AutismKB 2.0

Annotation Detail for MED15


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Basic Information Top
Gene Symbol:MED15 ( ARC105,CAG7A,CTG7A,DKFZp686A2214,DKFZp762B1216,FLJ42282,FLJ42935,PCQAP,TIG-1,TIG1,TNRC7 )
Gene Full Name: mediator complex subunit 15
Band: 22q11.21
Quick LinksEntrez ID:51586; OMIM: 607372; Uniprot ID:MED15_HUMAN; ENSEMBL ID: ENSG00000099917; HGNC ID: 14248
Relate to Another Database: SFARIGene; denovo-db
Related Pathway Information Top
No data
No data
Pathway IDPathway Name
Gene Expression
Pathway IDPathway Name
200002Regulation of nuclear SMAD2/3 signaling
No data
Pathway IDPathway Name
500652Generic Transcription Pathway
Related Diseases/Disorders Top
Comparative Toxicogenomics Database Top
Chemical ID Chemical Name Interaction Interaction Action Publication
C009505 4,4'-diaminodiphenylmethane 4,4'-diaminodiphenylmethane results in decreased expression of MED15 mRNAdecreases expression 18648102
D000082 Acetaminophen Acetaminophen affects the expression of MED15 mRNAaffects expression 17562736
D008727 Methotrexate MED15 protein affects the susceptibility to Methotrexateaffects response to substance 16217747
D012643 Selenium [Selenium co-treated with Vitamin E] results in increased expression of MED15 mRNAaffects cotreatment|increases expression 19244175
D012643 Selenium Selenium results in increased expression of MED15 mRNAincreases expression 19244175
D013467 Sulindac Sulindac results in increased expression of MED15 mRNAincreases expression 11906190
D014810 Vitamin E [Selenium co-treated with Vitamin E] results in increased expression of MED15 mRNAaffects cotreatment|increases expression 19244175
D014810 Vitamin E Vitamin E results in increased expression of MED15 mRNAincreases expression 19244175
Disease ID Disease Name Direct Evidence Inference Chemical Name Inference Score Publication
MESH:D000008 Abdominal Neoplasms Sulindac 6.0214745880
MESH:D000014 Abnormalities, Drug-Induced Methotrexate 4.7112039119
MESH:D058186 Acute Kidney Injury Sulindac 4.647897758
MESH:D000230 Adenocarcinoma Sulindac 3.1711910360
MESH:D000236 Adenoma 4,4'-diaminodiphenylmethane 7.563712494
MESH:D000236 Adenoma Sulindac 7.5610223192
MESH:D011125 Adenomatous Polyposis Coli Sulindac 4.9017611924 11535846 12394442 11874996 15623613 16460482 19003578
MESH:D000799 Angioedema Acetaminophen 4.3610982225
MESH:D001172 Arthritis, Rheumatoid Methotrexate 3.1517286800
MESH:D001321 Autistic Disorder Acetaminophen 1.4018445737
MESH:D001660 Biliary Tract Diseases 4,4'-diaminodiphenylmethane 5.541440618 11289319
MESH:D001913 Bowen's Disease Sulindac 5.8711207687
MESH:D001943 Breast Neoplasms Methotrexate 2.7916978400
MESH:D001943 Breast Neoplasms Sulindac 2.7916642371
MESH:D002252 Carbon Tetrachloride Poisoning Vitamin E 4.3516050911
MESH:D006528 Carcinoma, Hepatocellular 4,4'-diaminodiphenylmethane 2.933581430 7296757
MESH:D006528 Carcinoma, Hepatocellular Acetaminophen 2.933084413
MESH:D002292 Carcinoma, Renal Cell 4,4'-diaminodiphenylmethane 2.807296757
MESH:D002386 Cataract Acetaminophen 2.7510977129
MESH:D002471 Cell Transformation, Neoplastic 4,4'-diaminodiphenylmethane 2.967505956
MESH:D002779 Cholestasis 4,4'-diaminodiphenylmethane 3.389022650 19486331
MESH:D003092 Colitis Selenium 4.2017936198
MESH:D003110 Colonic Neoplasms Sulindac 2.9612902858 12458338
MESH:D015179 Colorectal Neoplasms Sulindac 2.6911197048 11076880 18059344 10666051
MESH:D019465 Craniofacial Abnormalities Methotrexate 3.079562676 12039119
MESH:D019465 Craniofacial Abnormalities Vitamin E 3.0719769572
MESH:D003550 Cystic Fibrosis Methotrexate 4.5419747007
MESH:D017449 Dermatitis, Allergic Contact 4,4'-diaminodiphenylmethane 3.212524372 18759878 11298694 8156756 14531868 12868966 11906362 8970840
MESH:D003877 Dermatitis, Contact 4,4'-diaminodiphenylmethane 3.842952479 3621924
MESH:D003882 Dermatomyositis Methotrexate 5.5120191521
MESH:D003930 Diabetic Retinopathy Sulindac 5.5612861449 17621415
MESH:D056486 Drug-Induced Liver Injury 4,4'-diaminodiphenylmethane 6.659022650 11289319 18692083 6482804 18289764 9653073 6679447 8291058 16192314 7440962 18648102 1440618 9328219
MESH:D056486 Drug-Induced Liver Injury Acetaminophen 6.6515619225 10915739 19370779 18071297 12540782 15968718 16485898 19085960 19923254 19416960 12392966 17522070 11739529 18713872 11529661 11421492 12594235 14725611 2444490 12705907 19420014 16781746 11834606 19739265 17562736 11461765 12153990 11287661 16393943 17906064 16227642 16177239 10774834 16109766 14550746 16081117 10663392 14986274 11743745 19164858 12958197
MESH:D056486 Drug-Induced Liver Injury Selenium 6.6515131321
MESH:D056487 Drug-Induced Liver Injury, Chronic Acetaminophen 4.6219426721
MESH:C538011 Eales disease Vitamin E 5.229068938
MESH:D004715 Endometriosis Sulindac 4.7815652904
MESH:D004938 Esophageal Neoplasms 4,4'-diaminodiphenylmethane 4.993581430
MESH:D004938 Esophageal Neoplasms Sulindac 4.9912235107
MESH:D005350 Fibroma 4,4'-diaminodiphenylmethane 5.546705139
MESH:D018221 Fibromatosis, Abdominal Sulindac 5.9414745880
MESH:D018222 Fibromatosis, Aggressive Sulindac 5.5919069698
MESH:D005756 Gastritis Acetaminophen 4.1916983495
MESH:D005764 Gastroesophageal Reflux Sulindac 5.3911910360
MESH:D006042 Goiter 4,4'-diaminodiphenylmethane 4.397505956
MESH:D006086 Graft vs Host Disease Methotrexate 5.5716518429
MESH:D006330 Heart Defects, Congenital Vitamin E 3.1316080930
MESH:D006333 Heart Failure Selenium 3.2517162251
MESH:D006505 Hepatitis 4,4'-diaminodiphenylmethane 3.896705139
MESH:D006548 Hernia, Diaphragmatic Vitamin E 2.7916490937 16863852
MESH:D019584 Hot Flashes Vitamin E 4.4914716179
MESH:D006930 Hyperalgesia Acetaminophen 2.9516870215
MESH:D006965 Hyperplasia 4,4'-diaminodiphenylmethane 4.3615034207
MESH:D007249 Inflammation Sulindac 3.443291741
MESH:D007251 Influenza, Human Selenium 12.7616624496
MESH:D007251 Influenza, Human Vitamin E 12.7616624496
MESH:D007414 Intestinal Neoplasms Sulindac 4.9412351151 12663524 12584176 12628509 10223192 10213222
MESH:D007417 Intestinal Polyps Sulindac 5.3411245490 12394442
MESH:D007565 Jaundice 4,4'-diaminodiphenylmethane 5.549022650 8074119
MESH:D007674 Kidney Diseases Acetaminophen 6.5115629191 12587719
MESH:D007674 Kidney Diseases Vitamin E 6.5112488133
MESH:D007676 Kidney Failure, Chronic Selenium 4.2116518626
MESH:D007680 Kidney Neoplasms 4,4'-diaminodiphenylmethane 3.236582329
MESH:D007805 Language Development Disorders Methotrexate 5.459562676
MESH:D008103 Liver Cirrhosis Methotrexate 3.8514986274
MESH:D008105 Liver Cirrhosis, Biliary 4,4'-diaminodiphenylmethane 9.1115034207 9327722
MESH:D008105 Liver Cirrhosis, Biliary Sulindac 9.1112468960
MESH:D008106 Liver Cirrhosis, Experimental Vitamin E 1.9016169303
MESH:D008107 Liver Diseases Acetaminophen 4.4619014921 11587558 16610002 16611625 19784758 12969438 19460945 12587719
MESH:D008107 Liver Diseases Sulindac 4.4616867024 14986274
MESH:D017114 Liver Failure, Acute Acetaminophen 3.5417185352 16871587
MESH:D008114 Liver Neoplasms, Experimental 4,4'-diaminodiphenylmethane 2.71598648 3712494 1399818 6587162
MESH:D008171 Lung Diseases Vitamin E 3.3716863852
MESH:D017563 Lung Diseases, Interstitial Methotrexate 5.5418516814
MESH:D008175 Lung Neoplasms Sulindac 2.9115713900 19359593
MESH:D008175 Lung Neoplasms Vitamin E 2.9111062179
MESH:D008223 Lymphoma Methotrexate 4.1717352296
MESH:D008325 Mammary Neoplasms, Experimental Selenium 2.9515318939
MESH:D008545 Melanoma Sulindac 2.8616642371
MESH:D008546 Melanoma, Experimental Acetaminophen 3.9819513568
MESH:D008654 Mesothelioma Selenium 2.8915107826
MESH:D052016 Mucositis Methotrexate 5.7417488658
MESH:D009362 Neoplasm Metastasis 4,4'-diaminodiphenylmethane 2.573581430
MESH:D009436 Neural Tube Defects 4,4'-diaminodiphenylmethane 3.106679447
MESH:D019636 Neurodegenerative Diseases Acetaminophen 9.4318514411
MESH:D019636 Neurodegenerative Diseases Sulindac 9.4316850258 17266991
MESH:D009784 Occupational Diseases 4,4'-diaminodiphenylmethane 3.726482804 4026338
MESH:D009902 Optic Neuritis 4,4'-diaminodiphenylmethane 5.543988306
MESH:D010146 Pain Acetaminophen 7.8116870215
MESH:D010146 Pain Sulindac 7.813291741
MESH:D010190 Pancreatic Neoplasms Sulindac 3.4416820089 11504793
MESH:D010212 Papilloma 4,4'-diaminodiphenylmethane 3.907296757
MESH:D010787 Photosensitivity Disorders 4,4'-diaminodiphenylmethane 4.996228378
MESH:D010954 Plasmacytoma Selenium 5.4115087411
MESH:D011471 Prostatic Neoplasms Vitamin E 3.2515084515
MESH:D011565 Psoriasis Methotrexate 3.5217410198
MESH:D051437 Renal Insufficiency Methotrexate 5.1317352296
MESH:D012162 Retinal Degeneration 4,4'-diaminodiphenylmethane 3.613692021
MESH:D012871 Skin Diseases Vitamin E 2.5018709164
MESH:D020521 Stroke Vitamin E 3.7716517955
MESH:D013576 Syndactyly Methotrexate 5.429562676
MESH:D013964 Thyroid Neoplasms 4,4'-diaminodiphenylmethane 3.126587162 3712494 1399818 7505956 6582329
MESH:D001749 Urinary Bladder Neoplasms 4,4'-diaminodiphenylmethane 2.378074119
MESH:D014581 Urticaria Acetaminophen 3.3310982225
MESH:D014594 Uterine Neoplasms Sulindac 4.9818645019
Pathway ID Pathway Name
REACT:15380 Diabetes pathways
REACT:71 Gene Expression
Pharmacogenomics Knowledge Base Top
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Simple Query:


  (e.g. CHD8)

Syndromic Genes

Non-syndromic Genes

AutismKB Statistics

  • Studies: 1,036
  • Genes: 1,379
  • CNVs/SVs: 5,420
  • SNVs/Indels: 11,669
  • de novo Mutations: 5,669
  • Mosaics: 789
  • Linkage Regions: 172
  • Paper Collected: 6/30/2018
  • Last Update: 8/26/2018


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