AutismKB 2.0

Annotation Detail for IL23A


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Basic Information Top
Gene Symbol:IL23A ( IL-23,IL-23A,IL23P19,MGC79388,P19,SGRF )
Gene Full Name: interleukin 23, alpha subunit p19
Band: 12q13.3
Quick LinksEntrez ID:51561; OMIM: 605580; Uniprot ID:IL23A_HUMAN; ENSEMBL ID: ENSG00000110944; HGNC ID: 15488
Relate to Another Database: SFARIGene; denovo-db
Related Pathway Information Top
No data
Pathway IDPathway Name
hsa04630Jak-STAT signaling pathway
hsa04060Cytokine-cytokine receptor interaction
No data
Pathway IDPathway Name
200131IL23-mediated signaling events
200116ATF-2 transcription factor network
Pathway IDPathway Name
P00036Interleukin signaling pathway
No data
Related Diseases/Disorders Top
No data
No data
Desease Name
Crohn's disease rheumatoid arthritis sclerosis, systemic
IMMUNE
psoriasis
Desease Name
Psoriasis
No data
Comparative Toxicogenomics Database Top
Chemical ID Chemical Name Interaction Interaction Action Publication
D000119 Acetylmuramyl-Alanyl-Isoglutamine [Acetylmuramyl-Alanyl-Isoglutamine co-treated with Pam(3)CSK(4) peptide co-treated with IFNG protein] results in increased expression of [IL12B protein binds to IL23A protein]affects binding|affects cotreatment|increases expression 18490488
D000643 Ammonium Chloride Ammonium Chloride affects the expression of IL23A mRNAaffects expression 16483693
D001104 Arbutin Arbutin results in decreased expression of IL23A mRNAdecreases expression 17103032
D001564 Benzo(a)pyrene Benzo(a)pyrene results in increased expression of IL23A mRNAincreases expression 20064835
D047071 beta-Glucans beta-Glucans results in increased expression of [IL12B protein binds to IL23A protein]affects binding|increases expression 18490488
D047071 beta-Glucans beta-Glucans results in increased expression of IL23A mRNAincreases expression 18490488
D047071 beta-Glucans IFNG protein inhibits the reaction [beta-Glucans results in increased expression of [IL12B protein binds to IL23A protein]]affects binding|decreases reaction|increases expression 18490488
D047071 beta-Glucans IFNG protein inhibits the reaction [beta-Glucans results in increased expression of IL23A mRNA]decreases reaction|increases expression 18490488
D047071 beta-Glucans R 848 promotes the reaction [beta-Glucans results in increased expression of [IL12B protein binds to IL23A protein]]affects binding|increases expression|increases reaction 18490488
D047071 beta-Glucans R 848 promotes the reaction [beta-Glucans results in increased expression of IL23A mRNA]increases expression|increases reaction 18490488
D004391 Dust Dust results in increased expression of IL23A mRNAincreases expression 17805423
D005576 Forskolin Forskolin results in increased expression of [IL12B protein binds to IL23A protein]affects binding|increases expression 15180965
D005576 Forskolin Forskolin results in increased expression of IL23A proteinincreases expression 15180965
C031927 hydroquinone hydroquinone inhibits the reaction [Lipopolysaccharides results in increased expression of IL23A mRNA]decreases reaction|increases expression 17464197
D008070 Lipopolysaccharides [Lipopolysaccharides co-treated with R 848] results in increased expression of [IL12B protein binds to IL23A protein]affects binding|affects cotreatment|increases expression 18490488
D008070 Lipopolysaccharides Lipopolysaccharides results in increased expression of IL23A mRNAincreases expression 15516327
15860229
D008070 Lipopolysaccharides hydroquinone inhibits the reaction [Lipopolysaccharides results in increased expression of IL23A mRNA]decreases reaction|increases expression 17464197
D008070 Lipopolysaccharides Lipopolysaccharides results in increased expression of IL23A mRNAincreases expression 17464197
C508075 Pam(3)CSK(4) peptide [Acetylmuramyl-Alanyl-Isoglutamine co-treated with Pam(3)CSK(4) peptide co-treated with IFNG protein] results in increased expression of [IL12B protein binds to IL23A protein]affects binding|affects cotreatment|increases expression 18490488
D010457 Peptidoglycan Peptidoglycan results in increased expression of IL23A mRNAincreases expression 15860229
D015240 Phorbol 12,13-Dibutyrate Phorbol 12,13-Dibutyrate results in increased expression of IL23A mRNAincreases expression 15516327
D015232 Dinoprostone CSF2 protein promotes the reaction [Dinoprostone results in increased expression of [IL12B protein binds to IL23A protein]]affects binding|increases expression|increases reaction 15180965
D015232 Dinoprostone Dinoprostone results in increased expression of [IL12B protein binds to IL23A protein]affects binding|increases expression 15180965
D015232 Dinoprostone Dinoprostone results in increased expression of IL23A proteinincreases expression 15180965
C402365 R 848 IFNG protein promotes the reaction [[Zymosan co-treated with R 848] results in increased expression of [IL12B protein binds to IL23A protein]]affects binding|affects cotreatment|increases expression|increases reaction 18490488
C402365 R 848 [Lipopolysaccharides co-treated with R 848] results in increased expression of [IL12B protein binds to IL23A protein]affects binding|affects cotreatment|increases expression 18490488
C402365 R 848 R 848 promotes the reaction [beta-Glucans results in increased expression of [IL12B protein binds to IL23A protein]]affects binding|increases expression|increases reaction 18490488
C402365 R 848 R 848 promotes the reaction [beta-Glucans results in increased expression of IL23A mRNA]increases expression|increases reaction 18490488
C402365 R 848 [Zymosan co-treated with R 848] results in increased expression of [IL12B protein binds to IL23A protein]affects binding|affects cotreatment|increases expression 18490488
C045282 roquinimex roquinimex results in decreased expression of IL23A mRNAdecreases expression 15270847
C121329 sanglifehrin A sanglifehrin A results in decreased expression of IL23A mRNAdecreases expression 12847216
D018038 Sodium Selenite Sodium Selenite results in increased expression of IL23A mRNAincreases expression 18175754
C009687 wortmannin wortmannin inhibits the reaction [C5 protein results in decreased expression of IL23A mRNA]decreases expression|decreases reaction 16116186
D015054 Zymosan IFNG protein promotes the reaction [[Zymosan co-treated with R 848] results in increased expression of [IL12B protein binds to IL23A protein]]affects binding|affects cotreatment|increases expression|increases reaction 18490488
D015054 Zymosan IFNG protein promotes the reaction [Zymosan results in increased expression of [IL12B protein binds to IL23A protein]]affects binding|increases expression|increases reaction 18490488
D015054 Zymosan [Zymosan co-treated with R 848] results in increased expression of [IL12B protein binds to IL23A protein]affects binding|affects cotreatment|increases expression 18490488
D015054 Zymosan Zymosan results in increased expression of [IL12B protein binds to IL23A protein]affects binding|increases expression 18490488
Disease ID Disease Name Direct Evidence Inference Chemical Name Inference Score Publication
MESH:D000138 Acidosis Ammonium Chloride 3.5018287403
MESH:D055371 Acute Lung Injury Lipopolysaccharides 3.9718653653 11850527
MESH:D000230 Adenocarcinoma Benzo(a)pyrene 1.9720464547 20127859
MESH:D000236 Adenoma Benzo(a)pyrene 2.616695378
MESH:D011125 Adenomatous Polyposis Coli Dinoprostone 4.9717942926
MESH:D000740 Anemia Zymosan 4.4918664788
MESH:D001014 Aortic Aneurysm Dinoprostone 5.5410231640
MESH:D017544 Aortic Aneurysm, Abdominal Benzo(a)pyrene 11.7819183758
MESH:D017544 Aortic Aneurysm, Abdominal Dinoprostone 11.7810388637
MESH:D001169 Arthritis, Experimental Zymosan 4.0815142272 15188379 16872482 15944321 17659584
MESH:D001477 Bartter Syndrome Dinoprostone 5.6815976003
MESH:D001943 Breast Neoplasms Benzo(a)pyrene 2.0520146248 17474063
MESH:D002294 Carcinoma, Squamous Cell Benzo(a)pyrene 2.0320419170
MESH:D002471 Cell Transformation, Neoplastic Dinoprostone 4.1716192471
MESH:D019457 Chromosome Breakage Sodium Selenite 4.6915894690
MESH:D003920 Diabetes Mellitus Sodium Selenite 3.7216285004
MESH:D003967 Diarrhea Dinoprostone 4.4911488427 10446763 7237001
MESH:D056486 Drug-Induced Liver Injury Sodium Selenite 2.2715131321
MESH:D004487 Edema Zymosan 3.937907874
MESH:D019446 Endotoxemia Lipopolysaccharides 4.3315328337 15821434 17637181
MESH:D004938 Esophageal Neoplasms Benzo(a)pyrene 1.9916530937
MESH:D005334 Fever Dinoprostone 9.4316997862 11852909
MESH:D005334 Fever Lipopolysaccharides 9.439205823 11852909
MESH:D006330 Heart Defects, Congenital Benzo(a)pyrene 2.6220471113
MESH:D006463 Hemolytic-Uremic Syndrome Lipopolysaccharides 4.3216366002
MESH:D006505 Hepatitis Zymosan 4.6319110552
MESH:D006930 Hyperalgesia Dinoprostone 4.4716793879
MESH:D007249 Inflammation Lipopolysaccharides 5.5617963957 17237260 9205823 12878042 17255318
MESH:D007249 Inflammation Zymosan 5.5611289658 8014878
MESH:D007333 Insulin Resistance Sodium Selenite 3.2314714311
MESH:D019189 Iron Metabolism Disorders Lipopolysaccharides 4.5717255318
MESH:D043183 Irritable Bowel Syndrome Zymosan 5.7817553498
MESH:D007970 Leukopenia Lipopolysaccharides 4.6415821434
MESH:D008106 Liver Cirrhosis, Experimental Dinoprostone 3.1415816358
MESH:D008106 Liver Cirrhosis, Experimental Lipopolysaccharides 3.1412878042
MESH:D008107 Liver Diseases Dinoprostone 3.4415816358
MESH:D008113 Liver Neoplasms Benzo(a)pyrene 2.0221137059 20195826
MESH:D055370 Lung Injury Lipopolysaccharides 3.9421114838
MESH:D008175 Lung Neoplasms Benzo(a)pyrene 1.5620464547 6695378 18816296 18520028 18569708 17053015 20869020 20135361 20064080
MESH:D016393 Lymphoma, B-Cell Sodium Selenite 4.0014737004
MESH:D020326 Migraine without Aura Dinoprostone 5.2011304026
MESH:D009062 Mouth Neoplasms Benzo(a)pyrene 3.1416381670
MESH:D009102 Multiple Organ Failure Zymosan 5.1415834315 10479408 10890648 18160304 15213630 12130978 12879239 15241586 17724436 15259001
MESH:D009369 Neoplasms Benzo(a)pyrene 2.1411141357
MESH:D010005 Osteoarthropathy, Secondary Hypertrophic Dinoprostone 6.4218500342
MESH:D010538 Peritonitis Zymosan 4.8219088179 15979727 18557954 14761945 17826846 11985352 15259001 18760300 19641140 18977430 17371808
MESH:D011014 Pneumonia Lipopolysaccharides 4.4912224865 11605937
MESH:D011471 Prostatic Neoplasms Benzo(a)pyrene 3.2417292933
MESH:D011471 Prostatic Neoplasms Sodium Selenite 3.2418760546
MESH:D011565 Psoriasis marker/mechanism 20953190 19169254
MESH:D012130 Respiratory Hypersensitivity Lipopolysaccharides 3.6910835634
MESH:D018805 Sepsis Zymosan 4.5911441115
MESH:D012878 Skin Neoplasms Benzo(a)pyrene 2.3419755658 10029692
MESH:D013274 Stomach Neoplasms Benzo(a)pyrene 1.562093021 20155912
MESH:D013921 Thrombocytopenia Lipopolysaccharides 4.1015821434
MESH:D001749 Urinary Bladder Neoplasms Benzo(a)pyrene 2.1517053015
MESH:D014605 Uveitis Zymosan 5.3411006244
Pathway ID Pathway Name
KEGG:04060 Cytokine-cytokine receptor interaction
KEGG:04630 Jak-STAT signaling pathway
KEGG:05323 Rheumatoid arthritis
KEGG:05152 Tuberculosis
Pharmacogenomics Knowledge Base Top
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Syndromic Genes

Non-syndromic Genes

AutismKB Statistics

  • Studies: 1,036
  • Genes: 1,379
  • CNVs/SVs: 5,420
  • SNVs/Indels: 11,669
  • de novo Mutations: 5,669
  • Mosaics: 789
  • Linkage Regions: 172
  • Paper Collected: 6/30/2018
  • Last Update: 8/26/2018


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