AutismKB 2.0

Annotation Detail for ENPP2


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Basic Information Top
Gene Symbol:ENPP2 ( ATX,ATX-X,AUTOTAXIN,FLJ26803,LysoPLD,NPP2,PD-IALPHA,PDNP2 )
Gene Full Name: ectonucleotide pyrophosphatase/phosphodiesterase 2
Band: 8q24.12
Quick LinksEntrez ID:5168; OMIM: 601060; Uniprot ID:ENPP2_HUMAN; ENSEMBL ID: ENSG00000136960; HGNC ID: 3357
Relate to Another Database: SFARIGene; denovo-db
Related Pathway Information Top
No data
Pathway IDPathway Name
hsa00565Ether lipid metabolism
No data
No data
No data
No data
Related Diseases/Disorders Top
Comparative Toxicogenomics Database Top
Chemical ID Chemical Name Interaction Interaction Action Publication
C016403 2,4-dinitrotoluene 2,4-dinitrotoluene affects the expression of ENPP2 mRNAaffects expression 21346803
C023514 2,6-dinitrotoluene 2,6-dinitrotoluene affects the expression of ENPP2 mRNAaffects expression 21346803
D016604 Aflatoxin B1 Aflatoxin B1 affects the expression of ENPP2 proteinaffects expression 20106945
C011512 alpha-naphthoflavone alpha-naphthoflavone inhibits the reaction [Oxygen deficiency inhibits the reaction [Tetrachlorodibenzodioxin results in increased activity of ENPP2 mRNA]]decreases reaction|increases activity 19028555
C011512 alpha-naphthoflavone alpha-naphthoflavone inhibits the reaction [Tetrachlorodibenzodioxin results in increased activity of ENPP2 mRNA]decreases reaction|increases activity 19028555
C006632 arsenic trioxide arsenic trioxide results in increased expression of ENPP2 mRNAincreases expression 20458559
D001564 Benzo(a)pyrene Benzo(a)pyrene results in decreased expression of ENPP2 mRNAdecreases expression 20106945
D001564 Benzo(a)pyrene Benzo(a)pyrene results in decreased expression of ENPP2 mRNAdecreases expression 20713471
D015123 7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide 7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide affects the expression of ENPP2 mRNAaffects expression 20382639
C095105 bexarotene bexarotene results in decreased expression of ENPP2 mRNAdecreases expression 16648578
C006780 bisphenol A bisphenol A results in decreased expression of ENPP2 mRNAdecreases expression 12075121
D002251 Carbon Tetrachloride Carbon Tetrachloride results in increased activity of ENPP2 proteinincreases activity 17850827
D020111 Chlorodiphenyl (54% Chlorine) Chlorodiphenyl (54% Chlorine) results in increased expression of ENPP2 mRNAincreases expression 18178546
D002994 Clofibrate Clofibrate results in increased expression of ENPP2 mRNAincreases expression 15585944
D016572 Cyclosporine Cyclosporine results in decreased expression of ENPP2 mRNAdecreases expression 20106945
D003907 Dexamethasone [Dexamethasone co-treated with rosiglitazone co-treated with 1-Methyl-3-isobutylxanthine co-treated with INS1 protein] results in increased expression of ENPP2 mRNAaffects cotreatment|increases expression 16054899
D003907 Dexamethasone [Tetrachlorodibenzodioxin co-treated with EGF protein] inhibits the reaction [[Dexamethasone co-treated with rosiglitazone co-treated with 1-Methyl-3-isobutylxanthine co-treated with INS1 protein] results in increased expression of ENPP2 mRNA]affects cotreatment|decreases reaction|increases expression 16054899
D003907 Dexamethasone Tetrachlorodibenzodioxin inhibits the reaction [[Dexamethasone co-treated with rosiglitazone co-treated with 1-Methyl-3-isobutylxanthine co-treated with INS1 protein] results in increased expression of ENPP2 mRNA]affects cotreatment|decreases reaction|increases expression 16054899
D002945 Cisplatin ENPP2 protein affects the susceptibility to Cisplatinaffects response to substance 16217747
D004052 Diethylnitrosamine Diethylnitrosamine results in decreased expression of ENPP2 mRNAdecreases expression 19638242
D004128 Dimethylnitrosamine Dimethylnitrosamine results in decreased expression of ENPP2 mRNAdecreases expression 17072980
D004958 Estradiol Estradiol affects the expression of ENPP2 mRNAaffects expression 14699072
D000431 Ethanol Ethanol results in increased expression of ENPP2 mRNAincreases expression 15353170
D004997 Ethinyl Estradiol Ethinyl Estradiol affects the expression of ENPP2 mRNAaffects expression 17555576
D004997 Ethinyl Estradiol Ethinyl Estradiol results in decreased expression of ENPP2 mRNAdecreases expression 17942748
16174780
D004997 Ethinyl Estradiol [Tetrachlorodibenzodioxin co-treated with Ethinyl Estradiol] results in decreased expression of ENPP2 mRNAaffects cotreatment|decreases expression 17942748
D004997 Ethinyl Estradiol Ethinyl Estradiol results in decreased expression of ENPP2 mRNAdecreases expression 15901920
15834898
17557909
16174780
15576828
12075121
D005480 Flurbiprofen Flurbiprofen results in decreased expression of ENPP2 mRNAdecreases expression 16949054
D019833 Genistein Genistein results in decreased expression of ENPP2 mRNAdecreases expression 15256057
D019833 Genistein Genistein results in decreased expression of ENPP2 mRNAdecreases expression 12075121
D015056 1-Methyl-3-isobutylxanthine [Dexamethasone co-treated with rosiglitazone co-treated with 1-Methyl-3-isobutylxanthine co-treated with INS1 protein] results in increased expression of ENPP2 mRNAaffects cotreatment|increases expression 16054899
D015056 1-Methyl-3-isobutylxanthine [Tetrachlorodibenzodioxin co-treated with EGF protein] inhibits the reaction [[Dexamethasone co-treated with rosiglitazone co-treated with 1-Methyl-3-isobutylxanthine co-treated with INS1 protein] results in increased expression of ENPP2 mRNA]affects cotreatment|decreases reaction|increases expression 16054899
D015056 1-Methyl-3-isobutylxanthine Tetrachlorodibenzodioxin inhibits the reaction [[Dexamethasone co-treated with rosiglitazone co-treated with 1-Methyl-3-isobutylxanthine co-treated with INS1 protein] results in increased expression of ENPP2 mRNA]affects cotreatment|decreases reaction|increases expression 16054899
D008701 Methapyrilene Methapyrilene results in decreased expression of ENPP2 mRNAdecreases expression 16393664
D008748 Methylcholanthrene Methylcholanthrene results in decreased expression of ENPP2 mRNAdecreases expression 20713471
D008769 Methylnitronitrosoguanidine Methylnitronitrosoguanidine results in increased expression of ENPP2 mRNAincreases expression 15120970
D010100 Oxygen alpha-naphthoflavone inhibits the reaction [Oxygen deficiency inhibits the reaction [Tetrachlorodibenzodioxin results in increased activity of ENPP2 mRNA]]decreases reaction|increases activity 19028555
D010100 Oxygen Oxygen deficiency inhibits the reaction [Tetrachlorodibenzodioxin results in increased activity of ENPP2 mRNA]decreases reaction|increases activity 19028555
D010100 Oxygen Oxygen deficiency results in increased activity of ENPP2 mRNAincreases activity 19028555
D010100 Oxygen Oxygen deficiency results in increased expression of ENPP2 mRNAincreases expression 19028555
D017239 Paclitaxel Paclitaxel results in increased expression of ENPP2 mRNAincreases expression 19682730
D011374 Progesterone Progesterone affects the expression of ENPP2 mRNAaffects expression 17251523
D020849 Raloxifene Raloxifene affects the expression of ENPP2 mRNAaffects expression 14699072
D020849 Raloxifene [Raloxifene co-treated with ESR1 protein] results in increased expression of ENPP2 mRNAaffects cotreatment|increases expression 19059307
C089730 rosiglitazone [Dexamethasone co-treated with rosiglitazone co-treated with 1-Methyl-3-isobutylxanthine co-treated with INS1 protein] results in increased expression of ENPP2 mRNAaffects cotreatment|increases expression 16054899
C089730 rosiglitazone [Tetrachlorodibenzodioxin co-treated with EGF protein] inhibits the reaction [[Dexamethasone co-treated with rosiglitazone co-treated with 1-Methyl-3-isobutylxanthine co-treated with INS1 protein] results in increased expression of ENPP2 mRNA]affects cotreatment|decreases reaction|increases expression 16054899
C089730 rosiglitazone Tetrachlorodibenzodioxin inhibits the reaction [[Dexamethasone co-treated with rosiglitazone co-treated with 1-Methyl-3-isobutylxanthine co-treated with INS1 protein] results in increased expression of ENPP2 mRNA]affects cotreatment|decreases reaction|increases expression 16054899
D013629 Tamoxifen [Tamoxifen co-treated with ESR1 protein] results in increased expression of ENPP2 mRNAaffects cotreatment|increases expression 19059307
D013629 Tamoxifen Tamoxifen affects the expression of ENPP2 mRNAaffects expression 17555576
D013749 Tetrachlorodibenzodioxin alpha-naphthoflavone inhibits the reaction [Oxygen deficiency inhibits the reaction [Tetrachlorodibenzodioxin results in increased activity of ENPP2 mRNA]]decreases reaction|increases activity 19028555
D013749 Tetrachlorodibenzodioxin alpha-naphthoflavone inhibits the reaction [Tetrachlorodibenzodioxin results in increased activity of ENPP2 mRNA]decreases reaction|increases activity 19028555
D013749 Tetrachlorodibenzodioxin Oxygen deficiency inhibits the reaction [Tetrachlorodibenzodioxin results in increased activity of ENPP2 mRNA]decreases reaction|increases activity 19028555
D013749 Tetrachlorodibenzodioxin Tetrachlorodibenzodioxin results in decreased expression of ENPP2 mRNAdecreases expression 20106945
D013749 Tetrachlorodibenzodioxin Tetrachlorodibenzodioxin results in increased activity of ENPP2 mRNAincreases activity 19028555
D013749 Tetrachlorodibenzodioxin Tetrachlorodibenzodioxin results in increased expression of ENPP2 mRNAincreases expression 19028555
17555868
D013749 Tetrachlorodibenzodioxin [Tetrachlorodibenzodioxin co-treated with EGF protein] inhibits the reaction [[Dexamethasone co-treated with rosiglitazone co-treated with 1-Methyl-3-isobutylxanthine co-treated with INS1 protein] results in increased expression of ENPP2 mRNA]affects cotreatment|decreases reaction|increases expression 16054899
D013749 Tetrachlorodibenzodioxin [Tetrachlorodibenzodioxin co-treated with Ethinyl Estradiol] results in decreased expression of ENPP2 mRNAaffects cotreatment|decreases expression 17942748
D013749 Tetrachlorodibenzodioxin Tetrachlorodibenzodioxin inhibits the reaction [[Dexamethasone co-treated with rosiglitazone co-treated with 1-Methyl-3-isobutylxanthine co-treated with INS1 protein] results in increased expression of ENPP2 mRNA]affects cotreatment|decreases reaction|increases expression 16054899
D013749 Tetrachlorodibenzodioxin Tetrachlorodibenzodioxin results in increased expression of ENPP2 mRNAincreases expression 16960034
D013749 Tetrachlorodibenzodioxin Tetrachlorodibenzodioxin results in increased expression of ENPP2 mRNAincreases expression 16054898
18796159
18178546
16960034
D014241 Trichloroethylene Trichloroethylene results in increased expression of ENPP2 mRNAincreases expression 17905399
Disease ID Disease Name Direct Evidence Inference Chemical Name Inference Score Publication
MESH:D000008 Abdominal Neoplasms Tamoxifen 4.2014745880
MESH:D000014 Abnormalities, Drug-Induced Ethanol 7.3418926900 17676605
MESH:D000014 Abnormalities, Drug-Induced Tetrachlorodibenzodioxin 7.3415322242 14514962 11752688
MESH:D000138 Acidosis Ethanol 4.1611192467
MESH:D000152 Acne Vulgaris Ethinyl Estradiol 3.6017505938
MESH:D058186 Acute Kidney Injury Cisplatin 3.6615814532 17670903 12690470
MESH:D055371 Acute Lung Injury Oxygen 4.2216759491
MESH:D000230 Adenocarcinoma arsenic trioxide 19.4219825857 11798837
MESH:D000230 Adenocarcinoma Benzo(a)pyrene 19.4220464547 20127859
MESH:D000230 Adenocarcinoma Cisplatin 19.4211798837 17638652
MESH:D000230 Adenocarcinoma Dimethylnitrosamine 19.4216033868
MESH:D000230 Adenocarcinoma Estradiol 19.4211473722
MESH:D000230 Adenocarcinoma Ethinyl Estradiol 19.4214692618
MESH:D000230 Adenocarcinoma Genistein 19.4211473722
MESH:D000236 Adenoma Benzo(a)pyrene 14.396695378
MESH:D000236 Adenoma Diethylnitrosamine 14.396695378 10737359
MESH:D000236 Adenoma Dimethylnitrosamine 14.3919555203
MESH:D000236 Adenoma Methylcholanthrene 14.396695378 10545420
MESH:D018248 Adenoma, Liver Cell Diethylnitrosamine 8.9219052882 17162532 19061943 18056438 16434500 17620307
MESH:D018248 Adenoma, Liver Cell Tetrachlorodibenzodioxin 8.9216835633
MESH:D011125 Adenomatous Polyposis Coli Flurbiprofen 4.7710680582
MESH:D000419 Albuminuria Raloxifene 4.2717451421 17308373
MESH:D020268 Alcohol-Induced Disorders, Nervous System Ethanol 4.9715451040 15451039
MESH:D000544 Alzheimer Disease Raloxifene 4.2415800139
MESH:D000544 Alzheimer Disease rosiglitazone 4.2419621015
MESH:D000740 Anemia Tetrachlorodibenzodioxin 2.6511748828
MESH:D000853 Anophthalmos Ethanol 4.4915513904
MESH:D000860 Anoxia Oxygen 4.7120872349
MESH:D001008 Anxiety Disorders Ethanol 3.7411141031
MESH:D017544 Aortic Aneurysm, Abdominal Benzo(a)pyrene 3.7419183758
MESH:D001161 Arteriosclerosis Ethinyl Estradiol 3.1311256880
MESH:D001169 Arthritis, Experimental Dexamethasone 6.6717659584
MESH:D001169 Arthritis, Experimental Ethinyl Estradiol 6.6715885639
MESH:D050197 Atherosclerosis Methylcholanthrene 6.4811922910
MESH:D050197 Atherosclerosis Oxygen 6.4816391483
MESH:D001778 Blood Coagulation Disorders arsenic trioxide 13.6716206674
MESH:D001778 Blood Coagulation Disorders Clofibrate 13.6719483382
MESH:D001778 Blood Coagulation Disorders Tetrachlorodibenzodioxin 13.6712125929
MESH:D001836 Body Weight Changes Tetrachlorodibenzodioxin 3.4415340226
MESH:D001848 Bone Diseases, Developmental Tetrachlorodibenzodioxin 2.5515746008
MESH:D019046 Bone Marrow Neoplasms Cisplatin 4.5414601052
MESH:D001859 Bone Neoplasms Paclitaxel 4.2515867366
MESH:D001862 Bone Resorption bisphenol A 3.5611985600
MESH:D020201 Brain Hemorrhage, Traumatic Progesterone 4.9917868700
MESH:D001930 Brain Injuries Progesterone 9.8615665606 15845082 15380490
MESH:D001930 Brain Injuries Raloxifene 9.8616580743
MESH:D001943 Breast Neoplasms Benzo(a)pyrene 13.7120146248 17474063
MESH:D001943 Breast Neoplasms bexarotene 13.7116818667 16344269
MESH:D001943 Breast Neoplasms bisphenol A 13.7117123778
MESH:D001943 Breast Neoplasms Cisplatin 13.7118382427 19526202
MESH:D001943 Breast Neoplasms Diethylnitrosamine 13.7117474063
MESH:D001943 Breast Neoplasms Estradiol 13.7112948864 17261762 17289903 14630087 17018787 16675129 19861407 18497071
MESH:D001943 Breast Neoplasms Genistein 13.7116873071 17200150 16541309
MESH:D001943 Breast Neoplasms Methylcholanthrene 13.7117474063
MESH:D001943 Breast Neoplasms Oxygen 13.7117263869
MESH:D001943 Breast Neoplasms Paclitaxel 13.7118234424 16244791 18323546 15136595 18223236 16273361 16115903 11325840
MESH:D001943 Breast Neoplasms Progesterone 13.7116175315 17614352 15562024
MESH:D001943 Breast Neoplasms Raloxifene 13.7117242785 17952589 17440819 15758505 16837676 17261762 15775269 15572757 17595753 17893378 17049068 16912660
MESH:D001943 Breast Neoplasms Tamoxifen 13.7120544844 19059307 19221464 19103187 19011961 17440819 15565566 16818667 18855134 19487384 18629630 19244106 18351453 19066611 18815881 17049068 15668708 20065188 18425577 21138602 19289846 20005174 16202921 18997820 11161223 18821012 19142967 18984771 20135344 19410462 19155303 19288272 17893378 16273361 19115204 20390343 21152245 17261762 19189210 17242785 19200415 19084267 16873071 19189212 20859285
MESH:D001943 Breast Neoplasms Tetrachlorodibenzodioxin 13.7120435547
MESH:D001943 Breast Neoplasms Trichloroethylene 13.7115986119
MESH:D002051 Burkitt Lymphoma arsenic trioxide 4.0211589617
MESH:D002056 Burns Ethanol 4.3216374292
MESH:D002181 Candidiasis, Vulvovaginal Estradiol 4.1216111702
MESH:D002252 Carbon Tetrachloride Poisoning Carbon Tetrachloride 3.4516097048 16011737 10355542 15673190 18705752 16227642 16124888 15700767 3786805 16192424 15721981 16050911
MESH:D002277 Carcinoma Dimethylnitrosamine 12.5119555203
MESH:D002277 Carcinoma Methylcholanthrene 12.5110545420
MESH:D002277 Carcinoma Tetrachlorodibenzodioxin 12.5116835633
MESH:D018270 Carcinoma, Ductal, Breast Tamoxifen 4.1719066611
MESH:D006528 Carcinoma, Hepatocellular 2,4-dinitrotoluene 27.8716705839
MESH:D006528 Carcinoma, Hepatocellular 2,6-dinitrotoluene 27.8716705839
MESH:D006528 Carcinoma, Hepatocellular Aflatoxin B1 27.8712907637 21507988 12619106
MESH:D006528 Carcinoma, Hepatocellular arsenic trioxide 27.8715553829 14691202 15073043 16217749 11135700
MESH:D006528 Carcinoma, Hepatocellular Carbon Tetrachloride 27.8718788625
MESH:D006528 Carcinoma, Hepatocellular Cisplatin 27.8717982673
MESH:D006528 Carcinoma, Hepatocellular Diethylnitrosamine 27.8716807293 20214788 20007298 16935385 20101231 18978308 18691550 19208518 19107877 19919837 20432363 16569478 19335982 20514400 19822196 10672840 18665156 17761372 19383236 17173139 16681979 16288022 20935162 18393292 10737359 17978847 20524982 19539802 17162532 17138121 19519916 19171122 3084413 17055752 3581430 20727157 19418558 18506893 16779866 16328049 16540662 16878318 11831363 18788625 17428255 16502159 19052882 19701751 16830150 16698587 19394651 18494052 18971187 21159647 20084675 18785209 18210153 18056438 20512989
MESH:D006528 Carcinoma, Hepatocellular Estradiol 27.8716924424
MESH:D006528 Carcinoma, Hepatocellular Ethanol 27.8715289165 15763234 18788625
MESH:D006528 Carcinoma, Hepatocellular Genistein 27.8716924424
MESH:D006528 Carcinoma, Hepatocellular Paclitaxel 27.8716313753
MESH:D006528 Carcinoma, Hepatocellular Tamoxifen 27.8716924424
MESH:D002278 Carcinoma in Situ bisphenol A 4.6517123778
MESH:D002289 Carcinoma, Non-Small-Cell Lung bexarotene 5.4616247446
MESH:D002289 Carcinoma, Non-Small-Cell Lung Cisplatin 5.4612023789 16685392
MESH:D002291 Carcinoma, Papillary arsenic trioxide 4.5319014326
MESH:D018288 Carcinoma, Small Cell arsenic trioxide 3.8212490120
MESH:D002294 Carcinoma, Squamous Cell Benzo(a)pyrene 7.0320419170
MESH:D002294 Carcinoma, Squamous Cell Cisplatin 7.0317066447 18337622 6189445
MESH:D002294 Carcinoma, Squamous Cell Dimethylnitrosamine 7.0316033868
MESH:D002295 Carcinoma, Transitional Cell Raloxifene 8.5217572228
MESH:D002295 Carcinoma, Transitional Cell Tamoxifen 8.5217572228
MESH:D006332 Cardiomegaly Ethanol 6.2119332462
MESH:D006332 Cardiomegaly Tetrachlorodibenzodioxin 6.2118850075 18670907 16120746
MESH:D002318 Cardiovascular Diseases Genistein 6.7216332659
MESH:D002318 Cardiovascular Diseases Raloxifene 6.7215775269
MESH:D002471 Cell Transformation, Neoplastic 2,6-dinitrotoluene 33.286135515
MESH:D002471 Cell Transformation, Neoplastic 7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide 33.2820889678
MESH:D002471 Cell Transformation, Neoplastic Clofibrate 33.281399818
MESH:D002471 Cell Transformation, Neoplastic Cyclosporine 33.2812371664
MESH:D002471 Cell Transformation, Neoplastic Diethylnitrosamine 33.282727394 7505956 17174075 21159647
MESH:D002471 Cell Transformation, Neoplastic Estradiol 33.2818566989
MESH:D002471 Cell Transformation, Neoplastic Methylcholanthrene 33.2816192471
MESH:D002471 Cell Transformation, Neoplastic Methylnitronitrosoguanidine 33.282727394
MESH:D018281 Cholangiocarcinoma Diethylnitrosamine 8.3819052882
MESH:D018281 Cholangiocarcinoma Tetrachlorodibenzodioxin 8.3816835633
MESH:D002779 Cholestasis Cyclosporine 6.9519486331
MESH:D002779 Cholestasis Ethinyl Estradiol 6.9517110522 16919318 17681005 11677210 16105132 17333356 15861022
MESH:D002971 Cleft Lip Ethanol 3.4115513904
MESH:D002972 Cleft Palate Ethanol 5.4615513904
MESH:D002972 Cleft Palate Tetrachlorodibenzodioxin 5.4615668235 12621046 16354765 15340226 8697196
MESH:D003072 Cognition Disorders Raloxifene 4.2915800139
MESH:D003110 Colonic Neoplasms Dexamethasone 3.7115824018
MESH:D003110 Colonic Neoplasms Genistein 3.7117182828
MESH:D015179 Colorectal Neoplasms arsenic trioxide 3.3720501625
MESH:D015179 Colorectal Neoplasms Cisplatin 3.3715273666
MESH:D015179 Colorectal Neoplasms Paclitaxel 3.3718802399
MESH:D000013 Congenital Abnormalities Tetrachlorodibenzodioxin 2.7817141729 14669216
MESH:D023903 Coronary Restenosis arsenic trioxide 3.8612609071
MESH:D019465 Craniofacial Abnormalities arsenic trioxide 5.0910525206
MESH:D019465 Craniofacial Abnormalities Dexamethasone 5.0917728286
MESH:D019465 Craniofacial Abnormalities Ethanol 5.0911873399 19302082 11198716 15451039 10194807 15513904 15451040
MESH:D019465 Craniofacial Abnormalities Tetrachlorodibenzodioxin 5.0910048152 20055451 15322242
MESH:D003490 Cyanosis 2,4-dinitrotoluene 9.7918551238
MESH:D003490 Cyanosis 2,6-dinitrotoluene 9.7918551238
MESH:D016757 Death, Sudden, Cardiac arsenic trioxide 3.7815213294
MESH:D003711 Demyelinating Diseases Tamoxifen 4.0319031437
MESH:D003865 Depressive Disorder, Major Raloxifene 3.8817474826
MESH:D017449 Dermatitis, Allergic Contact Dexamethasone 3.0912438553
MESH:D003920 Diabetes Mellitus rosiglitazone 4.0217446233
MESH:D003924 Diabetes Mellitus, Type 2 Diethylnitrosamine 9.5020387270
MESH:D003924 Diabetes Mellitus, Type 2 Genistein 9.5016647724
MESH:D003924 Diabetes Mellitus, Type 2 rosiglitazone 9.5012642470
MESH:D003924 Diabetes Mellitus, Type 2 Tetrachlorodibenzodioxin 9.5017107852
MESH:D003928 Diabetic Nephropathies Estradiol 13.3819279558
MESH:D003928 Diabetic Nephropathies Raloxifene 13.3815920148 17451421 17308373
MESH:D003928 Diabetic Nephropathies Tamoxifen 13.3819279558
MESH:D003929 Diabetic Neuropathies Progesterone 4.1617187935
MESH:D003967 Diarrhea Dexamethasone 3.387237001
MESH:D056486 Drug-Induced Liver Injury 2,4-dinitrotoluene 23.7621346803 18551238
MESH:D056486 Drug-Induced Liver Injury 2,6-dinitrotoluene 23.7621346803 18551238
MESH:D056486 Drug-Induced Liver Injury Carbon Tetrachloride 23.7615998439 16177239 6623471 17522070 16227642 4309450 9327722 7440962 3786805 21278145 3732212 2869522 7179309 19085960 15027814 15968718 19336974 10915739 11566570 7120509 10092053 6884620
MESH:D056486 Drug-Induced Liver Injury Chlorodiphenyl (54% Chlorine) 23.7617851650
MESH:D056486 Drug-Induced Liver Injury Diethylnitrosamine 23.7619107877
MESH:D056486 Drug-Induced Liver Injury Dimethylnitrosamine 23.768172417
MESH:D056486 Drug-Induced Liver Injury Ethanol 23.7611566570
MESH:D056486 Drug-Induced Liver Injury Tetrachlorodibenzodioxin 23.7620420201
MESH:D056486 Drug-Induced Liver Injury Trichloroethylene 23.767120509
MESH:D004362 Drug Toxicity Cisplatin 7.3512231392 12649298 15033597 19839026
MESH:D004362 Drug Toxicity Tetrachlorodibenzodioxin 7.3511462148
MESH:D050171 Dyslipidemias Clofibrate 3.8216707586
MESH:D004417 Dyspnea Oxygen 4.4920016425
MESH:D004485 Eczema Dexamethasone 4.1412438553
MESH:D004487 Edema Dexamethasone 14.0419703484
MESH:D004487 Edema Raloxifene 14.0415860553
MESH:D004487 Edema rosiglitazone 14.0412083418
MESH:D004487 Edema Tetrachlorodibenzodioxin 14.0411000095 12711302
MESH:D004489 Edema, Cardiac Tetrachlorodibenzodioxin 3.5616714409 15322242 18230668
MESH:D004681 Encephalomyelitis, Autoimmune, Experimental Ethinyl Estradiol 19.2712538720
MESH:D004681 Encephalomyelitis, Autoimmune, Experimental Progesterone 19.2717692515
MESH:D004681 Encephalomyelitis, Autoimmune, Experimental Raloxifene 19.2715845917
MESH:D004681 Encephalomyelitis, Autoimmune, Experimental Tamoxifen 19.2719031437
MESH:D004714 Endometrial Hyperplasia Genistein 4.2516402032
MESH:D016889 Endometrial Neoplasms Estradiol 11.1711473722 18566989 19148513
MESH:D016889 Endometrial Neoplasms Genistein 11.1711473722
MESH:D016889 Endometrial Neoplasms Tamoxifen 11.1717893378 16202921 19155303 20544844
MESH:D004715 Endometriosis Progesterone 7.9516134523
MESH:D004715 Endometriosis Tetrachlorodibenzodioxin 7.959294722 10568697
MESH:D004931 Esophageal Achalasia Diethylnitrosamine 4.7716302075
MESH:D004938 Esophageal Neoplasms 7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide 19.8020426865
MESH:D004938 Esophageal Neoplasms arsenic trioxide 19.8012903497
MESH:D004938 Esophageal Neoplasms Benzo(a)pyrene 19.8016530937
MESH:D004938 Esophageal Neoplasms Cisplatin 19.8017638652 15173087 16785472 15464296 16481741
MESH:D004938 Esophageal Neoplasms Dimethylnitrosamine 19.8017016578
MESH:D004938 Esophageal Neoplasms Ethanol 19.8016704527
MESH:D004938 Esophageal Neoplasms Paclitaxel 19.8016481741
MESH:D005124 Eye Abnormalities Tetrachlorodibenzodioxin 2.7611564622
MESH:D005234 Fatty Liver arsenic trioxide 49.9815073043
MESH:D005234 Fatty Liver Carbon Tetrachloride 49.9861145 15959796 16045604 12631006 17595544 12795759 19224547 16239168
MESH:D005234 Fatty Liver Clofibrate 49.9819224547
MESH:D005234 Fatty Liver Cyclosporine 49.9819224547
MESH:D005234 Fatty Liver Diethylnitrosamine 49.9820387270 21071580
MESH:D005234 Fatty Liver Ethanol 49.9816409862 19236843 18620774
MESH:D005234 Fatty Liver Ethinyl Estradiol 49.9815345470
MESH:D005234 Fatty Liver Raloxifene 49.9817473493
MESH:D005234 Fatty Liver rosiglitazone 49.9819196556
MESH:D005234 Fatty Liver Tamoxifen 49.9814986274 19224547
MESH:D005235 Fatty Liver, Alcoholic Ethanol 5.3217920746
MESH:D052776 Female Urogenital Diseases Tamoxifen 3.0316709447
MESH:D005310 Fetal Alcohol Syndrome Ethanol 4.9616946407 15451040 10194807 15513904
MESH:D005313 Fetal Death Tetrachlorodibenzodioxin 3.1211858732
MESH:D018221 Fibromatosis, Abdominal Tamoxifen 4.1914745880
MESH:D018222 Fibromatosis, Aggressive Tamoxifen 3.8419069698
MESH:D005354 Fibrosarcoma Methylcholanthrene 4.6014633661 10962813
MESH:D005355 Fibrosis Carbon Tetrachloride 12.7918705752
MESH:D005355 Fibrosis Cyclosporine 12.7912639820 12168785
MESH:D005355 Fibrosis Tetrachlorodibenzodioxin 12.7920067830
MESH:D005706 Gallbladder Neoplasms arsenic trioxide 3.9416904648
MESH:D005739 Gas Poisoning Oxygen 4.8720016425
MESH:D005756 Gastritis Ethanol 4.3515046732
MESH:D005885 Gingival Hyperplasia Cyclosporine 3.888708960
MESH:D005909 Glioblastoma Genistein 3.0416598420
MESH:D006058 Gonadal Disorders Tetrachlorodibenzodioxin 4.2510696789
MESH:D006258 Head and Neck Neoplasms Cisplatin 3.4915464296 15102660
MESH:D034381 Hearing Loss Cisplatin 4.0119898482
MESH:D006319 Hearing Loss, Sensorineural Cisplatin 4.1415464296
MESH:D006330 Heart Defects, Congenital Benzo(a)pyrene 5.8420471113
MESH:D006330 Heart Defects, Congenital Tetrachlorodibenzodioxin 5.8410048152 11294989
MESH:D006331 Heart Diseases Raloxifene 3.3011110106
MESH:D006457 Hemoglobinuria, Paroxysmal Cyclosporine 4.0815720958
MESH:D006470 Hemorrhage Tetrachlorodibenzodioxin 3.0311000095
MESH:D006505 Hepatitis marker/mechanism 17850827
MESH:D006505 Hepatitis Carbon Tetrachloride 3.2719110552 19900420
MESH:D006529 Hepatomegaly Tetrachlorodibenzodioxin 2.5716120746 12621046 15340226
MESH:D006548 Hernia, Diaphragmatic Dexamethasone 2.957520565
MESH:D006558 Herpes Genitalis Estradiol 4.6915709030
MESH:D006689 Hodgkin Disease Cisplatin 3.3216200630 16170182
MESH:D019584 Hot Flashes Estradiol 3.4117088409
MESH:D006869 Hydronephrosis Tetrachlorodibenzodioxin 3.7016354765 15340226 18606429 8697196 16959395
MESH:D006930 Hyperalgesia Ethanol 7.3818783367
MESH:D006930 Hyperalgesia rosiglitazone 7.3812083418
MESH:D006932 Hyperbilirubinemia Carbon Tetrachloride 4.1916899240
MESH:D006973 Hypertension Cyclosporine 11.2610903974
MESH:D006973 Hypertension Dexamethasone 11.2617042910
MESH:D006973 Hypertension Raloxifene 11.2617577099 15787275
MESH:D006973 Hypertension Tetrachlorodibenzodioxin 11.2618670907 18850075
MESH:D006975 Hypertension, Portal Carbon Tetrachloride 3.7515338365
MESH:D007021 Hypospadias Ethinyl Estradiol 3.4816569931 16945680
MESH:D007077 Ileal Diseases 1-Methyl-3-isobutylxanthine 5.1018306037
MESH:D020244 Infarction, Middle Cerebral Artery Progesterone 4.0715869954
MESH:D007247 Infertility, Female Ethinyl Estradiol 3.1512013081
MESH:D007248 Infertility, Male Ethinyl Estradiol 2.2617937319
MESH:D007249 Inflammation Dexamethasone 21.4711099482 8960868
MESH:D007249 Inflammation Diethylnitrosamine 21.4718785209
MESH:D007249 Inflammation Flurbiprofen 21.4711099482
MESH:D007249 Inflammation Progesterone 21.4715869954
MESH:D007249 Inflammation rosiglitazone 21.4712083418
MESH:D007249 Inflammation Tamoxifen 21.4719457130
MESH:D007249 Inflammation Tetrachlorodibenzodioxin 21.4712878042 12200463
MESH:D007333 Insulin Resistance bisphenol A 11.1816393666
MESH:D007333 Insulin Resistance Estradiol 11.1816393666 16627594
MESH:D007333 Insulin Resistance rosiglitazone 11.1816306350
MESH:D007569 Jaw Abnormalities Ethanol 9.1115513904
MESH:D007569 Jaw Abnormalities Tetrachlorodibenzodioxin 9.1116580747
MESH:D007579 Jejunal Diseases 1-Methyl-3-isobutylxanthine 5.1018306037
MESH:D007638 Keratoconjunctivitis Sicca Cyclosporine 4.0915604871
MESH:D007673 Kidney Cortex Necrosis Cisplatin 4.7915464296
MESH:D007674 Kidney Diseases Cisplatin 8.9719839026 12649298 18289764 15190930 12231392
MESH:D007674 Kidney Diseases Cyclosporine 8.978314463 10903974 18776723
MESH:D007674 Kidney Diseases Estradiol 8.9715618244
MESH:D007680 Kidney Neoplasms 2,4-dinitrotoluene 20.4216705839
MESH:D007680 Kidney Neoplasms 2,6-dinitrotoluene 20.4216705839
MESH:D007680 Kidney Neoplasms Cyclosporine 20.4212371664
MESH:D007680 Kidney Neoplasms Estradiol 20.4215610895
MESH:D007680 Kidney Neoplasms Tamoxifen 20.4218625569
MESH:D007683 Kidney Tubular Necrosis, Acute Cisplatin 4.4511231351
MESH:D007859 Learning Disorders Ethanol 3.8815451040
MESH:D007889 Leiomyoma Raloxifene 4.1816973256
MESH:D007938 Leukemia arsenic trioxide 5.8615070760
MESH:D007938 Leukemia Genistein 5.8617468513 18980019
MESH:D015459 Leukemia-Lymphoma, Adult T-Cell arsenic trioxide 3.4917077332 12560223
MESH:D007948 Leukemia, Monocytic, Acute arsenic trioxide 3.9716972261
MESH:D015464 Leukemia, Myelogenous, Chronic, BCR-ABL Positive arsenic trioxide 3.1814633726
MESH:D007951 Leukemia, Myeloid arsenic trioxide 3.4619077051
MESH:D015470 Leukemia, Myeloid, Acute arsenic trioxide 2.0816467208 16968895 20471514 17050201 19850784
MESH:D015473 Leukemia, Promyelocytic, Acute arsenic trioxide 2.999834237 16331271 17712046 16966277 19035177 17217047 17107899 15336539 16823087 12679006 15748426 16330433 16112521 17869043 12712474 11161223 11468182 12018890 19075265 19225113 19642359 17649720 16891316 15622746 15213294
MESH:D015458 Leukemia, T-Cell arsenic trioxide 4.0316882451
MESH:D017880 Limb Deformities, Congenital Ethanol 3.5717676605
MESH:D008064 Lipidoses Tamoxifen 2.9117567588 15342952
MESH:D008080 Liposarcoma Paclitaxel 4.5117353645
MESH:D008103 Liver Cirrhosis Carbon Tetrachloride 9.9816943688 16239168 17157831 11408273 16221502 17334410 11903743 21278145 17174718
MESH:D008103 Liver Cirrhosis Diethylnitrosamine 9.9820032147 19638242 18522880 18407596 18665156
MESH:D008103 Liver Cirrhosis Ethanol 9.9815289165
MESH:D008104 Liver Cirrhosis, Alcoholic Ethanol 4.7618295389
MESH:D008106 Liver Cirrhosis, Experimental marker/mechanism 17072980
MESH:D008106 Liver Cirrhosis, Experimental Carbon Tetrachloride 14.7517721639 17714472 18166357 12649538 17565644 15730626 12445421 18376398 16027843 15818738 11481614 18251166 17944888 14512876 15650968 18277467 12667390 12546737 20821823 17869086 15959796 18472094 12609069 14620537 16033810 14748882 17976157 16136751 18156304 14716496 15876570 15925388 10355542 18472332 13678700 18006644 18429990 15370692 14716833 12632514 16097048 12898905 14724832 17481882 18263696 17557913 12445418 12666154 12586293 18412020 18395095 17922224 17525996 16638106 18705752 18395914 16011737 17698563 18317297 17823541 18481824 12389079 17640975 15931870 18054572 15673190 12741479 18187930 18418968 17708605 15893842 18210741 17900296 17761835 18420326 15362042 18279442 17805973 16116963 15996030 18205269 18339082 15057751 17766677 16015684 16192424 15052691 15123356 17631135 12958196 16248980 15338365 12632512
MESH:D008106 Liver Cirrhosis, Experimental Dexamethasone 14.7516718785
MESH:D008106 Liver Cirrhosis, Experimental Dimethylnitrosamine 14.7514726149 15138612 17201889 18239293 15942678 16169303 15383259 15744066 15067225 17724770 14643895 18637143 17666798 14568256 15492853 15723089 15864749 17198567 18672772 15571005 16042886 15298665 17036385 16570917 15369754 16009107 18095165 18210741 17348192 15504291 14709902 16627068 16270385 18629640 15339415 15577212 18237412 18567088 12925901 15798949 17465448 16603200 15479170 17203207 15086199 17196135 17881167 15161499 17640959 17534399 15099470 15591649 17432682 15793283 15763062 16544323 14659978 15733078 17719030 12918455 15842777 18364076 18371158 15366600 15081153
MESH:D008106 Liver Cirrhosis, Experimental Estradiol 14.7514659978 14716833
MESH:D008106 Liver Cirrhosis, Experimental Ethanol 14.7518166357
MESH:D008106 Liver Cirrhosis, Experimental Genistein 14.7517823541
MESH:D008106 Liver Cirrhosis, Experimental rosiglitazone 14.7515980055 17347453
MESH:D008106 Liver Cirrhosis, Experimental Tamoxifen 14.7518564211
MESH:D008106 Liver Cirrhosis, Experimental Tetrachlorodibenzodioxin 14.7512878042
MESH:D008107 Liver Diseases Carbon Tetrachloride 3.7615720792 16246199 17285989 15830285 16964402
MESH:D008107 Liver Diseases Diethylnitrosamine 3.7617034775
MESH:D008108 Liver Diseases, Alcoholic Ethanol 4.3217347304 17207112
MESH:D017093 Liver Failure Carbon Tetrachloride 3.8315123358
MESH:D017114 Liver Failure, Acute Carbon Tetrachloride 8.8614706259 16899240
MESH:D017114 Liver Failure, Acute Dimethylnitrosamine 8.8617457977
MESH:D008113 Liver Neoplasms 2,6-dinitrotoluene 31.507678174
MESH:D008113 Liver Neoplasms Aflatoxin B1 31.509163691 18177683 2125692 15890375
MESH:D008113 Liver Neoplasms arsenic trioxide 31.5014682389
MESH:D008113 Liver Neoplasms Benzo(a)pyrene 31.5020195826 21137059
MESH:D008113 Liver Neoplasms Carbon Tetrachloride 31.5019294768
MESH:D008113 Liver Neoplasms Diethylnitrosamine 31.5010737359 19812893 19850985 12771043 20118626 20137499 19255062 12112319 19833225 19426721 18644402 21278145 19090486 20452335 19551842 19638242 21047994 19294768 19073162 19690152 18754104 19499222 19996281 15175105 20492335 21071580 19427195 18977376 19256749 20101389 20434301 19254457 15885732 19642983 20501860 18648771 20405173 2862719 9163691 21167192 18978307 20583210 16942905 2422723
MESH:D008113 Liver Neoplasms Dimethylnitrosamine 31.5015890375 3113478
MESH:D008113 Liver Neoplasms Methapyrilene 31.5015890375
MESH:D008113 Liver Neoplasms Tamoxifen 31.5016684651
MESH:D008113 Liver Neoplasms Tetrachlorodibenzodioxin 31.5016984957
MESH:D008114 Liver Neoplasms, Experimental 2,6-dinitrotoluene 34.272876784 6135515 2876786
MESH:D008114 Liver Neoplasms, Experimental Aflatoxin B1 34.278603461
MESH:D008114 Liver Neoplasms, Experimental arsenic trioxide 34.2720377131
MESH:D008114 Liver Neoplasms, Experimental Carbon Tetrachloride 34.2715583823 12014681
MESH:D008114 Liver Neoplasms, Experimental Diethylnitrosamine 34.2719009564 3124819 18544905 19126423 18079962 18093689 19539802 17174075 16267830 18253720 18308698 18282651 9362446 18775883 16842330 19004024 17942915 19519916 17854601 2563599 18164116 21159647
MESH:D008114 Liver Neoplasms, Experimental Dimethylnitrosamine 34.2715603536 6150874 1848544
MESH:D008114 Liver Neoplasms, Experimental Methylcholanthrene 34.27598648 1399818
MESH:D008114 Liver Neoplasms, Experimental Tetrachlorodibenzodioxin 34.2712151625
MESH:D008114 Liver Neoplasms, Experimental Trichloroethylene 34.277955063
MESH:D008133 Long QT Syndrome arsenic trioxide 3.0915213294
MESH:D055370 Lung Injury Oxygen 4.1818339021
MESH:D008175 Lung Neoplasms Aflatoxin B1 19.4414755239
MESH:D008175 Lung Neoplasms arsenic trioxide 19.4419825857 11798837
MESH:D008175 Lung Neoplasms Benzo(a)pyrene 19.4418816296 20064080 18569708 20869020 20464547 20135361 18520028 6695378 17053015
MESH:D008175 Lung Neoplasms bexarotene 19.4417849452
MESH:D008175 Lung Neoplasms Cisplatin 19.4411798837 6189445 17225452
MESH:D008175 Lung Neoplasms Dexamethasone 19.4415824018 11195469
MESH:D008175 Lung Neoplasms Diethylnitrosamine 19.4420970405 21163286 20512841 6695378
MESH:D008175 Lung Neoplasms Dimethylnitrosamine 19.4416061637 11884234 19555203
MESH:D008175 Lung Neoplasms Methylcholanthrene 19.441399818 10545420 16337739 11893704 9230183 20512841 16271038 15390079 7750092 17909032 20970405 21163286 6695378
MESH:D008175 Lung Neoplasms Tamoxifen 19.4418625569
MESH:D008175 Lung Neoplasms Tetrachlorodibenzodioxin 19.4419555203 11884234
MESH:D008228 Lymphoma, Non-Hodgkin Paclitaxel 3.8214749477
MESH:D016410 Lymphoma, T-Cell, Cutaneous bexarotene 4.8111161223
MESH:D015674 Mammary Neoplasms, Animal Tamoxifen 3.4219428831
MESH:D008325 Mammary Neoplasms, Experimental bexarotene 20.7419196722 15591091 19196723
MESH:D008325 Mammary Neoplasms, Experimental Estradiol 20.7417203775 11807958 16891317 11408345
MESH:D008325 Mammary Neoplasms, Experimental Genistein 20.7412929590 14578162
MESH:D008325 Mammary Neoplasms, Experimental Progesterone 20.7411408345 17203775
MESH:D008325 Mammary Neoplasms, Experimental rosiglitazone 20.7416827153
MESH:D008325 Mammary Neoplasms, Experimental Tamoxifen 20.7419196723 19196722 11731420 14580682 16827153
MESH:D020149 Manganese Poisoning Estradiol 11.4919453300
MESH:D020149 Manganese Poisoning Tamoxifen 11.4919453300
MESH:D008545 Melanoma Cisplatin 4.8518505091 17761969 16809738 18332650 18176117 17023156 11135225 15577323 12374674 12883367 12393984 16248763 16432458
MESH:D008545 Melanoma Paclitaxel 4.8512025231 12040289 16342250
MESH:D008545 Melanoma Tamoxifen 4.8519393235 12393984
MESH:D018328 Melanoma, Amelanotic Cisplatin 10.3715990972
MESH:D018328 Melanoma, Amelanotic Tamoxifen 10.3715990972
MESH:D008569 Memory Disorders Ethanol 3.8718411066 15451040
MESH:D008654 Mesothelioma Cisplatin 3.1117638057
MESH:D024821 Metabolic Syndrome X rosiglitazone 4.1017261469
MESH:D008664 Metal Metabolism, Inborn Errors Cyclosporine 4.4416801185
MESH:D053842 Microsatellite Instability Methylnitronitrosoguanidine 5.5517671175
MESH:D018200 Mixed Tumor, Mullerian Raloxifene 5.2115863610
MESH:D009062 Mouth Neoplasms Benzo(a)pyrene 2.9316381670
MESH:D009101 Multiple Myeloma arsenic trioxide 15.3315949261 11468182 19417148 19549372 14977855
MESH:D009101 Multiple Myeloma Dexamethasone 15.3316118317 15867202 15744524
MESH:D009101 Multiple Myeloma Paclitaxel 15.3314749477
MESH:D009101 Multiple Myeloma Raloxifene 15.3316497877
MESH:D009182 Mycosis Fungoides arsenic trioxide 4.3318349030
MESH:D009190 Myelodysplastic Syndromes arsenic trioxide 6.9116882451 16105982
MESH:D009190 Myelodysplastic Syndromes Dexamethasone 6.919809623
MESH:D009203 Myocardial Infarction Genistein 2.7217141266
MESH:D017202 Myocardial Ischemia Tetrachlorodibenzodioxin 2.7512213967
MESH:D015428 Myocardial Reperfusion Injury Estradiol 7.6516810080
MESH:D015428 Myocardial Reperfusion Injury Genistein 7.6517141266
MESH:D009232 Myxoma Raloxifene 5.2116343187
MESH:D009336 Necrosis 2,4-dinitrotoluene 9.2118551238
MESH:D009336 Necrosis 2,6-dinitrotoluene 9.2118551238 7678174
MESH:D009361 Neoplasm Invasiveness arsenic trioxide 3.6416624393
MESH:D009362 Neoplasm Metastasis Diethylnitrosamine 8.743581430 9029167
MESH:D009362 Neoplasm Metastasis Paclitaxel 8.7415867366
MESH:D009362 Neoplasm Metastasis Tamoxifen 8.7419393235
MESH:D009364 Neoplasm Recurrence, Local Tamoxifen 2.4019410462
MESH:D009369 Neoplasms Benzo(a)pyrene 7.4811141357
MESH:D009369 Neoplasms Cisplatin 7.4816773208
MESH:D009369 Neoplasms Trichloroethylene 7.4811911487
MESH:D009376 Neoplasms, Hormone-Dependent bexarotene 9.7819196722
MESH:D009376 Neoplasms, Hormone-Dependent Tamoxifen 9.7819189210 19200415 19196722
MESH:D009389 Neovascularization, Pathologic Estradiol 3.3917289903
MESH:D009395 Nephritis, Interstitial Cisplatin 4.1515464296
MESH:D009402 Nephrosis, Lipoid Cyclosporine 4.0917954296
MESH:D009404 Nephrotic Syndrome Cyclosporine 3.0018481113 19348381
MESH:D009421 Nervous System Malformations bisphenol A 20.7916427766 11399458
MESH:D009421 Nervous System Malformations Estradiol 20.7911399458 16427766
MESH:D009421 Nervous System Malformations Genistein 20.7916427766
MESH:D009421 Nervous System Malformations Tetrachlorodibenzodioxin 20.7914600291
MESH:D009436 Neural Tube Defects arsenic trioxide 2.9010525206
MESH:D009447 Neuroblastoma Cisplatin 3.278761367
MESH:D019636 Neurodegenerative Diseases Diethylnitrosamine 3.0720387270
MESH:D017599 Neuroectodermal Tumors Cisplatin 4.368761367
MESH:D009461 Neurologic Manifestations Diethylnitrosamine 4.7720387270
MESH:D052556 Niemann-Pick Disease, Type C Clofibrate 4.619802331
MESH:D009784 Occupational Diseases 2,4-dinitrotoluene 7.9116049721 12819281
MESH:D009784 Occupational Diseases 2,6-dinitrotoluene 7.9116049721
MESH:D010014 Osteolysis Paclitaxel 4.6415867366
MESH:D010024 Osteoporosis Genistein 6.6319401787
MESH:D010024 Osteoporosis Raloxifene 6.6317882678 15775268 19059307
MESH:D015663 Osteoporosis, Postmenopausal Genistein 9.1016169203
MESH:D015663 Osteoporosis, Postmenopausal Raloxifene 9.1015758505 17823083 17893378 15579764
MESH:D010049 Ovarian Diseases bisphenol A 4.6511985600
MESH:D010051 Ovarian Neoplasms arsenic trioxide 17.3819769630 12452020 16624393
MESH:D010051 Ovarian Neoplasms Cisplatin 17.3819769630 6897625 17225452 15464296
MESH:D010051 Ovarian Neoplasms Estradiol 17.3819401270
MESH:D010051 Ovarian Neoplasms Genistein 17.3819005980
MESH:D010051 Ovarian Neoplasms Paclitaxel 17.3811161223
MESH:D010051 Ovarian Neoplasms Progesterone 17.3817393432 16525653
MESH:D010190 Pancreatic Neoplasms arsenic trioxide 11.3115580305
MESH:D010190 Pancreatic Neoplasms Cisplatin 11.3119003803
MESH:D010190 Pancreatic Neoplasms Diethylnitrosamine 11.3116540662
MESH:D010190 Pancreatic Neoplasms Ethanol 11.3112384795
MESH:D016584 Panic Disorder Ethinyl Estradiol 3.3711578682
MESH:D010235 Paraganglioma arsenic trioxide 3.8519927285
MESH:D010382 Peliosis Hepatis Tetrachlorodibenzodioxin 3.9012520081
MESH:D010523 Peripheral Nervous System Diseases Cisplatin 3.9915464296
MESH:D010997 Pleural Neoplasms Cisplatin 5.0017638057
MESH:D017119 Porphyria Cutanea Tarda Tetrachlorodibenzodioxin 3.2418163543
MESH:D011230 Precancerous Conditions Cyclosporine 8.0012371664
MESH:D011230 Precancerous Conditions Diethylnitrosamine 8.002563599
MESH:D054198 Precursor Cell Lymphoblastic Leukemia-Lymphoma Dexamethasone 3.3521297632
MESH:D011297 Prenatal Exposure Delayed Effects bisphenol A 8.3810548101
MESH:D011297 Prenatal Exposure Delayed Effects Tetrachlorodibenzodioxin 8.3811399792 11118676 11222880 11896295
MESH:D019048 Prostatic Intraepithelial Neoplasia bisphenol A 9.5420887781
MESH:D019048 Prostatic Intraepithelial Neoplasia Estradiol 9.5420887781
MESH:D011471 Prostatic Neoplasms arsenic trioxide 2.8219131511
MESH:D011471 Prostatic Neoplasms Benzo(a)pyrene 2.8217292933
MESH:D011471 Prostatic Neoplasms bisphenol A 2.8216740699
MESH:D011471 Prostatic Neoplasms Estradiol 2.8216740699
MESH:D011471 Prostatic Neoplasms Flurbiprofen 2.8217409433
MESH:D011471 Prostatic Neoplasms Genistein 2.8216925846 15378649 15256057
MESH:D011471 Prostatic Neoplasms Paclitaxel 2.8217172428 16729912 17136230 16356831
MESH:D011471 Prostatic Neoplasms Raloxifene 2.8216536755 15731164 16220300
MESH:D011471 Prostatic Neoplasms Tamoxifen 2.8215067354
MESH:D011537 Pruritus Ethinyl Estradiol 2.9816919318 15861022
MESH:D011565 Psoriasis Cyclosporine 2.1116882103
MESH:D011629 Puberty, Precocious bisphenol A 4.4410548101
MESH:D011693 Purpura Raloxifene 5.2115770314
MESH:D051437 Renal Insufficiency Cisplatin 4.0815464296
MESH:D012128 Respiratory Distress Syndrome, Adult Dexamethasone 8.4511700416 18379247
MESH:D012128 Respiratory Distress Syndrome, Adult Oxygen 8.4518339021 17627322
MESH:D015619 Respiratory System Abnormalities Tetrachlorodibenzodioxin 3.5118990726
MESH:D012468 Salivary Gland Neoplasms Progesterone 2.7318045962
MESH:D012512 Sarcoma, Ewing's arsenic trioxide 9.2716646077
MESH:D012512 Sarcoma, Ewing's Cisplatin 9.2714601052
MESH:D012640 Seizures 2,4-dinitrotoluene 8.5418551238
MESH:D012640 Seizures 2,6-dinitrotoluene 8.5418551238
MESH:D012640 Seizures Ethanol 8.549754883
MESH:D012878 Skin Neoplasms Benzo(a)pyrene 4.9319755658 10029692
MESH:D012878 Skin Neoplasms Tetrachlorodibenzodioxin 4.9316192470
MESH:D055752 Small Cell Lung Carcinoma Cisplatin 5.0015464296
MESH:D013088 Spermatocele Ethinyl Estradiol 10.4116709447
MESH:D013088 Spermatocele Tamoxifen 10.4116709447
MESH:D013119 Spinal Cord Injuries Progesterone 9.7415862959 16503802
MESH:D013119 Spinal Cord Injuries Tamoxifen 9.7419457130
MESH:D013158 Splenic Diseases Dimethylnitrosamine 4.9212587719
MESH:D013272 Stomach Diseases Dexamethasone 3.9815472012
MESH:D013274 Stomach Neoplasms arsenic trioxide 9.7817007042
MESH:D013274 Stomach Neoplasms Benzo(a)pyrene 9.7820155912 2093021
MESH:D013274 Stomach Neoplasms Cisplatin 9.7815958060 17522103 18396642
MESH:D013274 Stomach Neoplasms Diethylnitrosamine 9.7818456281
MESH:D013274 Stomach Neoplasms Dimethylnitrosamine 9.7816033868
MESH:D013274 Stomach Neoplasms Ethanol 9.7818456281
MESH:D013274 Stomach Neoplasms Paclitaxel 9.7818506536 18396642
MESH:D013276 Stomach Ulcer Dexamethasone 6.5615138204
MESH:D013276 Stomach Ulcer Ethanol 6.569211565 11906479 17918041 9562338 16755016 17189318
MESH:D020521 Stroke Raloxifene 3.5616837676
MESH:D019966 Substance-Related Disorders bisphenol A 3.6516045194 16684133
MESH:D013375 Substance Withdrawal Syndrome Ethanol 3.969754883
MESH:D013398 Sudden Infant Death Oxygen 5.2012563064
MESH:D024801 Tauopathies Paclitaxel 4.4716930453
MESH:D013736 Testicular Neoplasms Cisplatin 4.3215464296 17225452
MESH:D019851 Thrombophilia Ethinyl Estradiol 3.3111994571
MESH:D013927 Thrombosis Ethinyl Estradiol 2.8715669648
MESH:D013959 Thyroid Diseases Tetrachlorodibenzodioxin 3.5612697716
MESH:D013964 Thyroid Neoplasms arsenic trioxide 6.3419014326
MESH:D013964 Thyroid Neoplasms Diethylnitrosamine 6.347505956
MESH:D013978 Tibial Fractures Estradiol 12.5619048282
MESH:D013978 Tibial Fractures Raloxifene 12.5619048282
MESH:D016171 Torsades de Pointes arsenic trioxide 3.6215213294
MESH:D001749 Urinary Bladder Neoplasms 2,4-dinitrotoluene 21.9916049721
MESH:D001749 Urinary Bladder Neoplasms 2,6-dinitrotoluene 21.9916049721
MESH:D001749 Urinary Bladder Neoplasms arsenic trioxide 21.9911780464 20435036 12973940 12845720
MESH:D001749 Urinary Bladder Neoplasms Benzo(a)pyrene 21.9917053015
MESH:D001749 Urinary Bladder Neoplasms Cisplatin 21.9915464296 12973940 17225452
MESH:D001749 Urinary Bladder Neoplasms Raloxifene 21.9917572228
MESH:D001749 Urinary Bladder Neoplasms Tamoxifen 21.998653321 17572228 16712894
MESH:D014571 Urologic Neoplasms 2,4-dinitrotoluene 10.8510091137
MESH:D014571 Urologic Neoplasms 2,6-dinitrotoluene 10.8510091137
MESH:D002583 Uterine Cervical Neoplasms Cisplatin 3.9116803524
MESH:D014591 Uterine Diseases bisphenol A 4.6614652134
MESH:D014594 Uterine Neoplasms Ethinyl Estradiol 2.9814692618
MESH:D014605 Uveitis Cyclosporine 10.611336536
MESH:D014605 Uveitis Dexamethasone 10.611336536
MESH:D014625 Vaginal Neoplasms Cisplatin 4.2815577323
MESH:D054079 Vascular Malformations Tetrachlorodibenzodioxin 4.2512125929
MESH:D054556 Venous Thromboembolism Raloxifene 4.8616837676
MESH:D020246 Venous Thrombosis Ethinyl Estradiol 3.2414671159 15869587
MESH:D014839 Vomiting Cisplatin 4.3711897121
MESH:D014846 Vulvar Neoplasms Raloxifene 5.2116343187
MESH:D019282 Wasting Syndrome Tetrachlorodibenzodioxin 3.9015886252
MESH:D014985 Xerophthalmia Cyclosporine 4.0917120751
Pathway ID Pathway Name
KEGG:00565 Ether lipid metabolism
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Simple Query:


  (e.g. CHD8)

Syndromic Genes

Non-syndromic Genes

AutismKB Statistics

  • Studies: 1,036
  • Genes: 1,379
  • CNVs/SVs: 5,420
  • SNVs/Indels: 11,669
  • de novo Mutations: 5,669
  • Mosaics: 789
  • Linkage Regions: 172
  • Paper Collected: 6/30/2018
  • Last Update: 8/26/2018


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