AutismKB 2.0

Annotation Detail for KLF13


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Basic Information Top
Gene Symbol:KLF13 ( BTEB3,FKLF2,NSLP1,RFLAT-1,RFLAT1 )
Gene Full Name: Kruppel-like factor 13
Band: 15q13.3
Quick LinksEntrez ID:51621; OMIM: 605328; Uniprot ID:KLF13_HUMAN; ENSEMBL ID: ENSG00000169926; HGNC ID: 13672
Relate to Another Database: SFARIGene; denovo-db
Related Pathway Information Top
Related Diseases/Disorders Top
Comparative Toxicogenomics Database Top
Chemical ID Chemical Name Interaction Interaction Action Publication
C472791 3-(4'-hydroxy-3'-adamantylbiphenyl-4-yl)acrylic acid 3-(4'-hydroxy-3'-adamantylbiphenyl-4-yl)acrylic acid results in decreased expression of KLF13 mRNAdecreases expression 16788091
C006632 arsenic trioxide arsenic trioxide results in decreased expression of KLF13 mRNAdecreases expression 20458559
D001554 Benzene Benzene results in increased expression of KLF13 mRNAincreases expression 15929907
D015123 7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide 7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide results in decreased expression of KLF13 mRNAdecreases expression 19150397
20018196
D020111 Chlorodiphenyl (54% Chlorine) Chlorodiphenyl (54% Chlorine) results in increased expression of KLF13 mRNAincreases expression 16934159
D004997 Ethinyl Estradiol Ethinyl Estradiol results in increased expression of KLF13 mRNAincreases expression 17942748
D010634 Phenobarbital Phenobarbital results in decreased expression of KLF13 mRNAdecreases expression 19270015
D010634 Phenobarbital Phenobarbital results in increased expression of KLF13 mRNAincreases expression 19270015
C006253 pirinixic acid [pirinixic acid binds to and results in increased activity of PPARA protein] which results in decreased expression of KLF13 mRNAaffects binding|decreases expression|increases activity 19710929
C064116 S-(1,1,2,2-tetrafluoroethyl)cysteine S-(1,1,2,2-tetrafluoroethyl)cysteine results in decreased expression of KLF13 mRNAdecreases expression 16678137
D013749 Tetrachlorodibenzodioxin Tetrachlorodibenzodioxin results in increased expression of KLF13 mRNAincreases expression 17035482
D014212 Tretinoin Tretinoin results in decreased expression of KLF13 mRNAdecreases expression 16788091
Disease ID Disease Name Direct Evidence Inference Chemical Name Inference Score Publication
MESH:D000014 Abnormalities, Drug-Induced Phenobarbital 8.956195326
MESH:D000014 Abnormalities, Drug-Induced Tetrachlorodibenzodioxin 8.9515322242 11752688 14514962
MESH:D000152 Acne Vulgaris Ethinyl Estradiol 4.1617505938
MESH:D055371 Acute Lung Injury pirinixic acid 3.2718653653
MESH:D000230 Adenocarcinoma arsenic trioxide 4.3919825857 11798837
MESH:D000230 Adenocarcinoma Ethinyl Estradiol 4.3914692618
MESH:D018248 Adenoma, Liver Cell Phenobarbital 18.4717620307
MESH:D018248 Adenoma, Liver Cell pirinixic acid 18.4716434500
MESH:D018248 Adenoma, Liver Cell Tetrachlorodibenzodioxin 18.4716835633
MESH:D000505 Alopecia Tretinoin 3.7315955085
MESH:D000740 Anemia Tetrachlorodibenzodioxin 3.0811748828
MESH:D000741 Anemia, Aplastic Benzene 4.4817661222 11369114 14761424
MESH:D001161 Arteriosclerosis Ethinyl Estradiol 3.6411256880
MESH:D001169 Arthritis, Experimental Ethinyl Estradiol 7.4815885639
MESH:D001169 Arthritis, Experimental Tretinoin 7.4816412693
MESH:D001172 Arthritis, Rheumatoid Tretinoin 2.2916292516
MESH:D001249 Asthma Tretinoin 2.3816456186
MESH:D001471 Barrett Esophagus Tretinoin 4.5616935849
MESH:D001778 Blood Coagulation Disorders arsenic trioxide 23.1616206674
MESH:D001778 Blood Coagulation Disorders pirinixic acid 23.1619483382
MESH:D001778 Blood Coagulation Disorders Tetrachlorodibenzodioxin 23.1612125929
MESH:D001778 Blood Coagulation Disorders Tretinoin 23.1616206674 16197459
MESH:D001836 Body Weight Changes Tetrachlorodibenzodioxin 4.0115340226
MESH:D001848 Bone Diseases, Developmental Tetrachlorodibenzodioxin 2.8515746008
MESH:D001855 Bone Marrow Diseases Benzene 5.4516183116
MESH:D001943 Breast Neoplasms Benzene 1.9211921183 17162533
MESH:D001943 Breast Neoplasms Tetrachlorodibenzodioxin 1.9220435547
MESH:D001943 Breast Neoplasms Tretinoin 1.9216166294 16443354 16873071
MESH:D001997 Bronchopulmonary Dysplasia Tretinoin 4.7816813970
MESH:D002051 Burkitt Lymphoma arsenic trioxide 4.4811589617
MESH:D002277 Carcinoma Tetrachlorodibenzodioxin 2.9116835633
MESH:D018236 Carcinoma, Embryonal Tretinoin 5.3816168501
MESH:D006528 Carcinoma, Hepatocellular arsenic trioxide 4.7315553829 14691202 15073043 16217749 11135700
MESH:D006528 Carcinoma, Hepatocellular Phenobarbital 4.7317173139 20007298 20935162 1701930 6705139
MESH:D006528 Carcinoma, Hepatocellular Tretinoin 4.731917145
MESH:D002291 Carcinoma, Papillary arsenic trioxide 5.0919014326
MESH:D018288 Carcinoma, Small Cell arsenic trioxide 4.2512490120
MESH:D002294 Carcinoma, Squamous Cell Tretinoin 2.3216096774 16051514
MESH:D006332 Cardiomegaly Tetrachlorodibenzodioxin 2.4418850075 18670907 16120746
MESH:D002386 Cataract Tretinoin 3.1717460283
MESH:D002471 Cell Transformation, Neoplastic 7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide 2.8220889678
MESH:D002493 Central Nervous System Diseases Phenobarbital 4.434080065
MESH:D018290 Cervical Intraepithelial Neoplasia Tretinoin 4.7816129372
MESH:D018281 Cholangiocarcinoma Tetrachlorodibenzodioxin 3.2916835633
MESH:D002779 Cholestasis Ethinyl Estradiol 8.0915861022 16919318 17333356 16105132 11677210 17110522 17681005
MESH:D002779 Cholestasis pirinixic acid 8.0919176532
MESH:D002822 Choriocarcinoma Tretinoin 5.3816461808
MESH:D002972 Cleft Palate Tetrachlorodibenzodioxin 5.9416354765 12621046 15668235 15340226 8697196
MESH:D002972 Cleft Palate Tretinoin 5.949407595
MESH:D003092 Colitis Tretinoin 3.8817035595
MESH:D003110 Colonic Neoplasms marker/mechanism 19050079
MESH:D015179 Colorectal Neoplasms arsenic trioxide 1.8620501625
MESH:D000013 Congenital Abnormalities Tetrachlorodibenzodioxin 3.1817141729 14669216
MESH:D023903 Coronary Restenosis arsenic trioxide 4.3512609071
MESH:D019465 Craniofacial Abnormalities arsenic trioxide 5.5410525206
MESH:D019465 Craniofacial Abnormalities Benzene 5.5415643154
MESH:D019465 Craniofacial Abnormalities Tetrachlorodibenzodioxin 5.5410048152 20055451 15322242
MESH:D019465 Craniofacial Abnormalities Tretinoin 5.549664655 8800419 9142499 10589399 9211117 17551590 9125849 16925845 14991402 9224671
MESH:D016757 Death, Sudden, Cardiac arsenic trioxide 4.2415213294
MESH:D003872 Dermatitis Benzene 4.9415902427
MESH:D003876 Dermatitis, Atopic pirinixic acid 2.4818249437
MESH:D003924 Diabetes Mellitus, Type 2 Tetrachlorodibenzodioxin 1.6917107852
MESH:D056486 Drug-Induced Liver Injury Chlorodiphenyl (54% Chlorine) 4.1817851650
MESH:D056486 Drug-Induced Liver Injury Tetrachlorodibenzodioxin 4.1820420201
MESH:D004362 Drug Toxicity Tetrachlorodibenzodioxin 2.8611462148
MESH:D004421 Dystonia Phenobarbital 4.151851702
MESH:D004487 Edema pirinixic acid 7.0012083418
MESH:D004487 Edema Tetrachlorodibenzodioxin 7.0011000095 12711302
MESH:D004489 Edema, Cardiac Tetrachlorodibenzodioxin 12.6816714409 15322242 18230668
MESH:D004489 Edema, Cardiac Tretinoin 12.6818230668
MESH:D004681 Encephalomyelitis, Autoimmune, Experimental Ethinyl Estradiol 3.3512538720
MESH:D016889 Endometrial Neoplasms Tretinoin 3.1916569247
MESH:D004715 Endometriosis Tetrachlorodibenzodioxin 3.159294722 10568697
MESH:D004831 Epilepsies, Myoclonic Phenobarbital 4.283659116
MESH:D004828 Epilepsies, Partial Phenobarbital 4.093922381 11558140
MESH:D004827 Epilepsy Phenobarbital 2.9520417680
MESH:D004832 Epilepsy, Absence Phenobarbital 3.676401628
MESH:D017029 Epilepsy, Complex Partial Phenobarbital 4.437750514
MESH:D004830 Epilepsy, Tonic-Clonic Phenobarbital 4.213659116
MESH:D004938 Esophageal Neoplasms 7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide 4.5720426865
MESH:D004938 Esophageal Neoplasms arsenic trioxide 4.5712903497
MESH:D005124 Eye Abnormalities Tetrachlorodibenzodioxin 9.1811564622
MESH:D005124 Eye Abnormalities Tretinoin 9.1816938888 9664655
MESH:D005234 Fatty Liver arsenic trioxide 13.8915073043
MESH:D005234 Fatty Liver Ethinyl Estradiol 13.8915345470
MESH:D005234 Fatty Liver pirinixic acid 13.8920131406 19236843
MESH:D005313 Fetal Death Tetrachlorodibenzodioxin 3.6311858732
MESH:D005355 Fibrosis Tetrachlorodibenzodioxin 9.2120067830
MESH:D005355 Fibrosis Tretinoin 9.2117994277
MESH:D005706 Gallbladder Neoplasms arsenic trioxide 4.4216904648
MESH:D005909 Glioblastoma Tretinoin 3.0917312396
MESH:D006058 Gonadal Disorders Tetrachlorodibenzodioxin 4.8110696789
MESH:D006258 Head and Neck Neoplasms Tretinoin 3.2716096774
MESH:D006317 Hearing Loss, Noise-Induced Tretinoin 5.3816084493
MESH:D006330 Heart Defects, Congenital Tetrachlorodibenzodioxin 6.7611294989 10048152
MESH:D006330 Heart Defects, Congenital Tretinoin 6.769664655 14991402
MESH:D006333 Heart Failure pirinixic acid 2.6220558911
MESH:D006402 Hematologic Diseases Benzene 4.8016183116
MESH:D006470 Hemorrhage Tetrachlorodibenzodioxin 3.4811000095
MESH:D006529 Hepatomegaly Phenobarbital 15.4416109766
MESH:D006529 Hepatomegaly pirinixic acid 15.4418467677 16221962 19176532 19772884
MESH:D006529 Hepatomegaly Tetrachlorodibenzodioxin 15.4415340226 16120746 12621046
MESH:D006869 Hydronephrosis Tetrachlorodibenzodioxin 4.268697196 16959395 15340226 18606429 16354765
MESH:D006930 Hyperalgesia Tretinoin 3.3216870215
MESH:D017681 Hypereosinophilic Syndrome Tretinoin 4.7416778211
MESH:D006943 Hyperglycemia pirinixic acid 3.3120558911
MESH:D006973 Hypertension Benzene 5.4717940673
MESH:D006973 Hypertension Tetrachlorodibenzodioxin 5.4718670907 18850075
MESH:D007021 Hypospadias Ethinyl Estradiol 3.9816945680 16569931
MESH:D007247 Infertility, Female Ethinyl Estradiol 3.6112013081
MESH:D007248 Infertility, Male Ethinyl Estradiol 2.5717937319
MESH:D007249 Inflammation Tetrachlorodibenzodioxin 1.9212200463 12878042
MESH:D007333 Insulin Resistance pirinixic acid 2.7216306350
MESH:D007410 Intestinal Diseases Tretinoin 3.9417994277
MESH:D007569 Jaw Abnormalities Tetrachlorodibenzodioxin 10.4016580747
MESH:D007569 Jaw Abnormalities Tretinoin 10.4015992940 17551590
MESH:D007938 Leukemia arsenic trioxide 10.9315070760
MESH:D007938 Leukemia Benzene 10.9317119257 14694614 15935818 18335105
MESH:D007938 Leukemia Tretinoin 10.9317143497
MESH:D015459 Leukemia-Lymphoma, Adult T-Cell arsenic trioxide 3.9312560223 17077332
MESH:D007948 Leukemia, Monocytic, Acute arsenic trioxide 4.5016972261
MESH:D015464 Leukemia, Myelogenous, Chronic, BCR-ABL Positive arsenic trioxide 3.5314633726
MESH:D007951 Leukemia, Myeloid arsenic trioxide 16.8819077051
MESH:D007951 Leukemia, Myeloid Benzene 16.8817506065
MESH:D007951 Leukemia, Myeloid Tretinoin 16.8819285840 16932348 16482212
MESH:D015470 Leukemia, Myeloid, Acute arsenic trioxide 6.3317050201 16467208 19850784 16968895 20471514
MESH:D015470 Leukemia, Myeloid, Acute Benzene 6.3319478238
MESH:D015470 Leukemia, Myeloid, Acute Tretinoin 6.3316294345 17596541 19850784
MESH:D015473 Leukemia, Promyelocytic, Acute arsenic trioxide 7.9312679006 16823087 19225113 17107899 15748426 16112521 16966277 19642359 12018890 16891316 15622746 19035177 17869043 17649720 17217047 11468182 11161223 12712474 15336539 15213294 16331271 19075265 16330433 17712046 9834237
MESH:D015473 Leukemia, Promyelocytic, Acute Tretinoin 7.9316140955 16823087 12679006 16788101 17217047 17361223 15748426 17339181 16331271 19035177 17368321 9834237 16766008 17712046 16935935 19075265 17506722 17294898 17301526 17107899 19029980 17649720 19225113 19642359 16891316
MESH:D015458 Leukemia, T-Cell arsenic trioxide 4.5116882451
MESH:D017880 Limb Deformities, Congenital Tretinoin 3.419224671
MESH:D008103 Liver Cirrhosis Phenobarbital 2.9621047994
MESH:D008106 Liver Cirrhosis, Experimental pirinixic acid 3.4715474484
MESH:D008106 Liver Cirrhosis, Experimental Tetrachlorodibenzodioxin 3.4712878042
MESH:D008106 Liver Cirrhosis, Experimental Tretinoin 3.4716248980 18397230
MESH:D008107 Liver Diseases Phenobarbital 2.2019363144
MESH:D008113 Liver Neoplasms arsenic trioxide 11.0814682389
MESH:D008113 Liver Neoplasms Phenobarbital 11.0819812893 15975961 19482888 8742319 21047994 19073162
MESH:D008113 Liver Neoplasms pirinixic acid 11.0820007298 15890375 16377806
MESH:D008113 Liver Neoplasms Tetrachlorodibenzodioxin 11.0816984957
MESH:D008114 Liver Neoplasms, Experimental arsenic trioxide 14.8620377131
MESH:D008114 Liver Neoplasms, Experimental Benzene 14.8612562636
MESH:D008114 Liver Neoplasms, Experimental Phenobarbital 14.8618308698 17172636 2563599 1399818 6150874
MESH:D008114 Liver Neoplasms, Experimental Tetrachlorodibenzodioxin 14.8612151625
MESH:D008133 Long QT Syndrome arsenic trioxide 3.4615213294
MESH:D017563 Lung Diseases, Interstitial Benzene 5.0214698565
MESH:D008175 Lung Neoplasms arsenic trioxide 3.5511798837 19825857
MESH:D008175 Lung Neoplasms Benzene 3.5512562636
MESH:D008175 Lung Neoplasms Tetrachlorodibenzodioxin 3.5511884234 19555203
MESH:D008223 Lymphoma Benzene 3.8317119257 17584886
MESH:D015674 Mammary Neoplasms, Animal Benzene 4.6412562636
MESH:D008325 Mammary Neoplasms, Experimental Benzene 3.3911921183
MESH:D008527 Medulloblastoma Tretinoin 2.8317453147
MESH:D008545 Melanoma Tretinoin 1.9616752155
MESH:D008591 Meningomyelocele Tretinoin 4.6016940565
MESH:D009101 Multiple Myeloma arsenic trioxide 7.8219417148 19549372 11468182 14977855 15949261
MESH:D009101 Multiple Myeloma Benzene 7.8217119195
MESH:D009135 Muscular Diseases pirinixic acid 3.6816239165
MESH:D009182 Mycosis Fungoides arsenic trioxide 4.8918349030
MESH:D009190 Myelodysplastic Syndromes arsenic trioxide 7.6416105982 16882451
MESH:D009190 Myelodysplastic Syndromes Tretinoin 7.6417596541
MESH:D009203 Myocardial Infarction pirinixic acid 2.1919151258
MESH:D017202 Myocardial Ischemia Tetrachlorodibenzodioxin 3.1312213967
MESH:D015428 Myocardial Reperfusion Injury pirinixic acid 3.0516411023
MESH:D020191 Myoclonic Epilepsies, Progressive Phenobarbital 4.6717484760
MESH:D009361 Neoplasm Invasiveness arsenic trioxide 4.1216624393
MESH:D009364 Neoplasm Recurrence, Local marker/mechanism 19050079
MESH:D009369 Neoplasms pirinixic acid 5.1217405874
MESH:D009369 Neoplasms Tretinoin 5.1216594593 16946489
MESH:D009421 Nervous System Malformations Tetrachlorodibenzodioxin 10.0614600291
MESH:D009421 Nervous System Malformations Tretinoin 10.069125849
MESH:D009436 Neural Tube Defects arsenic trioxide 12.7510525206
MESH:D009436 Neural Tube Defects Benzene 12.7515643154
MESH:D009436 Neural Tube Defects Tretinoin 12.759142499
MESH:D009765 Obesity pirinixic acid 1.8420558911
MESH:D009784 Occupational Diseases Benzene 4.3116737584 17119257 15913788 15935809 15727169 17178637 15612468 17479406 15576619
MESH:D010018 Osteomalacia Phenobarbital 4.5617016548
MESH:D010051 Ovarian Neoplasms arsenic trioxide 8.2016624393 19769630 12452020
MESH:D010051 Ovarian Neoplasms Benzene 8.2012562636
MESH:D010051 Ovarian Neoplasms Tretinoin 8.2016936753
MESH:D010146 Pain Tretinoin 3.0216870215
MESH:D010190 Pancreatic Neoplasms arsenic trioxide 8.8915580305
MESH:D010190 Pancreatic Neoplasms Phenobarbital 8.8916965848
MESH:D010190 Pancreatic Neoplasms Tretinoin 8.8915976015
MESH:D016584 Panic Disorder Ethinyl Estradiol 3.8411578682
MESH:D010235 Paraganglioma arsenic trioxide 4.3119927285
MESH:D010382 Peliosis Hepatis Tetrachlorodibenzodioxin 4.4712520081
MESH:D017119 Porphyria Cutanea Tarda Tetrachlorodibenzodioxin 3.7218163543
MESH:D011230 Precancerous Conditions Phenobarbital 3.752563599
MESH:D011297 Prenatal Exposure Delayed Effects Tetrachlorodibenzodioxin 3.3811222880 11118676 11896295 11399792
MESH:D011471 Prostatic Neoplasms arsenic trioxide 3.2519131511
MESH:D011507 Proteinuria Tretinoin 3.7516636307
MESH:D011537 Pruritus Ethinyl Estradiol 3.5116919318 15861022
MESH:D019310 Pseudolymphoma Phenobarbital 4.7112752131
MESH:D011625 Pterygium Tretinoin 4.9916723453
MESH:D015427 Reperfusion Injury pirinixic acid 2.4519058328
MESH:D015619 Respiratory System Abnormalities Tetrachlorodibenzodioxin 4.0018990726
MESH:D012208 Rhabdomyosarcoma Tretinoin 4.2516283617 16116481
MESH:D012512 Sarcoma, Ewing's arsenic trioxide 4.1216646077
MESH:D012640 Seizures Phenobarbital 2.783137016 4039156 16876388 11442880
MESH:D003294 Seizures, Febrile Phenobarbital 5.026407741
MESH:D012878 Skin Neoplasms Tetrachlorodibenzodioxin 5.7616192470
MESH:D012878 Skin Neoplasms Tretinoin 5.7616467112
MESH:D013088 Spermatocele Ethinyl Estradiol 4.1616709447
MESH:D013274 Stomach Neoplasms arsenic trioxide 3.5217007042
MESH:D013274 Stomach Neoplasms Benzene 3.5212562636
MESH:D013274 Stomach Neoplasms Tretinoin 3.5217261132
MESH:D019851 Thrombophilia Ethinyl Estradiol 3.7711994571
MESH:D013927 Thrombosis Ethinyl Estradiol 3.2815669648
MESH:D013953 Thymus Neoplasms Benzene 5.1510850423
MESH:D013959 Thyroid Diseases Tetrachlorodibenzodioxin 4.1212697716
MESH:D013964 Thyroid Neoplasms arsenic trioxide 12.6219014326
MESH:D013964 Thyroid Neoplasms Phenobarbital 12.621399818
MESH:D013964 Thyroid Neoplasms Tretinoin 12.6216026305 17045167
MESH:D014062 Tongue Neoplasms Tretinoin 3.9216051514
MESH:D016171 Torsades de Pointes arsenic trioxide 4.1515213294
MESH:D014376 Tuberculosis Tretinoin 3.3116040207
MESH:D001749 Urinary Bladder Neoplasms arsenic trioxide 2.5320435036 12973940 12845720 11780464
MESH:D002583 Uterine Cervical Neoplasms Tretinoin 3.8116129372
MESH:D014594 Uterine Neoplasms Benzene 10.1212562636
MESH:D014594 Uterine Neoplasms Ethinyl Estradiol 10.1214692618
MESH:D014604 Uveal Neoplasms Tretinoin 4.8316752155
MESH:D054079 Vascular Malformations Tetrachlorodibenzodioxin 4.8112125929
MESH:D020246 Venous Thrombosis Ethinyl Estradiol 3.6814671159 15869587
MESH:D014820 Vitiligo Tretinoin 4.2216761959
MESH:D019282 Wasting Syndrome Tetrachlorodibenzodioxin 4.4715886252
MESH:D009396 Wilms Tumor Tretinoin 4.0916287080
No data
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Syndromic Genes

Non-syndromic Genes

AutismKB Statistics

  • Studies: 1,036
  • Genes: 1,379
  • CNVs/SVs: 5,420
  • SNVs/Indels: 11,669
  • de novo Mutations: 5,669
  • Mosaics: 789
  • Linkage Regions: 172
  • Paper Collected: 6/30/2018
  • Last Update: 8/26/2018


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