AutismKB 2.0

Annotation Detail for PIAS4


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Basic Information Top
Gene Symbol:PIAS4 ( FLJ12419,MGC35296,PIASY,Piasg,ZMIZ6 )
Gene Full Name: protein inhibitor of activated STAT, 4
Band: 19p13.3
Quick LinksEntrez ID:51588; OMIM: 605989; Uniprot ID:PIAS4_HUMAN; ENSEMBL ID: ENSG00000105229; HGNC ID: 17002
Relate to Another Database: SFARIGene; denovo-db
Related Pathway Information Top
No data
Pathway IDPathway Name
hsa05160Hepatitis C
hsa04630Jak-STAT signaling pathway
hsa04120Ubiquitin mediated proteolysis
hsa05222Small cell lung cancer
hsa05200Pathways in cancer
No data
Pathway IDPathway Name
200038Coregulation of Androgen receptor activity
200002Regulation of nuclear SMAD2/3 signaling
200152Regulation of cytoplasmic and nuclear SMAD2/3 signaling
200110IFN-gamma pathway
Pathway IDPathway Name
P00035Interferon-gamma signaling pathway
No data
Related Diseases/Disorders Top
Comparative Toxicogenomics Database Top
Chemical ID Chemical Name Interaction Interaction Action Publication
C016403 2,4-dinitrotoluene 2,4-dinitrotoluene affects the expression of PIAS4 mRNAaffects expression 21346803
C023514 2,6-dinitrotoluene 2,6-dinitrotoluene affects the expression of PIAS4 mRNAaffects expression 21346803
D012643 Selenium [Selenium co-treated with Vitamin E] results in decreased expression of PIAS4 mRNAaffects cotreatment|decreases expression 19244175
D014810 Vitamin E [Selenium co-treated with Vitamin E] results in decreased expression of PIAS4 mRNAaffects cotreatment|decreases expression 19244175
D014810 Vitamin E Vitamin E results in decreased expression of PIAS4 mRNAdecreases expression 19244175
Disease ID Disease Name Direct Evidence Inference Chemical Name Inference Score Publication
MESH:D002252 Carbon Tetrachloride Poisoning Vitamin E 4.4916050911
MESH:D006528 Carcinoma, Hepatocellular 2,4-dinitrotoluene 3.1016705839
MESH:D006528 Carcinoma, Hepatocellular 2,6-dinitrotoluene 3.1016705839
MESH:D002471 Cell Transformation, Neoplastic 2,6-dinitrotoluene 3.036135515
MESH:D003092 Colitis Selenium 4.3417936198
MESH:D019465 Craniofacial Abnormalities Vitamin E 1.9319769572
MESH:D003490 Cyanosis 2,4-dinitrotoluene 12.8318551238
MESH:D003490 Cyanosis 2,6-dinitrotoluene 12.8318551238
MESH:D056486 Drug-Induced Liver Injury 2,4-dinitrotoluene 6.8018551238 21346803
MESH:D056486 Drug-Induced Liver Injury 2,6-dinitrotoluene 6.8021346803 18551238
MESH:D056486 Drug-Induced Liver Injury Selenium 6.8015131321
MESH:C538011 Eales disease Vitamin E 5.439068938
MESH:D006330 Heart Defects, Congenital Vitamin E 3.1716080930
MESH:D006333 Heart Failure Selenium 3.2917162251
MESH:D006548 Hernia, Diaphragmatic Vitamin E 2.8116490937 16863852
MESH:D019584 Hot Flashes Vitamin E 4.6914716179
MESH:D007251 Influenza, Human Selenium 13.5016624496
MESH:D007251 Influenza, Human Vitamin E 13.5016624496
MESH:D007674 Kidney Diseases Vitamin E 3.0012488133
MESH:D007676 Kidney Failure, Chronic Selenium 4.3116518626
MESH:D007680 Kidney Neoplasms 2,4-dinitrotoluene 8.5316705839
MESH:D007680 Kidney Neoplasms 2,6-dinitrotoluene 8.5316705839
MESH:D008106 Liver Cirrhosis, Experimental Vitamin E 1.9116169303
MESH:D008113 Liver Neoplasms 2,6-dinitrotoluene 2.277678174
MESH:D008114 Liver Neoplasms, Experimental 2,6-dinitrotoluene 2.772876786 2876784 6135515
MESH:D008171 Lung Diseases Vitamin E 3.4316863852
MESH:D008175 Lung Neoplasms Vitamin E 1.9011062179
MESH:D008325 Mammary Neoplasms, Experimental Selenium 2.9915318939
MESH:D008654 Mesothelioma Selenium 2.9215107826
MESH:D009336 Necrosis 2,4-dinitrotoluene 12.5418551238
MESH:D009336 Necrosis 2,6-dinitrotoluene 12.5418551238 7678174
MESH:D009784 Occupational Diseases 2,4-dinitrotoluene 10.2312819281 16049721
MESH:D009784 Occupational Diseases 2,6-dinitrotoluene 10.2316049721
MESH:D010954 Plasmacytoma Selenium 5.6115087411
MESH:D011471 Prostatic Neoplasms Vitamin E 3.2415084515
MESH:D012640 Seizures 2,4-dinitrotoluene 6.7418551238
MESH:D012640 Seizures 2,6-dinitrotoluene 6.7418551238
MESH:D012871 Skin Diseases Vitamin E 2.5218709164
MESH:D020521 Stroke Vitamin E 3.8416517955
MESH:D001749 Urinary Bladder Neoplasms 2,4-dinitrotoluene 5.4316049721
MESH:D001749 Urinary Bladder Neoplasms 2,6-dinitrotoluene 5.4316049721
MESH:D014571 Urologic Neoplasms 2,4-dinitrotoluene 14.1910091137
MESH:D014571 Urologic Neoplasms 2,6-dinitrotoluene 14.1910091137
Pathway ID Pathway Name
KEGG:05160 Hepatitis C
KEGG:04630 Jak-STAT signaling pathway
KEGG:05200 Pathways in cancer
KEGG:05222 Small cell lung cancer
KEGG:04120 Ubiquitin mediated proteolysis
Pharmacogenomics Knowledge Base Top
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Syndromic Genes

Non-syndromic Genes

AutismKB Statistics

  • Studies: 1,036
  • Genes: 1,379
  • CNVs/SVs: 5,420
  • SNVs/Indels: 11,669
  • de novo Mutations: 5,669
  • Mosaics: 789
  • Linkage Regions: 172
  • Paper Collected: 6/30/2018
  • Last Update: 8/26/2018


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