AutismKB 2.0

Annotation Detail for ENPP3


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Basic Information Top
Gene Symbol:ENPP3 ( B10,CD203c,NPP3,PD-IBETA,PDNP3 )
Gene Full Name: ectonucleotide pyrophosphatase/phosphodiesterase 3
Band: 6q23.2
Quick LinksEntrez ID:5169; OMIM: 602182; Uniprot ID:ENPP3_HUMAN; ENSEMBL ID: ENSG00000154269; HGNC ID: 3358
Relate to Another Database: SFARIGene; denovo-db
Related Pathway Information Top
No data
Pathway IDPathway Name
hsa00740Riboflavin metabolism
hsa00230Purine metabolism
hsa00770Pantothenate and CoA biosynthesis
hsa00760Nicotinate and nicotinamide metabolism
hsa01100Metabolic pathways
hsa00500Starch and sucrose metabolism
No data
No data
No data
No data
Related Diseases/Disorders Top
Comparative Toxicogenomics Database Top
Chemical ID Chemical Name Interaction Interaction Action Publication
C548651 2-(1'H-indolo-3'-carbonyl)thiazole-4-carboxylic acid methyl ester 2-(1'H-indolo-3'-carbonyl)thiazole-4-carboxylic acid methyl ester results in increased expression of ENPP3 mRNAincreases expression 19933214
C016403 2,4-dinitrotoluene 2,4-dinitrotoluene affects the expression of ENPP3 mRNAaffects expression 21346803
C023514 2,6-dinitrotoluene 2,6-dinitrotoluene affects the expression of ENPP3 mRNAaffects expression 21346803
D000082 Acetaminophen Acetaminophen affects the expression of ENPP3 mRNAaffects expression 17562736
D016604 Aflatoxin B1 Aflatoxin B1 affects the expression of ENPP3 proteinaffects expression 20106945
D000643 Ammonium Chloride Ammonium Chloride affects the expression of ENPP3 mRNAaffects expression 16483693
D001151 Arsenic Arsenic results in increased expression of ENPP3 mRNAincreases expression 18315880
D020111 Chlorodiphenyl (54% Chlorine) Chlorodiphenyl (54% Chlorine) results in decreased expression of ENPP3 mRNAdecreases expression 18178546
D016572 Cyclosporine Cyclosporine results in decreased expression of ENPP3 mRNAdecreases expression 20106945
D004997 Ethinyl Estradiol Ethinyl Estradiol results in increased expression of ENPP3 mRNAincreases expression 17557909
C006253 pirinixic acid [pirinixic acid binds to and results in increased activity of PPARA protein] which results in decreased expression of ENPP3 mRNAaffects binding|decreases expression|increases activity 19710929
C006253 pirinixic acid pirinixic acid results in decreased expression of ENPP3 mRNAdecreases expression 18445702
17426115
D013749 Tetrachlorodibenzodioxin Tetrachlorodibenzodioxin results in increased expression of ENPP3 mRNAincreases expression 19933214
D013749 Tetrachlorodibenzodioxin Tetrachlorodibenzodioxin results in decreased expression of ENPP3 mRNAdecreases expression 18178546
18796159
16054898
Disease ID Disease Name Direct Evidence Inference Chemical Name Inference Score Publication
MESH:D000014 Abnormalities, Drug-Induced Tetrachlorodibenzodioxin 3.0014514962 15322242 11752688
MESH:D000138 Acidosis Ammonium Chloride 3.7118287403
MESH:D000152 Acne Vulgaris Ethinyl Estradiol 4.1217505938
MESH:D055371 Acute Lung Injury pirinixic acid 3.2318653653
MESH:D000230 Adenocarcinoma Ethinyl Estradiol 1.8314692618
MESH:D018248 Adenoma, Liver Cell pirinixic acid 10.4216434500
MESH:D018248 Adenoma, Liver Cell Tetrachlorodibenzodioxin 10.4216835633
MESH:D018246 Adrenocortical Adenoma Arsenic 5.3917306315
MESH:D000740 Anemia Tetrachlorodibenzodioxin 3.0511748828
MESH:D000799 Angioedema Acetaminophen 4.0210982225
MESH:D020261 Arsenic Poisoning Arsenic 2.8916251483 16835338 18414634 12569548
MESH:D001161 Arteriosclerosis Ethinyl Estradiol 3.6011256880
MESH:D001169 Arthritis, Experimental Ethinyl Estradiol 2.7315885639
MESH:D050197 Atherosclerosis Arsenic 3.3112928151 19371607
MESH:D001321 Autistic Disorder Acetaminophen 1.4118445737
MESH:D001778 Blood Coagulation Disorders pirinixic acid 9.1419483382
MESH:D001778 Blood Coagulation Disorders Tetrachlorodibenzodioxin 9.1412125929
MESH:D001836 Body Weight Changes Tetrachlorodibenzodioxin 3.9615340226
MESH:D001848 Bone Diseases, Developmental Tetrachlorodibenzodioxin 2.8315746008
MESH:D001943 Breast Neoplasms Tetrachlorodibenzodioxin 1.7020435547
MESH:D002277 Carcinoma Tetrachlorodibenzodioxin 2.8916835633
MESH:D002280 Carcinoma, Basal Cell Arsenic 3.6517687452 15504454
MESH:D006528 Carcinoma, Hepatocellular 2,4-dinitrotoluene 9.0516705839
MESH:D006528 Carcinoma, Hepatocellular 2,6-dinitrotoluene 9.0516705839
MESH:D006528 Carcinoma, Hepatocellular Acetaminophen 9.053084413
MESH:D006528 Carcinoma, Hepatocellular Aflatoxin B1 9.0512907637 12619106 21507988
MESH:D006528 Carcinoma, Hepatocellular Arsenic 9.0517306315 16507464
MESH:D002294 Carcinoma, Squamous Cell Arsenic 2.7215504454 17687452 18922899
MESH:D002295 Carcinoma, Transitional Cell Arsenic 4.1818640142
MESH:D006332 Cardiomegaly Tetrachlorodibenzodioxin 2.4218670907 16120746 18850075
MESH:D002318 Cardiovascular Diseases Arsenic 3.5215738583 17938729 19152805
MESH:D002340 Carotid Artery Diseases Arsenic 4.4118022660 16973168
MESH:D002386 Cataract Acetaminophen 2.6410977129
MESH:D002471 Cell Transformation, Neoplastic 2,6-dinitrotoluene 6.826135515
MESH:D002471 Cell Transformation, Neoplastic Cyclosporine 6.8212371664
MESH:D018281 Cholangiocarcinoma Tetrachlorodibenzodioxin 3.2616835633
MESH:D002779 Cholestasis Cyclosporine 13.8219486331
MESH:D002779 Cholestasis Ethinyl Estradiol 13.8216105132 11677210 16919318 17333356 17681005 17110522 15861022
MESH:D002779 Cholestasis pirinixic acid 13.8219176532
MESH:D002972 Cleft Palate Tetrachlorodibenzodioxin 2.1415668235 15340226 12621046 16354765 8697196
MESH:D000013 Congenital Abnormalities Tetrachlorodibenzodioxin 3.1617141729 14669216
MESH:D019465 Craniofacial Abnormalities Tetrachlorodibenzodioxin 1.2620055451 10048152 15322242
MESH:D003490 Cyanosis 2,4-dinitrotoluene 11.3618551238
MESH:D003490 Cyanosis 2,6-dinitrotoluene 11.3618551238
MESH:D003876 Dermatitis, Atopic pirinixic acid 2.4718249437
MESH:D003924 Diabetes Mellitus, Type 2 Tetrachlorodibenzodioxin 1.6917107852
MESH:D056486 Drug-Induced Liver Injury 2,4-dinitrotoluene 12.3518551238 21346803
MESH:D056486 Drug-Induced Liver Injury 2,6-dinitrotoluene 12.3521346803 18551238
MESH:D056486 Drug-Induced Liver Injury Acetaminophen 12.3519420014 11461765 17562736 16109766 11743745 17906064 10663392 19739265 16485898 19416960 11529661 16781746 11739529 19085960 12392966 12958197 18713872 16177239 16393943 14725611 12153990 11421492 12540782 12705907 10774834 11287661 14550746 16081117 19370779 17522070 15619225 15968718 16227642 18071297 11834606 10915739 12594235 19164858 19923254 14986274 2444490
MESH:D056486 Drug-Induced Liver Injury Chlorodiphenyl (54% Chlorine) 12.3517851650
MESH:D056486 Drug-Induced Liver Injury Tetrachlorodibenzodioxin 12.3520420201
MESH:D056487 Drug-Induced Liver Injury, Chronic Acetaminophen 4.2719426721
MESH:D004362 Drug Toxicity Tetrachlorodibenzodioxin 2.8411462148
MESH:D004487 Edema pirinixic acid 6.9012083418
MESH:D004487 Edema Tetrachlorodibenzodioxin 6.9011000095 12711302
MESH:D004489 Edema, Cardiac Tetrachlorodibenzodioxin 4.0818230668 16714409 15322242
MESH:D004681 Encephalomyelitis, Autoimmune, Experimental Ethinyl Estradiol 3.3112538720
MESH:D004715 Endometriosis Tetrachlorodibenzodioxin 3.129294722 10568697
MESH:D005124 Eye Abnormalities Tetrachlorodibenzodioxin 3.0911564622
MESH:D005234 Fatty Liver Cyclosporine 13.6519224547
MESH:D005234 Fatty Liver Ethinyl Estradiol 13.6515345470
MESH:D005234 Fatty Liver pirinixic acid 13.6520131406 19236843
MESH:D005313 Fetal Death Tetrachlorodibenzodioxin 3.5911858732
MESH:D005355 Fibrosis Cyclosporine 8.9512168785 12639820
MESH:D005355 Fibrosis Tetrachlorodibenzodioxin 8.9520067830
MESH:D005534 Foot Diseases Arsenic 5.736392382
MESH:D005756 Gastritis Acetaminophen 3.8516983495
MESH:D005885 Gingival Hyperplasia Cyclosporine 4.378708960
MESH:D006058 Gonadal Disorders Tetrachlorodibenzodioxin 4.7710696789
MESH:D006330 Heart Defects, Congenital Tetrachlorodibenzodioxin 2.3811294989 10048152
MESH:D006333 Heart Failure pirinixic acid 2.6020558911
MESH:D006457 Hemoglobinuria, Paroxysmal Cyclosporine 4.5815720958
MESH:D006470 Hemorrhage Tetrachlorodibenzodioxin 3.4411000095
MESH:D006529 Hepatomegaly pirinixic acid 8.7316221962 19772884 19176532 18467677
MESH:D006529 Hepatomegaly Tetrachlorodibenzodioxin 8.7315340226 12621046 16120746
MESH:D006869 Hydronephrosis Tetrachlorodibenzodioxin 4.2215340226 18606429 8697196 16354765 16959395
MESH:D006930 Hyperalgesia Acetaminophen 2.7916870215
MESH:D006943 Hyperglycemia pirinixic acid 3.2920558911
MESH:D017488 Hyperkeratosis, Epidermolytic Arsenic 4.5617050553
MESH:D006973 Hypertension Arsenic 8.8016076760 9931084 11953799
MESH:D006973 Hypertension Cyclosporine 8.8010903974
MESH:D006973 Hypertension Tetrachlorodibenzodioxin 8.8018670907 18850075
MESH:D006987 Hypesthesia Arsenic 5.7316093927
MESH:D007021 Hypospadias Ethinyl Estradiol 3.9516569931 16945680
MESH:D007247 Infertility, Female Ethinyl Estradiol 3.5812013081
MESH:D007248 Infertility, Male Ethinyl Estradiol 2.5617937319
MESH:D007249 Inflammation Tetrachlorodibenzodioxin 1.9112878042 12200463
MESH:D007333 Insulin Resistance pirinixic acid 2.7016306350
MESH:D007569 Jaw Abnormalities Tetrachlorodibenzodioxin 3.4416580747
MESH:D007638 Keratoconjunctivitis Sicca Cyclosporine 4.6215604871
MESH:D007642 Keratosis Arsenic 5.1416930632 12749816
MESH:D007674 Kidney Diseases Acetaminophen 5.9912587719 15629191
MESH:D007674 Kidney Diseases Cyclosporine 5.9910903974 8314463 18776723
MESH:D007680 Kidney Neoplasms 2,4-dinitrotoluene 12.9116705839
MESH:D007680 Kidney Neoplasms 2,6-dinitrotoluene 12.9116705839
MESH:D007680 Kidney Neoplasms Cyclosporine 12.9112371664
MESH:D015473 Leukemia, Promyelocytic, Acute Arsenic 3.6217339181
MESH:D008106 Liver Cirrhosis, Experimental pirinixic acid 2.1615474484
MESH:D008106 Liver Cirrhosis, Experimental Tetrachlorodibenzodioxin 2.1612878042
MESH:D008107 Liver Diseases Acetaminophen 4.1519014921 16610002 12587719 12969438 19784758 16611625 11587558 19460945
MESH:D008107 Liver Diseases Arsenic 4.1511134558
MESH:D017114 Liver Failure, Acute Acetaminophen 3.3417185352 16871587
MESH:D008113 Liver Neoplasms 2,6-dinitrotoluene 14.667678174
MESH:D008113 Liver Neoplasms Aflatoxin B1 14.6618177683 9163691 15890375 2125692
MESH:D008113 Liver Neoplasms Arsenic 14.6616368122
MESH:D008113 Liver Neoplasms pirinixic acid 14.6620007298 16377806 15890375
MESH:D008113 Liver Neoplasms Tetrachlorodibenzodioxin 14.6616984957
MESH:D008114 Liver Neoplasms, Experimental 2,6-dinitrotoluene 10.192876784 2876786 6135515
MESH:D008114 Liver Neoplasms, Experimental Aflatoxin B1 10.198603461
MESH:D008114 Liver Neoplasms, Experimental Tetrachlorodibenzodioxin 10.1912151625
MESH:D008175 Lung Neoplasms Aflatoxin B1 3.5114755239
MESH:D008175 Lung Neoplasms Arsenic 3.5117306315 19168569 17976673
MESH:D008175 Lung Neoplasms Tetrachlorodibenzodioxin 3.5111884234 19555203
MESH:D008546 Melanoma, Experimental Acetaminophen 3.7119513568
MESH:D008664 Metal Metabolism, Inborn Errors Cyclosporine 4.9616801185
MESH:D009135 Muscular Diseases pirinixic acid 3.6416239165
MESH:D009203 Myocardial Infarction pirinixic acid 2.1819151258
MESH:D017202 Myocardial Ischemia Arsenic 9.3015371236
MESH:D017202 Myocardial Ischemia Tetrachlorodibenzodioxin 9.3012213967
MESH:D015428 Myocardial Reperfusion Injury pirinixic acid 3.0316411023
MESH:D009336 Necrosis 2,4-dinitrotoluene 10.8718551238
MESH:D009336 Necrosis 2,6-dinitrotoluene 10.877678174 18551238
MESH:D009369 Neoplasms pirinixic acid 1.9917405874
MESH:D009402 Nephrosis, Lipoid Cyclosporine 4.6217954296
MESH:D009404 Nephrotic Syndrome Cyclosporine 3.3818481113 19348381
MESH:D009421 Nervous System Malformations Tetrachlorodibenzodioxin 3.3414600291
MESH:D009436 Neural Tube Defects Arsenic 3.5216620997
MESH:D019636 Neurodegenerative Diseases Acetaminophen 2.9618514411
MESH:D020078 Neurogenic Inflammation Arsenic 4.4917056641
MESH:D009765 Obesity pirinixic acid 1.8420558911
MESH:D009784 Occupational Diseases 2,4-dinitrotoluene 9.2316049721 12819281
MESH:D009784 Occupational Diseases 2,6-dinitrotoluene 9.2316049721
MESH:D010051 Ovarian Neoplasms Arsenic 2.7717306315
MESH:D010146 Pain Acetaminophen 2.4816870215
MESH:D016584 Panic Disorder Ethinyl Estradiol 3.8011578682
MESH:D010382 Peliosis Hepatis Tetrachlorodibenzodioxin 4.4212520081
MESH:D010523 Peripheral Nervous System Diseases Arsenic 4.3016093927
MESH:D016491 Peripheral Vascular Diseases Arsenic 5.1415371236 6392382 16905509
MESH:D017119 Porphyria Cutanea Tarda Tetrachlorodibenzodioxin 3.6918163543
MESH:D011230 Precancerous Conditions Cyclosporine 3.3212371664
MESH:D011297 Prenatal Exposure Delayed Effects Tetrachlorodibenzodioxin 3.3411399792 11222880 11896295 11118676
MESH:D011471 Prostatic Neoplasms Arsenic 3.5916140617
MESH:D011507 Proteinuria Arsenic 4.1221343184
MESH:D011537 Pruritus Ethinyl Estradiol 3.4715861022 16919318
MESH:D011565 Psoriasis Cyclosporine 2.2616882103
MESH:D015427 Reperfusion Injury pirinixic acid 2.4319058328
MESH:D015619 Respiratory System Abnormalities Tetrachlorodibenzodioxin 3.9618990726
MESH:D012640 Seizures 2,4-dinitrotoluene 6.1118551238
MESH:D012640 Seizures 2,6-dinitrotoluene 6.1118551238
MESH:D012871 Skin Diseases Arsenic 2.7719834688 6392382 15952646 17938729 17050553 16759981 18709164 16702368 17453740 17548696 16353154
MESH:D012878 Skin Neoplasms Arsenic 5.8717976673 16251483 17029826 17050553 15504454 19538983
MESH:D012878 Skin Neoplasms Tetrachlorodibenzodioxin 5.8716192470
MESH:D013088 Spermatocele Ethinyl Estradiol 4.1216709447
MESH:D019851 Thrombophilia Ethinyl Estradiol 3.7411994571
MESH:D013927 Thrombosis Ethinyl Estradiol 3.2515669648
MESH:D013959 Thyroid Diseases Tetrachlorodibenzodioxin 4.0812697716
MESH:D001749 Urinary Bladder Neoplasms 2,4-dinitrotoluene 8.5816049721
MESH:D001749 Urinary Bladder Neoplasms 2,6-dinitrotoluene 8.5816049721
MESH:D001749 Urinary Bladder Neoplasms Arsenic 8.5811144890 18640142 19322015 15987713 17976673 19429237 17306315
MESH:D014571 Urologic Neoplasms 2,4-dinitrotoluene 12.5110091137
MESH:D014571 Urologic Neoplasms 2,6-dinitrotoluene 12.5110091137
MESH:D014581 Urticaria Acetaminophen 3.0910982225
MESH:D014594 Uterine Neoplasms Ethinyl Estradiol 3.4214692618
MESH:D014605 Uveitis Cyclosporine 4.161336536
MESH:D014652 Vascular Diseases Arsenic 4.8917056641
MESH:D054079 Vascular Malformations Tetrachlorodibenzodioxin 4.7712125929
MESH:D020246 Venous Thrombosis Ethinyl Estradiol 3.6514671159 15869587
MESH:D019282 Wasting Syndrome Tetrachlorodibenzodioxin 4.4215886252
MESH:D014985 Xerophthalmia Cyclosporine 4.6217120751
Pathway ID Pathway Name
KEGG:01100 Metabolic pathways
KEGG:00760 Nicotinate and nicotinamide metabolism
KEGG:00770 Pantothenate and CoA biosynthesis
KEGG:00230 Purine metabolism
KEGG:00740 Riboflavin metabolism
KEGG:00500 Starch and sucrose metabolism
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  (e.g. CHD8)

Syndromic Genes

Non-syndromic Genes

AutismKB Statistics

  • Studies: 1,036
  • Genes: 1,379
  • CNVs/SVs: 5,420
  • SNVs/Indels: 11,669
  • de novo Mutations: 5,669
  • Mosaics: 789
  • Linkage Regions: 172
  • Paper Collected: 6/30/2018
  • Last Update: 8/26/2018


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