AutismKB 2.0

Annotation Detail for LUC7L2


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Basic Information Top
Gene Symbol:LUC7L2 ( CGI-74,FLJ10657,LUC7B2,hLuc7B2 )
Gene Full Name: LUC7-like 2 (S. cerevisiae)
Band: 7q34
Quick LinksEntrez ID:51631; OMIM: 613056; Uniprot ID:LC7L2_HUMAN; ENSEMBL ID: ENSG00000146963; HGNC ID: 21608
Relate to Another Database: SFARIGene; denovo-db
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Comparative Toxicogenomics Database Top
Chemical ID Chemical Name Interaction Interaction Action Publication
C040534 alpha-hexachlorocyclohexane alpha-hexachlorocyclohexane affects the expression of LUC7L2 mRNAaffects expression 17785943
D015123 7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide 7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide results in decreased expression of LUC7L2 mRNAdecreases expression 19150397
D012643 Selenium Selenium results in decreased expression of LUC7L2 mRNAdecreases expression 19244175
C017947 sodium arsenite sodium arsenite results in increased expression of LUC7L2 mRNAincreases expression 19072884
D013749 Tetrachlorodibenzodioxin Tetrachlorodibenzodioxin results in increased expression of LUC7L2 mRNAincreases expression 12377990
D013749 Tetrachlorodibenzodioxin Tetrachlorodibenzodioxin affects the expression of LUC7L2 mRNAaffects expression 18691609
D013749 Tetrachlorodibenzodioxin Tetrachlorodibenzodioxin results in increased expression of LUC7L2 mRNAincreases expression 19465110
D014810 Vitamin E Vitamin E results in decreased expression of LUC7L2 mRNAdecreases expression 19244175
Disease ID Disease Name Direct Evidence Inference Chemical Name Inference Score Publication
MESH:D000014 Abnormalities, Drug-Induced Tetrachlorodibenzodioxin 3.3114514962 15322242 11752688
MESH:D018248 Adenoma, Liver Cell Tetrachlorodibenzodioxin 3.8416835633
MESH:D000310 Adrenal Gland Neoplasms sodium arsenite 5.2215276417
MESH:D018246 Adrenocortical Adenoma sodium arsenite 5.4217306315 16712894
MESH:D000740 Anemia Tetrachlorodibenzodioxin 3.2511748828
MESH:D001778 Blood Coagulation Disorders Tetrachlorodibenzodioxin 3.3712125929
MESH:D001836 Body Weight Changes Tetrachlorodibenzodioxin 4.3115340226
MESH:D001848 Bone Diseases, Developmental Tetrachlorodibenzodioxin 2.9515746008
MESH:D001943 Breast Neoplasms Tetrachlorodibenzodioxin 1.6720435547
MESH:D002252 Carbon Tetrachloride Poisoning Vitamin E 4.3516050911
MESH:D002277 Carcinoma Tetrachlorodibenzodioxin 3.0516835633
MESH:D006528 Carcinoma, Hepatocellular sodium arsenite 2.0016507464 17306315 15276417
MESH:D002294 Carcinoma, Squamous Cell sodium arsenite 2.4518572023
MESH:D006332 Cardiomegaly Tetrachlorodibenzodioxin 2.5218670907 18850075 16120746
MESH:D002471 Cell Transformation, Neoplastic 7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide 7.4320889678
MESH:D002471 Cell Transformation, Neoplastic sodium arsenite 7.4320056578 19524636
MESH:D018281 Cholangiocarcinoma Tetrachlorodibenzodioxin 3.4516835633
MESH:D002972 Cleft Palate Tetrachlorodibenzodioxin 2.2115668235 8697196 12621046 15340226 16354765
MESH:D003092 Colitis Selenium 4.2017936198
MESH:D000013 Congenital Abnormalities Tetrachlorodibenzodioxin 3.3417141729 14669216
MESH:D019465 Craniofacial Abnormalities Tetrachlorodibenzodioxin 2.5515322242 10048152 20055451
MESH:D019465 Craniofacial Abnormalities Vitamin E 2.5519769572
MESH:D003924 Diabetes Mellitus, Type 2 Tetrachlorodibenzodioxin 1.7217107852
MESH:D056486 Drug-Induced Liver Injury Selenium 4.0215131321
MESH:D056486 Drug-Induced Liver Injury Tetrachlorodibenzodioxin 4.0220420201
MESH:D004362 Drug Toxicity Tetrachlorodibenzodioxin 2.9911462148
MESH:C538011 Eales disease Vitamin E 5.229068938
MESH:D004487 Edema Tetrachlorodibenzodioxin 2.7012711302 11000095
MESH:D004489 Edema, Cardiac Tetrachlorodibenzodioxin 4.4215322242 18230668 16714409
MESH:D004715 Endometriosis Tetrachlorodibenzodioxin 3.339294722 10568697
MESH:D004938 Esophageal Neoplasms 7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide 2.1320426865
MESH:D005124 Eye Abnormalities Tetrachlorodibenzodioxin 3.2411564622
MESH:D005313 Fetal Death Tetrachlorodibenzodioxin 3.8711858732
MESH:D005355 Fibrosis Tetrachlorodibenzodioxin 3.3620067830
MESH:D005833 Genital Neoplasms, Female sodium arsenite 5.1416452187
MESH:D006058 Gonadal Disorders Tetrachlorodibenzodioxin 5.1210696789
MESH:D006330 Heart Defects, Congenital Tetrachlorodibenzodioxin 7.0610048152 11294989
MESH:D006330 Heart Defects, Congenital Vitamin E 7.0616080930
MESH:D006333 Heart Failure Selenium 3.2517162251
MESH:D006470 Hemorrhage Tetrachlorodibenzodioxin 3.6611000095
MESH:D006529 Hepatomegaly Tetrachlorodibenzodioxin 3.3115340226 12621046 16120746
MESH:D006548 Hernia, Diaphragmatic Vitamin E 2.7916490937 16863852
MESH:D006689 Hodgkin Disease sodium arsenite 3.4312676792
MESH:D019584 Hot Flashes Vitamin E 4.4914716179
MESH:D006869 Hydronephrosis Tetrachlorodibenzodioxin 4.5716959395 15340226 18606429 8697196 16354765
MESH:D006973 Hypertension Tetrachlorodibenzodioxin 2.0018850075 18670907
MESH:D007248 Infertility, Male sodium arsenite 3.1915346721 12646999
MESH:D007249 Inflammation Tetrachlorodibenzodioxin 1.9912878042 12200463
MESH:D007251 Influenza, Human Selenium 12.7616624496
MESH:D007251 Influenza, Human Vitamin E 12.7616624496
MESH:D007569 Jaw Abnormalities Tetrachlorodibenzodioxin 3.6616580747
MESH:D007674 Kidney Diseases sodium arsenite 6.7420008137
MESH:D007674 Kidney Diseases Vitamin E 6.7412488133
MESH:D007676 Kidney Failure, Chronic Selenium 4.2116518626
MESH:D008106 Liver Cirrhosis, Experimental Tetrachlorodibenzodioxin 2.4212878042
MESH:D008106 Liver Cirrhosis, Experimental Vitamin E 2.4216169303
MESH:D008113 Liver Neoplasms sodium arsenite 4.7815276417 16712894
MESH:D008113 Liver Neoplasms Tetrachlorodibenzodioxin 4.7816984957
MESH:D008114 Liver Neoplasms, Experimental Tetrachlorodibenzodioxin 2.2812151625
MESH:D008171 Lung Diseases sodium arsenite 8.1219095001
MESH:D008171 Lung Diseases Vitamin E 8.1216863852
MESH:D008175 Lung Neoplasms sodium arsenite 3.5617077188 17306315 19931552 16712894 15276417
MESH:D008175 Lung Neoplasms Tetrachlorodibenzodioxin 3.5611884234 19555203
MESH:D008175 Lung Neoplasms Vitamin E 3.5611062179
MESH:D008325 Mammary Neoplasms, Experimental Selenium 2.9515318939
MESH:D008545 Melanoma sodium arsenite 2.0616487513 19082730
MESH:D008654 Mesothelioma Selenium 2.8915107826
MESH:D017202 Myocardial Ischemia Tetrachlorodibenzodioxin 3.2712213967
MESH:D009369 Neoplasms sodium arsenite 2.6311559025
MESH:D009374 Neoplasms, Experimental sodium arsenite 4.0820056578
MESH:D009421 Nervous System Malformations Tetrachlorodibenzodioxin 3.5914600291
MESH:D009436 Neural Tube Defects sodium arsenite 3.3312854658
MESH:D010051 Ovarian Neoplasms sodium arsenite 2.5117306315 15276417
MESH:D010382 Peliosis Hepatis Tetrachlorodibenzodioxin 4.7712520081
MESH:D010954 Plasmacytoma Selenium 5.4115087411
MESH:D017119 Porphyria Cutanea Tarda Tetrachlorodibenzodioxin 3.9418163543
MESH:D011297 Prenatal Exposure Delayed Effects Tetrachlorodibenzodioxin 3.6511896295 11118676 11399792 11222880
MESH:D011471 Prostatic Neoplasms sodium arsenite 3.2416039940
MESH:D011471 Prostatic Neoplasms Vitamin E 3.2415084515
MESH:D015619 Respiratory System Abnormalities Tetrachlorodibenzodioxin 4.2218990726
MESH:D012871 Skin Diseases Vitamin E 2.5018709164
MESH:D012878 Skin Neoplasms sodium arsenite 6.0218572023 19524636
MESH:D012878 Skin Neoplasms Tetrachlorodibenzodioxin 6.0216192470
MESH:D016135 Spinal Dysraphism sodium arsenite 4.0412854658
MESH:D020521 Stroke Vitamin E 3.7716517955
MESH:D013959 Thyroid Diseases Tetrachlorodibenzodioxin 4.4212697716
MESH:D001749 Urinary Bladder Neoplasms sodium arsenite 2.6016712894 11723127 17306315 16452187
MESH:D002583 Uterine Cervical Neoplasms sodium arsenite 4.0711813266
MESH:D014652 Vascular Diseases sodium arsenite 4.8917056641
MESH:D054079 Vascular Malformations Tetrachlorodibenzodioxin 5.1212125929
MESH:D019282 Wasting Syndrome Tetrachlorodibenzodioxin 4.7715886252
No data
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Syndromic Genes

Non-syndromic Genes

AutismKB Statistics

  • Studies: 1,036
  • Genes: 1,379
  • CNVs/SVs: 5,420
  • SNVs/Indels: 11,669
  • de novo Mutations: 5,669
  • Mosaics: 789
  • Linkage Regions: 172
  • Paper Collected: 6/30/2018
  • Last Update: 8/26/2018


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