AutismKB 2.0

Annotation Detail for PDGFRL


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Basic Information Top
Gene Symbol:PDGFRL ( PDGRL,PRLTS )
Gene Full Name: platelet-derived growth factor receptor-like
Band: 8p22
Quick LinksEntrez ID:5157; OMIM: 604584; Uniprot ID:PGFRL_HUMAN; ENSEMBL ID: ENSG00000104213; HGNC ID: 8805
Relate to Another Database: SFARIGene; denovo-db
Related Pathway Information Top
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Pathway IDPathway Name
P00047PDGF signaling pathway
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Related Diseases/Disorders Top
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Desease Name
Colorectal cancer
Hepatocellular cancer
Comparative Toxicogenomics Database Top
Chemical ID Chemical Name Interaction Interaction Action Publication
D000082 Acetaminophen Acetaminophen affects the expression of PDGFRL mRNAaffects expression 17562736
D000638 Amiodarone Amiodarone results in increased expression of PDGFRL mRNAincreases expression 19774075
D001564 Benzo(a)pyrene Benzo(a)pyrene results in decreased expression of PDGFRL mRNAdecreases expression 20106945
D016572 Cyclosporine Cyclosporine results in increased expression of PDGFRL mRNAincreases expression 20106945
C014347 decitabine decitabine results in increased expression of PDGFRL mRNAincreases expression 15251184
C014347 decitabine [Tetrachlorodibenzodioxin co-treated with decitabine] results in increased expression of PDGFRL mRNAaffects cotreatment|increases expression 15251184
D004041 Dietary Fats Dietary Fats results in increased expression of PDGFRL mRNAincreases expression 18042831
D004054 Diethylstilbestrol Diethylstilbestrol results in increased expression of PDGFRL mRNAincreases expression 17005392
C041786 palm oil palm oil results in increased expression of PDGFRL mRNAincreases expression 18042831
C006253 pirinixic acid pirinixic acid results in increased expression of PDGFRL mRNAincreases expression 18301758
D013749 Tetrachlorodibenzodioxin Tetrachlorodibenzodioxin results in decreased expression of PDGFRL mRNAdecreases expression 20106945
D013749 Tetrachlorodibenzodioxin [Tetrachlorodibenzodioxin co-treated with decitabine] results in increased expression of PDGFRL mRNAaffects cotreatment|increases expression 15251184
D013749 Tetrachlorodibenzodioxin Tetrachlorodibenzodioxin results in increased expression of PDGFRL mRNAincreases expression 15251184
Disease ID Disease Name Direct Evidence Inference Chemical Name Inference Score Publication
MESH:D000014 Abnormalities, Drug-Induced Tetrachlorodibenzodioxin 3.0814514962 15322242 11752688
MESH:D055371 Acute Lung Injury pirinixic acid 3.3018653653
MESH:D000230 Adenocarcinoma Benzo(a)pyrene 2.0220464547 20127859
MESH:D000236 Adenoma Benzo(a)pyrene 2.746695378
MESH:D018248 Adenoma, Liver Cell pirinixic acid 10.7116434500
MESH:D018248 Adenoma, Liver Cell Tetrachlorodibenzodioxin 10.7116835633
MESH:D000686 Amyloidosis Diethylstilbestrol 4.6815469931
MESH:D000740 Anemia Tetrachlorodibenzodioxin 3.1111748828
MESH:D000799 Angioedema Acetaminophen 4.1110982225
MESH:D017544 Aortic Aneurysm, Abdominal Benzo(a)pyrene 4.2919183758
MESH:D001145 Arrhythmias, Cardiac Amiodarone 3.9618218290 18057881 20041841
MESH:D001161 Arteriosclerosis Dietary Fats 4.1015238619
MESH:D001281 Atrial Fibrillation Amiodarone 4.0319698954 18651412
MESH:D001321 Autistic Disorder Acetaminophen 1.4118445737
MESH:D001778 Blood Coagulation Disorders Amiodarone 16.3419483382
MESH:D001778 Blood Coagulation Disorders pirinixic acid 16.3419483382
MESH:D001778 Blood Coagulation Disorders Tetrachlorodibenzodioxin 16.3412125929
MESH:D001836 Body Weight Changes Tetrachlorodibenzodioxin 4.0615340226
MESH:D001848 Bone Diseases, Developmental Tetrachlorodibenzodioxin 2.8715746008
MESH:D001943 Breast Neoplasms Benzo(a)pyrene 2.3820146248 17474063
MESH:D001943 Breast Neoplasms decitabine 2.3819208741 18320071
MESH:D001943 Breast Neoplasms Dietary Fats 2.3820435547
MESH:D001943 Breast Neoplasms Diethylstilbestrol 2.3815324884 17129689
MESH:D001943 Breast Neoplasms Tetrachlorodibenzodioxin 2.3820435547
MESH:D002277 Carcinoma Tetrachlorodibenzodioxin 2.9316835633
MESH:D006528 Carcinoma, Hepatocellular marker/mechanism
MESH:D006528 Carcinoma, Hepatocellular Acetaminophen 3.073084413
MESH:D006528 Carcinoma, Hepatocellular Diethylstilbestrol 3.0716924424 15948411
MESH:D002294 Carcinoma, Squamous Cell Benzo(a)pyrene 4.8220419170
MESH:D002294 Carcinoma, Squamous Cell decitabine 4.8219215824
MESH:D006332 Cardiomegaly Tetrachlorodibenzodioxin 2.4516120746 18850075 18670907
MESH:D002311 Cardiomyopathy, Dilated Amiodarone 2.9419225199 15710769
MESH:D002341 Carotid Artery Thrombosis Amiodarone 5.3218974383
MESH:D002386 Cataract Acetaminophen 2.6710977129
MESH:D002471 Cell Transformation, Neoplastic Cyclosporine 2.6412371664
MESH:D018281 Cholangiocarcinoma Tetrachlorodibenzodioxin 3.3116835633
MESH:D002779 Cholestasis Cyclosporine 8.1819486331
MESH:D002779 Cholestasis pirinixic acid 8.1819176532
MESH:D002972 Cleft Palate Tetrachlorodibenzodioxin 2.1612621046 8697196 15668235 15340226 16354765
MESH:D003110 Colonic Neoplasms decitabine 2.3617616700
MESH:D015179 Colorectal Neoplasms marker/mechanism
MESH:D015179 Colorectal Neoplasms decitabine 2.1018981723
MESH:D000013 Congenital Abnormalities Tetrachlorodibenzodioxin 3.2117141729 14669216
MESH:D019465 Craniofacial Abnormalities Tetrachlorodibenzodioxin 1.2620055451 15322242 10048152
MESH:D003456 Cryptorchidism Diethylstilbestrol 4.7516002989 12952375
MESH:D003876 Dermatitis, Atopic pirinixic acid 2.4918249437
MESH:D003924 Diabetes Mellitus, Type 2 Tetrachlorodibenzodioxin 1.7017107852
MESH:D056486 Drug-Induced Liver Injury Acetaminophen 6.4318713872 11834606 16177239 12153990 19164858 12540782 11739529 16227642 19085960 19416960 11529661 18071297 12392966 11461765 16485898 10663392 11743745 10915739 12594235 19739265 10774834 11287661 16109766 14986274 19420014 12705907 19923254 15968718 16393943 17906064 19370779 17522070 12958197 14725611 17562736 14550746 2444490 11421492 15619225 16781746 16081117
MESH:D056486 Drug-Induced Liver Injury Amiodarone 6.4318218290 15265979
MESH:D056486 Drug-Induced Liver Injury Tetrachlorodibenzodioxin 6.4320420201
MESH:D056487 Drug-Induced Liver Injury, Chronic Acetaminophen 4.3619426721
MESH:D004362 Drug Toxicity Tetrachlorodibenzodioxin 2.8911462148
MESH:D050171 Dyslipidemias Dietary Fats 3.5718367378
MESH:D004487 Edema pirinixic acid 7.1112083418
MESH:D004487 Edema Tetrachlorodibenzodioxin 7.1111000095 12711302
MESH:D004489 Edema, Cardiac Tetrachlorodibenzodioxin 4.1716714409 15322242 18230668
MESH:D004701 Endocrine Gland Neoplasms decitabine 5.3819294695
MESH:D004714 Endometrial Hyperplasia Diethylstilbestrol 4.9316402032
MESH:D016889 Endometrial Neoplasms Diethylstilbestrol 3.5715700306 16804899
MESH:D004715 Endometriosis Tetrachlorodibenzodioxin 3.189294722 10568697
MESH:D004938 Esophageal Neoplasms Benzo(a)pyrene 2.0416530937
MESH:D005124 Eye Abnormalities Tetrachlorodibenzodioxin 3.1411564622
MESH:D005234 Fatty Liver Amiodarone 20.2614986274
MESH:D005234 Fatty Liver Cyclosporine 20.2619224547
MESH:D005234 Fatty Liver Dietary Fats 20.2617967931 18296743 19004024 19551842
MESH:D005234 Fatty Liver pirinixic acid 20.2619236843 20131406
MESH:D052776 Female Urogenital Diseases Diethylstilbestrol 3.7516611131 16002989 16513791 15751030 16534752
MESH:D005313 Fetal Death Tetrachlorodibenzodioxin 3.6711858732
MESH:D005355 Fibrosis Cyclosporine 16.0312168785 12639820
MESH:D005355 Fibrosis Dietary Fats 16.0318296743
MESH:D005355 Fibrosis Tetrachlorodibenzodioxin 16.0320067830
MESH:D005756 Gastritis Acetaminophen 3.9416983495
MESH:D005833 Genital Neoplasms, Female Diethylstilbestrol 5.1816452187
MESH:D005885 Gingival Hyperplasia Cyclosporine 4.468708960
MESH:D006058 Gonadal Disorders Tetrachlorodibenzodioxin 4.8610696789
MESH:D006258 Head and Neck Neoplasms decitabine 3.6019215824
MESH:D006330 Heart Defects, Congenital Benzo(a)pyrene 6.7220471113
MESH:D006330 Heart Defects, Congenital Tetrachlorodibenzodioxin 6.7210048152 11294989
MESH:D006333 Heart Failure pirinixic acid 2.6320558911
MESH:D006457 Hemoglobinuria, Paroxysmal Cyclosporine 4.6615720958
MESH:D006470 Hemorrhage Tetrachlorodibenzodioxin 3.5111000095
MESH:D006529 Hepatomegaly Amiodarone 15.7215265979
MESH:D006529 Hepatomegaly pirinixic acid 15.7218467677 16221962 19176532 19772884
MESH:D006529 Hepatomegaly Tetrachlorodibenzodioxin 15.7212621046 16120746 15340226
MESH:D006869 Hydronephrosis Tetrachlorodibenzodioxin 4.318697196 15340226 18606429 16354765 16959395
MESH:D006930 Hyperalgesia Acetaminophen 2.8416870215
MESH:D006937 Hypercholesterolemia Amiodarone 9.759751232 8137927
MESH:D006937 Hypercholesterolemia Dietary Fats 9.7521332399
MESH:D006943 Hyperglycemia pirinixic acid 3.3420558911
MESH:D006949 Hyperlipidemias Dietary Fats 3.8021332399
MESH:D006965 Hyperplasia Diethylstilbestrol 4.6512960047 14722030
MESH:D006973 Hypertension Cyclosporine 5.1410903974
MESH:D006973 Hypertension Tetrachlorodibenzodioxin 5.1418670907 18850075
MESH:D007021 Hypospadias Diethylstilbestrol 4.7916002989
MESH:D007037 Hypothyroidism Amiodarone 4.7318020914 17991464
MESH:D007246 Infertility Diethylstilbestrol 4.5515036965
MESH:D007248 Infertility, Male decitabine 3.3117581917
MESH:D007249 Inflammation Dietary Fats 5.1920412841
MESH:D007249 Inflammation Tetrachlorodibenzodioxin 5.1912878042 12200463
MESH:D007333 Insulin Resistance Dietary Fats 7.6118457598 11836018
MESH:D007333 Insulin Resistance pirinixic acid 7.6116306350
MESH:D007569 Jaw Abnormalities Tetrachlorodibenzodioxin 3.5116580747
MESH:D007638 Keratoconjunctivitis Sicca Cyclosporine 4.7115604871
MESH:D007674 Kidney Diseases Acetaminophen 6.1015629191 12587719
MESH:D007674 Kidney Diseases Cyclosporine 6.108314463 10903974 18776723
MESH:D007680 Kidney Neoplasms Cyclosporine 7.9412371664
MESH:D007680 Kidney Neoplasms Diethylstilbestrol 7.9415003126 16762066 14681315
MESH:D007859 Learning Disorders Diethylstilbestrol 4.2817184923
MESH:D007938 Leukemia decitabine 3.1519235587 18980019
MESH:D007951 Leukemia, Myeloid decitabine 4.1719117987 18454857 17236224
MESH:D015470 Leukemia, Myeloid, Acute decitabine 2.4017679729 18206229 19387464 18704418 18460780 19010910
MESH:D015477 Leukemia, Myelomonocytic, Chronic decitabine 5.7318055864
MESH:D008064 Lipidoses Amiodarone 3.6315342952 17567588
MESH:D008103 Liver Cirrhosis Dietary Fats 2.9618296743
MESH:D008106 Liver Cirrhosis, Experimental pirinixic acid 2.1815474484
MESH:D008106 Liver Cirrhosis, Experimental Tetrachlorodibenzodioxin 2.1812878042
MESH:D008107 Liver Diseases Acetaminophen 1.6619784758 16611625 19014921 16610002 19460945 11587558 12969438 12587719
MESH:D017114 Liver Failure, Acute Acetaminophen 3.4017185352 16871587
MESH:D008113 Liver Neoplasms Benzo(a)pyrene 11.1721137059 20195826
MESH:D008113 Liver Neoplasms Diethylstilbestrol 11.1716712894 15890375
MESH:D008113 Liver Neoplasms pirinixic acid 11.1720007298 15890375 16377806
MESH:D008113 Liver Neoplasms Tetrachlorodibenzodioxin 11.1716984957
MESH:D008114 Liver Neoplasms, Experimental Tetrachlorodibenzodioxin 2.2012151625
MESH:D008133 Long QT Syndrome Amiodarone 3.7111989578 15350150 17391786
MESH:D008171 Lung Diseases Amiodarone 3.4812587719
MESH:D017563 Lung Diseases, Interstitial Amiodarone 4.7418516814
MESH:D008175 Lung Neoplasms Benzo(a)pyrene 2.2220064080 20464547 18569708 6695378 18816296 20135361 20869020 17053015 18520028
MESH:D008175 Lung Neoplasms Tetrachlorodibenzodioxin 2.2219555203 11884234
MESH:D008181 Lupus Nephritis Diethylstilbestrol 5.3915166399
MESH:D008223 Lymphoma decitabine 8.1319470736
MESH:D008223 Lymphoma Diethylstilbestrol 8.1315700306
MESH:D052801 Male Urogenital Diseases Diethylstilbestrol 5.7816002989
MESH:D008545 Melanoma decitabine 2.2617785578 16505122
MESH:D008546 Melanoma, Experimental Acetaminophen 3.7819513568
MESH:D008664 Metal Metabolism, Inborn Errors Cyclosporine 5.0516801185
MESH:D009062 Mouth Neoplasms Benzo(a)pyrene 3.3216381670
MESH:D009101 Multiple Myeloma decitabine 3.4618172295
MESH:D009135 Muscular Diseases pirinixic acid 3.7216239165
MESH:D009181 Mycoses Amiodarone 5.1717974566 12754197
MESH:D009190 Myelodysplastic Syndromes decitabine 3.4719157545 16882708 18608210 19010910
MESH:D009203 Myocardial Infarction pirinixic acid 2.2019151258
MESH:D017202 Myocardial Ischemia Tetrachlorodibenzodioxin 3.1612213967
MESH:D015428 Myocardial Reperfusion Injury pirinixic acid 3.0816411023
MESH:D009369 Neoplasms Benzo(a)pyrene 12.5311141357
MESH:D009369 Neoplasms decitabine 12.5317925555 19116145 19470736
MESH:D009369 Neoplasms Diethylstilbestrol 12.5315313581
MESH:D009369 Neoplasms pirinixic acid 12.5317405874
MESH:D009402 Nephrosis, Lipoid Cyclosporine 4.7117954296
MESH:D009404 Nephrotic Syndrome Cyclosporine 3.4418481113 19348381
MESH:D009421 Nervous System Malformations Diethylstilbestrol 10.3111399458
MESH:D009421 Nervous System Malformations Tetrachlorodibenzodioxin 10.3114600291
MESH:D019636 Neurodegenerative Diseases Acetaminophen 3.0118514411
MESH:D009765 Obesity Dietary Fats 4.5611836018 17217161 16723640 18674790 18457598 21332399 19632207 20132043 20518802
MESH:D009765 Obesity pirinixic acid 4.5620558911
MESH:D010051 Ovarian Neoplasms decitabine 2.6919331143 19259094
MESH:D010146 Pain Acetaminophen 2.5316870215
MESH:D010190 Pancreatic Neoplasms decitabine 2.8219294695
MESH:D010382 Peliosis Hepatis Tetrachlorodibenzodioxin 4.5112520081
MESH:D010900 Pituitary Diseases Diethylstilbestrol 5.4314722030
MESH:D010911 Pituitary Neoplasms Diethylstilbestrol 4.8915687265 16977796
MESH:D017119 Porphyria Cutanea Tarda Tetrachlorodibenzodioxin 3.7618163543
MESH:D011230 Precancerous Conditions Cyclosporine 3.3712371664
MESH:D011297 Prenatal Exposure Delayed Effects Diethylstilbestrol 10.3717184923
MESH:D011297 Prenatal Exposure Delayed Effects Tetrachlorodibenzodioxin 10.3711896295 11118676 11222880 11399792
MESH:D055728 Primary Myelofibrosis decitabine 4.9417616702
MESH:D011471 Prostatic Neoplasms Benzo(a)pyrene 3.2417292933
MESH:D011471 Prostatic Neoplasms Diethylstilbestrol 3.2415046698 17136230 15846301
MESH:D011565 Psoriasis Cyclosporine 2.2816882103
MESH:D011658 Pulmonary Fibrosis Amiodarone 2.9112490602 11597910 12832656
MESH:D015427 Reperfusion Injury pirinixic acid 2.4619058328
MESH:D015619 Respiratory System Abnormalities Tetrachlorodibenzodioxin 4.0418990726
MESH:D012208 Rhabdomyosarcoma decitabine 4.5919155313
OMIM:609620 SHORT QT SYNDROME 1 Amiodarone 5.3218724381
MESH:D012878 Skin Neoplasms Benzo(a)pyrene 5.7219755658 10029692
MESH:D012878 Skin Neoplasms Tetrachlorodibenzodioxin 5.7216192470
MESH:D013088 Spermatocele Diethylstilbestrol 4.9816709447 16002989
MESH:D013274 Stomach Neoplasms Benzo(a)pyrene 2.492093021 20155912
MESH:D013274 Stomach Neoplasms decitabine 2.4919037991
MESH:D013276 Stomach Ulcer Amiodarone 3.4818087811
MESH:D013610 Tachycardia Amiodarone 4.4911238279
MESH:D017180 Tachycardia, Ventricular Amiodarone 4.3919225199
MESH:D013959 Thyroid Diseases Amiodarone 12.9519731979
MESH:D013959 Thyroid Diseases Tetrachlorodibenzodioxin 12.9512697716
MESH:D013964 Thyroid Neoplasms decitabine 3.4617967635
MESH:D013971 Thyrotoxicosis Amiodarone 5.0819584973 18020914
MESH:D016171 Torsades de Pointes Amiodarone 4.4317467628 11989578
MESH:D001749 Urinary Bladder Neoplasms Benzo(a)pyrene 8.7417053015
MESH:D001749 Urinary Bladder Neoplasms decitabine 8.7417616700 19087683
MESH:D001749 Urinary Bladder Neoplasms Diethylstilbestrol 8.7416712894 16452187 17306315
MESH:D014581 Urticaria Acetaminophen 3.1610982225
MESH:D002583 Uterine Cervical Neoplasms Diethylstilbestrol 4.1916175088
MESH:D014591 Uterine Diseases Diethylstilbestrol 5.4314652134
MESH:D014594 Uterine Neoplasms Diethylstilbestrol 4.2716690809 15809267
MESH:D014604 Uveal Neoplasms decitabine 5.1817785578
MESH:D014605 Uveitis Cyclosporine 4.251336536
MESH:D014625 Vaginal Neoplasms Diethylstilbestrol 4.6516513791 16002989
MESH:D054079 Vascular Malformations Tetrachlorodibenzodioxin 4.8612125929
MESH:D019282 Wasting Syndrome Tetrachlorodibenzodioxin 4.5115886252
MESH:D015430 Weight Gain Dietary Fats 3.8916723640
MESH:D014985 Xerophthalmia Cyclosporine 4.7117120751
No data
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Syndromic Genes

Non-syndromic Genes

AutismKB Statistics

  • Studies: 1,036
  • Genes: 1,379
  • CNVs/SVs: 5,420
  • SNVs/Indels: 11,669
  • de novo Mutations: 5,669
  • Mosaics: 789
  • Linkage Regions: 172
  • Paper Collected: 6/30/2018
  • Last Update: 8/26/2018


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