AutismKB 2.0

Annotation Detail for LSR


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Basic Information Top
Gene Symbol:LSR ( ILDR3,LISCH7,MGC10659,MGC48312,MGC48503 )
Gene Full Name: lipolysis stimulated lipoprotein receptor
Band: 19q13.12
Quick LinksEntrez ID:51599; OMIM: NA; Uniprot ID:LSR_HUMAN; ENSEMBL ID: ENSG00000105699; HGNC ID: 29572
Relate to Another Database: SFARIGene; denovo-db
Related Pathway Information Top
Related Diseases/Disorders Top
Comparative Toxicogenomics Database Top
Chemical ID Chemical Name Interaction Interaction Action Publication
C016403 2,4-dinitrotoluene 2,4-dinitrotoluene affects the expression of LSR mRNAaffects expression 21346803
C009505 4,4'-diaminodiphenylmethane 4,4'-diaminodiphenylmethane results in decreased expression of LSR mRNAdecreases expression 18648102
D000643 Ammonium Chloride Ammonium Chloride affects the expression of LSR mRNAaffects expression 16483693
D001554 Benzene Benzene affects the expression of LSR mRNAaffects expression 15878777
D004054 Diethylstilbestrol Diethylstilbestrol results in increased expression of LSR mRNAincreases expression 15289156
D004958 Estradiol Estradiol results in increased expression of LSR mRNAincreases expression 15289156
C056933 fumonisin B1 fumonisin B1 results in increased expression of LSR mRNAincreases expression 16221962
D019833 Genistein Genistein results in increased expression of LSR mRNAincreases expression 15289156
C006253 pirinixic acid pirinixic acid results in decreased expression of LSR mRNAdecreases expression 16221962
D012643 Selenium Selenium results in increased expression of LSR mRNAincreases expression 19244175
D014810 Vitamin E Vitamin E results in increased expression of LSR mRNAincreases expression 19244175
Disease ID Disease Name Direct Evidence Inference Chemical Name Inference Score Publication
MESH:D000138 Acidosis Ammonium Chloride 3.7518287403
MESH:D055371 Acute Lung Injury pirinixic acid 3.2718653653
MESH:D000230 Adenocarcinoma Estradiol 4.5711473722
MESH:D000230 Adenocarcinoma Genistein 4.5711473722
MESH:D000236 Adenoma 4,4'-diaminodiphenylmethane 2.833712494
MESH:D018248 Adenoma, Liver Cell pirinixic acid 3.6716434500
MESH:D000686 Amyloidosis Diethylstilbestrol 4.6415469931
MESH:D000741 Anemia, Aplastic Benzene 4.4811369114 14761424 17661222
MESH:D001660 Biliary Tract Diseases 4,4'-diaminodiphenylmethane 5.2411289319 1440618
MESH:D001778 Blood Coagulation Disorders pirinixic acid 3.2919483382
MESH:D001855 Bone Marrow Diseases Benzene 5.4516183116
MESH:D001943 Breast Neoplasms Benzene 2.0411921183 17162533
MESH:D001943 Breast Neoplasms Diethylstilbestrol 2.0415324884 17129689
MESH:D001943 Breast Neoplasms Estradiol 2.0419861407 17261762 17289903 16675129 17018787 14630087 18497071 12948864
MESH:D001943 Breast Neoplasms Genistein 2.0416873071 17200150 16541309
MESH:D002181 Candidiasis, Vulvovaginal Estradiol 4.6616111702
MESH:D002252 Carbon Tetrachloride Poisoning Vitamin E 4.1116050911
MESH:D006528 Carcinoma, Hepatocellular 2,4-dinitrotoluene 9.1016705839
MESH:D006528 Carcinoma, Hepatocellular 4,4'-diaminodiphenylmethane 9.103581430 7296757
MESH:D006528 Carcinoma, Hepatocellular Diethylstilbestrol 9.1015948411 16924424
MESH:D006528 Carcinoma, Hepatocellular Estradiol 9.1016924424
MESH:D006528 Carcinoma, Hepatocellular Genistein 9.1016924424
MESH:D002292 Carcinoma, Renal Cell 4,4'-diaminodiphenylmethane 2.737296757
MESH:D002318 Cardiovascular Diseases Genistein 3.4016332659
MESH:D002471 Cell Transformation, Neoplastic 4,4'-diaminodiphenylmethane 6.977505956
MESH:D002471 Cell Transformation, Neoplastic Estradiol 6.9718566989
MESH:D002779 Cholestasis 4,4'-diaminodiphenylmethane 8.199022650 19486331
MESH:D002779 Cholestasis pirinixic acid 8.1919176532
MESH:D003092 Colitis Selenium 3.9517936198
MESH:D003110 Colonic Neoplasms Genistein 2.3017182828
MESH:D019465 Craniofacial Abnormalities Benzene 2.9515643154
MESH:D019465 Craniofacial Abnormalities Vitamin E 2.9519769572
MESH:D003456 Cryptorchidism Diethylstilbestrol 4.7216002989 12952375
MESH:D003490 Cyanosis 2,4-dinitrotoluene 4.1918551238
MESH:D003872 Dermatitis Benzene 4.9415902427
MESH:D017449 Dermatitis, Allergic Contact 4,4'-diaminodiphenylmethane 2.9718759878 14531868 8156756 11298694 2524372 8970840 12868966 11906362
MESH:D003876 Dermatitis, Atopic pirinixic acid 2.4818249437
MESH:D003877 Dermatitis, Contact 4,4'-diaminodiphenylmethane 3.643621924 2952479
MESH:D003924 Diabetes Mellitus, Type 2 Genistein 2.5116647724
MESH:D003928 Diabetic Nephropathies Estradiol 3.5419279558
MESH:D056486 Drug-Induced Liver Injury 2,4-dinitrotoluene 9.3521346803 18551238
MESH:D056486 Drug-Induced Liver Injury 4,4'-diaminodiphenylmethane 9.3516192314 1440618 18289764 9022650 7440962 6679447 8291058 18692083 9653073 9328219 11289319 18648102 6482804
MESH:D056486 Drug-Induced Liver Injury fumonisin B1 9.3516221962
MESH:D056486 Drug-Induced Liver Injury Selenium 9.3515131321
MESH:C538011 Eales disease Vitamin E 4.929068938
MESH:D004487 Edema pirinixic acid 2.6212083418
MESH:D004714 Endometrial Hyperplasia Diethylstilbestrol 12.5516402032
MESH:D004714 Endometrial Hyperplasia Genistein 12.5516402032
MESH:D016889 Endometrial Neoplasms Diethylstilbestrol 13.0416804899 15700306
MESH:D016889 Endometrial Neoplasms Estradiol 13.0418566989 11473722 19148513
MESH:D016889 Endometrial Neoplasms Genistein 13.0411473722
MESH:D004938 Esophageal Neoplasms 4,4'-diaminodiphenylmethane 2.143581430
MESH:D005234 Fatty Liver pirinixic acid 2.9019236843 20131406
MESH:D052776 Female Urogenital Diseases Diethylstilbestrol 3.7316513791 15751030 16611131 16002989 16534752
MESH:D005350 Fibroma 4,4'-diaminodiphenylmethane 5.246705139
MESH:D005833 Genital Neoplasms, Female Diethylstilbestrol 5.1416452187
MESH:D005909 Glioblastoma Genistein 3.3416598420
MESH:D006042 Goiter 4,4'-diaminodiphenylmethane 4.197505956
MESH:D006330 Heart Defects, Congenital Vitamin E 3.0516080930
MESH:D006333 Heart Failure pirinixic acid 7.2220558911
MESH:D006333 Heart Failure Selenium 7.2217162251
MESH:D006402 Hematologic Diseases Benzene 4.8016183116
MESH:D006505 Hepatitis 4,4'-diaminodiphenylmethane 3.676705139
MESH:D006529 Hepatomegaly fumonisin B1 9.3616221962
MESH:D006529 Hepatomegaly pirinixic acid 9.3616221962 19176532 18467677 19772884
MESH:D006548 Hernia, Diaphragmatic Vitamin E 2.7416490937 16863852
MESH:D006558 Herpes Genitalis Estradiol 5.2515709030
MESH:D019584 Hot Flashes Estradiol 10.7917088409
MESH:D019584 Hot Flashes Vitamin E 10.7914716179
MESH:D006943 Hyperglycemia pirinixic acid 3.3120558911
MESH:D006965 Hyperplasia 4,4'-diaminodiphenylmethane 11.4315034207
MESH:D006965 Hyperplasia Diethylstilbestrol 11.4314722030 12960047
MESH:D006973 Hypertension Benzene 3.1317940673
MESH:D007021 Hypospadias Diethylstilbestrol 4.7516002989
MESH:D007246 Infertility Diethylstilbestrol 4.5215036965
MESH:D007251 Influenza, Human Selenium 11.7016624496
MESH:D007251 Influenza, Human Vitamin E 11.7016624496
MESH:D007333 Insulin Resistance Estradiol 7.4916627594 16393666
MESH:D007333 Insulin Resistance pirinixic acid 7.4916306350
MESH:D007565 Jaundice 4,4'-diaminodiphenylmethane 5.248074119 9022650
MESH:D007674 Kidney Diseases Estradiol 6.3615618244
MESH:D007674 Kidney Diseases Vitamin E 6.3612488133
MESH:D007676 Kidney Failure, Chronic Selenium 4.0216518626
MESH:D007680 Kidney Neoplasms 2,4-dinitrotoluene 18.7816705839
MESH:D007680 Kidney Neoplasms 4,4'-diaminodiphenylmethane 18.786582329
MESH:D007680 Kidney Neoplasms Diethylstilbestrol 18.7816762066 15003126 14681315
MESH:D007680 Kidney Neoplasms Estradiol 18.7815610895
MESH:D007859 Learning Disorders Diethylstilbestrol 4.2417184923
MESH:D007938 Leukemia Benzene 6.8518335105 15935818 17119257 14694614
MESH:D007938 Leukemia Genistein 6.8517468513 18980019
MESH:D007951 Leukemia, Myeloid Benzene 4.4617506065
MESH:D015470 Leukemia, Myeloid, Acute Benzene 2.7219478238
MESH:D008105 Liver Cirrhosis, Biliary 4,4'-diaminodiphenylmethane 3.289327722 15034207
MESH:D008106 Liver Cirrhosis, Experimental Estradiol 5.0814659978 14716833
MESH:D008106 Liver Cirrhosis, Experimental Genistein 5.0817823541
MESH:D008106 Liver Cirrhosis, Experimental pirinixic acid 5.0815474484
MESH:D008106 Liver Cirrhosis, Experimental Vitamin E 5.0816169303
MESH:D008113 Liver Neoplasms Diethylstilbestrol 4.7415890375 16712894
MESH:D008113 Liver Neoplasms pirinixic acid 4.7416377806 20007298 15890375
MESH:D008114 Liver Neoplasms, Experimental 4,4'-diaminodiphenylmethane 6.446587162 3712494 598648 1399818
MESH:D008114 Liver Neoplasms, Experimental Benzene 6.4412562636
MESH:D008171 Lung Diseases Vitamin E 3.2716863852
MESH:D017563 Lung Diseases, Interstitial Benzene 5.0214698565
MESH:D008175 Lung Neoplasms Benzene 2.7812562636
MESH:D008175 Lung Neoplasms Vitamin E 2.7811062179
MESH:D008181 Lupus Nephritis Diethylstilbestrol 5.3415166399
MESH:D008223 Lymphoma Benzene 8.1817119257 17584886
MESH:D008223 Lymphoma Diethylstilbestrol 8.1815700306
MESH:D052801 Male Urogenital Diseases Diethylstilbestrol 5.7316002989
MESH:D015674 Mammary Neoplasms, Animal Benzene 4.6412562636
MESH:D008325 Mammary Neoplasms, Experimental Benzene 15.0411921183
MESH:D008325 Mammary Neoplasms, Experimental Estradiol 15.0411807958 16891317 17203775 11408345
MESH:D008325 Mammary Neoplasms, Experimental Genistein 15.0414578162 12929590
MESH:D008325 Mammary Neoplasms, Experimental Selenium 15.0415318939
MESH:D020149 Manganese Poisoning Estradiol 4.7019453300
MESH:D008654 Mesothelioma Selenium 2.8415107826
MESH:D009101 Multiple Myeloma Benzene 3.7617119195
MESH:D009135 Muscular Diseases pirinixic acid 3.6816239165
MESH:D009203 Myocardial Infarction Genistein 5.8517141266
MESH:D009203 Myocardial Infarction pirinixic acid 5.8519151258
MESH:D015428 Myocardial Reperfusion Injury Estradiol 14.8116810080
MESH:D015428 Myocardial Reperfusion Injury Genistein 14.8117141266
MESH:D015428 Myocardial Reperfusion Injury pirinixic acid 14.8116411023
MESH:D009336 Necrosis 2,4-dinitrotoluene 4.0518551238
MESH:D009362 Neoplasm Metastasis 4,4'-diaminodiphenylmethane 2.523581430
MESH:D009369 Neoplasms Diethylstilbestrol 5.2515313581
MESH:D009369 Neoplasms pirinixic acid 5.2517405874
MESH:D009389 Neovascularization, Pathologic Estradiol 3.9317289903
MESH:D009421 Nervous System Malformations Diethylstilbestrol 17.4711399458
MESH:D009421 Nervous System Malformations Estradiol 17.4716427766 11399458
MESH:D009421 Nervous System Malformations Genistein 17.4716427766
MESH:D009436 Neural Tube Defects 4,4'-diaminodiphenylmethane 7.756679447
MESH:D009436 Neural Tube Defects Benzene 7.7515643154
MESH:D009765 Obesity pirinixic acid 1.8420558911
MESH:D009784 Occupational Diseases 2,4-dinitrotoluene 15.9516049721 12819281
MESH:D009784 Occupational Diseases 4,4'-diaminodiphenylmethane 15.956482804 4026338
MESH:D009784 Occupational Diseases Benzene 15.9517119257 15913788 17178637 15612468 17479406 16737584 15576619 15935809 15727169
MESH:D009902 Optic Neuritis 4,4'-diaminodiphenylmethane 5.243988306
MESH:D010024 Osteoporosis Genistein 3.3319401787
MESH:D015663 Osteoporosis, Postmenopausal Genistein 4.2316169203
MESH:D010051 Ovarian Neoplasms Benzene 8.2112562636
MESH:D010051 Ovarian Neoplasms Estradiol 8.2119401270
MESH:D010051 Ovarian Neoplasms Genistein 8.2119005980
MESH:D010212 Papilloma 4,4'-diaminodiphenylmethane 3.667296757
MESH:D010787 Photosensitivity Disorders 4,4'-diaminodiphenylmethane 4.696228378
MESH:D010900 Pituitary Diseases Diethylstilbestrol 5.3914722030
MESH:D010911 Pituitary Neoplasms Diethylstilbestrol 4.8515687265 16977796
MESH:D010954 Plasmacytoma Selenium 5.1115087411
MESH:D011297 Prenatal Exposure Delayed Effects Diethylstilbestrol 4.3117184923
MESH:D019048 Prostatic Intraepithelial Neoplasia Estradiol 4.0220887781
MESH:D011471 Prostatic Neoplasms Diethylstilbestrol 2.0817136230 15846301 15046698
MESH:D011471 Prostatic Neoplasms Estradiol 2.0816740699
MESH:D011471 Prostatic Neoplasms Genistein 2.0815378649 16925846 15256057
MESH:D011471 Prostatic Neoplasms Vitamin E 2.0815084515
MESH:D015427 Reperfusion Injury pirinixic acid 2.4519058328
MESH:D012162 Retinal Degeneration 4,4'-diaminodiphenylmethane 3.483692021
MESH:D012640 Seizures 2,4-dinitrotoluene 2.6218551238
MESH:D012871 Skin Diseases Vitamin E 2.4718709164
MESH:D013088 Spermatocele Diethylstilbestrol 4.9316002989 16709447
MESH:D013274 Stomach Neoplasms Benzene 2.4212562636
MESH:D020521 Stroke Vitamin E 3.6316517955
MESH:D013953 Thymus Neoplasms Benzene 5.1510850423
MESH:D013964 Thyroid Neoplasms 4,4'-diaminodiphenylmethane 2.997505956 1399818 3712494 6582329 6587162
MESH:D013978 Tibial Fractures Estradiol 4.9019048282
MESH:D001749 Urinary Bladder Neoplasms 2,4-dinitrotoluene 8.6316049721
MESH:D001749 Urinary Bladder Neoplasms 4,4'-diaminodiphenylmethane 8.638074119
MESH:D001749 Urinary Bladder Neoplasms Diethylstilbestrol 8.6316712894 16452187 17306315
MESH:D014571 Urologic Neoplasms 2,4-dinitrotoluene 4.5110091137
MESH:D002583 Uterine Cervical Neoplasms Diethylstilbestrol 4.1616175088
MESH:D014591 Uterine Diseases Diethylstilbestrol 5.3914652134
MESH:D014594 Uterine Neoplasms Benzene 10.4012562636
MESH:D014594 Uterine Neoplasms Diethylstilbestrol 10.4015809267 16690809
MESH:D014625 Vaginal Neoplasms Diethylstilbestrol 4.6116002989 16513791
No data
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Syndromic Genes

Non-syndromic Genes

AutismKB Statistics

  • Studies: 1,036
  • Genes: 1,379
  • CNVs/SVs: 5,420
  • SNVs/Indels: 11,669
  • de novo Mutations: 5,669
  • Mosaics: 789
  • Linkage Regions: 172
  • Paper Collected: 6/30/2018
  • Last Update: 8/26/2018


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