbol:RAB6B ( - )
Gene Full Name: RAB6B, member RAS oncogene family
Band: 3q22.1
Quick LinksEntrez ID:51560; OMIM: NA; Uniprot ID:RAB6B_HUMAN; ENSEMBL ID: ENSG00000154917; HGNC ID: 14902
Relate to Another Database: SFARIGene; denovo-db
Related Pathway Information Top
Related Diseases/Disorders Top
Comparative Toxicogenomics Database Top
Chemical ID Chemical Name Interaction Interaction Action Publication
D001104 Arbutin Arbutin results in decreased expression of RAB6B mRNAdecreases expression 17103032
D004040 Dietary Carbohydrates Dietary Carbohydrates results in decreased expression of RAB6B mRNAdecreases expression 17490981
D004052 Diethylnitrosamine Diethylnitrosamine results in increased expression of RAB6B mRNAincreases expression 17942915
D004052 Diethylnitrosamine MET protein inhibits the reaction [Diethylnitrosamine results in increased expression of RAB6B mRNA]decreases reaction|increases expression 17942915
C011890 kojic acid kojic acid results in decreased expression of RAB6B mRNAdecreases expression 16595896
D024505 Tocopherols Tocopherols results in increased expression of RAB6B mRNAincreases expression 17654050
D014635 Valproic Acid Valproic Acid results in increased expression of RAB6B mRNAincreases expression 19101580
Disease ID Disease Name Direct Evidence Inference Chemical Name Inference Score Publication
MESH:D000014 Abnormalities, Drug-Induced Valproic Acid 3.958875741
MESH:D000015 Abnormalities, Multiple Valproic Acid 4.2519490988
MESH:D000236 Adenoma Diethylnitrosamine 3.016695378 10737359
MESH:D018248 Adenoma, Liver Cell Diethylnitrosamine 4.3616434500 17620307 19061943 17162532 18056438 19052882
MESH:D000550 Amblyopia Valproic Acid 5.7517688650
MESH:D001008 Anxiety Disorders Valproic Acid 3.8317497229
MESH:D001321 Autistic Disorder Valproic Acid 1.9917688650 15238991 19460635 18177632 18396377 20603192 17157402 18316065 18940202 18775368 19232924 17507914 18558336 16609825 18985861
MESH:D001714 Bipolar Disorder Valproic Acid 3.2117594078 20046352
MESH:D001848 Bone Diseases, Developmental Valproic Acid 3.598888407
MESH:D001943 Breast Neoplasms Diethylnitrosamine 2.2017474063
MESH:D006528 Carcinoma, Hepatocellular Diethylnitrosamine 1.8717761372 18691550 18210153 16681979 20514400 10672840 20007298 19208518 3581430 20214788 19335982 16935385 16878318 18971187 17055752 11831363 17173139 20084675 18393292 20512989 17138121 16807293 19539802 16779866 17978847 19519916 19171122 19418558 19701751 18665156 18506893 16830150 19052882 10737359 19919837 16328049 18788625 16698587 16288022 18785209 3084413 16569478 20727157 20524982 16502159 19822196 17162532 17428255 20101231 19107877 19383236 19394651 16540662 20935162 18978308 20432363 18494052 21159647 18056438
MESH:D002471 Cell Transformation, Neoplastic Diethylnitrosamine 3.062727394 17174075 21159647 7505956
MESH:D002659 Child Development Disorders, Pervasive Valproic Acid 2.8020734317
MESH:D018281 Cholangiocarcinoma Diethylnitrosamine 3.9719052882
MESH:D019465 Craniofacial Abnormalities Valproic Acid 1.9017688650 8888407 16575769
MESH:D003924 Diabetes Mellitus, Type 2 Diethylnitrosamine 2.2520387270
MESH:D056486 Drug-Induced Liver Injury Diethylnitrosamine 4.2119107877
MESH:D056486 Drug-Induced Liver Injury Valproic Acid 4.2119641884 1733752
MESH:D004421 Dystonia Valproic Acid 4.401851702
MESH:D004831 Epilepsies, Myoclonic Valproic Acid 4.5717275665 3659116
MESH:D004828 Epilepsies, Partial Valproic Acid 4.443922381 16628512
MESH:D004827 Epilepsy Valproic Acid 3.0720417680 18234410
MESH:D004832 Epilepsy, Absence Valproic Acid 3.876254150 7562514 6426943
MESH:D017029 Epilepsy, Complex Partial Valproic Acid 4.717750514
MESH:D004830 Epilepsy, Tonic-Clonic Valproic Acid 4.533659116
MESH:D004931 Esophageal Achalasia Diethylnitrosamine 5.6416302075
MESH:D005234 Fatty Liver Diethylnitrosamine 8.9820387270 21071580
MESH:D005234 Fatty Liver Valproic Acid 8.9814986274 19224547
MESH:D005315 Fetal Diseases Valproic Acid 5.4116575769
MESH:D005317 Fetal Growth Retardation Valproic Acid 4.518888407 18558336
MESH:D006849 Hydrocephalus Valproic Acid 5.3317688650
MESH:D007249 Inflammation Diethylnitrosamine 2.5218785209
MESH:D015470 Leukemia, Myeloid, Acute Valproic Acid 2.1917596541 16294345
MESH:D008103 Liver Cirrhosis Diethylnitrosamine 2.9820032147 18522880 18665156 19638242 18407596
MESH:D008107 Liver Diseases Diethylnitrosamine 2.1617034775
MESH:D008113 Liver Neoplasms Diethylnitrosamine 2.3320452335 18977376 16942905 2422723 18754104 20583210 19812893 19090486 19427195 19073162 21278145 2862719 18644402 19254457 12112319 19996281 19833225 21167192 12771043 19642983 19690152 20434301 20137499 20405173 19638242 20501860 19499222 9163691 19426721 21071580 21047994 18648771 19256749 20118626 20492335 19850985 18978307 15175105 20101389 10737359 19551842 19294768 19255062 15885732
MESH:D008114 Liver Neoplasms, Experimental Diethylnitrosamine 6.8318544905 9362446 19126423 19004024 19539802 16842330 3124819 17942915 18079962 17854601 18775883 2563599 16267830 19519916 19009564 18282651 18093689 18164116 18253720 17174075 21159647 18308698
MESH:D008114 Liver Neoplasms, Experimental kojic acid 6.8318544905
MESH:D017563 Lung Diseases, Interstitial Valproic Acid 4.7817228818
MESH:D008175 Lung Neoplasms Diethylnitrosamine 1.7620512841 21163286 6695378 20970405
MESH:D008325 Mammary Neoplasms, Experimental Tocopherols 4.2617927505
MESH:D008654 Mesothelioma Tocopherols 4.2115878867
MESH:D008881 Migraine Disorders Valproic Acid 3.4118765137 18803445
MESH:D009139 Musculoskeletal Abnormalities Valproic Acid 4.358888407
MESH:D009190 Myelodysplastic Syndromes Valproic Acid 3.3117596541
MESH:D009362 Neoplasm Metastasis Diethylnitrosamine 2.673581430 9029167
MESH:D009436 Neural Tube Defects Valproic Acid 3.3216359493 8888407
MESH:D019636 Neurodegenerative Diseases Diethylnitrosamine 3.6120387270
MESH:D009461 Neurologic Manifestations Diethylnitrosamine 5.6420387270
MESH:D010190 Pancreatic Neoplasms Diethylnitrosamine 2.5116540662
MESH:D011230 Precancerous Conditions Diethylnitrosamine 3.842563599
MESH:D011297 Prenatal Exposure Delayed Effects Valproic Acid 4.2920603192
MESH:D011471 Prostatic Neoplasms Tocopherols 4.5512504091
MESH:D019310 Pseudolymphoma Valproic Acid 5.0612752131 11422049
MESH:D012208 Rhabdomyosarcoma Valproic Acid 4.5319155313
MESH:D012559 Schizophrenia Valproic Acid 2.1019110320 15737665
MESH:D012640 Seizures Valproic Acid 2.9416876388 3137016 14763951 11044598 11738929 17978042 1511512 15475178
MESH:D016135 Spinal Dysraphism Valproic Acid 4.0219490988
MESH:D013226 Status Epilepticus Valproic Acid 5.0612833885
MESH:D013274 Stomach Neoplasms Diethylnitrosamine 1.7618456281
MESH:D013964 Thyroid Neoplasms Diethylnitrosamine 3.227505956
MESH:D014178 Translocation, Genetic Valproic Acid 5.7517262798
MESH:D020194 Unverricht-Lundborg Syndrome Valproic Acid 4.983119515
MESH:D014564 Urogenital Abnormalities Valproic Acid 5.068888407
No data
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AutismKB Statistics

  • Studies: 1,036
  • Genes: 1,379
  • CNVs/SVs: 5,420
  • SNVs/Indels: 11,669
  • de novo Mutations: 5,669
  • Mosaics: 789
  • Linkage Regions: 172
  • Paper Collected: 6/30/2018
  • Last Update: 8/26/2018


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