AutismKB 2.0

Annotation Detail for MPP6


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Basic Information Top
Gene Symbol:MPP6 ( PALS2,VAM-1,VAM1,p55T )
Gene Full Name: membrane protein, palmitoylated 6 (MAGUK p55 subfamily member 6)
Band: 7p15.3
Quick LinksEntrez ID:51678; OMIM: 606959; Uniprot ID:MPP6_HUMAN; ENSEMBL ID: ENSG00000105926; HGNC ID: 18167
Relate to Another Database: SFARIGene; denovo-db
Related Pathway Information Top
Related Diseases/Disorders Top
Comparative Toxicogenomics Database Top
Chemical ID Chemical Name Interaction Interaction Action Publication
D001564 Benzo(a)pyrene Benzo(a)pyrene results in decreased expression of MPP6 mRNAdecreases expression 20064835
D001564 Benzo(a)pyrene Benzo(a)pyrene results in increased expression of MPP6 mRNAincreases expression 20713471
D015123 7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide 7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide results in decreased expression of MPP6 mRNAdecreases expression 19150397
D004997 Ethinyl Estradiol Ethinyl Estradiol affects the expression of MPP6 mRNAaffects expression 17555576
D008748 Methylcholanthrene Methylcholanthrene results in increased expression of MPP6 mRNAincreases expression 20713471
D013629 Tamoxifen Tamoxifen affects the expression of MPP6 mRNAaffects expression 17555576
C025643 vinclozolin vinclozolin affects the expression of MPP6 mRNAaffects expression 19015723
Disease ID Disease Name Direct Evidence Inference Chemical Name Inference Score Publication
MESH:D000008 Abdominal Neoplasms Tamoxifen 5.0714745880
MESH:D000152 Acne Vulgaris Ethinyl Estradiol 4.4617505938
MESH:D000230 Adenocarcinoma Benzo(a)pyrene 4.3920464547 20127859
MESH:D000230 Adenocarcinoma Ethinyl Estradiol 4.3914692618
MESH:D000236 Adenoma Benzo(a)pyrene 7.426695378
MESH:D000236 Adenoma Methylcholanthrene 7.426695378 10545420
MESH:D001008 Anxiety Disorders vinclozolin 3.8919015723
MESH:D017544 Aortic Aneurysm, Abdominal Benzo(a)pyrene 4.4919183758
MESH:D001161 Arteriosclerosis Ethinyl Estradiol 3.8811256880
MESH:D001169 Arthritis, Experimental Ethinyl Estradiol 2.8415885639
MESH:D050197 Atherosclerosis Methylcholanthrene 3.6211922910
MESH:D001943 Breast Neoplasms Benzo(a)pyrene 1.9517474063 20146248
MESH:D001943 Breast Neoplasms Methylcholanthrene 1.9517474063
MESH:D001943 Breast Neoplasms Tamoxifen 1.9518984771 21152245 19487384 16202921 19059307 18815881 18351453 19142967 20859285 11161223 16873071 18855134 16818667 19084267 18997820 19115204 19066611 20135344 17049068 19221464 17242785 18629630 19410462 19200415 19103187 17261762 19288272 15668708 18821012 15565566 20065188 19189212 19289846 19189210 16273361 19011961 19244106 20544844 17440819 17893378 21138602 20390343 20005174 19155303 18425577
MESH:D002277 Carcinoma Methylcholanthrene 4.2210545420
MESH:D018270 Carcinoma, Ductal, Breast Tamoxifen 4.9219066611
MESH:D006528 Carcinoma, Hepatocellular Tamoxifen 1.8516924424
MESH:D002294 Carcinoma, Squamous Cell Benzo(a)pyrene 2.1220419170
MESH:D002295 Carcinoma, Transitional Cell Tamoxifen 3.9217572228
MESH:D002471 Cell Transformation, Neoplastic 7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide 7.6220889678
MESH:D002471 Cell Transformation, Neoplastic Methylcholanthrene 7.6216192471
MESH:D002779 Cholestasis Ethinyl Estradiol 3.1015861022 16919318 17110522 16105132 17333356 11677210 17681005
MESH:D003456 Cryptorchidism vinclozolin 4.7214966744
MESH:D003711 Demyelinating Diseases Tamoxifen 4.7819031437
MESH:D003928 Diabetic Nephropathies Tamoxifen 3.7619279558
MESH:D004681 Encephalomyelitis, Autoimmune, Experimental Ethinyl Estradiol 10.2412538720
MESH:D004681 Encephalomyelitis, Autoimmune, Experimental Tamoxifen 10.2419031437
MESH:D016889 Endometrial Neoplasms Tamoxifen 3.2416202921 17893378 20544844 19155303
MESH:D004938 Esophageal Neoplasms 7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide 4.5720426865
MESH:D004938 Esophageal Neoplasms Benzo(a)pyrene 4.5716530937
MESH:D005234 Fatty Liver Ethinyl Estradiol 8.7915345470
MESH:D005234 Fatty Liver Tamoxifen 8.7919224547 14986274
MESH:D052776 Female Urogenital Diseases Tamoxifen 3.4116709447
MESH:D018221 Fibromatosis, Abdominal Tamoxifen 4.9914745880
MESH:D018222 Fibromatosis, Aggressive Tamoxifen 4.6419069698
MESH:D005354 Fibrosarcoma Methylcholanthrene 5.4014633661 10962813
MESH:D030342 Genetic Diseases, Inborn vinclozolin 5.4016973722
MESH:D005832 Genital Diseases, Male vinclozolin 5.8216417039
MESH:D006330 Heart Defects, Congenital Benzo(a)pyrene 2.8020471113
MESH:D007021 Hypospadias Ethinyl Estradiol 4.2316945680 16569931
MESH:D007247 Infertility, Female Ethinyl Estradiol 3.8112013081
MESH:D007248 Infertility, Male Ethinyl Estradiol 7.3317937319
MESH:D007248 Infertility, Male vinclozolin 7.3316467254
MESH:D007249 Inflammation Tamoxifen 2.4919457130
MESH:D007680 Kidney Neoplasms Tamoxifen 3.3118625569
MESH:D007984 Leydig Cell Tumor vinclozolin 5.1916417039
MESH:D008064 Lipidoses Tamoxifen 3.3717567588 15342952
MESH:D008106 Liver Cirrhosis, Experimental Tamoxifen 1.7518564211
MESH:D008113 Liver Neoplasms Benzo(a)pyrene 4.8420195826 21137059
MESH:D008113 Liver Neoplasms Tamoxifen 4.8416684651
MESH:D008114 Liver Neoplasms, Experimental Methylcholanthrene 3.451399818 598648
MESH:D008175 Lung Neoplasms Benzo(a)pyrene 3.6620064080 18816296 20869020 18569708 20464547 6695378 17053015 18520028 20135361
MESH:D008175 Lung Neoplasms Methylcholanthrene 3.6615390079 21163286 7750092 11893704 1399818 6695378 16271038 20512841 16337739 17909032 20970405 10545420 9230183
MESH:D008175 Lung Neoplasms Tamoxifen 3.6618625569
MESH:D015674 Mammary Neoplasms, Animal Tamoxifen 4.2219428831
MESH:D008325 Mammary Neoplasms, Experimental Tamoxifen 2.8111731420 16827153 14580682 19196723 19196722
MESH:D020149 Manganese Poisoning Tamoxifen 5.0719453300
MESH:D008545 Melanoma Tamoxifen 1.9112393984 19393235
MESH:D018328 Melanoma, Amelanotic Tamoxifen 4.6415990972
MESH:D009062 Mouth Neoplasms Benzo(a)pyrene 3.4316381670
MESH:D009362 Neoplasm Metastasis Tamoxifen 2.6519393235
MESH:D009364 Neoplasm Recurrence, Local Tamoxifen 2.6019410462
MESH:D009369 Neoplasms Benzo(a)pyrene 2.3011141357
MESH:D009376 Neoplasms, Hormone-Dependent Tamoxifen 4.5219189210 19200415 19196722
MESH:D016584 Panic Disorder Ethinyl Estradiol 4.0411578682
MESH:D011297 Prenatal Exposure Delayed Effects vinclozolin 4.3618042343 18220299 19015723
MESH:D011469 Prostatic Diseases vinclozolin 5.4018220299
MESH:D011471 Prostatic Neoplasms Benzo(a)pyrene 3.0617292933
MESH:D011471 Prostatic Neoplasms Tamoxifen 3.0615067354
MESH:D011472 Prostatitis vinclozolin 5.4018629315
MESH:D011537 Pruritus Ethinyl Estradiol 3.7716919318 15861022
MESH:D012878 Skin Neoplasms Benzo(a)pyrene 2.4910029692 19755658
MESH:D013088 Spermatocele Ethinyl Estradiol 13.3616709447
MESH:D013088 Spermatocele Tamoxifen 13.3616709447
MESH:D013119 Spinal Cord Injuries Tamoxifen 4.5019457130
MESH:D013274 Stomach Neoplasms Benzo(a)pyrene 1.562093021 20155912
MESH:D019851 Thrombophilia Ethinyl Estradiol 3.9711994571
MESH:D013927 Thrombosis Ethinyl Estradiol 3.4415669648
MESH:D001749 Urinary Bladder Neoplasms Benzo(a)pyrene 5.3417053015
MESH:D001749 Urinary Bladder Neoplasms Tamoxifen 5.3417572228 16712894 8653321
MESH:D014594 Uterine Neoplasms Ethinyl Estradiol 3.6814692618
MESH:D020246 Venous Thrombosis Ethinyl Estradiol 3.8714671159 15869587
Pathway ID Pathway Name
KEGG:03018 RNA degradation
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Syndromic Genes

Non-syndromic Genes

AutismKB Statistics

  • Studies: 1,036
  • Genes: 1,379
  • CNVs/SVs: 5,420
  • SNVs/Indels: 11,669
  • de novo Mutations: 5,669
  • Mosaics: 789
  • Linkage Regions: 172
  • Paper Collected: 6/30/2018
  • Last Update: 8/26/2018


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