AutismKB 2.0

Annotation Detail for STYXL1


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Basic Information Top
Gene Symbol:STYXL1 ( DUSP24,MK-STYX )
Gene Full Name: serine/threonine/tyrosine interacting-like 1
Band: 7q11.23
Quick LinksEntrez ID:51657; OMIM: NA; Uniprot ID:STYL1_HUMAN; ENSEMBL ID: ENSG00000127952; HGNC ID: 18165
Relate to Another Database: SFARIGene; denovo-db
Related Pathway Information Top
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Pathway IDPathway Name
P00046Oxidative stress response
No data
Related Diseases/Disorders Top
Comparative Toxicogenomics Database Top
Chemical ID Chemical Name Interaction Interaction Action Publication
C016403 2,4-dinitrotoluene 2,4-dinitrotoluene affects the expression of STYXL1 mRNAaffects expression 21346803
C035208 2-amino-4,6-dinitrotoluene 2-amino-4,6-dinitrotoluene affects the expression of STYXL1 mRNAaffects expression 21346803
C035207 4-amino-2,6-dinitrotoluene 4-amino-2,6-dinitrotoluene affects the expression of STYXL1 mRNAaffects expression 21346803
D016572 Cyclosporine Cyclosporine results in increased expression of STYXL1 mRNAincreases expression 20106945
D012643 Selenium Selenium results in increased expression of STYXL1 mRNAincreases expression 19244175
D014303 Trinitrotoluene Trinitrotoluene affects the expression of STYXL1 mRNAaffects expression 21346803
D014810 Vitamin E Vitamin E results in increased expression of STYXL1 mRNAincreases expression 19244175
Disease ID Disease Name Direct Evidence Inference Chemical Name Inference Score Publication
MESH:D000014 Abnormalities, Drug-Induced 2-amino-4,6-dinitrotoluene 17.107525203
MESH:D000014 Abnormalities, Drug-Induced 4-amino-2,6-dinitrotoluene 17.107525203
MESH:D000014 Abnormalities, Drug-Induced Trinitrotoluene 17.107525203
MESH:D002252 Carbon Tetrachloride Poisoning Vitamin E 4.2916050911
MESH:D006528 Carcinoma, Hepatocellular 2,4-dinitrotoluene 1.7816705839
MESH:D002386 Cataract 4-amino-2,6-dinitrotoluene 8.3914694615
MESH:D002386 Cataract Trinitrotoluene 8.3914694615 15817613
MESH:D002471 Cell Transformation, Neoplastic Cyclosporine 2.7112371664
MESH:D002779 Cholestasis Cyclosporine 3.1219486331
MESH:D003092 Colitis Selenium 4.1417936198
MESH:D000013 Congenital Abnormalities 2-amino-4,6-dinitrotoluene 17.3915095906
MESH:D000013 Congenital Abnormalities 4-amino-2,6-dinitrotoluene 17.3915095906
MESH:D000013 Congenital Abnormalities Trinitrotoluene 17.3915095906
MESH:D019465 Craniofacial Abnormalities Vitamin E 1.9219769572
MESH:D003490 Cyanosis 2,4-dinitrotoluene 12.4518551238
MESH:D003490 Cyanosis Trinitrotoluene 12.4518551238
MESH:D056486 Drug-Induced Liver Injury 2,4-dinitrotoluene 12.8418551238 21346803
MESH:D056486 Drug-Induced Liver Injury 2-amino-4,6-dinitrotoluene 12.8421346803
MESH:D056486 Drug-Induced Liver Injury 4-amino-2,6-dinitrotoluene 12.8421346803
MESH:D056486 Drug-Induced Liver Injury Selenium 12.8415131321
MESH:D056486 Drug-Induced Liver Injury Trinitrotoluene 12.8418551238 21346803
MESH:C538011 Eales disease Vitamin E 5.159068938
MESH:D005234 Fatty Liver Cyclosporine 3.1419224547
MESH:D005355 Fibrosis Cyclosporine 3.5012639820 12168785
MESH:D005885 Gingival Hyperplasia Cyclosporine 4.628708960
MESH:D006330 Heart Defects, Congenital Vitamin E 3.1216080930
MESH:D006333 Heart Failure Selenium 3.2317162251
MESH:D006457 Hemoglobinuria, Paroxysmal Cyclosporine 4.8215720958
MESH:D006529 Hepatomegaly Trinitrotoluene 4.5915817613
MESH:D006548 Hernia, Diaphragmatic Vitamin E 2.7816490937 16863852
MESH:D019584 Hot Flashes Vitamin E 4.4114716179
MESH:D006973 Hypertension Cyclosporine 2.1810903974
MESH:D007248 Infertility, Male Trinitrotoluene 3.8512150543
MESH:D007251 Influenza, Human Selenium 12.4816624496
MESH:D007251 Influenza, Human Vitamin E 12.4816624496
MESH:D007638 Keratoconjunctivitis Sicca Cyclosporine 4.8815604871
MESH:D007674 Kidney Diseases Cyclosporine 6.508314463 10903974 18776723
MESH:D007674 Kidney Diseases Vitamin E 6.5012488133
MESH:D007676 Kidney Failure, Chronic Selenium 4.1716518626
MESH:D007680 Kidney Neoplasms 2,4-dinitrotoluene 8.0616705839
MESH:D007680 Kidney Neoplasms Cyclosporine 8.0612371664
MESH:D008106 Liver Cirrhosis, Experimental Vitamin E 1.9016169303
MESH:D008171 Lung Diseases Vitamin E 3.3516863852
MESH:D008175 Lung Neoplasms Vitamin E 1.9011062179
MESH:D008325 Mammary Neoplasms, Experimental Selenium 2.9215318939
MESH:D008654 Mesothelioma Selenium 2.8815107826
MESH:D008664 Metal Metabolism, Inborn Errors Cyclosporine 5.2316801185
MESH:D009336 Necrosis 2,4-dinitrotoluene 12.0418551238
MESH:D009336 Necrosis Trinitrotoluene 12.0418551238
MESH:D009402 Nephrosis, Lipoid Cyclosporine 4.8817954296
MESH:D009404 Nephrotic Syndrome Cyclosporine 3.5319348381 18481113
MESH:D009784 Occupational Diseases 2,4-dinitrotoluene 16.8716049721 12819281
MESH:D009784 Occupational Diseases 4-amino-2,6-dinitrotoluene 16.8714694615
MESH:D009784 Occupational Diseases Trinitrotoluene 16.8717852074 12819281 14694615
MESH:D010954 Plasmacytoma Selenium 5.3315087411
MESH:D011230 Precancerous Conditions Cyclosporine 3.4712371664
MESH:D011471 Prostatic Neoplasms Vitamin E 3.2615084515
MESH:D011565 Psoriasis Cyclosporine 2.3016882103
MESH:D012640 Seizures 2,4-dinitrotoluene 6.8118551238
MESH:D012640 Seizures Trinitrotoluene 6.8118551238
MESH:D012871 Skin Diseases Vitamin E 2.5018709164
MESH:D013163 Splenomegaly Trinitrotoluene 5.5615817613
MESH:D020521 Stroke Vitamin E 3.7416517955
MESH:D001749 Urinary Bladder Neoplasms 2,4-dinitrotoluene 2.3716049721
MESH:D014571 Urologic Neoplasms 2,4-dinitrotoluene 4.7110091137
MESH:D014605 Uveitis Cyclosporine 4.431336536
MESH:D014985 Xerophthalmia Cyclosporine 4.8817120751
No data
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AutismKB Statistics

  • Studies: 1,036
  • Genes: 1,379
  • CNVs/SVs: 5,420
  • SNVs/Indels: 11,669
  • de novo Mutations: 5,669
  • Mosaics: 789
  • Linkage Regions: 172
  • Paper Collected: 6/30/2018
  • Last Update: 8/26/2018


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