AutismKB 2.0

Annotation Detail for GDE1


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Basic Information Top
Gene Symbol:GDE1 ( 363E6.2,MIR16 )
Gene Full Name: glycerophosphodiester phosphodiesterase 1
Band: 16p12.3
Quick LinksEntrez ID:51573; OMIM: 605943; Uniprot ID:GDE1_HUMAN; ENSEMBL ID: ENSG00000006007; HGNC ID: 29644
Relate to Another Database: SFARIGene; denovo-db
Related Pathway Information Top
Pathway IDPathway Name
PWY0-381glycerol degradation I
No data
No data
No data
No data
No data
Related Diseases/Disorders Top
Comparative Toxicogenomics Database Top
Chemical ID Chemical Name Interaction Interaction Action Publication
D015123 7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide 7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide results in decreased expression of GDE1 mRNAdecreases expression 20018196
C010176 halofuginone halofuginone results in decreased expression of GDE1 mRNAdecreases expression 17180598
C006253 pirinixic acid pirinixic acid results in increased expression of GDE1 mRNAincreases expression 12832660
D013752 Tetracycline Tetracycline results in decreased expression of GDE1 mRNAdecreases expression 16917069
Disease ID Disease Name Direct Evidence Inference Chemical Name Inference Score Publication
MESH:D055371 Acute Lung Injury pirinixic acid 3.5818653653
MESH:D018248 Adenoma, Liver Cell pirinixic acid 4.1116434500
MESH:D001778 Blood Coagulation Disorders pirinixic acid 3.5719483382
MESH:D002471 Cell Transformation, Neoplastic 7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide 2.9820889678
MESH:D002779 Cholestasis pirinixic acid 3.1219176532
MESH:D003876 Dermatitis, Atopic pirinixic acid 2.5718249437
MESH:D056486 Drug-Induced Liver Injury Tetracycline 3.0017522070
MESH:D004487 Edema pirinixic acid 2.9012083418
MESH:D004938 Esophageal Neoplasms 7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide 2.1520426865
MESH:D005234 Fatty Liver pirinixic acid 9.4420131406 19236843
MESH:D005234 Fatty Liver Tetracycline 9.4416917069 19224547
MESH:D006333 Heart Failure pirinixic acid 2.7620558911
MESH:D006529 Hepatomegaly pirinixic acid 3.5519176532 19772884 16221962 18467677
MESH:D006943 Hyperglycemia pirinixic acid 3.5820558911
MESH:D006965 Hyperplasia halofuginone 5.8111874485
MESH:D007333 Insulin Resistance pirinixic acid 2.8716306350
MESH:D008103 Liver Cirrhosis halofuginone 4.2217180598
MESH:D008106 Liver Cirrhosis, Experimental halofuginone 2.8616489207 18458672 14739098 11172339 12175628
MESH:D008106 Liver Cirrhosis, Experimental pirinixic acid 2.8615474484
MESH:D008113 Liver Neoplasms pirinixic acid 1.9320007298 16377806 15890375
MESH:D009135 Muscular Diseases pirinixic acid 4.0716239165
MESH:D009203 Myocardial Infarction pirinixic acid 2.2719151258
MESH:D015428 Myocardial Reperfusion Injury pirinixic acid 3.2516411023
MESH:D009369 Neoplasms pirinixic acid 2.1117405874
MESH:D009395 Nephritis, Interstitial Tetracycline 5.519884423
MESH:D009765 Obesity pirinixic acid 1.8820558911
MESH:D010391 Pemphigoid, Bullous Tetracycline 6.1611026799
MESH:D017096 Prion Diseases Tetracycline 6.0410903871
MESH:D015427 Reperfusion Injury pirinixic acid 2.5519058328
MESH:D012871 Skin Diseases halofuginone 3.5911874485
No data
Pharmacogenomics Knowledge Base Top
  • PharmGKB Accession:PA128394662
    • No data
    Releated disease ID Related disease Name
    PA446155Precursor Cell Lymphoblastic Leukemia-Lymphoma
    No data
    Drug Bank Top

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    Syndromic Genes

    Non-syndromic Genes

    AutismKB Statistics

    • Studies: 1,036
    • Genes: 1,379
    • CNVs/SVs: 5,420
    • SNVs/Indels: 11,669
    • de novo Mutations: 5,669
    • Mosaics: 789
    • Linkage Regions: 172
    • Paper Collected: 6/30/2018
    • Last Update: 8/26/2018


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