AutismKB 2.0

Annotation Detail for CPSF3


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Basic Information Top
Gene Symbol:CPSF3 ( CPSF,CPSF-73,CPSF73,YSH1 )
Gene Full Name: cleavage and polyadenylation specific factor 3, 73kDa
Band: 2p25.1
Quick LinksEntrez ID:51692; OMIM: 606029; Uniprot ID:CPSF3_HUMAN; ENSEMBL ID: ENSG00000119203; HGNC ID: 2326
Relate to Another Database: SFARIGene; denovo-db
Related Pathway Information Top
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Pathway IDPathway Name
Post-Elongation Processing of the Transcript
Transcription
mRNA Processing
Gene Expression
No data
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Related Diseases/Disorders Top
Comparative Toxicogenomics Database Top
Chemical ID Chemical Name Interaction Interaction Action Publication
C016403 2,4-dinitrotoluene 2,4-dinitrotoluene affects the expression of CPSF3 mRNAaffects expression 21346803
D002995 Clofibric Acid [Diethylnitrosamine co-treated with Clofibric Acid] affects the expression of CPSF3 mRNAaffects cotreatment|affects expression 17602206
D004052 Diethylnitrosamine [Diethylnitrosamine co-treated with Clofibric Acid] affects the expression of CPSF3 mRNAaffects cotreatment|affects expression 17602206
Disease ID Disease Name Direct Evidence Inference Chemical Name Inference Score Publication
MESH:D000236 Adenoma Diethylnitrosamine 3.0810737359 6695378
MESH:D018248 Adenoma, Liver Cell Diethylnitrosamine 4.6419061943 19052882 18056438 17620307 17162532 16434500
MESH:D001943 Breast Neoplasms Diethylnitrosamine 2.1917474063
MESH:D006528 Carcinoma, Hepatocellular 2,4-dinitrotoluene 3.1516705839
MESH:D006528 Carcinoma, Hepatocellular Diethylnitrosamine 3.1520007298 16328049 19701751 18210153 18506893 18393292 17173139 19171122 19822196 17761372 17428255 17138121 20084675 19539802 16807293 19208518 3581430 20514400 18691550 16878318 19394651 20727157 16540662 3084413 16779866 18788625 20524982 16502159 21159647 19052882 11831363 17978847 19335982 18665156 16830150 20432363 20935162 20512989 18785209 10737359 18978308 19383236 16681979 18971187 16288022 17162532 16698587 17055752 19519916 19107877 16935385 16569478 18494052 10672840 20214788 20101231 19919837 19418558 18056438
MESH:D002471 Cell Transformation, Neoplastic Diethylnitrosamine 3.1517174075 21159647 2727394 7505956
MESH:D018281 Cholangiocarcinoma Diethylnitrosamine 4.1019052882
MESH:D003490 Cyanosis 2,4-dinitrotoluene 4.6718551238
MESH:D003924 Diabetes Mellitus, Type 2 Diethylnitrosamine 2.2720387270
MESH:D056486 Drug-Induced Liver Injury 2,4-dinitrotoluene 4.2218551238 21346803
MESH:D056486 Drug-Induced Liver Injury Diethylnitrosamine 4.2219107877
MESH:D004931 Esophageal Achalasia Diethylnitrosamine 5.9816302075
MESH:D005234 Fatty Liver Diethylnitrosamine 3.6720387270 21071580
MESH:D007249 Inflammation Diethylnitrosamine 2.5718785209
MESH:D007680 Kidney Neoplasms 2,4-dinitrotoluene 3.3616705839
MESH:D008103 Liver Cirrhosis Diethylnitrosamine 3.0319638242 18407596 18522880 20032147 18665156
MESH:D008107 Liver Diseases Diethylnitrosamine 2.1817034775
MESH:D008113 Liver Neoplasms Clofibric Acid 5.2117602206
MESH:D008113 Liver Neoplasms Diethylnitrosamine 5.2120101389 21047994 18648771 20583210 12112319 20492335 20452335 9163691 19812893 19255062 15175105 19996281 19294768 2862719 19690152 19642983 19254457 19833225 18644402 15885732 18754104 19499222 20118626 19638242 2422723 19073162 19850985 19256749 20434301 21167192 19551842 20405173 20501860 21278145 19090486 10737359 18978307 16942905 18977376 20137499 21071580 19426721 19427195 12771043
MESH:D008114 Liver Neoplasms, Experimental Diethylnitrosamine 2.8821159647 19519916 2563599 18253720 17174075 18164116 17854601 3124819 18079962 19126423 18544905 18282651 19539802 18093689 18775883 16842330 16267830 9362446 19009564 18308698 17942915 19004024
MESH:D008175 Lung Neoplasms Diethylnitrosamine 1.7721163286 20970405 6695378 20512841
MESH:D009336 Necrosis 2,4-dinitrotoluene 4.6018551238
MESH:D009362 Neoplasm Metastasis Diethylnitrosamine 2.703581430 9029167
MESH:D019636 Neurodegenerative Diseases Diethylnitrosamine 3.7320387270
MESH:D009461 Neurologic Manifestations Diethylnitrosamine 5.9820387270
MESH:D009784 Occupational Diseases 2,4-dinitrotoluene 3.8816049721 12819281
MESH:D010190 Pancreatic Neoplasms Diethylnitrosamine 2.5416540662
MESH:D011230 Precancerous Conditions Diethylnitrosamine 3.972563599
MESH:D012640 Seizures 2,4-dinitrotoluene 2.8118551238
MESH:D013274 Stomach Neoplasms Diethylnitrosamine 1.7618456281
MESH:D013964 Thyroid Neoplasms Diethylnitrosamine 3.327505956
MESH:D001749 Urinary Bladder Neoplasms 2,4-dinitrotoluene 2.4216049721
MESH:D014571 Urologic Neoplasms 2,4-dinitrotoluene 5.0610091137
Pathway ID Pathway Name
REACT:71 Gene Expression
REACT:1675 mRNA Processing
KEGG:03015 mRNA surveillance pathway
REACT:78 Post-Elongation Processing of the Transcript
REACT:1788 Transcription
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AutismKB Statistics

  • Studies: 1,036
  • Genes: 1,379
  • CNVs/SVs: 5,420
  • SNVs/Indels: 11,669
  • de novo Mutations: 5,669
  • Mosaics: 789
  • Linkage Regions: 172
  • Paper Collected: 6/30/2018
  • Last Update: 8/26/2018


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