AutismKB 2.0

Annotation Detail for ENPP1


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Basic Information Top
Gene Symbol:ENPP1 ( ARHR2,M6S1,NPP1,NPPS,PC-1,PCA1,PDNP1 )
Gene Full Name: ectonucleotide pyrophosphatase/phosphodiesterase 1
Band: 6q23.2
Quick LinksEntrez ID:5167; OMIM: 173335; Uniprot ID:ENPP1_HUMAN; ENSEMBL ID: ENSG00000197594; HGNC ID: 3356
Relate to Another Database: SFARIGene; denovo-db
Related Pathway Information Top
No data
Pathway IDPathway Name
hsa00740Riboflavin metabolism
hsa00230Purine metabolism
hsa00770Pantothenate and CoA biosynthesis
hsa00760Nicotinate and nicotinamide metabolism
hsa01100Metabolic pathways
hsa00500Starch and sucrose metabolism
Pathway IDPathway Name
Metabolism of vitamins and cofactors
No data
No data
Pathway IDPathway Name
500885Vitamin B2 (riboflavin) metabolism
Related Diseases/Disorders Top
Desease IDDesease Name
Metabolic diseases
Diabetes
H00409Type II diabetes mellitus
No data
Desease Name
cholesterol
glucose
atherosclerosis, coronary
CARDIOVASCULAR
ossification of the posterior longitudinal ligament of the spine
systolic blood pressure
lipids
body mass
nephropathy in other diseases
nephropathy, diabetic
RENAL
glucose insulin obesity
ossification of the posterior longitudinal ligament of the spine (OPLL)
lipoprotein
metabolic syndrome
insulin left ventricular mass
PC-1 protein content
METABOLIC
osteoarthritis
obesity
insulin
diabetes, type 2
Insulin Resistance
No data
Desease Name
Arterial calcification, generalized, of infancy
Obesity, susceptibility to
Hypophosphatemic rickets, autosomal recessive, 2
Ossification of posterior longitudinal ligament of spine
Diabetes mellitus, non-insulin-dependent, susceptibility to
Comparative Toxicogenomics Database Top
Chemical ID Chemical Name Interaction Interaction Action Publication
C548651 2-(1'H-indolo-3'-carbonyl)thiazole-4-carboxylic acid methyl ester 2-(1'H-indolo-3'-carbonyl)thiazole-4-carboxylic acid methyl ester results in increased expression of ENPP1 mRNAincreases expression 19933214
C016403 2,4-dinitrotoluene 2,4-dinitrotoluene affects the expression of ENPP1 mRNAaffects expression 21346803
C023514 2,6-dinitrotoluene 2,6-dinitrotoluene affects the expression of ENPP1 mRNAaffects expression 21346803
D000638 Amiodarone Amiodarone affects the expression of ENPP1 mRNAaffects expression 19483382
D000643 Ammonium Chloride Ammonium Chloride affects the expression of ENPP1 mRNAaffects expression 16483693
D001104 Arbutin Arbutin results in decreased expression of ENPP1 mRNAdecreases expression 17103032
D001553 Benzbromarone Benzbromarone affects the expression of ENPP1 mRNAaffects expression 19483382
D015123 7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide 7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide results in decreased expression of ENPP1 mRNAdecreases expression 20382639
C031463 beta-glycerophosphoric acid beta-glycerophosphoric acid results in increased activity of ENPP1 proteinincreases activity 18500657
C031463 beta-glycerophosphoric acid beta-glycerophosphoric acid results in increased expression of ENPP1 mRNAincreases expression 18500657
C031463 beta-glycerophosphoric acid Levamisole inhibits the reaction [beta-glycerophosphoric acid results in increased activity of ENPP1 protein]decreases reaction|increases activity 18500657
C031463 beta-glycerophosphoric acid Levamisole inhibits the reaction [beta-glycerophosphoric acid results in increased expression of ENPP1 mRNA]decreases reaction|increases expression 18500657
C006780 bisphenol A bisphenol A results in decreased expression of ENPP1 mRNAdecreases expression 20739668
D002251 Carbon Tetrachloride Carbon Tetrachloride results in increased expression of ENPP1 mRNAincreases expression 17484886
D002857 Chromium Chromium results in increased expression of ENPP1 mRNAincreases expression 17547211
D002994 Clofibrate Clofibrate affects the expression of ENPP1 mRNAaffects expression 19483382
D016572 Cyclosporine Cyclosporine results in decreased expression of ENPP1 mRNAdecreases expression 20106945
D004052 Diethylnitrosamine Diethylnitrosamine results in increased expression of ENPP1 mRNAincreases expression 19638242
D004128 Dimethylnitrosamine Dimethylnitrosamine results in increased expression of ENPP1 mRNAincreases expression 17547211
D011756 Diphosphates Diphosphates results in decreased expression of ENPP1 mRNAdecreases expression 17383965
D004997 Ethinyl Estradiol Ethinyl Estradiol results in increased expression of ENPP1 mRNAincreases expression 17942748
D005001 Ethionine Ethionine affects the expression of ENPP1 mRNAaffects expression 19483382
D005419 Flavonoids Flavonoids results in increased expression of ENPP1 mRNAincreases expression 18035473
C440499 lipopolysaccharide, Escherichia coli 0111 B4 lipopolysaccharide, Escherichia coli 0111 B4 results in increased activity of ENPP1 proteinincreases activity 17573159
D008628 Mercury Mercury results in increased expression of ENPP1 mRNAincreases expression 17547211
D009853 Omeprazole Omeprazole affects the expression of ENPP1 mRNAaffects expression 19483382
C006253 pirinixic acid pirinixic acid affects the expression of ENPP1 mRNAaffects expression 19483382
C025299 polyphenols polyphenols results in decreased expression of ENPP1 mRNAdecreases expression 16293270
D011192 Potassium Dichromate Potassium Dichromate results in increased expression of ENPP1 mRNAincreases expression 17547211
D011374 Progesterone Progesterone results in decreased expression of ENPP1decreases expression 17510236
D011441 Propylthiouracil Propylthiouracil affects the expression of ENPP1 mRNAaffects expression 19483382
D012402 Rotenone Rotenone results in increased expression of ENPP1 mRNAincreases expression 19013527
C004648 testosterone enanthate testosterone enanthate affects the expression of ENPP1 mRNAaffects expression 17440010
D013749 Tetrachlorodibenzodioxin Tetrachlorodibenzodioxin results in decreased expression of ENPP1 mRNAdecreases expression 20106945
D013749 Tetrachlorodibenzodioxin Tetrachlorodibenzodioxin results in increased expression of ENPP1 mRNAincreases expression 19933214
D007978 Levamisole Levamisole inhibits the reaction [beta-glycerophosphoric acid results in increased activity of ENPP1 protein]decreases reaction|increases activity 18500657
D007978 Levamisole Levamisole inhibits the reaction [beta-glycerophosphoric acid results in increased expression of ENPP1 mRNA]decreases reaction|increases expression 18500657
D013853 Thioacetamide Thioacetamide affects the expression of ENPP1 mRNAaffects expression 19483382
Disease ID Disease Name Direct Evidence Inference Chemical Name Inference Score Publication
MESH:D000014 Abnormalities, Drug-Induced Tetrachlorodibenzodioxin 2.5315322242 14514962 11752688
MESH:D000138 Acidosis Ammonium Chloride 3.2318287403
MESH:D000152 Acne Vulgaris Ethinyl Estradiol 3.6117505938
MESH:D055371 Acute Lung Injury pirinixic acid 2.8218653653
MESH:D000230 Adenocarcinoma Dimethylnitrosamine 4.2116033868
MESH:D000230 Adenocarcinoma Ethinyl Estradiol 4.2114692618
MESH:D000236 Adenoma Diethylnitrosamine 6.336695378 10737359
MESH:D000236 Adenoma Dimethylnitrosamine 6.3319555203
MESH:D018248 Adenoma, Liver Cell Diethylnitrosamine 15.3916434500 19061943 17162532 17620307 18056438 19052882
MESH:D018248 Adenoma, Liver Cell pirinixic acid 15.3916434500
MESH:D018248 Adenoma, Liver Cell Tetrachlorodibenzodioxin 15.3916835633
MESH:D000740 Anemia Tetrachlorodibenzodioxin 2.6711748828
MESH:D001145 Arrhythmias, Cardiac Amiodarone 3.5218218290 18057881 20041841
MESH:C537440 Arterial calcification of infancy marker/mechanism
MESH:D001161 Arteriosclerosis Ethinyl Estradiol 3.1511256880
MESH:D001169 Arthritis, Experimental Ethinyl Estradiol 2.4615885639
MESH:D001281 Atrial Fibrillation Amiodarone 3.6618651412 19698954
MESH:D001321 Autistic Disorder Mercury 2.8117497416
MESH:D001327 Autoimmune Diseases Mercury 4.5516634805
MESH:D001778 Blood Coagulation Disorders Amiodarone 52.5419483382
MESH:D001778 Blood Coagulation Disorders Benzbromarone 52.5419483382
MESH:D001778 Blood Coagulation Disorders Clofibrate 52.5419483382
MESH:D001778 Blood Coagulation Disorders Ethionine 52.5419483382
MESH:D001778 Blood Coagulation Disorders Omeprazole 52.5419483382
MESH:D001778 Blood Coagulation Disorders pirinixic acid 52.5419483382
MESH:D001778 Blood Coagulation Disorders Propylthiouracil 52.5419483382
MESH:D001778 Blood Coagulation Disorders Tetrachlorodibenzodioxin 52.5412125929
MESH:D001778 Blood Coagulation Disorders Thioacetamide 52.5419483382
MESH:D001836 Body Weight Changes Tetrachlorodibenzodioxin 3.4615340226
MESH:D001848 Bone Diseases, Developmental Tetrachlorodibenzodioxin 2.5615746008
MESH:D001862 Bone Resorption bisphenol A 3.5711985600
MESH:D020201 Brain Hemorrhage, Traumatic Progesterone 5.0117868700
MESH:D001930 Brain Injuries Progesterone 3.9415845082 15380490 15665606
MESH:D001943 Breast Neoplasms bisphenol A 2.2417123778
MESH:D001943 Breast Neoplasms Chromium 2.2415986119
MESH:D001943 Breast Neoplasms Diethylnitrosamine 2.2417474063
MESH:D001943 Breast Neoplasms Progesterone 2.2416175315 15562024 17614352
MESH:D001943 Breast Neoplasms Tetrachlorodibenzodioxin 2.2420435547
MESH:D002252 Carbon Tetrachloride Poisoning Carbon Tetrachloride 3.4616227642 16124888 15673190 10355542 15721981 16097048 15700767 16011737 18705752 16192424 16050911 3786805
MESH:D002277 Carcinoma Dimethylnitrosamine 7.5119555203
MESH:D002277 Carcinoma Tetrachlorodibenzodioxin 7.5116835633
MESH:D006528 Carcinoma, Hepatocellular 2,4-dinitrotoluene 10.6316705839
MESH:D006528 Carcinoma, Hepatocellular 2,6-dinitrotoluene 10.6316705839
MESH:D006528 Carcinoma, Hepatocellular Benzbromarone 10.631701930
MESH:D006528 Carcinoma, Hepatocellular Carbon Tetrachloride 10.6318788625
MESH:D006528 Carcinoma, Hepatocellular Diethylnitrosamine 10.6316540662 17055752 20935162 18210153 16830150 19171122 20101231 10672840 18691550 20727157 18056438 18665156 21159647 17978847 17162532 19919837 16698587 17173139 3581430 20214788 19335982 10737359 20432363 20514400 18494052 17761372 19107877 19052882 19383236 19418558 16779866 16935385 18978308 17138121 20007298 16878318 16681979 19539802 17428255 16502159 19822196 18971187 18506893 16569478 19701751 16328049 11831363 18788625 18785209 19208518 20524982 18393292 19394651 20512989 19519916 16288022 16807293 3084413 20084675
MESH:D006528 Carcinoma, Hepatocellular Thioacetamide 10.6317997003
MESH:D002278 Carcinoma in Situ bisphenol A 4.6617123778
MESH:D002294 Carcinoma, Squamous Cell Dimethylnitrosamine 2.8616033868
MESH:D006332 Cardiomegaly Tetrachlorodibenzodioxin 2.1918850075 18670907 16120746
MESH:D002311 Cardiomyopathy, Dilated Amiodarone 5.7715710769 19225199
MESH:D002311 Cardiomyopathy, Dilated Mercury 5.7710334427
MESH:D002341 Carotid Artery Thrombosis Amiodarone 4.7618974383
MESH:D002418 Cattle Diseases Levamisole 6.1014651886
MESH:D002471 Cell Transformation, Neoplastic 2,6-dinitrotoluene 18.736135515
MESH:D002471 Cell Transformation, Neoplastic 7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide 18.7320889678
MESH:D002471 Cell Transformation, Neoplastic Clofibrate 18.731399818
MESH:D002471 Cell Transformation, Neoplastic Cyclosporine 18.7312371664
MESH:D002471 Cell Transformation, Neoplastic Diethylnitrosamine 18.7317174075 2727394 21159647 7505956
MESH:D002637 Chest Pain Omeprazole 4.7815447763
MESH:D018281 Cholangiocarcinoma Diethylnitrosamine 14.5519052882
MESH:D018281 Cholangiocarcinoma Tetrachlorodibenzodioxin 14.5516835633
MESH:D018281 Cholangiocarcinoma Thioacetamide 14.5518291259
MESH:D002779 Cholestasis Cyclosporine 11.9619486331
MESH:D002779 Cholestasis Ethinyl Estradiol 11.9616105132 17681005 16919318 17333356 15861022 11677210 17110522
MESH:D002779 Cholestasis pirinixic acid 11.9619176532
MESH:D002972 Cleft Palate Tetrachlorodibenzodioxin 1.9716354765 15340226 12621046 8697196 15668235
MESH:D003110 Colonic Neoplasms polyphenols 2.6216293270
MESH:D015179 Colorectal Neoplasms Levamisole 4.1115148649
MESH:D000013 Congenital Abnormalities Tetrachlorodibenzodioxin 2.7914669216 17141729
MESH:D019465 Craniofacial Abnormalities Tetrachlorodibenzodioxin 1.2410048152 20055451 15322242
MESH:D003490 Cyanosis 2,4-dinitrotoluene 9.8318551238
MESH:D003490 Cyanosis 2,6-dinitrotoluene 9.8318551238
MESH:D017449 Dermatitis, Allergic Contact Mercury 6.7016823706
MESH:D017449 Dermatitis, Allergic Contact Potassium Dichromate 6.7016823706
MESH:D003876 Dermatitis, Atopic pirinixic acid 2.2718249437
MESH:D003924 Diabetes Mellitus, Type 2 marker/mechanism
MESH:D003924 Diabetes Mellitus, Type 2 Diethylnitrosamine 3.9320387270
MESH:D003924 Diabetes Mellitus, Type 2 Tetrachlorodibenzodioxin 3.9317107852
MESH:D003929 Diabetic Neuropathies Progesterone 4.1717187935
MESH:D056486 Drug-Induced Liver Injury 2,4-dinitrotoluene 23.8821346803 18551238
MESH:D056486 Drug-Induced Liver Injury 2,6-dinitrotoluene 23.8818551238 21346803
MESH:D056486 Drug-Induced Liver Injury Amiodarone 23.8818218290 15265979
MESH:D056486 Drug-Induced Liver Injury Carbon Tetrachloride 23.8815027814 6884620 3786805 2869522 19336974 21278145 15998439 10092053 7120509 17522070 7440962 15968718 3732212 4309450 7179309 10915739 6623471 16177239 11566570 19085960 16227642 9327722
MESH:D056486 Drug-Induced Liver Injury Diethylnitrosamine 23.8819107877
MESH:D056486 Drug-Induced Liver Injury Dimethylnitrosamine 23.888172417
MESH:D056486 Drug-Induced Liver Injury polyphenols 23.8819370779
MESH:D056486 Drug-Induced Liver Injury Tetrachlorodibenzodioxin 23.8820420201
MESH:D056486 Drug-Induced Liver Injury Thioacetamide 23.8812963478
MESH:D004362 Drug Toxicity Tetrachlorodibenzodioxin 2.5211462148
MESH:D004381 Duodenal Ulcer Omeprazole 4.0221218061 15991576 16613094 17151854
MESH:D050171 Dyslipidemias Clofibrate 3.8316707586
MESH:D004487 Edema pirinixic acid 5.5912083418
MESH:D004487 Edema Tetrachlorodibenzodioxin 5.5911000095 12711302
MESH:D004489 Edema, Cardiac Tetrachlorodibenzodioxin 3.5715322242 16714409 18230668
MESH:D004681 Encephalomyelitis, Autoimmune, Experimental Ethinyl Estradiol 8.0112538720
MESH:D004681 Encephalomyelitis, Autoimmune, Experimental Progesterone 8.0117692515
MESH:D004715 Endometriosis Progesterone 8.0016134523
MESH:D004715 Endometriosis Tetrachlorodibenzodioxin 8.0010568697 9294722
MESH:D019446 Endotoxemia lipopolysaccharide, Escherichia coli 0111 B4 5.2612954792
MESH:D004931 Esophageal Achalasia Diethylnitrosamine 4.7916302075
MESH:D004938 Esophageal Neoplasms 7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide 4.3820426865
MESH:D004938 Esophageal Neoplasms Dimethylnitrosamine 4.3817016578
MESH:D005124 Eye Abnormalities Tetrachlorodibenzodioxin 2.7711564622
MESH:D005218 Fat Necrosis Thioacetamide 5.3916456712
MESH:D005234 Fatty Liver Amiodarone 32.5114986274
MESH:D005234 Fatty Liver Carbon Tetrachloride 32.5116045604 12631006 17595544 15959796 16239168 19224547 12795759 61145
MESH:D005234 Fatty Liver Clofibrate 32.5119224547
MESH:D005234 Fatty Liver Cyclosporine 32.5119224547
MESH:D005234 Fatty Liver Diethylnitrosamine 32.5121071580 20387270
MESH:D005234 Fatty Liver Ethinyl Estradiol 32.5115345470
MESH:D005234 Fatty Liver pirinixic acid 32.5120131406 19236843
MESH:D005313 Fetal Death Tetrachlorodibenzodioxin 3.1411858732
MESH:D005334 Fever lipopolysaccharide, Escherichia coli 0111 B4 4.9216997862
MESH:D005355 Fibrosis Carbon Tetrachloride 12.8718705752
MESH:D005355 Fibrosis Cyclosporine 12.8712639820 12168785
MESH:D005355 Fibrosis Tetrachlorodibenzodioxin 12.8720067830
MESH:D005885 Gingival Hyperplasia Cyclosporine 3.898708960
MESH:D006058 Gonadal Disorders Tetrachlorodibenzodioxin 4.2610696789
MESH:D006330 Heart Defects, Congenital Tetrachlorodibenzodioxin 2.1611294989 10048152
MESH:D006333 Heart Failure pirinixic acid 2.3420558911
MESH:D006457 Hemoglobinuria, Paroxysmal Cyclosporine 4.0915720958
MESH:D006470 Hemorrhage Tetrachlorodibenzodioxin 3.0511000095
MESH:D006501 Hepatic Encephalopathy Thioacetamide 4.2818665440 17276928 15929193
MESH:D006505 Hepatitis Carbon Tetrachloride 8.4519900420 19110552
MESH:D006505 Hepatitis Thioacetamide 8.4516456712
MESH:D006529 Hepatomegaly Amiodarone 12.5715265979
MESH:D006529 Hepatomegaly pirinixic acid 12.5719176532 16221962 19772884 18467677
MESH:D006529 Hepatomegaly Tetrachlorodibenzodioxin 12.5715340226 16120746 12621046
MESH:D019247 HIV Wasting Syndrome testosterone enanthate 5.4117440010
MESH:D006869 Hydronephrosis Tetrachlorodibenzodioxin 3.7116959395 15340226 16354765 8697196 18606429
MESH:D006932 Hyperbilirubinemia Carbon Tetrachloride 4.2116899240
MESH:D006937 Hypercholesterolemia Amiodarone 3.588137927 9751232
MESH:D006943 Hyperglycemia pirinixic acid 2.9020558911
MESH:D006973 Hypertension Cyclosporine 4.5210903974
MESH:D006973 Hypertension Tetrachlorodibenzodioxin 4.5218670907 18850075
MESH:D006975 Hypertension, Portal Carbon Tetrachloride 3.7715338365
OMIM:613312 HYPOPHOSPHATEMIC RICKETS, AUTOSOMAL RECESSIVE, 2 marker/mechanism
MESH:D007021 Hypospadias Ethinyl Estradiol 3.4916945680 16569931
MESH:D007037 Hypothyroidism Amiodarone 10.5518020914 17991464
MESH:D007037 Hypothyroidism Propylthiouracil 10.558137927 18031379
MESH:D020244 Infarction, Middle Cerebral Artery Progesterone 4.0815869954
MESH:D007247 Infertility, Female Ethinyl Estradiol 3.1612013081
MESH:D007248 Infertility, Male Ethinyl Estradiol 2.2717937319
MESH:D007249 Inflammation Diethylnitrosamine 14.0318785209
MESH:D007249 Inflammation Flavonoids 14.0317296493
MESH:D007249 Inflammation polyphenols 14.0316366677
MESH:D007249 Inflammation Progesterone 14.0315869954
MESH:D007249 Inflammation Tetrachlorodibenzodioxin 14.0312878042 12200463
MESH:D007333 Insulin Resistance bisphenol A 6.6116393666
MESH:D007333 Insulin Resistance pirinixic acid 6.6116306350
MESH:D007569 Jaw Abnormalities Tetrachlorodibenzodioxin 3.0516580747
MESH:D007638 Keratoconjunctivitis Sicca Cyclosporine 4.1115604871
MESH:D007674 Kidney Diseases Chromium 13.0517934191
MESH:D007674 Kidney Diseases Cyclosporine 13.058314463 10903974 18776723
MESH:D007674 Kidney Diseases Mercury 13.0517934191
MESH:D007674 Kidney Diseases Potassium Dichromate 13.0519665454
MESH:D007680 Kidney Neoplasms 2,4-dinitrotoluene 10.8516705839
MESH:D007680 Kidney Neoplasms 2,6-dinitrotoluene 10.8516705839
MESH:D007680 Kidney Neoplasms Cyclosporine 10.8512371664
MESH:D016773 Leishmaniasis, Cutaneous Omeprazole 3.8419248655
MESH:D008064 Lipidoses Amiodarone 3.2815342952 17567588
MESH:D008103 Liver Cirrhosis Carbon Tetrachloride 6.0116943688 16221502 11408273 21278145 17334410 17174718 11903743 16239168 17157831
MESH:D008103 Liver Cirrhosis Diethylnitrosamine 6.0118522880 19638242 20032147 18407596 18665156
MESH:D008106 Liver Cirrhosis, Experimental Carbon Tetrachloride 6.2615362042 17565644 18339082 17976157 18187930 17922224 12586293 14748882 15650968 15052691 11481614 16116963 18420326 15959796 12741479 15931870 20821823 16638106 15996030 16011737 12609069 18263696 12958196 18317297 18395095 12546737 17900296 18429990 17944888 18156304 10355542 18412020 15057751 14620537 18705752 12898905 15893842 14716496 18279442 12389079 16033810 17714472 14724832 15925388 13678700 12445421 18205269 17761835 18481824 12667390 18166357 18376398 16192424 12649538 12632512 17823541 17631135 16015684 17721639 18277467 14716833 18210741 16097048 17805973 15123356 14512876 17766677 17525996 12632514 12666154 17557913 15370692 18395914 18251166 15876570 16248980 15338365 15730626 18472094 18418968 16027843 17481882 18006644 17698563 15673190 16136751 17869086 18472332 17640975 17708605 18054572 15818738 12445418
MESH:D008106 Liver Cirrhosis, Experimental Dimethylnitrosamine 6.2616627068 17666798 17724770 15138612 18239293 15763062 16009107 15099470 14568256 15081153 18629640 18095165 16169303 16544323 15504291 15298665 15591649 12925901 16603200 15942678 15571005 15086199 15577212 14659978 15723089 17640959 15744066 17036385 15793283 15479170 17203207 17196135 15369754 17348192 14643895 18237412 16570917 14709902 14726149 17881167 15161499 16270385 17201889 17198567 15383259 18210741 18637143 15339415 15798949 18364076 18567088 17465448 15733078 17719030 17534399 15067225 15366600 15864749 18371158 15492853 15842777 18672772 12918455 16042886 17432682
MESH:D008106 Liver Cirrhosis, Experimental pirinixic acid 6.2615474484
MESH:D008106 Liver Cirrhosis, Experimental Tetrachlorodibenzodioxin 6.2612878042
MESH:D008106 Liver Cirrhosis, Experimental Thioacetamide 6.2617050028 18295389 18416461 11682029 16098781 12679928 10677585 15474484 18395095 17127702 15465738 14739098 15334695 18263696 12085344 17629604 12531686 18615449 15075984 15078482 15288473 18380797 12175628 18458672 15362042 11172339 11481614 15316131 16489207 18606216 16097051 16511523 12891558 16126171 15716488 15158331 18032466 18031379 15288472 16248980 16343077 12557150 17355460 17292413 15095483
MESH:D008107 Liver Diseases Carbon Tetrachloride 8.6816964402 17285989 15720792 16246199 15830285
MESH:D008107 Liver Diseases Diethylnitrosamine 8.6817034775
MESH:D008107 Liver Diseases polyphenols 8.6816698588
MESH:D008107 Liver Diseases Thioacetamide 8.6818374380 15158337 16337175
MESH:D017093 Liver Failure Carbon Tetrachloride 3.8515123358
MESH:D017114 Liver Failure, Acute Carbon Tetrachloride 14.7816899240 14706259
MESH:D017114 Liver Failure, Acute Dimethylnitrosamine 14.7817457977
MESH:D017114 Liver Failure, Acute Thioacetamide 14.7815633222 15313186 12479984 17276928
MESH:D008113 Liver Neoplasms 2,6-dinitrotoluene 16.297678174
MESH:D008113 Liver Neoplasms Carbon Tetrachloride 16.2919294768
MESH:D008113 Liver Neoplasms Diethylnitrosamine 16.2919833225 20137499 19996281 18754104 19256749 18644402 19255062 12771043 20583210 19090486 20118626 19812893 15885732 19690152 21047994 18977376 16942905 20101389 19427195 15175105 2422723 19850985 19073162 20452335 18978307 19254457 2862719 20434301 19642983 18648771 21071580 19294768 20501860 19551842 9163691 21278145 21167192 10737359 19638242 19426721 20405173 20492335 12112319 19499222
MESH:D008113 Liver Neoplasms Dimethylnitrosamine 16.2915890375 3113478
MESH:D008113 Liver Neoplasms pirinixic acid 16.2920007298 15890375 16377806
MESH:D008113 Liver Neoplasms Tetrachlorodibenzodioxin 16.2916984957
MESH:D008114 Liver Neoplasms, Experimental 2,6-dinitrotoluene 16.492876784 2876786 6135515
MESH:D008114 Liver Neoplasms, Experimental Carbon Tetrachloride 16.4912014681 15583823
MESH:D008114 Liver Neoplasms, Experimental Diethylnitrosamine 16.4919519916 19539802 18282651 18079962 21159647 18775883 18093689 18544905 3124819 17854601 16842330 2563599 9362446 19009564 18308698 16267830 17174075 18164116 19004024 18253720 19126423 17942915
MESH:D008114 Liver Neoplasms, Experimental Dimethylnitrosamine 16.496150874 1848544 15603536
MESH:D008114 Liver Neoplasms, Experimental Tetrachlorodibenzodioxin 16.4912151625
MESH:D008133 Long QT Syndrome Amiodarone 3.3317391786 15350150 11989578
MESH:D008171 Lung Diseases Amiodarone 3.1612587719
MESH:D017563 Lung Diseases, Interstitial Amiodarone 4.1518516814
MESH:D008175 Lung Neoplasms Diethylnitrosamine 3.2420970405 20512841 21163286 6695378
MESH:D008175 Lung Neoplasms Dimethylnitrosamine 3.2416061637 11884234 19555203
MESH:D008175 Lung Neoplasms Tetrachlorodibenzodioxin 3.2411884234 19555203
MESH:D008325 Mammary Neoplasms, Experimental Progesterone 2.6617203775 11408345
MESH:D008664 Metal Metabolism, Inborn Errors Cyclosporine 4.4616801185
MESH:D009135 Muscular Diseases pirinixic acid 3.1916239165
MESH:D009181 Mycoses Amiodarone 4.5717974566 12754197
MESH:D009203 Myocardial Infarction pirinixic acid 2.0119151258
MESH:D017202 Myocardial Ischemia Tetrachlorodibenzodioxin 2.7612213967
MESH:D015428 Myocardial Reperfusion Injury pirinixic acid 2.7016411023
MESH:D009336 Necrosis 2,4-dinitrotoluene 9.2618551238
MESH:D009336 Necrosis 2,6-dinitrotoluene 9.267678174 18551238
MESH:D009362 Neoplasm Metastasis Diethylnitrosamine 2.443581430 9029167
MESH:D009369 Neoplasms pirinixic acid 1.8017405874
MESH:D009402 Nephrosis, Lipoid Cyclosporine 4.1117954296
MESH:D009404 Nephrotic Syndrome Cyclosporine 3.0119348381 18481113
MESH:D009410 Nerve Degeneration Rotenone 3.6315790535 17356569 18619942
MESH:D009421 Nervous System Malformations bisphenol A 8.5616427766 11399458
MESH:D009421 Nervous System Malformations Tetrachlorodibenzodioxin 8.5614600291
MESH:D019636 Neurodegenerative Diseases Diethylnitrosamine 3.0820387270
MESH:D009461 Neurologic Manifestations Diethylnitrosamine 4.7920387270
MESH:D052556 Niemann-Pick Disease, Type C Clofibrate 4.629802331
MESH:D009765 Obesity marker/mechanism
MESH:D009765 Obesity pirinixic acid 1.7320558911
MESH:D009784 Occupational Diseases 2,4-dinitrotoluene 7.9516049721 12819281
MESH:D009784 Occupational Diseases 2,6-dinitrotoluene 7.9516049721
MESH:D017887 Ossification of Posterior Longitudinal Ligament marker/mechanism
MESH:D010049 Ovarian Diseases bisphenol A 4.6611985600
MESH:D010051 Ovarian Neoplasms Progesterone 2.4216525653 17393432
MESH:D010190 Pancreatic Neoplasms Diethylnitrosamine 2.3016540662
MESH:D016584 Panic Disorder Ethinyl Estradiol 3.3911578682
MESH:D010300 Parkinson Disease Rotenone 2.8619114014 18191903 16140633 19232380 11535288 16412576 15451049 18619942 11445065
MESH:D020734 Parkinsonian Disorders Rotenone 3.8018197244 15927086 15574749 15795934
MESH:D010382 Peliosis Hepatis Tetrachlorodibenzodioxin 3.9212520081
MESH:D017119 Porphyria Cutanea Tarda Tetrachlorodibenzodioxin 3.2518163543
MESH:D011230 Precancerous Conditions Cyclosporine 8.0412371664
MESH:D011230 Precancerous Conditions Diethylnitrosamine 8.042563599
MESH:D011297 Prenatal Exposure Delayed Effects bisphenol A 8.4210548101
MESH:D011297 Prenatal Exposure Delayed Effects Tetrachlorodibenzodioxin 8.4211399792 11222880 11118676 11896295
MESH:D019048 Prostatic Intraepithelial Neoplasia bisphenol A 3.9220887781
MESH:D011471 Prostatic Neoplasms bisphenol A 3.5116740699
MESH:D011537 Pruritus Ethinyl Estradiol 2.9915861022 16919318
MESH:D011565 Psoriasis Cyclosporine 2.1116882103
MESH:D011629 Puberty, Precocious bisphenol A 4.4610548101
MESH:D011658 Pulmonary Fibrosis Amiodarone 2.7312490602 11597910 12832656
MESH:D015427 Reperfusion Injury pirinixic acid 2.2319058328
MESH:D015619 Respiratory System Abnormalities Tetrachlorodibenzodioxin 3.5318990726
MESH:D012468 Salivary Gland Neoplasms Progesterone 2.7418045962
MESH:D012640 Seizures 2,4-dinitrotoluene 5.1418551238
MESH:D012640 Seizures 2,6-dinitrotoluene 5.1418551238
OMIM:609620 SHORT QT SYNDROME 1 Amiodarone 4.7618724381
MESH:D012878 Skin Neoplasms Tetrachlorodibenzodioxin 1.8916192470
MESH:D013088 Spermatocele Ethinyl Estradiol 3.6116709447
MESH:D013119 Spinal Cord Injuries Progesterone 3.9515862959 16503802
MESH:D013158 Splenic Diseases Dimethylnitrosamine 4.9412587719
MESH:D013272 Stomach Diseases Omeprazole 4.2918545984
MESH:D013274 Stomach Neoplasms Diethylnitrosamine 2.5718456281
MESH:D013274 Stomach Neoplasms Dimethylnitrosamine 2.5716033868
MESH:D013276 Stomach Ulcer Amiodarone 6.6318087811
MESH:D013276 Stomach Ulcer Omeprazole 6.6315991576 18237397 16755016 17977527 10750652 11906479
MESH:D013322 Strongyloidiasis Levamisole 6.5914651886
MESH:D019966 Substance-Related Disorders bisphenol A 3.6616045194 16684133
MESH:D013610 Tachycardia Amiodarone 3.9811238279
MESH:D017180 Tachycardia, Ventricular Amiodarone 3.8819225199
MESH:D013705 Temporomandibular Joint Disorders polyphenols 4.9217997062
MESH:D019851 Thrombophilia Ethinyl Estradiol 3.3211994571
MESH:D013927 Thrombosis Ethinyl Estradiol 2.8815669648
MESH:D013959 Thyroid Diseases Amiodarone 10.9519731979
MESH:D013959 Thyroid Diseases Tetrachlorodibenzodioxin 10.9512697716
MESH:D013964 Thyroid Neoplasms Diethylnitrosamine 6.607505956
MESH:D013964 Thyroid Neoplasms Propylthiouracil 6.6015710170
MESH:D013971 Thyrotoxicosis Amiodarone 4.5419584973 18020914
MESH:D016171 Torsades de Pointes Amiodarone 3.8711989578 17467628
MESH:D001749 Urinary Bladder Neoplasms 2,4-dinitrotoluene 4.5716049721
MESH:D001749 Urinary Bladder Neoplasms 2,6-dinitrotoluene 4.5716049721
MESH:D014571 Urologic Neoplasms 2,4-dinitrotoluene 10.9010091137
MESH:D014571 Urologic Neoplasms 2,6-dinitrotoluene 10.9010091137
MESH:D014591 Uterine Diseases bisphenol A 4.6814652134
MESH:D014594 Uterine Neoplasms Ethinyl Estradiol 2.9914692618
MESH:D014605 Uveitis Cyclosporine 3.651336536
MESH:D054079 Vascular Malformations Tetrachlorodibenzodioxin 4.2612125929
MESH:D020246 Venous Thrombosis Ethinyl Estradiol 3.2514671159 15869587
MESH:D019282 Wasting Syndrome Tetrachlorodibenzodioxin 3.9215886252
MESH:D014985 Xerophthalmia Cyclosporine 4.1117120751
Pathway ID Pathway Name
KEGG:01100 Metabolic pathways
REACT:11193 Metabolism of vitamins and cofactors
KEGG:00760 Nicotinate and nicotinamide metabolism
KEGG:00770 Pantothenate and CoA biosynthesis
KEGG:00230 Purine metabolism
KEGG:00740 Riboflavin metabolism
KEGG:00500 Starch and sucrose metabolism
Pharmacogenomics Knowledge Base Top
  • PharmGKB Accession:PA27791
    • No data
    Releated disease ID Related disease Name
    PA444626Insulin Resistance
    PA445131Obesity
    PA443890Diabetes Mellitus, Type 2
    Releated drug ID Related drug Name
    PA164744376adenosine monophosphate
    PA164743471adenosine triphosphate
    Drug Bank Top
    Drugbank ID Action Drug Name Description
    DB00811 antagonist Rebetron (Schering-Plough) Antiviral Agents;Antimetabolites
    DB01143 agonist Amifostine Radiation-Protective Agents
    No data
    No data
    No data

    Simple Query:


      (e.g. CHD8)

    Syndromic Genes

    Non-syndromic Genes

    AutismKB Statistics

    • Studies: 1,036
    • Genes: 1,379
    • CNVs/SVs: 5,420
    • SNVs/Indels: 11,669
    • de novo Mutations: 5,669
    • Mosaics: 789
    • Linkage Regions: 172
    • Paper Collected: 6/30/2018
    • Last Update: 8/26/2018


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