Gene Symbol:	PDK1 ( - )
Gene Full Name:	pyruvate dehydrogenase kinase, isozyme 1
Band:	2q31.1
Quick Links	Entrez ID:5163; OMIM: 602524; Uniprot ID:PDK1_HUMAN; ENSEMBL ID: ENSG00000152256; HGNC ID: 8809
Relate to Another Database:	SFARIGene; denovo-db

Pathway ID	Pathway Name
hsa05160	Hepatitis C
hsa05145	Toxoplasmosis
hsa04722	Neurotrophin signaling pathway
hsa04660	T cell receptor signaling pathway
hsa04664	Fc epsilon RI signaling pathway

Chemical ID	Chemical Name	Interaction	Interaction Action	Publication
C548651	2-(1'H-indolo-3'-carbonyl)thiazole-4-carboxylic acid methyl ester	2-(1'H-indolo-3'-carbonyl)thiazole-4-carboxylic acid methyl ester results in increased expression of PDK1 mRNA	increases expression	19933214
C016403	2,4-dinitrotoluene	2,4-dinitrotoluene affects the expression of PDK1 mRNA	affects expression	21346803
C023514	2,6-dinitrotoluene	2,6-dinitrotoluene results in increased expression of PDK1 mRNA	increases expression	20406850
C031278	2-chloroethyl ethyl sulfide	2-chloroethyl ethyl sulfide results in decreased expression of PDK1 mRNA	decreases expression	12208782
C031278	2-chloroethyl ethyl sulfide	2-chloroethyl ethyl sulfide results in decreased expression of PDK1 protein	decreases expression	12208782
D000082	Acetaminophen	Acetaminophen affects the expression of PDK1 mRNA	affects expression	17562736
D000111	Acetylcysteine	Acetylcysteine inhibits the reaction [Curcumin results in increased phosphorylation of PDK1 protein]	decreases reaction\|increases phosphorylation	17171638
D000643	Ammonium Chloride	Ammonium Chloride affects the expression of PDK1 mRNA	affects expression	16483693
D001564	Benzo(a)pyrene	Benzo(a)pyrene results in decreased expression of PDK1 mRNA	decreases expression	20106945
D015123	7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide	7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide results in decreased expression of PDK1 mRNA	decreases expression	20382639
C002791	bismuth tripotassium dicitrate	bismuth tripotassium dicitrate results in increased expression of PDK1 mRNA	increases expression	15912405
C006780	bisphenol A	bisphenol A results in increased expression of PDK1 mRNA	increases expression	12075121
D019328	Buthionine Sulfoximine	Buthionine Sulfoximine promotes the reaction [Curcumin results in increased phosphorylation of PDK1 protein]	increases phosphorylation\|increases reaction	17171638
D003035	Cobalt	[tungsten carbide binds to Cobalt] which results in increased expression of PDK1 mRNA	affects binding\|increases expression	20105288
C018021	cobaltous chloride	cobaltous chloride results in increased expression of PDK1 mRNA	increases expression	20105288
D003474	Curcumin	Acetylcysteine inhibits the reaction [Curcumin results in increased phosphorylation of PDK1 protein]	decreases reaction\|increases phosphorylation	17171638
D003474	Curcumin	Buthionine Sulfoximine promotes the reaction [Curcumin results in increased phosphorylation of PDK1 protein]	increases phosphorylation\|increases reaction	17171638
D003474	Curcumin	Curcumin results in increased phosphorylation of PDK1 protein	increases phosphorylation	17171638
D003474	Curcumin	Glutathione inhibits the reaction [Curcumin results in increased phosphorylation of PDK1 protein]	decreases reaction\|increases phosphorylation	17171638
C107676	deguelin	deguelin metabolite results in decreased expression of PDK1 protein	decreases expression	19139008
C107676	deguelin	deguelin results in decreased expression of PDK1 protein	decreases expression	19139008
D004052	Diethylnitrosamine	CTNNB1 protein inhibits the reaction [Diethylnitrosamine results in increased phosphorylation of PDK1 protein]	decreases reaction\|increases phosphorylation	20583210
D004052	Diethylnitrosamine	Diethylnitrosamine results in increased phosphorylation of PDK1 protein	increases phosphorylation	20583210
D019833	Genistein	Genistein results in decreased phosphorylation of PDK1 protein	decreases phosphorylation	18431742
D005947	Glucose	PDK1 protein promotes the reaction [NRG1 protein results in increased transport of Glucose]	increases reaction\|increases transport	14711829
D005978	Glutathione	Glutathione inhibits the reaction [Curcumin results in increased phosphorylation of PDK1 protein]	decreases reaction\|increases phosphorylation	17171638
D008345	Manganese	Manganese results in increased expression of PDK1 mRNA	increases expression	17175027
C025340	manganese chloride	manganese chloride results in increased expression of PDK1 mRNA	increases expression	17175027
D008727	Methotrexate	PDK1 protein affects the susceptibility to Methotrexate	affects response to substance	16217747
D008770	Methylnitrosourea	Methylnitrosourea results in increased expression of PDK1 mRNA	increases expression	16525678
D010100	Oxygen	Oxygen deficiency results in increased expression of PDK1 mRNA	increases expression	17671207 17175027
D010100	Oxygen	[Rotenone co-treated with Thenoyltrifluoroacetone] inhibits the reaction [Oxygen deficiency results in increased expression of PDK1 mRNA]	affects cotreatment\|decreases reaction\|increases expression	17671207
C006253	pirinixic acid	[pirinixic acid binds to and results in increased activity of PPARA protein] which results in increased expression of PDK1 mRNA	affects binding\|increases activity\|increases expression	19710929
C006253	pirinixic acid	pirinixic acid results in increased expression of PDK1 mRNA	increases expression	17426115
C025299	polyphenols	polyphenols results in decreased expression of PDK1 mRNA	decreases expression	16293270
D012402	Rotenone	[Rotenone co-treated with Thenoyltrifluoroacetone] inhibits the reaction [Oxygen deficiency results in increased expression of PDK1 mRNA]	affects cotreatment\|decreases reaction\|increases expression	17671207
D013749	Tetrachlorodibenzodioxin	Tetrachlorodibenzodioxin results in increased expression of PDK1 mRNA	increases expression	19933214
D013804	Thenoyltrifluoroacetone	[Rotenone co-treated with Thenoyltrifluoroacetone] inhibits the reaction [Oxygen deficiency results in increased expression of PDK1 mRNA]	affects cotreatment\|decreases reaction\|increases expression	17671207
D014212	Tretinoin	Tretinoin results in decreased expression of PDK1 mRNA	decreases expression	16604517
C002802	tungsten carbide	[tungsten carbide binds to Cobalt] which results in increased expression of PDK1 mRNA	affects binding\|increases expression	20105288
C002802	tungsten carbide	tungsten carbide results in increased expression of PDK1 mRNA	increases expression	20105288

Pathway ID	Pathway Name
KEGG:04664	Fc epsilon RI signaling pathway
KEGG:05160	Hepatitis C
KEGG:04722	Neurotrophin signaling pathway
REACT:1046	Pyruvate metabolism and Citric Acid (TCA) cycle
KEGG:04660	T cell receptor signaling pathway
KEGG:05145	Toxoplasmosis

Drugbank ID	Action	Drug Name	Description
DB07403	-	4-[(3-CHLORO-4-{[(2R)-3,3,3-TRIFLUORO-2-HYDROXY-2-METHYLPROPANOYL]AMINO}PHENYL)SULFONYL]-N,N-DIMETHYLBENZAMIDE
DB08809	inhibitor	Dichloroacetic Acid

Disease ID	Disease Name	Inference Chemical Name	Inference Score	Publication
MESH:D000014	Abnormalities, Drug-Induced	Methotrexate	7.56	12039119
MESH:D000014	Abnormalities, Drug-Induced	Tetrachlorodibenzodioxin	7.56	15322242 11752688 14514962
MESH:D000138	Acidosis	Ammonium Chloride	3.25	18287403
MESH:D055371	Acute Lung Injury	Oxygen	8.28	16759491
MESH:D055371	Acute Lung Injury	pirinixic acid	8.28	18653653
MESH:D000230	Adenocarcinoma	Benzo(a)pyrene	6.73	20127859 20464547
MESH:D000230	Adenocarcinoma	Genistein	6.73	11473722
MESH:D000230	Adenocarcinoma	Methylnitrosourea	6.73	15688392 15113128
MESH:D000236	Adenoma	Benzo(a)pyrene	6.03	6695378
MESH:D000236	Adenoma	Diethylnitrosamine	6.03	6695378 10737359
MESH:D018248	Adenoma, Liver Cell	Diethylnitrosamine	15.47	17162532 16434500 17620307 19061943 19052882 18056438
MESH:D018248	Adenoma, Liver Cell	pirinixic acid	15.47	16434500
MESH:D018248	Adenoma, Liver Cell	Tetrachlorodibenzodioxin	15.47	16835633
MESH:D019973	Alcohol-Related Disorders	Curcumin	4.77	17887948
MESH:D000505	Alopecia	Tretinoin	3.37	15955085
MESH:D000544	Alzheimer Disease	Curcumin	2.55	15590663
MESH:D000740	Anemia	Tetrachlorodibenzodioxin	2.68	11748828
MESH:D000756	Anemia, Sideroblastic	Manganese	10.11	16910769
MESH:D000756	Anemia, Sideroblastic	manganese chloride	10.11	16910769
MESH:D000799	Angioedema	Acetaminophen	3.53	10982225
MESH:D000860	Anoxia	Oxygen	4.74	20872349
MESH:D017544	Aortic Aneurysm, Abdominal	Benzo(a)pyrene	3.77	19183758
MESH:D001169	Arthritis, Experimental	Tretinoin	2.89	16412693
MESH:D001172	Arthritis, Rheumatoid	Curcumin	7.07	16807698
MESH:D001172	Arthritis, Rheumatoid	Methotrexate	7.07	17286800
MESH:D001172	Arthritis, Rheumatoid	Tretinoin	7.07	16292516
MESH:D001249	Asthma	Tretinoin	2.25	16456186
MESH:D050197	Atherosclerosis	Curcumin	6.50	18704882
MESH:D050197	Atherosclerosis	Oxygen	6.50	16391483
MESH:D001321	Autistic Disorder	Acetaminophen	2.22	18445737
MESH:D001321	Autistic Disorder	Glutathione	2.22	16917939 19267885 19056591 18929414
MESH:D001327	Autoimmune Diseases	Curcumin	4.19	19761891
MESH:D001471	Barrett Esophagus	Tretinoin	4.11	16935849
MESH:D001778	Blood Coagulation Disorders	pirinixic acid	13.66	19483382
MESH:D001778	Blood Coagulation Disorders	Tetrachlorodibenzodioxin	13.66	12125929
MESH:D001778	Blood Coagulation Disorders	Tretinoin	13.66	16206674 16197459
MESH:D001836	Body Weight Changes	Tetrachlorodibenzodioxin	3.47	15340226
MESH:D001848	Bone Diseases, Developmental	Tetrachlorodibenzodioxin	2.57	15746008
MESH:D001862	Bone Resorption	bisphenol A	3.59	11985600
MESH:D002545	Brain Ischemia	Curcumin	4.02	16770732

Releated drug ID	Related drug Name
PA448871	celecoxib
PA164749238	exenatide

AutismKB 2.0

Annotation Detail for PDK1

Simple Query:

Syndromic Genes

Non-syndromic Genes

AutismKB Statistics