AutismKB 2.0

Annotation Detail for AZIN1


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Basic Information Top
Gene Symbol:AZIN1 ( MGC3832,MGC691,OAZI,OAZIN,ODC1L )
Gene Full Name: antizyme inhibitor 1
Band: 8q22.3
Quick LinksEntrez ID:51582; OMIM: 607909; Uniprot ID:AZIN1_HUMAN; ENSEMBL ID: ENSG00000155096; HGNC ID: 16432
Relate to Another Database: SFARIGene; denovo-db
Related Pathway Information Top
No data
No data
Pathway IDPathway Name
Metabolism of amino acids and derivatives
No data
Pathway IDPathway Name
P02758Ornithine degradation
Pathway IDPathway Name
500789Regulation of ornithine decarboxylase (ODC)
Related Diseases/Disorders Top
Comparative Toxicogenomics Database Top
Chemical ID Chemical Name Interaction Interaction Action Publication
C016403 2,4-dinitrotoluene 2,4-dinitrotoluene affects the expression of AZIN1 mRNAaffects expression 21346803
C023514 2,6-dinitrotoluene 2,6-dinitrotoluene affects the expression of AZIN1 mRNAaffects expression 21346803
D000082 Acetaminophen Acetaminophen affects the expression of AZIN1 mRNAaffects expression 17562736
D000082 Acetaminophen Acetaminophen results in decreased expression of AZIN1 mRNAdecreases expression 11264010
D000643 Ammonium Chloride Ammonium Chloride affects the expression of AZIN1 mRNAaffects expression 16483693
D015123 7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide 7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide results in decreased expression of AZIN1 mRNAdecreases expression 19150397
C006780 bisphenol A bisphenol A results in increased expression of AZIN1 mRNAincreases expression 18007998
D020122 tert-Butylhydroperoxide tert-Butylhydroperoxide results in decreased expression of AZIN1 mRNAdecreases expression 15336504
D016572 Cyclosporine Cyclosporine results in increased expression of AZIN1 mRNAincreases expression 20106945
D004997 Ethinyl Estradiol Ethinyl Estradiol results in increased expression of AZIN1 mRNAincreases expression 17942748
D008701 Methapyrilene Methapyrilene results in increased expression of AZIN1 mRNAincreases expression 16393664
D010634 Phenobarbital Phenobarbital results in increased expression of AZIN1 mRNAincreases expression 19270015
C006253 pirinixic acid [pirinixic acid binds to and results in increased activity of PPARA protein] which results in increased expression of AZIN1 mRNAaffects binding|increases activity|increases expression 19710929
C006253 pirinixic acid pirinixic acid results in decreased expression of AZIN1 mRNAdecreases expression 18445702
C006253 pirinixic acid pirinixic acid results in increased expression of AZIN1 mRNAincreases expression 18301758
D013629 Tamoxifen Tamoxifen affects the expression of AZIN1 mRNAaffects expression 14699072
Disease ID Disease Name Direct Evidence Inference Chemical Name Inference Score Publication
MESH:D000008 Abdominal Neoplasms Tamoxifen 4.6814745880
MESH:D000014 Abnormalities, Drug-Induced Phenobarbital 3.566195326
MESH:D000138 Acidosis Ammonium Chloride 3.6818287403
MESH:D000152 Acne Vulgaris Ethinyl Estradiol 4.0817505938
MESH:D055371 Acute Lung Injury pirinixic acid 3.2018653653
MESH:D000230 Adenocarcinoma Ethinyl Estradiol 1.8314692618
MESH:D018248 Adenoma, Liver Cell Phenobarbital 10.5217620307
MESH:D018248 Adenoma, Liver Cell pirinixic acid 10.5216434500
MESH:D000799 Angioedema Acetaminophen 3.9810982225
MESH:D001161 Arteriosclerosis Ethinyl Estradiol 3.5711256880
MESH:D001169 Arthritis, Experimental Ethinyl Estradiol 2.7115885639
MESH:D001321 Autistic Disorder Acetaminophen 1.4118445737
MESH:D001778 Blood Coagulation Disorders pirinixic acid 3.2319483382
MESH:D001862 Bone Resorption bisphenol A 3.9411985600
MESH:D001943 Breast Neoplasms bisphenol A 2.2317123778
MESH:D001943 Breast Neoplasms Tamoxifen 2.2317440819 19288272 15565566 19244106 17049068 20859285 19189212 18997820 21138602 19103187 19115204 19200415 20390343 20005174 20544844 19289846 19487384 17261762 19410462 20065188 19189210 19066611 16873071 18629630 19011961 18984771 18351453 17242785 17893378 21152245 18815881 18425577 18855134 19155303 15668708 16818667 19221464 16273361 19142967 11161223 19084267 20135344 16202921 19059307 18821012
MESH:D018270 Carcinoma, Ductal, Breast Tamoxifen 4.6119066611
MESH:D006528 Carcinoma, Hepatocellular 2,4-dinitrotoluene 8.9916705839
MESH:D006528 Carcinoma, Hepatocellular 2,6-dinitrotoluene 8.9916705839
MESH:D006528 Carcinoma, Hepatocellular Acetaminophen 8.993084413
MESH:D006528 Carcinoma, Hepatocellular Phenobarbital 8.9920007298 1701930 17173139 20935162 6705139
MESH:D006528 Carcinoma, Hepatocellular Tamoxifen 8.9916924424
MESH:D002278 Carcinoma in Situ bisphenol A 5.1117123778
MESH:D002295 Carcinoma, Transitional Cell Tamoxifen 3.6917572228
MESH:D002386 Cataract Acetaminophen 2.6310977129
MESH:D002471 Cell Transformation, Neoplastic 2,6-dinitrotoluene 11.466135515
MESH:D002471 Cell Transformation, Neoplastic 7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide 11.4620889678
MESH:D002471 Cell Transformation, Neoplastic Cyclosporine 11.4612371664
MESH:D002493 Central Nervous System Diseases Phenobarbital 4.364080065
MESH:D002779 Cholestasis Cyclosporine 13.7019486331
MESH:D002779 Cholestasis Ethinyl Estradiol 13.7016105132 17333356 17681005 17110522 11677210 15861022 16919318
MESH:D002779 Cholestasis pirinixic acid 13.7019176532
MESH:D003490 Cyanosis 2,4-dinitrotoluene 11.2518551238
MESH:D003490 Cyanosis 2,6-dinitrotoluene 11.2518551238
MESH:D003711 Demyelinating Diseases Tamoxifen 4.4719031437
MESH:D003876 Dermatitis, Atopic pirinixic acid 2.4618249437
MESH:D003928 Diabetic Nephropathies Tamoxifen 3.5519279558
MESH:D056486 Drug-Induced Liver Injury 2,4-dinitrotoluene 6.3018551238 21346803
MESH:D056486 Drug-Induced Liver Injury 2,6-dinitrotoluene 6.3021346803 18551238
MESH:D056486 Drug-Induced Liver Injury Acetaminophen 6.3018071297 16081117 18713872 15968718 10915739 19085960 11529661 16781746 12705907 16177239 11739529 17906064 11743745 14725611 11287661 11461765 10663392 12958197 2444490 19416960 14986274 16109766 11834606 19739265 16393943 12594235 19923254 16227642 11421492 12540782 10774834 16485898 14550746 19164858 19370779 19420014 17522070 12392966 15619225 12153990 17562736
MESH:D056487 Drug-Induced Liver Injury, Chronic Acetaminophen 4.2319426721
MESH:D004421 Dystonia Phenobarbital 4.091851702
MESH:D004487 Edema pirinixic acid 2.5612083418
MESH:D004681 Encephalomyelitis, Autoimmune, Experimental Ethinyl Estradiol 9.2612538720
MESH:D004681 Encephalomyelitis, Autoimmune, Experimental Tamoxifen 9.2619031437
MESH:D016889 Endometrial Neoplasms Tamoxifen 3.1019155303 17893378 16202921 20544844
MESH:D004831 Epilepsies, Myoclonic Phenobarbital 4.213659116
MESH:D004828 Epilepsies, Partial Phenobarbital 4.003922381 11558140
MESH:D004827 Epilepsy Phenobarbital 2.9320417680
MESH:D004832 Epilepsy, Absence Phenobarbital 3.616401628
MESH:D017029 Epilepsy, Complex Partial Phenobarbital 4.367750514
MESH:D004830 Epilepsy, Tonic-Clonic Phenobarbital 4.143659116
MESH:D004938 Esophageal Neoplasms 7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide 2.0920426865
MESH:D005234 Fatty Liver Cyclosporine 19.4319224547
MESH:D005234 Fatty Liver Ethinyl Estradiol 19.4315345470
MESH:D005234 Fatty Liver pirinixic acid 19.4320131406 19236843
MESH:D005234 Fatty Liver Tamoxifen 19.4319224547 14986274
MESH:D052776 Female Urogenital Diseases Tamoxifen 3.2816709447
MESH:D018221 Fibromatosis, Abdominal Tamoxifen 4.6414745880
MESH:D018222 Fibromatosis, Aggressive Tamoxifen 4.3019069698
MESH:D005355 Fibrosis Cyclosporine 3.2412168785 12639820
MESH:D005756 Gastritis Acetaminophen 3.8116983495
MESH:D005885 Gingival Hyperplasia Cyclosporine 4.348708960
MESH:D006333 Heart Failure pirinixic acid 2.5820558911
MESH:D006457 Hemoglobinuria, Paroxysmal Cyclosporine 4.5415720958
MESH:D006529 Hepatomegaly Phenobarbital 8.8316109766
MESH:D006529 Hepatomegaly pirinixic acid 8.8318467677 16221962 19772884 19176532
MESH:D006930 Hyperalgesia Acetaminophen 2.7616870215
MESH:D006943 Hyperglycemia pirinixic acid 3.2620558911
MESH:D006973 Hypertension Cyclosporine 2.1210903974
MESH:D007021 Hypospadias Ethinyl Estradiol 3.9116945680 16569931
MESH:D007247 Infertility, Female Ethinyl Estradiol 3.5512013081
MESH:D007248 Infertility, Male Ethinyl Estradiol 2.5417937319
MESH:D007249 Inflammation Tamoxifen 2.3919457130
MESH:D007333 Insulin Resistance bisphenol A 7.4916393666
MESH:D007333 Insulin Resistance pirinixic acid 7.4916306350
MESH:D007638 Keratoconjunctivitis Sicca Cyclosporine 4.5815604871
MESH:D007674 Kidney Diseases Acetaminophen 5.9412587719 15629191
MESH:D007674 Kidney Diseases Cyclosporine 5.9410903974 8314463 18776723
MESH:D007680 Kidney Neoplasms 2,4-dinitrotoluene 18.3316705839
MESH:D007680 Kidney Neoplasms 2,6-dinitrotoluene 18.3316705839
MESH:D007680 Kidney Neoplasms Cyclosporine 18.3312371664
MESH:D007680 Kidney Neoplasms Tamoxifen 18.3318625569
MESH:D008064 Lipidoses Tamoxifen 3.2117567588 15342952
MESH:D008103 Liver Cirrhosis Phenobarbital 2.9421047994
MESH:D008106 Liver Cirrhosis, Experimental pirinixic acid 2.3415474484
MESH:D008106 Liver Cirrhosis, Experimental Tamoxifen 2.3418564211
MESH:D008107 Liver Diseases Acetaminophen 3.9919014921 12969438 19460945 16611625 19784758 11587558 12587719 16610002
MESH:D008107 Liver Diseases Phenobarbital 3.9919363144
MESH:D017114 Liver Failure, Acute Acetaminophen 3.3116871587 17185352
MESH:D008113 Liver Neoplasms 2,6-dinitrotoluene 14.577678174
MESH:D008113 Liver Neoplasms Methapyrilene 14.5715890375
MESH:D008113 Liver Neoplasms Phenobarbital 14.5721047994 19073162 19812893 15975961 19482888 8742319
MESH:D008113 Liver Neoplasms pirinixic acid 14.5715890375 16377806 20007298
MESH:D008113 Liver Neoplasms Tamoxifen 14.5716684651
MESH:D008114 Liver Neoplasms, Experimental 2,6-dinitrotoluene 6.112876784 6135515 2876786
MESH:D008114 Liver Neoplasms, Experimental Phenobarbital 6.116150874 1399818 18308698 17172636 2563599
MESH:D008175 Lung Neoplasms Tamoxifen 1.7418625569
MESH:D015674 Mammary Neoplasms, Animal Tamoxifen 3.8819428831
MESH:D008325 Mammary Neoplasms, Experimental Tamoxifen 2.6711731420 19196722 14580682 19196723 16827153
MESH:D020149 Manganese Poisoning Tamoxifen 4.6819453300
MESH:D008545 Melanoma Tamoxifen 1.8919393235 12393984
MESH:D018328 Melanoma, Amelanotic Tamoxifen 4.3015990972
MESH:D008546 Melanoma, Experimental Acetaminophen 3.6719513568
MESH:D008664 Metal Metabolism, Inborn Errors Cyclosporine 4.9216801185
MESH:D009135 Muscular Diseases pirinixic acid 3.6116239165
MESH:D009203 Myocardial Infarction pirinixic acid 2.1719151258
MESH:D015428 Myocardial Reperfusion Injury pirinixic acid 3.0116411023
MESH:D020191 Myoclonic Epilepsies, Progressive Phenobarbital 4.5917484760
MESH:D009336 Necrosis 2,4-dinitrotoluene 10.7418551238
MESH:D009336 Necrosis 2,6-dinitrotoluene 10.747678174 18551238
MESH:D009362 Neoplasm Metastasis Tamoxifen 2.5719393235
MESH:D009364 Neoplasm Recurrence, Local Tamoxifen 2.5419410462
MESH:D009369 Neoplasms pirinixic acid 1.9817405874
MESH:D009376 Neoplasms, Hormone-Dependent Tamoxifen 4.1319196722 19189210 19200415
MESH:D009402 Nephrosis, Lipoid Cyclosporine 4.5817954296
MESH:D009404 Nephrotic Syndrome Cyclosporine 3.3619348381 18481113
MESH:D009421 Nervous System Malformations bisphenol A 4.0716427766 11399458
MESH:D019636 Neurodegenerative Diseases Acetaminophen 2.9418514411
MESH:D009765 Obesity pirinixic acid 1.8320558911
MESH:D009784 Occupational Diseases 2,4-dinitrotoluene 9.1416049721 12819281
MESH:D009784 Occupational Diseases 2,6-dinitrotoluene 9.1416049721
MESH:D010018 Osteomalacia Phenobarbital 4.4817016548
MESH:D010049 Ovarian Diseases bisphenol A 5.1111985600
MESH:D010146 Pain Acetaminophen 2.4616870215
MESH:D010190 Pancreatic Neoplasms Phenobarbital 2.5216965848
MESH:D016584 Panic Disorder Ethinyl Estradiol 3.7711578682
MESH:D011230 Precancerous Conditions Cyclosporine 9.2112371664
MESH:D011230 Precancerous Conditions Phenobarbital 9.212563599
MESH:D011297 Prenatal Exposure Delayed Effects bisphenol A 4.0710548101
MESH:D019048 Prostatic Intraepithelial Neoplasia bisphenol A 4.2920887781
MESH:D011471 Prostatic Neoplasms bisphenol A 3.2716740699
MESH:D011471 Prostatic Neoplasms Tamoxifen 3.2715067354
MESH:D011537 Pruritus Ethinyl Estradiol 3.4315861022 16919318
MESH:D019310 Pseudolymphoma Phenobarbital 4.6312752131
MESH:D011565 Psoriasis Cyclosporine 2.2516882103
MESH:D011629 Puberty, Precocious bisphenol A 4.9010548101
MESH:D015427 Reperfusion Injury pirinixic acid 2.4219058328
MESH:D012640 Seizures 2,4-dinitrotoluene 10.1318551238
MESH:D012640 Seizures 2,6-dinitrotoluene 10.1318551238
MESH:D012640 Seizures Phenobarbital 10.133137016 16876388 11442880 4039156
MESH:D003294 Seizures, Febrile Phenobarbital 4.946407741
MESH:D012878 Skin Neoplasms tert-Butylhydroperoxide 2.728532709
MESH:D013088 Spermatocele Ethinyl Estradiol 12.0116709447
MESH:D013088 Spermatocele Tamoxifen 12.0116709447
MESH:D013119 Spinal Cord Injuries Tamoxifen 4.1519457130
MESH:D019966 Substance-Related Disorders bisphenol A 4.1016684133 16045194
MESH:D019851 Thrombophilia Ethinyl Estradiol 3.7111994571
MESH:D013927 Thrombosis Ethinyl Estradiol 3.2215669648
MESH:D013964 Thyroid Neoplasms Phenobarbital 3.111399818
MESH:D001749 Urinary Bladder Neoplasms 2,4-dinitrotoluene 8.4616049721
MESH:D001749 Urinary Bladder Neoplasms 2,6-dinitrotoluene 8.4616049721
MESH:D001749 Urinary Bladder Neoplasms Tamoxifen 8.4617572228 16712894 8653321
MESH:D014571 Urologic Neoplasms 2,4-dinitrotoluene 12.3910091137
MESH:D014571 Urologic Neoplasms 2,6-dinitrotoluene 12.3910091137
MESH:D014581 Urticaria Acetaminophen 3.0610982225
MESH:D014591 Uterine Diseases bisphenol A 5.1414652134
MESH:D014594 Uterine Neoplasms Ethinyl Estradiol 3.3914692618
MESH:D014605 Uveitis Cyclosporine 4.121336536
MESH:D020246 Venous Thrombosis Ethinyl Estradiol 3.6215869587 14671159
MESH:D014985 Xerophthalmia Cyclosporine 4.5817120751
Pathway ID Pathway Name
REACT:13 Metabolism of amino acids and derivatives
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  (e.g. CHD8)

Syndromic Genes

Non-syndromic Genes

AutismKB Statistics

  • Studies: 1,036
  • Genes: 1,379
  • CNVs/SVs: 5,420
  • SNVs/Indels: 11,669
  • de novo Mutations: 5,669
  • Mosaics: 789
  • Linkage Regions: 172
  • Paper Collected: 6/30/2018
  • Last Update: 8/26/2018


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