AutismKB 2.0

Annotation Detail for PDK4


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Basic Information Top
Gene Symbol:PDK4 ( FLJ40832 )
Gene Full Name: pyruvate dehydrogenase kinase, isozyme 4
Band: 7q21.3
Quick LinksEntrez ID:5166; OMIM: 602527; Uniprot ID:PDK4_HUMAN; ENSEMBL ID: ENSG00000004799; HGNC ID: 8812
Relate to Another Database: SFARIGene; denovo-db
Related Pathway Information Top
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No data
Pathway IDPathway Name
Pyruvate metabolism and Citric Acid (TCA) cycle
No data
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No data
Related Diseases/Disorders Top
Comparative Toxicogenomics Database Top
Chemical ID Chemical Name Interaction Interaction Action Publication
C016403 2,4-dinitrotoluene 2,4-dinitrotoluene affects the expression of PDK4 mRNAaffects expression 21346803
C518576 2-methylbutyric acid 4-((1,3)dioxan-5-ylmethoxyimino)-8-(2-(4-hydroxy-6-oxo-tetrahydropyran-2-yl)ethyl -7-methyl-6-oxo-1,2,3,4,6,7,8,8a-octahydronaphthyl)heptanoate 2-methylbutyric acid 4-((1,3)dioxan-5-ylmethoxyimino)-8-(2-(4-hydroxy-6-oxo-tetrahydropyran-2-yl)ethyl -7-methyl-6-oxo-1,2,3,4,6,7,8,8a-octahydronaphthyl)heptanoate results in increased expression of PDK4 mRNAincreases expression 17327690
C520164 4-(3-(2-propyl-3-hydroxy-4-acetyl)phenoxy)propyloxyphenoxy acetic acid 4-(3-(2-propyl-3-hydroxy-4-acetyl)phenoxy)propyloxyphenoxy acetic acid inhibits the reaction [Phenylephrine results in decreased expression of PDK4 mRNA]decreases expression|decreases reaction 15721863
D000082 Acetaminophen Acetaminophen affects the expression of PDK4 mRNAaffects expression 17562736
D000643 Ammonium Chloride Ammonium Chloride affects the expression of PDK4 mRNAaffects expression 16483693
C432165 anthra(1,9-cd)pyrazol-6(2H)-one anthra(1,9-cd)pyrazol-6(2H)-one inhibits the reaction [Ozone results in increased expression of PDK4 mRNA]decreases reaction|increases expression 17460151
C015001 arsenite arsenite results in increased expression of PDK4 mRNAincreases expression 18929588
C015001 arsenite TRP53 protein affects the reaction [arsenite results in increased expression of PDK4 mRNA]affects reaction|increases expression 18929588
D019324 beta-Naphthoflavone [Diethylnitrosamine co-treated with beta-Naphthoflavone] results in decreased expression of PDK4 mRNAaffects cotreatment|decreases expression 18164116
D015123 7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide 7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide affects the expression of PDK4 mRNAaffects expression 20382639
D015123 7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide 7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide results in decreased expression of PDK4 mRNAdecreases expression 20018196
C095105 bexarotene bexarotene results in increased expression of PDK4 mRNAincreases expression 16648578
D001629 Bezafibrate Bezafibrate results in increased expression of PDK4 mRNAincreases expression 17118139
C006780 bisphenol A bisphenol A affects the expression of PDK4 mRNAaffects expression 20170705
D002251 Carbon Tetrachloride Carbon Tetrachloride affects the expression of PDK4 mRNAaffects expression 17484886
C019304 ciprofibrate ciprofibrate results in increased expression of PDK4 mRNAincreases expression 12771043
D002976 Clenbuterol Clenbuterol results in increased expression of PDK4 mRNAincreases expression 17446185
D016572 Cyclosporine Cyclosporine results in decreased expression of PDK4 mRNAdecreases expression 20106945
D003907 Dexamethasone [Dexamethasone co-treated with rosiglitazone co-treated with 1-Methyl-3-isobutylxanthine co-treated with INS1 protein] results in increased expression of PDK4 mRNAaffects cotreatment|increases expression 16054899
D004041 Dietary Fats Dietary Fats results in decreased expression of PDK4 mRNAdecreases expression 18042831
D004041 Dietary Fats Dietary Fats results in increased expression of PDK4 mRNAincreases expression 18457598
16357043
D004052 Diethylnitrosamine [Diethylnitrosamine co-treated with beta-Naphthoflavone] results in decreased expression of PDK4 mRNAaffects cotreatment|decreases expression 18164116
D004317 Doxorubicin Doxorubicin results in increased expression of PDK4 mRNAincreases expression 16243910
D004958 Estradiol Estradiol results in decreased expression of PDK4 mRNAdecreases expression 20106945
D004958 Estradiol Estradiol affects the expression of PDK4 mRNAaffects expression 15598610
D000431 Ethanol Ethanol results in decreased expression of PDK4 mRNAdecreases expression 16098508
15353170
D011345 Fenofibrate Fenofibrate results in increased expression of PDK4 mRNAincreases expression 17118139
D005485 Flutamide Flutamide analog results in decreased expression of PDK4 mRNAdecreases expression 17702527
D005485 Flutamide Flutamide results in decreased expression of PDK4 mRNAdecreases expression 17702527
D015056 1-Methyl-3-isobutylxanthine [Dexamethasone co-treated with rosiglitazone co-treated with 1-Methyl-3-isobutylxanthine co-treated with INS1 protein] results in increased expression of PDK4 mRNAaffects cotreatment|increases expression 16054899
C042763 olive oil olive oil analog affects the expression of PDK4 mRNAaffects expression 17349074
D010126 Ozone anthra(1,9-cd)pyrazol-6(2H)-one inhibits the reaction [Ozone results in increased expression of PDK4 mRNA]decreases reaction|increases expression 17460151
C041786 palm oil palm oil results in decreased expression of PDK4 mRNAdecreases expression 18042831
D010269 Paraquat Paraquat results in increased expression of PDK4 mRNAincreases expression 12595580
C002669 parthenolide parthenolide inhibits the reaction [Phenylephrine results in decreased expression of PDK4 mRNA]decreases expression|decreases reaction 15728586
C023036 perfluorooctanoic acid perfluorooctanoic acid results in decreased expression of PDK4 mRNAdecreases expression 17560707
C023036 perfluorooctanoic acid perfluorooctanoic acid results in increased expression of PDK4 mRNAincreases expression 18467677
C023036 perfluorooctanoic acid PPARA protein promotes the reaction [perfluorooctanoic acid results in increased expression of PDK4 mRNA]increases expression|increases reaction 18467677
C023036 perfluorooctanoic acid perfluorooctanoic acid results in increased expression of PDK4 mRNAincreases expression 16221955
D010634 Phenobarbital NR1I3 protein affects the reaction [Phenobarbital results in increased expression of PDK4 mRNA]affects reaction|increases expression 19482888
D010634 Phenobarbital Phenobarbital results in decreased expression of PDK4 mRNAdecreases expression 19270015
D010634 Phenobarbital Phenobarbital results in increased expression of PDK4 mRNAincreases expression 19482888
D010656 Phenylephrine 4-(3-(2-propyl-3-hydroxy-4-acetyl)phenoxy)propyloxyphenoxy acetic acid inhibits the reaction [Phenylephrine results in decreased expression of PDK4 mRNA]decreases expression|decreases reaction 15721863
D010656 Phenylephrine parthenolide inhibits the reaction [Phenylephrine results in decreased expression of PDK4 mRNA]decreases expression|decreases reaction 15728586
D010656 Phenylephrine Phenylephrine results in decreased expression of PDK4 mRNAdecreases expression 15728586
15721863
D010833 Phytic Acid [resveratrol co-treated with Quercetin co-treated with Phytic Acid] results in increased expression of PDK4 mRNAaffects cotreatment|increases expression 18657603
C006253 pirinixic acid [pirinixic acid binds to and results in increased activity of PPARA protein] which results in increased expression of PDK4 mRNAaffects binding|increases activity|increases expression 19710929
C006253 pirinixic acid pirinixic acid results in increased expression of PDK4 mRNAincreases expression 18518955
15824748
C006253 pirinixic acid [pirinixic acid binds to and results in increased activity of PPARA protein] which results in increased expression of PDK4 mRNAaffects binding|increases activity|increases expression 19710929
C006253 pirinixic acid pirinixic acid results in increased expression of PDK4 mRNAincreases expression 17426115
17950772
16357043
18445702
18467677
20059764
18301758
17118139
C006253 pirinixic acid PPARA protein promotes the reaction [pirinixic acid results in increased expression of PDK4 mRNA]increases expression|increases reaction 18467677
20059764
17950772
C006253 pirinixic acid pirinixic acid results in increased expression of PDK4 mRNAincreases expression 19360380
12832660
C025299 polyphenols polyphenols results in decreased expression of PDK4 mRNAdecreases expression 16293270
D011794 Quercetin Quercetin results in increased expression of PDK4 mRNAincreases expression 15309432
D011794 Quercetin [resveratrol co-treated with Quercetin co-treated with Phytic Acid] results in increased expression of PDK4 mRNAaffects cotreatment|increases expression 18657603
C059514 resveratrol [resveratrol co-treated with Quercetin co-treated with Phytic Acid] results in increased expression of PDK4 mRNAaffects cotreatment|increases expression 18657603
C059514 resveratrol resveratrol results in increased expression of PDK4 mRNAincreases expression 18657603
C089730 rosiglitazone [Dexamethasone co-treated with rosiglitazone co-treated with 1-Methyl-3-isobutylxanthine co-treated with INS1 protein] results in increased expression of PDK4 mRNAaffects cotreatment|increases expression 16054899
D012402 Rotenone Rotenone results in decreased expression of PDK4 mRNAdecreases expression 17702527
C009250 sevoflurane sevoflurane affects the expression of PDK4 mRNAaffects expression 15967596
C004648 testosterone enanthate testosterone enanthate affects the expression of PDK4 mRNAaffects expression 17440010
D013749 Tetrachlorodibenzodioxin Tetrachlorodibenzodioxin results in decreased expression of PDK4 mRNAdecreases expression 12377990
17101203
D013749 Tetrachlorodibenzodioxin Tetrachlorodibenzodioxin results in increased expression of PDK4 mRNAincreases expression 16697128
C052342 topiramate topiramate results in decreased expression of PDK4 mRNAdecreases expression 16979414
D014212 Tretinoin [Tretinoin binds to [RXRA protein binds to RARA protein]] which binds to PDK4 promoteraffects binding 16757381
D014212 Tretinoin Tretinoin promotes the reaction [CREBBP protein binds to PDK4 promoter]affects binding|increases reaction 16757381
D014212 Tretinoin Tretinoin promotes the reaction [SP1 protein binds to PDK4 promoter]affects binding|increases reaction 16757381
D014212 Tretinoin Tretinoin results in increased expression of PDK4 mRNAincreases expression 16757381
C012589 trichostatin A trichostatin A promotes the reaction [CREBBP protein binds to PDK4 promoter]affects binding|increases reaction 16757381
C012589 trichostatin A trichostatin A promotes the reaction [SP1 protein binds to PDK4 promoter]affects binding|increases reaction 16757381
C012589 trichostatin A trichostatin A results in increased expression of PDK4 mRNAincreases expression 16757381
D014415 Tunicamycin Tunicamycin results in decreased expression of PDK4 mRNAdecreases expression 17127020
D015032 Zinc Zinc results in increased expression of PDK4 mRNAincreases expression 17074742
D019287 Zinc Sulfate Zinc Sulfate results in increased expression of PDK4 mRNAincreases expression 17074742
Disease ID Disease Name Direct Evidence Inference Chemical Name Inference Score Publication
MESH:D000014 Abnormalities, Drug-Induced Ethanol 11.2718926900 17676605
MESH:D000014 Abnormalities, Drug-Induced Phenobarbital 11.276195326
MESH:D000014 Abnormalities, Drug-Induced Tetrachlorodibenzodioxin 11.2715322242 11752688 14514962
MESH:D000138 Acidosis Ammonium Chloride 14.8618287403
MESH:D000138 Acidosis Ethanol 14.8611192467
MESH:D000138 Acidosis Zinc Sulfate 14.867265320
MESH:D000169 Acrodermatitis Zinc 4.8817190629 16889938 17202136
MESH:D058186 Acute Kidney Injury resveratrol 3.3916538975
MESH:D055371 Acute Lung Injury pirinixic acid 2.6418653653
MESH:D000230 Adenocarcinoma Doxorubicin 3.9717418594
MESH:D000230 Adenocarcinoma Estradiol 3.9711473722
MESH:D000236 Adenoma beta-Naphthoflavone 9.4519389873
MESH:D000236 Adenoma Diethylnitrosamine 9.4510737359 6695378
MESH:D000236 Adenoma resveratrol 9.4515688382
MESH:D018248 Adenoma, Liver Cell Diethylnitrosamine 20.6119061943 17620307 19052882 17162532 16434500 18056438
MESH:D018248 Adenoma, Liver Cell Phenobarbital 20.6117620307
MESH:D018248 Adenoma, Liver Cell pirinixic acid 20.6116434500
MESH:D018248 Adenoma, Liver Cell Tetrachlorodibenzodioxin 20.6116835633
MESH:D000382 Agricultural Workers' Diseases Paraquat 3.2611874814
MESH:D000419 Albuminuria Doxorubicin 4.0521441931
MESH:D020268 Alcohol-Induced Disorders, Nervous System Ethanol 4.7915451039 15451040
MESH:D000437 Alcoholism topiramate 4.6218552399 17925516 19331489
MESH:D000505 Alopecia Tretinoin 3.2015955085
MESH:D000544 Alzheimer Disease Ozone 8.2815513908
MESH:D000544 Alzheimer Disease resveratrol 8.2816183991 16162502
MESH:D000544 Alzheimer Disease rosiglitazone 8.2819621015
MESH:D000544 Alzheimer Disease Zinc 8.2816580781 16410023 16325427 17119284
MESH:D000740 Anemia Tetrachlorodibenzodioxin 2.5011748828
MESH:D000743 Anemia, Hemolytic Quercetin 3.7817084956
MESH:D000755 Anemia, Sickle Cell Zinc 4.4116916123
MESH:D000799 Angioedema Acetaminophen 3.3210982225
MESH:D000853 Anophthalmos Ethanol 4.3115513904
MESH:D000860 Anoxia Zinc Sulfate 4.507265320
MESH:D001008 Anxiety Disorders Ethanol 3.5911141031
MESH:D001145 Arrhythmias, Cardiac Phenylephrine 3.6717460149
MESH:D001161 Arteriosclerosis Dietary Fats 3.3915238619
MESH:D001169 Arthritis, Experimental Dexamethasone 10.4517659584
MESH:D001169 Arthritis, Experimental resveratrol 10.4517115116
MESH:D001169 Arthritis, Experimental Tretinoin 10.4516412693
MESH:D001172 Arthritis, Rheumatoid Ozone 4.1715570426
MESH:D001172 Arthritis, Rheumatoid Tretinoin 4.1716292516
MESH:D001249 Asthma Ozone 6.8817854713 16373670
MESH:D001249 Asthma Tretinoin 6.8816456186
MESH:D001249 Asthma Zinc 6.8817085522
MESH:D001260 Ataxia Telangiectasia Quercetin 4.4615336622
MESH:D050197 Atherosclerosis olive oil 6.2116216721
MESH:D050197 Atherosclerosis resveratrol 6.2117967414 16873680
MESH:D001321 Autistic Disorder Acetaminophen 1.4818445737
MESH:D001327 Autoimmune Diseases Quercetin 3.9019761891
MESH:D001471 Barrett Esophagus Tretinoin 3.9116935849
MESH:D001778 Blood Coagulation Disorders pirinixic acid 12.5919483382
MESH:D001778 Blood Coagulation Disorders Tetrachlorodibenzodioxin 12.5912125929
MESH:D001778 Blood Coagulation Disorders Tretinoin 12.5916206674 16197459
MESH:D001836 Body Weight Changes Tetrachlorodibenzodioxin 3.2615340226
MESH:D001848 Bone Diseases, Developmental Tetrachlorodibenzodioxin 2.4215746008
MESH:D019046 Bone Marrow Neoplasms Doxorubicin 4.1714601052
MESH:D001862 Bone Resorption bisphenol A 3.4011985600
MESH:D001919 Bradycardia Phenylephrine 4.0315306635
MESH:D001930 Brain Injuries Zinc 4.1817109824
MESH:D002545 Brain Ischemia resveratrol 3.7717600658
MESH:D001932 Brain Neoplasms Doxorubicin 3.3617150277
MESH:D001943 Breast Neoplasms bexarotene 7.4516818667 16344269
MESH:D001943 Breast Neoplasms bisphenol A 7.4517123778
MESH:D001943 Breast Neoplasms Dietary Fats 7.4520435547
MESH:D001943 Breast Neoplasms Diethylnitrosamine 7.4517474063
MESH:D001943 Breast Neoplasms Doxorubicin 7.4517983394 18382427 16096432 11325840 17369602 17426702 15136595 15692762 15939500 15993339 19526202 16935488 16115903 16595493 18628466 15668708 15567936 18234424 16826403 18695136 16322301 16264153 15994142 15634643
MESH:D001943 Breast Neoplasms Estradiol 7.4517289903 19861407 17018787 18497071 14630087 12948864 16675129 17261762
MESH:D001943 Breast Neoplasms parthenolide 7.4516873071
MESH:D001943 Breast Neoplasms Quercetin 7.4518628248
MESH:D001943 Breast Neoplasms resveratrol 7.4516393696 17651959 17534123
MESH:D001943 Breast Neoplasms Tetrachlorodibenzodioxin 7.4520435547
MESH:D001943 Breast Neoplasms Tretinoin 7.4516166294 16443354 16873071
MESH:D016535 Bronchial Hyperreactivity Ozone 3.2714754758 18315731 17626835 18417511 19059883 16777450 15516495
MESH:D001997 Bronchopulmonary Dysplasia Tretinoin 4.0716813970
MESH:D002056 Burns Ethanol 4.1516374292
MESH:D002100 Cachexia Ozone 4.2216183385
MESH:D002105 Cadmium Poisoning Quercetin 5.0216962696
MESH:D002181 Candidiasis, Vulvovaginal Estradiol 3.9416111702
MESH:D002252 Carbon Tetrachloride Poisoning Carbon Tetrachloride 3.2816011737 16097048 3786805 15673190 16124888 16227642 16050911 15700767 16192424 10355542 18705752 15721981
MESH:D002276 Carcinoid Tumor Doxorubicin 4.2816051944
MESH:D002277 Carcinoma Tetrachlorodibenzodioxin 2.3916835633
MESH:D018236 Carcinoma, Embryonal Tretinoin 4.6316168501
MESH:D006528 Carcinoma, Hepatocellular 2,4-dinitrotoluene 26.5716705839
MESH:D006528 Carcinoma, Hepatocellular Acetaminophen 26.573084413
MESH:D006528 Carcinoma, Hepatocellular anthra(1,9-cd)pyrazol-6(2H)-one 26.5719418558
MESH:D006528 Carcinoma, Hepatocellular Carbon Tetrachloride 26.5718788625
MESH:D006528 Carcinoma, Hepatocellular Diethylnitrosamine 26.5720935162 16569478 19539802 16328049 16830150 19701751 19335982 19919837 17428255 16935385 18665156 18788625 18785209 19208518 18210153 16698587 20512989 16878318 16681979 17761372 19519916 18978308 11831363 16502159 16779866 19171122 16540662 17978847 17162532 18506893 20101231 16288022 19418558 17173139 19052882 17055752 19394651 20727157 20432363 17138121 18056438 10672840 18971187 20214788 18494052 20514400 16807293 10737359 18691550 21159647 19822196 20007298 20084675 19383236 20524982 19107877 3581430 18393292 3084413
MESH:D006528 Carcinoma, Hepatocellular Doxorubicin 26.5718059187 16234567 17876044 16023760
MESH:D006528 Carcinoma, Hepatocellular Estradiol 26.5716924424
MESH:D006528 Carcinoma, Hepatocellular Ethanol 26.5718788625 15763234 15289165
MESH:D006528 Carcinoma, Hepatocellular Phenobarbital 26.571701930 17173139 6705139 20007298 20935162
MESH:D006528 Carcinoma, Hepatocellular Quercetin 26.5719519916 12508355
MESH:D006528 Carcinoma, Hepatocellular resveratrol 26.5719321006 16227395
MESH:D006528 Carcinoma, Hepatocellular Tretinoin 26.571917145
MESH:D002278 Carcinoma in Situ bisphenol A 4.4717123778
MESH:D018827 Carcinoma, Lewis Lung resveratrol 4.0716675471
MESH:D002289 Carcinoma, Non-Small-Cell Lung bexarotene 3.0316247446
MESH:D021441 Carcinoma, Pancreatic Ductal Quercetin 4.4517234771
MESH:D002292 Carcinoma, Renal Cell Doxorubicin 2.901485588 16201981
MESH:D002294 Carcinoma, Squamous Cell Doxorubicin 9.356189445
MESH:D002294 Carcinoma, Squamous Cell resveratrol 9.3516227395
MESH:D002294 Carcinoma, Squamous Cell Tretinoin 9.3516051514 16096774
MESH:D002294 Carcinoma, Squamous Cell Zinc 9.3516543248
MESH:D006332 Cardiomegaly Ethanol 13.8319332462
MESH:D006332 Cardiomegaly Phenylephrine 13.8315728586 16170337 17124262 17287366 11754973 11179087
MESH:D006332 Cardiomegaly Quercetin 13.8319794523
MESH:D006332 Cardiomegaly Tetrachlorodibenzodioxin 13.8316120746 18850075 18670907
MESH:D009202 Cardiomyopathies Doxorubicin 3.1817924179 15505089 15811867 17007740 15792986 17308081 16455267 16109756 17382496 15476868 17928571 17519947 17974986 16731534 16952015 17131338 16612575 17351982 16242529 17329180 16651473 16364871 16278810 18627295 16269455
MESH:D002311 Cardiomyopathy, Dilated Doxorubicin 2.7517334414 16243910
MESH:D002318 Cardiovascular Diseases olive oil 10.3116216721
MESH:D002318 Cardiovascular Diseases resveratrol 10.3115458977
MESH:D002318 Cardiovascular Diseases Zinc 10.3116936243
MESH:D002386 Cataract Acetaminophen 6.1510977129
MESH:D002386 Cataract Tretinoin 6.1517460283
MESH:D002471 Cell Transformation, Neoplastic 7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide 12.9920889678
MESH:D002471 Cell Transformation, Neoplastic Cyclosporine 12.9912371664
MESH:D002471 Cell Transformation, Neoplastic Diethylnitrosamine 12.9921159647 7505956 2727394 17174075
MESH:D002471 Cell Transformation, Neoplastic Estradiol 12.9918566989
MESH:D002493 Central Nervous System Diseases Phenobarbital 3.754080065
MESH:D018290 Cervical Intraepithelial Neoplasia Tretinoin 4.0716129372
MESH:D002659 Child Development Disorders, Pervasive topiramate 3.8915650499
MESH:D018281 Cholangiocarcinoma Diethylnitrosamine 7.8719052882
MESH:D018281 Cholangiocarcinoma Tetrachlorodibenzodioxin 7.8716835633
MESH:D002779 Cholestasis Cyclosporine 6.4619486331
MESH:D002779 Cholestasis pirinixic acid 6.4619176532
MESH:D002822 Choriocarcinoma Tretinoin 4.6316461808
MESH:D002971 Cleft Lip Ethanol 3.3015513904
MESH:D002972 Cleft Palate Ethanol 8.4315513904
MESH:D002972 Cleft Palate Tetrachlorodibenzodioxin 8.4316354765 15340226 12621046 15668235 8697196
MESH:D002972 Cleft Palate Tretinoin 8.439407595
MESH:D003092 Colitis resveratrol 7.9516474422
MESH:D003092 Colitis Tretinoin 7.9517035595
MESH:D003110 Colonic Neoplasms arsenite 9.7715037631
MESH:D003110 Colonic Neoplasms Dexamethasone 9.7715824018
MESH:D003110 Colonic Neoplasms polyphenols 9.7716293270
MESH:D003110 Colonic Neoplasms Quercetin 9.7717148506 17191121 19056647 15741050 16640504 19440933 11134977
MESH:D003110 Colonic Neoplasms resveratrol 9.7716338953
MESH:D015179 Colorectal Neoplasms Doxorubicin 3.2118802399 18259882
MESH:D015179 Colorectal Neoplasms Quercetin 3.2118095365 18852136
MESH:D015179 Colorectal Neoplasms resveratrol 3.2116550006
MESH:D000013 Congenital Abnormalities Tetrachlorodibenzodioxin 2.6217141729 14669216
MESH:D003327 Coronary Disease resveratrol 3.4116507316
MESH:D019465 Craniofacial Abnormalities Dexamethasone 6.5317728286
MESH:D019465 Craniofacial Abnormalities Ethanol 6.5315513904 11198716 15451039 19302082 15451040 11873399 10194807
MESH:D019465 Craniofacial Abnormalities Tetrachlorodibenzodioxin 6.5315322242 10048152 20055451
MESH:D019465 Craniofacial Abnormalities Tretinoin 6.5317551590 9664655 16925845 9211117 10589399 9142499 8800419 14991402 9125849 9224671
MESH:D019465 Craniofacial Abnormalities Zinc 6.5319302082
MESH:D003490 Cyanosis 2,4-dinitrotoluene 3.5118551238
MESH:D017449 Dermatitis, Allergic Contact Dexamethasone 2.9312438553
MESH:D003876 Dermatitis, Atopic pirinixic acid 2.1718249437
MESH:D003920 Diabetes Mellitus rosiglitazone 8.1317446233
MESH:D003920 Diabetes Mellitus Zinc 8.1316479319
MESH:D003921 Diabetes Mellitus, Experimental Quercetin 7.1519496084
MESH:D003921 Diabetes Mellitus, Experimental resveratrol 7.1516873680
MESH:D003924 Diabetes Mellitus, Type 2 Diethylnitrosamine 9.0220387270
MESH:D003924 Diabetes Mellitus, Type 2 rosiglitazone 9.0212642470
MESH:D003924 Diabetes Mellitus, Type 2 Tetrachlorodibenzodioxin 9.0217107852
MESH:D003924 Diabetes Mellitus, Type 2 topiramate 9.0216979414
MESH:D003928 Diabetic Nephropathies Estradiol 7.5719279558
MESH:D003928 Diabetic Nephropathies resveratrol 7.5716286809
MESH:D003967 Diarrhea Dexamethasone 3.227237001
MESH:D056486 Drug-Induced Liver Injury 2,4-dinitrotoluene 18.9618551238 21346803
MESH:D056486 Drug-Induced Liver Injury Acetaminophen 18.9611461765 11739529 16393943 11529661 19416960 11287661 17906064 12153990 16081117 12392966 12958197 14550746 14725611 10663392 2444490 12540782 14986274 15619225 11421492 19739265 16109766 19420014 16227642 10774834 16485898 10915739 12705907 18713872 19085960 19923254 11834606 11743745 18071297 19370779 12594235 17522070 16781746 17562736 19164858 15968718 16177239
MESH:D056486 Drug-Induced Liver Injury Carbon Tetrachloride 18.9617522070 2869522 16227642 21278145 6884620 16177239 10092053 10915739 7120509 15968718 6623471 4309450 15998439 19085960 3786805 7179309 3732212 7440962 9327722 11566570 15027814 19336974
MESH:D056486 Drug-Induced Liver Injury Diethylnitrosamine 18.9619107877
MESH:D056486 Drug-Induced Liver Injury Doxorubicin 18.9617416283
MESH:D056486 Drug-Induced Liver Injury Ethanol 18.9611566570
MESH:D056486 Drug-Induced Liver Injury polyphenols 18.9619370779
MESH:D056486 Drug-Induced Liver Injury Tetrachlorodibenzodioxin 18.9620420201
MESH:D056487 Drug-Induced Liver Injury, Chronic Acetaminophen 3.5719426721
MESH:D004362 Drug Toxicity Doxorubicin 6.8118602426
MESH:D004362 Drug Toxicity Tetrachlorodibenzodioxin 6.8111462148
MESH:D050171 Dyslipidemias Dietary Fats 7.6818367378
MESH:D050171 Dyslipidemias Fenofibrate 7.6816707586
MESH:D004421 Dystonia Phenobarbital 3.531851702
MESH:D004485 Eczema Dexamethasone 3.9712438553
MESH:D004487 Edema Dexamethasone 21.0919703484
MESH:D004487 Edema perfluorooctanoic acid 21.0912083418 17259670
MESH:D004487 Edema pirinixic acid 21.0912083418
MESH:D004487 Edema resveratrol 21.098985016
MESH:D004487 Edema rosiglitazone 21.0912083418
MESH:D004487 Edema Tetrachlorodibenzodioxin 21.0912711302 11000095
MESH:D004489 Edema, Cardiac Tetrachlorodibenzodioxin 10.1915322242 18230668 16714409
MESH:D004489 Edema, Cardiac Tretinoin 10.1918230668
MESH:D004681 Encephalomyelitis, Autoimmune, Experimental resveratrol 3.5417872969
MESH:D004701 Endocrine Gland Neoplasms trichostatin A 5.1119294695
MESH:D016889 Endometrial Neoplasms Doxorubicin 14.9517359293
MESH:D016889 Endometrial Neoplasms Estradiol 14.9518566989 11473722 19148513
MESH:D016889 Endometrial Neoplasms Fenofibrate 14.9516569247
MESH:D016889 Endometrial Neoplasms Tretinoin 14.9516569247
MESH:D004715 Endometriosis Tetrachlorodibenzodioxin 2.5710568697 9294722
MESH:D004719 Endomyocardial Fibrosis Doxorubicin 4.6318037988
MESH:D020345 Enterocolitis, Necrotizing resveratrol 4.3417923197
MESH:D004831 Epilepsies, Myoclonic Phenobarbital 3.603659116
MESH:D004828 Epilepsies, Partial Phenobarbital 3.3511558140 3922381
MESH:D004827 Epilepsy Phenobarbital 6.2220417680
MESH:D004827 Epilepsy topiramate 6.2219148780
MESH:D004832 Epilepsy, Absence Phenobarbital 3.116401628
MESH:D017029 Epilepsy, Complex Partial Phenobarbital 3.757750514
MESH:D004833 Epilepsy, Temporal Lobe topiramate 5.7516499746
MESH:D004830 Epilepsy, Tonic-Clonic Phenobarbital 3.503659116
MESH:D004931 Esophageal Achalasia Diethylnitrosamine 4.5916302075
MESH:D004938 Esophageal Neoplasms 7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide 6.4320426865
MESH:D004938 Esophageal Neoplasms Ethanol 6.4316704527
MESH:D004938 Esophageal Neoplasms Zinc 6.4316543248
MESH:D005124 Eye Abnormalities Tetrachlorodibenzodioxin 7.5311564622
MESH:D005124 Eye Abnormalities Tretinoin 7.5316938888 9664655
MESH:D005234 Fatty Liver arsenite 35.2118296743
MESH:D005234 Fatty Liver Carbon Tetrachloride 35.2116239168 12795759 17595544 16045604 61145 15959796 19224547 12631006
MESH:D005234 Fatty Liver Cyclosporine 35.2119224547
MESH:D005234 Fatty Liver Dietary Fats 35.2117967931 19551842 18296743 19004024
MESH:D005234 Fatty Liver Diethylnitrosamine 35.2120387270 21071580
MESH:D005234 Fatty Liver Ethanol 35.2118620774 16409862 19236843
MESH:D005234 Fatty Liver pirinixic acid 35.2120131406 19236843
MESH:D005234 Fatty Liver rosiglitazone 35.2119196556
MESH:D005235 Fatty Liver, Alcoholic Ethanol 5.1417920746
MESH:D005310 Fetal Alcohol Syndrome Ethanol 4.7810194807 15513904 16946407 15451040
MESH:D005313 Fetal Death Tetrachlorodibenzodioxin 2.9511858732
MESH:D018222 Fibromatosis, Aggressive Doxorubicin 4.0719069698
MESH:D005355 Fibrosis arsenite 33.7518296743
MESH:D005355 Fibrosis Carbon Tetrachloride 33.7518705752
MESH:D005355 Fibrosis Cyclosporine 33.7512639820 12168785
MESH:D005355 Fibrosis Dietary Fats 33.7518296743
MESH:D005355 Fibrosis Quercetin 33.7519474275
MESH:D005355 Fibrosis Tetrachlorodibenzodioxin 33.7520067830
MESH:D005355 Fibrosis Tretinoin 33.7517994277
MESH:D005756 Gastritis Acetaminophen 16.0116983495
MESH:D005756 Gastritis Ethanol 16.0115046732
MESH:D005756 Gastritis Zinc 16.0117241300
MESH:D005885 Gingival Hyperplasia Cyclosporine 3.708708960
MESH:D005909 Glioblastoma Doxorubicin 14.1217150277
MESH:D005909 Glioblastoma Quercetin 14.1219804834
MESH:D005909 Glioblastoma Tretinoin 14.1217312396
MESH:D005909 Glioblastoma trichostatin A 14.1218801729
MESH:D005910 Glioma Quercetin 2.8317643826
MESH:D005911 Gliosis Paraquat 4.6411124998
MESH:D006058 Gonadal Disorders Tetrachlorodibenzodioxin 4.0710696789
MESH:D006130 Growth Disorders Zinc 3.6217217573
MESH:D006258 Head and Neck Neoplasms Doxorubicin 6.6415692506
MESH:D006258 Head and Neck Neoplasms Tretinoin 6.6416096774
MESH:D006317 Hearing Loss, Noise-Induced Tretinoin 4.6316084493
MESH:D006330 Heart Defects, Congenital Tetrachlorodibenzodioxin 5.5611294989 10048152
MESH:D006330 Heart Defects, Congenital Tretinoin 5.569664655 14991402
MESH:D006331 Heart Diseases Doxorubicin 3.1216330681 16244372 14766674 16144979 16707910 17875725 18006777 16244371 12587719 18674790 16879835 16495754 17888722
MESH:D006333 Heart Failure Doxorubicin 9.9417481944
MESH:D006333 Heart Failure pirinixic acid 9.9420558911
MESH:D006333 Heart Failure Zinc 9.9417162251
MESH:D006335 Heart Injuries Zinc 5.2417074742
MESH:D016481 Helicobacter Infections Zinc 4.0617241300
MESH:D006394 Hemangiosarcoma Doxorubicin 3.4415692506
MESH:D006457 Hemoglobinuria, Paroxysmal Cyclosporine 3.9015720958
MESH:D006470 Hemorrhage Tetrachlorodibenzodioxin 2.8711000095
MESH:D006505 Hepatitis Carbon Tetrachloride 3.1119110552 19900420
MESH:D006527 Hepatolenticular Degeneration Zinc 9.6417276780
MESH:D006527 Hepatolenticular Degeneration Zinc Sulfate 9.6417063115
MESH:D006529 Hepatomegaly perfluorooctanoic acid 16.563609246
MESH:D006529 Hepatomegaly Phenobarbital 16.5616109766
MESH:D006529 Hepatomegaly pirinixic acid 16.5618467677 16221962 19176532 19772884
MESH:D006529 Hepatomegaly Tetrachlorodibenzodioxin 16.5616120746 15340226 12621046
MESH:D006548 Hernia, Diaphragmatic Dexamethasone 2.877520565
MESH:D006558 Herpes Genitalis Estradiol 4.5015709030
MESH:D006561 Herpes Simplex resveratrol 3.6716876885
MESH:D019247 HIV Wasting Syndrome testosterone enanthate 5.2217440010
MESH:D006689 Hodgkin Disease Doxorubicin 2.9917606976 18501091 15147373
MESH:D019584 Hot Flashes Estradiol 3.2317088409
MESH:D006869 Hydronephrosis Tetrachlorodibenzodioxin 3.528697196 18606429 16959395 16354765 15340226
MESH:D006930 Hyperalgesia Acetaminophen 20.1416870215
MESH:D006930 Hyperalgesia Ethanol 20.1418783367
MESH:D006930 Hyperalgesia perfluorooctanoic acid 20.1412083418
MESH:D006930 Hyperalgesia rosiglitazone 20.1412083418
MESH:D006930 Hyperalgesia Tretinoin 20.1416870215
MESH:D017588 Hyperandrogenism Flutamide 4.9315356085
MESH:D006932 Hyperbilirubinemia Carbon Tetrachloride 4.0116899240
MESH:D006937 Hypercholesterolemia Dietary Fats 7.6821332399
MESH:D006937 Hypercholesterolemia resveratrol 7.6817188708
MESH:D017681 Hypereosinophilic Syndrome Tretinoin 4.0616778211
MESH:D006943 Hyperglycemia pirinixic acid 7.7420558911
MESH:D006943 Hyperglycemia Quercetin 7.7411834736 18262572
MESH:D006949 Hyperlipidemias Dietary Fats 7.7121332399
MESH:D006949 Hyperlipidemias resveratrol 7.7116873680
MESH:D006973 Hypertension Cyclosporine 14.0010903974
MESH:D006973 Hypertension Dexamethasone 14.0017042910
MESH:D006973 Hypertension Phenylephrine 14.0012717712 8949925
MESH:D006973 Hypertension Quercetin 14.0018356687
MESH:D006973 Hypertension Tetrachlorodibenzodioxin 14.0018670907 18850075
MESH:D006975 Hypertension, Portal Carbon Tetrachloride 3.5815338365
MESH:D006984 Hypertrophy Phenylephrine 4.0918502941 12791704
MESH:D017379 Hypertrophy, Left Ventricular resveratrol 3.8517488730
MESH:D007022 Hypotension Zinc Sulfate 4.007265320
MESH:D007077 Ileal Diseases 1-Methyl-3-isobutylxanthine 4.9118306037
MESH:D020244 Infarction, Middle Cerebral Artery resveratrol 4.1417600658
MESH:D007248 Infertility, Male Paraquat 2.904850670
MESH:D007249 Inflammation Dexamethasone 23.528960868 11099482
MESH:D007249 Inflammation Dietary Fats 23.5220412841
MESH:D007249 Inflammation Diethylnitrosamine 23.5218785209
MESH:D007249 Inflammation perfluorooctanoic acid 23.5212083418
MESH:D007249 Inflammation polyphenols 23.5216366677
MESH:D007249 Inflammation resveratrol 23.5216366677
MESH:D007249 Inflammation rosiglitazone 23.5212083418
MESH:D007249 Inflammation Tetrachlorodibenzodioxin 23.5212878042 12200463
MESH:D007251 Influenza, Human Quercetin 9.4416624496
MESH:D007251 Influenza, Human resveratrol 9.4416624496
MESH:D007333 Insulin Resistance bisphenol A 19.4716393666
MESH:D007333 Insulin Resistance Dietary Fats 19.4711836018 18457598
MESH:D007333 Insulin Resistance Estradiol 19.4716393666 16627594
MESH:D007333 Insulin Resistance pirinixic acid 19.4716306350
MESH:D007333 Insulin Resistance rosiglitazone 19.4716306350
MESH:D007410 Intestinal Diseases Tretinoin 3.2617994277
MESH:D007511 Ischemia Zinc 4.1316584753
MESH:D007569 Jaw Abnormalities Ethanol 14.5015513904
MESH:D007569 Jaw Abnormalities Tetrachlorodibenzodioxin 14.5016580747
MESH:D007569 Jaw Abnormalities Tretinoin 14.5015992940 17551590
MESH:D007579 Jejunal Diseases 1-Methyl-3-isobutylxanthine 4.9118306037
MESH:D007627 Keloid Quercetin 4.4517086741
MESH:D007638 Keratoconjunctivitis Sicca Cyclosporine 3.9115604871
MESH:D007674 Kidney Diseases Acetaminophen 19.7612587719 15629191
MESH:D007674 Kidney Diseases Cyclosporine 19.768314463 10903974 18776723
MESH:D007674 Kidney Diseases Doxorubicin 19.7616775033 15369732 15699352
MESH:D007674 Kidney Diseases Estradiol 19.7615618244
MESH:D007674 Kidney Diseases Quercetin 19.7616962696
MESH:D007674 Kidney Diseases Zinc 19.7616960431
MESH:D007676 Kidney Failure, Chronic Doxorubicin 8.6416707910
MESH:D007676 Kidney Failure, Chronic Zinc 8.6416518626
MESH:D007680 Kidney Neoplasms 2,4-dinitrotoluene 9.9216705839
MESH:D007680 Kidney Neoplasms Cyclosporine 9.9212371664
MESH:D007680 Kidney Neoplasms Estradiol 9.9215610895
MESH:D007859 Learning Disorders Ethanol 8.3715451040
MESH:D007859 Learning Disorders sevoflurane 8.3719212262
MESH:D016773 Leishmaniasis, Cutaneous Zinc Sulfate 3.8415237267
MESH:D007938 Leukemia Quercetin 5.5317468513
MESH:D007938 Leukemia Tretinoin 5.5317143497
MESH:D004915 Leukemia, Erythroblastic, Acute Doxorubicin 4.6316085563
MESH:D007948 Leukemia, Monocytic, Acute anthra(1,9-cd)pyrazol-6(2H)-one 4.8616972261
MESH:D007951 Leukemia, Myeloid Tretinoin 3.2419285840 16482212 16932348
MESH:D015470 Leukemia, Myeloid, Acute Tretinoin 3.7719850784 16294345 17596541
MESH:D015470 Leukemia, Myeloid, Acute trichostatin A 3.7718206229
MESH:D015473 Leukemia, Promyelocytic, Acute resveratrol 6.6016087638
MESH:D015473 Leukemia, Promyelocytic, Acute Tretinoin 6.6017712046 12679006 17294898 19075265 17107899 19225113 19035177 16788101 17649720 16140955 19642359 16935935 17217047 17368321 9834237 19029980 16331271 17506722 16766008 17301526 17339181 16823087 16891316 17361223 15748426
MESH:D007984 Leydig Cell Tumor perfluorooctanoic acid 4.718812269
MESH:D017880 Limb Deformities, Congenital Ethanol 7.0517676605
MESH:D017880 Limb Deformities, Congenital Tretinoin 7.059224671
MESH:D008103 Liver Cirrhosis arsenite 21.9618296743
MESH:D008103 Liver Cirrhosis Carbon Tetrachloride 21.9617174718 11903743 17334410 16943688 11408273 16239168 17157831 21278145 16221502
MESH:D008103 Liver Cirrhosis Dietary Fats 21.9618296743
MESH:D008103 Liver Cirrhosis Diethylnitrosamine 21.9618522880 18407596 18665156 20032147 19638242
MESH:D008103 Liver Cirrhosis Ethanol 21.9615289165
MESH:D008103 Liver Cirrhosis Phenobarbital 21.9621047994
MESH:D008104 Liver Cirrhosis, Alcoholic Ethanol 4.5818295389
MESH:D008106 Liver Cirrhosis, Experimental Carbon Tetrachloride 18.8417631135 18481824 15362042 14716833 15673190 18205269 18210741 18156304 15996030 18395095 15931870 20821823 17481882 18705752 12632512 12445421 16248980 11481614 12445418 17565644 18395914 17640975 18376398 18277467 18339082 12741479 17761835 18418968 15338365 14716496 18412020 16116963 14512876 15893842 15370692 13678700 15123356 12666154 17708605 15052691 12389079 18263696 16638106 18279442 17869086 17976157 12958196 15959796 16136751 15650968 17805973 17944888 16192424 16015684 18054572 16097048 17766677 16033810 17922224 12609069 17698563 14724832 17557913 18317297 18472094 17823541 15925388 15876570 18251166 17900296 12632514 18472332 12898905 18429990 17714472 12586293 18006644 18166357 15818738 10355542 12546737 12667390 12649538 14748882 14620537 17721639 15730626 18420326 18187930 17525996 16011737 15057751 16027843
MESH:D008106 Liver Cirrhosis, Experimental Dexamethasone 18.8416718785
MESH:D008106 Liver Cirrhosis, Experimental Doxorubicin 18.8416439617 16595196
MESH:D008106 Liver Cirrhosis, Experimental Estradiol 18.8414716833 14659978
MESH:D008106 Liver Cirrhosis, Experimental Ethanol 18.8418166357
MESH:D008106 Liver Cirrhosis, Experimental Fenofibrate 18.8415474484
MESH:D008106 Liver Cirrhosis, Experimental pirinixic acid 18.8415474484
MESH:D008106 Liver Cirrhosis, Experimental Quercetin 18.8412741479
MESH:D008106 Liver Cirrhosis, Experimental rosiglitazone 18.8417347453 15980055
MESH:D008106 Liver Cirrhosis, Experimental Tetrachlorodibenzodioxin 18.8412878042
MESH:D008106 Liver Cirrhosis, Experimental Tretinoin 18.8418397230 16248980
MESH:D008107 Liver Diseases Acetaminophen 10.7619014921 12587719 19460945 11587558 19784758 16611625 12969438 16610002
MESH:D008107 Liver Diseases Carbon Tetrachloride 10.7617285989 16246199 15830285 16964402 15720792
MESH:D008107 Liver Diseases Diethylnitrosamine 10.7617034775
MESH:D008107 Liver Diseases Phenobarbital 10.7619363144
MESH:D008107 Liver Diseases polyphenols 10.7616698588
MESH:D008108 Liver Diseases, Alcoholic Ethanol 4.1517347304 17207112
MESH:D017093 Liver Failure Carbon Tetrachloride 3.6615123358
MESH:D017114 Liver Failure, Acute Acetaminophen 7.9117185352 16871587
MESH:D017114 Liver Failure, Acute Carbon Tetrachloride 7.9116899240 14706259
MESH:D008113 Liver Neoplasms beta-Naphthoflavone 33.4019389873 21295105
MESH:D008113 Liver Neoplasms Carbon Tetrachloride 33.4019294768
MESH:D008113 Liver Neoplasms ciprofibrate 33.4012771043
MESH:D008113 Liver Neoplasms Diethylnitrosamine 33.4019256749 19499222 19551842 19638242 19427195 19642983 18754104 19812893 18644402 15175105 2422723 18648771 19833225 21071580 19090486 19294768 20492335 19426721 9163691 21278145 20434301 20583210 21047994 12112319 10737359 20452335 18978307 20137499 20501860 12771043 19690152 19254457 19073162 21167192 19850985 2862719 19255062 20101389 19996281 18977376 16942905 20118626 15885732 20405173
MESH:D008113 Liver Neoplasms Fenofibrate 33.4018978307
MESH:D008113 Liver Neoplasms perfluorooctanoic acid 33.4018709148 14757943
MESH:D008113 Liver Neoplasms Phenobarbital 33.4019482888 19812893 8742319 19073162 21047994 15975961
MESH:D008113 Liver Neoplasms pirinixic acid 33.4020007298 15890375 16377806
MESH:D008113 Liver Neoplasms Quercetin 33.4018980244
MESH:D008113 Liver Neoplasms resveratrol 33.4019321006 19073162 20405173 19812893
MESH:D008113 Liver Neoplasms Tetrachlorodibenzodioxin 33.4016984957
MESH:D008114 Liver Neoplasms, Experimental beta-Naphthoflavone 27.3518164116
MESH:D008114 Liver Neoplasms, Experimental Carbon Tetrachloride 27.3515583823 12014681
MESH:D008114 Liver Neoplasms, Experimental Diethylnitrosamine 27.3518079962 18093689 16267830 17174075 16842330 19004024 19539802 3124819 18308698 19519916 18544905 18253720 18775883 17854601 19009564 19126423 9362446 2563599 18282651 17942915 18164116 21159647
MESH:D008114 Liver Neoplasms, Experimental Doxorubicin 27.3516842330 17085340
MESH:D008114 Liver Neoplasms, Experimental Fenofibrate 27.3518253720 18775883
MESH:D008114 Liver Neoplasms, Experimental Phenobarbital 27.352563599 17172636 6150874 18308698 1399818
MESH:D008114 Liver Neoplasms, Experimental Quercetin 27.3519519916
MESH:D008114 Liver Neoplasms, Experimental Tetrachlorodibenzodioxin 27.3512151625
MESH:D008171 Lung Diseases Ozone 3.0219066396 8266340
MESH:D055370 Lung Injury Ozone 3.3520417186
MESH:D008175 Lung Neoplasms arsenite 11.4916809336
MESH:D008175 Lung Neoplasms bexarotene 11.4917849452
MESH:D008175 Lung Neoplasms Dexamethasone 11.4915824018 11195469
MESH:D008175 Lung Neoplasms Diethylnitrosamine 11.4920970405 20512841 6695378 21163286
MESH:D008175 Lung Neoplasms Doxorubicin 11.4917418594 6189445
MESH:D008175 Lung Neoplasms Ozone 11.498597069 7614698
MESH:D008175 Lung Neoplasms Quercetin 11.4916280456
MESH:D008175 Lung Neoplasms Tetrachlorodibenzodioxin 11.4911884234 19555203
MESH:D008223 Lymphoma Doxorubicin 3.0916098063
MESH:D016393 Lymphoma, B-Cell resveratrol 3.8217088997
MESH:D008228 Lymphoma, Non-Hodgkin Doxorubicin 7.4717654614
MESH:D008228 Lymphoma, Non-Hodgkin resveratrol 7.4714749477
MESH:D016399 Lymphoma, T-Cell Doxorubicin 4.0615621674
MESH:D016410 Lymphoma, T-Cell, Cutaneous bexarotene 4.6411161223
MESH:D015674 Mammary Neoplasms, Animal resveratrol 3.7315688416
MESH:D008325 Mammary Neoplasms, Experimental bexarotene 19.1019196722 19196723 15591091
MESH:D008325 Mammary Neoplasms, Experimental Doxorubicin 19.1015458769
MESH:D008325 Mammary Neoplasms, Experimental Estradiol 19.1011408345 16891317 11807958 17203775
MESH:D008325 Mammary Neoplasms, Experimental resveratrol 19.108985016 11606380
MESH:D008325 Mammary Neoplasms, Experimental rosiglitazone 19.1016827153
MESH:D008325 Mammary Neoplasms, Experimental Zinc 19.1012773700
MESH:D020149 Manganese Poisoning Estradiol 3.9519453300
MESH:D008527 Medulloblastoma Tretinoin 2.5617453147
MESH:D008545 Melanoma Doxorubicin 6.3916827129
MESH:D008545 Melanoma resveratrol 6.3917992120
MESH:D008545 Melanoma Tretinoin 6.3916752155
MESH:D008545 Melanoma trichostatin A 6.3916505122
MESH:D008546 Melanoma, Experimental Acetaminophen 3.0619513568
MESH:D008569 Memory Disorders Ethanol 8.3415451040 18411066
MESH:D008569 Memory Disorders sevoflurane 8.3419212262
MESH:D008591 Meningomyelocele Tretinoin 3.9216940565
MESH:D008654 Mesothelioma Doxorubicin 2.8317638057
MESH:D008659 Metabolic Diseases resveratrol 3.9117112576
MESH:D024821 Metabolic Syndrome X rosiglitazone 3.9517261469
MESH:D008664 Metal Metabolism, Inborn Errors Cyclosporine 4.2616801185
MESH:D008679 Metaplasia Ozone 4.5810496685
MESH:D008881 Migraine Disorders topiramate 4.2018803445 16942474 18765137 18759728
MESH:D028361 Mitochondrial Diseases Doxorubicin 4.0315792986
MESH:D052016 Mucositis Doxorubicin 4.2717415656
MESH:D009101 Multiple Myeloma Dexamethasone 10.1216118317 15744524 15867202
MESH:D009101 Multiple Myeloma resveratrol 10.1217164350 14749477 16490592 17935668 17049120 16267019
MESH:D009101 Multiple Myeloma trichostatin A 10.1218172295
MESH:D009134 Muscular Atrophy, Spinal resveratrol 4.3517962980
MESH:D009135 Muscular Diseases Bezafibrate 9.0616239165
MESH:D009135 Muscular Diseases pirinixic acid 9.0616239165
MESH:D009190 Myelodysplastic Syndromes Dexamethasone 6.499809623
MESH:D009190 Myelodysplastic Syndromes Tretinoin 6.4917596541
MESH:D009203 Myocardial Infarction Doxorubicin 11.5819429709 15857846
MESH:D009203 Myocardial Infarction pirinixic acid 11.5819151258
MESH:D009203 Myocardial Infarction Quercetin 11.5819595682
MESH:D009203 Myocardial Infarction resveratrol 11.5816317513 17125593 17015251 16525036 17188708 16456233
MESH:D017202 Myocardial Ischemia resveratrol 7.6317015251 17125593
MESH:D017202 Myocardial Ischemia Tetrachlorodibenzodioxin 7.6312213967
MESH:D015428 Myocardial Reperfusion Injury Estradiol 11.8616810080
MESH:D015428 Myocardial Reperfusion Injury pirinixic acid 11.8616411023
MESH:D015428 Myocardial Reperfusion Injury Quercetin 11.8619207477
MESH:D009205 Myocarditis resveratrol 4.2417322642
MESH:D020191 Myoclonic Epilepsies, Progressive Phenobarbital 3.9617484760
MESH:D009336 Necrosis 2,4-dinitrotoluene 3.3418551238
MESH:D009362 Neoplasm Metastasis Diethylnitrosamine 5.109029167 3581430
MESH:D009362 Neoplasm Metastasis Doxorubicin 5.1018259882
MESH:D009369 Neoplasms pirinixic acid 6.6617405874
MESH:D009369 Neoplasms Quercetin 6.6615185748
MESH:D009369 Neoplasms Tretinoin 6.6616946489 16594593
MESH:D009374 Neoplasms, Experimental resveratrol 3.508985016
MESH:D009376 Neoplasms, Hormone-Dependent bexarotene 4.2619196722
MESH:D009389 Neovascularization, Pathologic arsenite 14.2015738583
MESH:D009389 Neovascularization, Pathologic Estradiol 14.2017289903
MESH:D009389 Neovascularization, Pathologic parthenolide 14.2016921510
MESH:D009401 Nephrosis Doxorubicin 4.2616636307 16899518
MESH:D009402 Nephrosis, Lipoid Cyclosporine 3.9117954296
MESH:D009404 Nephrotic Syndrome Cyclosporine 7.8419348381 18481113
MESH:D009404 Nephrotic Syndrome Doxorubicin 7.8416889571 15640375
MESH:D009410 Nerve Degeneration Paraquat 7.3116893418
MESH:D009410 Nerve Degeneration Rotenone 7.3117356569 18619942 15790535
MESH:D009421 Nervous System Malformations bisphenol A 19.4011399458 16427766
MESH:D009421 Nervous System Malformations Estradiol 19.4016427766 11399458
MESH:D009421 Nervous System Malformations Tetrachlorodibenzodioxin 19.4014600291
MESH:D009421 Nervous System Malformations Tretinoin 19.409125849
MESH:D009436 Neural Tube Defects Tretinoin 2.719142499
MESH:D009447 Neuroblastoma Doxorubicin 2.9815555623
MESH:D019636 Neurodegenerative Diseases Acetaminophen 11.6018514411
MESH:D019636 Neurodegenerative Diseases Diethylnitrosamine 11.6020387270
MESH:D019636 Neurodegenerative Diseases resveratrol 11.6017652729
MESH:D020078 Neurogenic Inflammation Quercetin 9.1117929310
MESH:D020078 Neurogenic Inflammation resveratrol 9.1117929310
MESH:D009461 Neurologic Manifestations Diethylnitrosamine 4.5920387270
MESH:D052556 Niemann-Pick Disease, Type C perfluorooctanoic acid 4.459802331
MESH:D009765 Obesity Dietary Fats 3.9111836018 21332399 16723640 20518802 19632207 17217161 18457598 18674790 20132043
MESH:D009765 Obesity pirinixic acid 3.9120558911
MESH:D009784 Occupational Diseases 2,4-dinitrotoluene 2.9812819281 16049721
MESH:D010018 Osteomalacia Phenobarbital 3.8517016548
MESH:D015663 Osteoporosis, Postmenopausal Quercetin 8.6119495926
MESH:D015663 Osteoporosis, Postmenopausal resveratrol 8.6117513867
MESH:D012516 Osteosarcoma Doxorubicin 3.7015930896
MESH:D010049 Ovarian Diseases bisphenol A 4.4711985600
MESH:D010051 Ovarian Neoplasms Estradiol 9.7519401270
MESH:D010051 Ovarian Neoplasms Quercetin 9.7519005980
MESH:D010051 Ovarian Neoplasms Tretinoin 9.7516936753
MESH:D010051 Ovarian Neoplasms trichostatin A 9.7519331143
MESH:D010146 Pain Acetaminophen 5.2116870215
MESH:D010146 Pain Tretinoin 5.2116870215
MESH:D010190 Pancreatic Neoplasms Diethylnitrosamine 17.7216540662
MESH:D010190 Pancreatic Neoplasms Ethanol 17.7212384795
MESH:D010190 Pancreatic Neoplasms Phenobarbital 17.7216965848
MESH:D010190 Pancreatic Neoplasms Quercetin 17.7216965848
MESH:D010190 Pancreatic Neoplasms Tretinoin 17.7215976015
MESH:D010190 Pancreatic Neoplasms trichostatin A 17.7219294695
MESH:D010300 Parkinson Disease Paraquat 4.8511124998 12911755 16510128 11445065 16140633 15824117 11181820 15451049
MESH:D010300 Parkinson Disease Rotenone 4.8518619942 11445065 18191903 15451049 16140633 19114014 19232380 11535288 16412576
MESH:D010302 Parkinson Disease, Secondary Paraquat 3.9316190885
MESH:D020734 Parkinsonian Disorders Rotenone 3.6318197244 15927086 15795934 15574749
MESH:D010382 Peliosis Hepatis Tetrachlorodibenzodioxin 3.7212520081
MESH:D010538 Peritonitis Ozone 3.6316369182
MESH:D003557 Phyllodes Tumor Doxorubicin 4.6317983394
MESH:D010997 Pleural Neoplasms Doxorubicin 4.6317638057
MESH:D011014 Pneumonia Ozone 9.3418929643 18007984 18381685
MESH:D011014 Pneumonia Paraquat 9.3412504350
MESH:D011085 Polycystic Ovary Syndrome Flutamide 4.5415356085
MESH:D017119 Porphyria Cutanea Tarda Tetrachlorodibenzodioxin 3.0718163543
MESH:D011230 Precancerous Conditions Cyclosporine 18.2912371664
MESH:D011230 Precancerous Conditions Diethylnitrosamine 18.292563599
MESH:D011230 Precancerous Conditions Phenobarbital 18.292563599
MESH:D011230 Precancerous Conditions Quercetin 18.2919056647
MESH:D054198 Precursor Cell Lymphoblastic Leukemia-Lymphoma Dexamethasone 3.2421297632
MESH:D011225 Pre-Eclampsia Zinc 3.7717114810
MESH:D011297 Prenatal Exposure Delayed Effects bisphenol A 19.0410548101
MESH:D011297 Prenatal Exposure Delayed Effects perfluorooctanoic acid 19.0417132714
MESH:D011297 Prenatal Exposure Delayed Effects resveratrol 19.0416679765
MESH:D011297 Prenatal Exposure Delayed Effects Tetrachlorodibenzodioxin 19.0411118676 11222880 11399792 11896295
MESH:D055728 Primary Myelofibrosis trichostatin A 4.7417616702
MESH:D019048 Prostatic Intraepithelial Neoplasia bisphenol A 9.0120887781
MESH:D019048 Prostatic Intraepithelial Neoplasia Estradiol 9.0120887781
MESH:D011471 Prostatic Neoplasms bisphenol A 2.7116740699
MESH:D011471 Prostatic Neoplasms Doxorubicin 2.7116868541 18437689 15749863 15897917 16888761 16729912
MESH:D011471 Prostatic Neoplasms Estradiol 2.7116740699
MESH:D011471 Prostatic Neoplasms Flutamide 2.713169114
MESH:D011471 Prostatic Neoplasms parthenolide 2.7116921510
MESH:D011471 Prostatic Neoplasms Quercetin 2.7117292933 14715546
MESH:D011471 Prostatic Neoplasms resveratrol 2.7116731767 17636462 17718901 17675339 17804756 15767336
MESH:D011471 Prostatic Neoplasms trichostatin A 2.7118798265 19789329
MESH:D011471 Prostatic Neoplasms Zinc 2.7116606632 16517595 12429649 16700911
MESH:D011507 Proteinuria Tretinoin 3.1316636307
MESH:D019310 Pseudolymphoma Phenobarbital 3.9712752131
MESH:D011565 Psoriasis Cyclosporine 2.0316882103
MESH:D011625 Pterygium Tretinoin 4.2716723453
MESH:D011629 Puberty, Precocious bisphenol A 4.2710548101
MESH:D011658 Pulmonary Fibrosis Paraquat 2.7017997886 16324872
MESH:D051437 Renal Insufficiency Doxorubicin 3.7217922066
MESH:D051436 Renal Insufficiency, Chronic resveratrol 5.0516325855
MESH:D015427 Reperfusion Injury pirinixic acid 5.6519058328
MESH:D015427 Reperfusion Injury resveratrol 5.6517058453 16314181 15827377 16317513 17520802
MESH:D012128 Respiratory Distress Syndrome, Adult Dexamethasone 7.6811700416 18379247
MESH:D012128 Respiratory Distress Syndrome, Adult Paraquat 7.6811700416
MESH:D012135 Respiratory Sounds Paraquat 3.5511874814
MESH:D015619 Respiratory System Abnormalities Tetrachlorodibenzodioxin 3.3418990726
MESH:D012162 Retinal Degeneration Paraquat 7.8816458197
MESH:D012162 Retinal Degeneration Zinc 7.8816584753
MESH:D012208 Rhabdomyosarcoma Tretinoin 3.6216283617 16116481
MESH:D012509 Sarcoma Doxorubicin 3.5416767912 17203757 15625365 15675481 18313854 17710206
MESH:D012512 Sarcoma, Ewing's Doxorubicin 3.7514601052 16326096
MESH:D012514 Sarcoma, Kaposi Doxorubicin 4.2717846226
MESH:D012554 Schistosomiasis japonica Quercetin 5.0216862918
MESH:D012640 Seizures 2,4-dinitrotoluene 11.2018551238
MESH:D012640 Seizures Ethanol 11.209754883
MESH:D012640 Seizures Phenobarbital 11.203137016 11442880 4039156 16876388
MESH:D012640 Seizures topiramate 11.2016499746
MESH:D003294 Seizures, Febrile Phenobarbital 4.306407741
MESH:D012852 Sinusitis Phenylephrine 4.197327846
MESH:D012878 Skin Neoplasms Doxorubicin 11.3815692506
MESH:D012878 Skin Neoplasms resveratrol 11.388985016 15837718
MESH:D012878 Skin Neoplasms Tetrachlorodibenzodioxin 11.3816192470
MESH:D012878 Skin Neoplasms Tretinoin 11.3816467112
MESH:D012983 Soft Tissue Neoplasms Doxorubicin 4.0617203757 15625365 16767912
MESH:D013272 Stomach Diseases Dexamethasone 3.8115472012
MESH:D013274 Stomach Neoplasms Diethylnitrosamine 3.0818456281
MESH:D013274 Stomach Neoplasms Ethanol 3.0818456281
MESH:D013274 Stomach Neoplasms Tretinoin 3.0817261132
MESH:D013276 Stomach Ulcer Dexamethasone 9.6715138204
MESH:D013276 Stomach Ulcer Ethanol 9.6717189318 16755016 9562338 11906479 17918041 9211565
MESH:D013276 Stomach Ulcer olive oil 9.6712498302 16252198
OMIM:601367 STROKE, ISCHEMIC resveratrol 4.0316321402
MESH:D019966 Substance-Related Disorders bisphenol A 3.4716684133 16045194
MESH:D013375 Substance Withdrawal Syndrome Ethanol 3.809754883
MESH:D013705 Temporomandibular Joint Disorders polyphenols 4.7217997062
MESH:D013959 Thyroid Diseases Tetrachlorodibenzodioxin 3.3712697716
MESH:D013964 Thyroid Neoplasms Diethylnitrosamine 13.857505956
MESH:D013964 Thyroid Neoplasms Doxorubicin 13.8517909728 16010429
MESH:D013964 Thyroid Neoplasms Phenobarbital 13.851399818
MESH:D013964 Thyroid Neoplasms Tretinoin 13.8516026305 17045167
MESH:D013978 Tibial Fractures Estradiol 4.1619048282
MESH:D014062 Tongue Neoplasms resveratrol 14.0316227395
MESH:D014062 Tongue Neoplasms Tretinoin 14.0316051514
MESH:D014062 Tongue Neoplasms Zinc 14.0316543248
MESH:D014376 Tuberculosis Tretinoin 2.8916040207
MESH:D001749 Urinary Bladder Neoplasms 2,4-dinitrotoluene 7.0716049721
MESH:D001749 Urinary Bladder Neoplasms Doxorubicin 7.0717653716
MESH:D001749 Urinary Bladder Neoplasms Quercetin 7.0716720314
MESH:D014571 Urologic Neoplasms 2,4-dinitrotoluene 3.8010091137
MESH:D014581 Urticaria Acetaminophen 2.5010982225
MESH:D002583 Uterine Cervical Neoplasms resveratrol 8.0417473185
MESH:D002583 Uterine Cervical Neoplasms Tretinoin 8.0416129372
MESH:D014591 Uterine Diseases bisphenol A 4.4814652134
MESH:D014594 Uterine Neoplasms resveratrol 3.6517044934
MESH:D014604 Uveal Neoplasms Tretinoin 4.0816752155
MESH:D014605 Uveitis Cyclosporine 10.011336536
MESH:D014605 Uveitis Dexamethasone 10.011336536
MESH:D054079 Vascular Malformations Tetrachlorodibenzodioxin 4.0712125929
MESH:D018487 Ventricular Dysfunction, Left Doxorubicin 8.6617678736 16364871 17334414 17638931
MESH:D018487 Ventricular Dysfunction, Left resveratrol 8.6617488730
MESH:D014820 Vitiligo Tretinoin 3.5616761959
MESH:D019282 Wasting Syndrome Tetrachlorodibenzodioxin 3.7215886252
MESH:D015430 Weight Gain Dietary Fats 3.3016723640
MESH:D009396 Wilms Tumor Tretinoin 3.5316287080
MESH:D014985 Xerophthalmia Cyclosporine 3.9117120751
Pathway ID Pathway Name
REACT:1046 Pyruvate metabolism and Citric Acid (TCA) cycle
Pharmacogenomics Knowledge Base Top
Drug Bank Top
Drugbank ID Action Drug Name Description
DB08356 - 4-[4-(4-methoxyphenyl)-5-methyl-1H-pyrazol-3-yl]benzene-1,3-diol
No data
No data
No data

Simple Query:


  (e.g. CHD8)

Syndromic Genes

Non-syndromic Genes

AutismKB Statistics

  • Studies: 1,036
  • Genes: 1,379
  • CNVs/SVs: 5,420
  • SNVs/Indels: 11,669
  • de novo Mutations: 5,669
  • Mosaics: 789
  • Linkage Regions: 172
  • Paper Collected: 6/30/2018
  • Last Update: 8/26/2018


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