AutismKB 2.0

Annotation Detail for PDPK1


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Basic Information Top
Gene Symbol:PDPK1 ( MGC20087,MGC35290,PDK1,PRO0461 )
Gene Full Name: 3-phosphoinositide dependent protein kinase-1
Band: 16p13.3
Quick LinksEntrez ID:5170; OMIM: 605213; Uniprot ID:PDPK1_HUMAN; ENSEMBL ID: ENSG00000140992; HGNC ID: 8816
Relate to Another Database: SFARIGene; denovo-db
Related Pathway Information Top
No data
Pathway IDPathway Name
hsa04910Insulin signaling pathway
hsa04150mTOR signaling pathway
hsa03320PPAR signaling pathway
hsa04960Aldosterone-regulated sodium reabsorption
hsa05223Non-small cell lung cancer
hsa05213Endometrial cancer
hsa05215Prostate cancer
hsa04510Focal adhesion
Pathway IDPathway Name
Signaling by GPCR
Synaptic Transmission
Signalling by NGF
Hemostasis
Signaling by Insulin receptor
Signaling in Immune system
Integrin cell surface interactions
Pathway IDPathway Name
200183Trk receptor signaling mediated by PI3K and PLC-gamma
200189FGF signaling pathway
200032Signaling events mediated by Hepatocyte Growth Factor Receptor (c-Met)
200005BCR signaling pathway
200156Signaling events mediated by Stem cell factor receptor (c-Kit)
200151VEGFR1 specific signals
200012Insulin Pathway
200080mTOR signaling pathway
200083CXCR4-mediated signaling events
200084IGF1 pathway
200062TCR signaling in naive CD8+ T cells
200067FAS (CD95) signaling pathway
200098Class I PI3K signaling events
200150CXCR3-mediated signaling events
200169Class I PI3K signaling events mediated by Akt
200161Signaling events mediated by VEGFR1 and VEGFR2
200113ErbB1 downstream signaling
200022TCR signaling in naive CD4+ T cells
200195TGF-beta receptor signaling
Pathway IDPathway Name
P04398p53 pathway feedback loops 2
P00033Insulin/IGF pathway-protein kinase B signaling cascade
P00048PI3 kinase pathway
P00047PDGF signaling pathway
P00059p53 pathway
P00036Interleukin signaling pathway
P00031Inflammation mediated by chemokine and cytokine signaling pathway
P04393Ras Pathway
Pathway IDPathway Name
500179RSK activation
501026Activation of PKB
500640AKT phosphorylates targets in the cytosol
500485CD28 dependent PI3K/Akt signaling
500482Downstream TCR signaling
500639PI3K/AKT signalling
500487CTLA4 inhibitory signaling
Related Diseases/Disorders Top
Comparative Toxicogenomics Database Top
Chemical ID Chemical Name Interaction Interaction Action Publication
C016403 2,4-dinitrotoluene 2,4-dinitrotoluene affects the expression of PDPK1 mRNAaffects expression 21346803
C023514 2,6-dinitrotoluene 2,6-dinitrotoluene affects the expression of PDPK1 mRNAaffects expression 21346803
C518576 2-methylbutyric acid 4-((1,3)dioxan-5-ylmethoxyimino)-8-(2-(4-hydroxy-6-oxo-tetrahydropyran-2-yl)ethyl -7-methyl-6-oxo-1,2,3,4,6,7,8,8a-octahydronaphthyl)heptanoate 2-methylbutyric acid 4-((1,3)dioxan-5-ylmethoxyimino)-8-(2-(4-hydroxy-6-oxo-tetrahydropyran-2-yl)ethyl -7-methyl-6-oxo-1,2,3,4,6,7,8,8a-octahydronaphthyl)heptanoate results in decreased expression of PDPK1 mRNAdecreases expression 17327690
C009505 4,4'-diaminodiphenylmethane 4,4'-diaminodiphenylmethane affects the expression of PDPK1 mRNAaffects expression 18648102
C054852 7-hydroxystaurosporine 7-hydroxystaurosporine results in decreased activity of PDPK1 proteindecreases activity 16178010
D000584 Amiloride Amiloride results in decreased phosphorylation of PDPK1 proteindecreases phosphorylation 16059913
D000643 Ammonium Chloride Ammonium Chloride affects the expression of PDPK1 mRNAaffects expression 16483693
C006632 arsenic trioxide arsenic trioxide results in decreased activity of PDPK1 proteindecreases activity 14633726
D015123 7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide 7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide results in decreased expression of PDPK1 mRNAdecreases expression 19150397
C105934 celecoxib celecoxib results in decreased activity of PDPK1 proteindecreases activity 16178010
D004317 Doxorubicin PDPK1 protein results in decreased susceptibility to Doxorubicindecreases response to substance 16782806
D004317 Doxorubicin Doxorubicin results in decreased expression of PDPK1 proteindecreases expression 19429709
D004958 Estradiol [Progesterone co-treated with Estradiol] results in decreased expression of PDPK1 mRNAaffects cotreatment|decreases expression 17404688
D004997 Ethinyl Estradiol Ethinyl Estradiol affects the expression of PDPK1 mRNAaffects expression 17555576
D004997 Ethinyl Estradiol [Tetrachlorodibenzodioxin co-treated with Ethinyl Estradiol] results in increased expression of PDPK1 mRNAaffects cotreatment|increases expression 17942748
C056507 gemcitabine PDPK1 protein modified form results in decreased susceptibility to gemcitabinedecreases response to substance 16782806
D017239 Paclitaxel PDPK1 protein results in decreased susceptibility to Paclitaxeldecreases response to substance 16782806
C006253 pirinixic acid pirinixic acid results in increased expression of PDPK1 mRNAincreases expression 18301758
C025299 polyphenols polyphenols results in decreased expression of PDPK1 mRNAdecreases expression 16293270
D011374 Progesterone [Progesterone co-treated with Estradiol] results in decreased expression of PDPK1 mRNAaffects cotreatment|decreases expression 17404688
C059514 resveratrol resveratrol inhibits the reaction [EGF protein results in increased phosphorylation of PDPK1 protein]decreases reaction|increases phosphorylation 16343977
D012643 Selenium [Selenium co-treated with Vitamin E] results in decreased expression of PDPK1 mRNAaffects cotreatment|decreases expression 19244175
D013749 Tetrachlorodibenzodioxin [Tetrachlorodibenzodioxin co-treated with Ethinyl Estradiol] results in increased expression of PDPK1 mRNAaffects cotreatment|increases expression 17942748
D014108 Tosylphenylalanyl Chloromethyl Ketone Tosylphenylalanyl Chloromethyl Ketone inhibits the reaction [IL1B protein results in increased phosphorylation of PDPK1 protein]decreases reaction|increases phosphorylation 17136479
D014108 Tosylphenylalanyl Chloromethyl Ketone Tosylphenylalanyl Chloromethyl Ketone results in decreased activity of PDPK1 proteindecreases activity 17136479
D014108 Tosylphenylalanyl Chloromethyl Ketone Tosylphenylalanyl Chloromethyl Ketone results in decreased activity of PDPK1 proteindecreases activity 16178010
D014638 Vanadates Vanadates results in increased expression of PDPK1 proteinincreases expression 17874149
D014810 Vitamin E [Selenium co-treated with Vitamin E] results in decreased expression of PDPK1 mRNAaffects cotreatment|decreases expression 19244175
D014810 Vitamin E Vitamin E results in decreased expression of PDPK1 mRNAdecreases expression 19244175
Disease ID Disease Name Direct Evidence Inference Chemical Name Inference Score Publication
MESH:D000014 Abnormalities, Drug-Induced Tetrachlorodibenzodioxin 2.6815322242 11752688 14514962
MESH:D000138 Acidosis Ammonium Chloride 3.3918287403
MESH:D000152 Acne Vulgaris Ethinyl Estradiol 3.7717505938
MESH:D058186 Acute Kidney Injury resveratrol 3.7016538975
MESH:D055371 Acute Lung Injury pirinixic acid 2.9618653653
MESH:D000230 Adenocarcinoma arsenic trioxide 9.8111798837 19825857
MESH:D000230 Adenocarcinoma Doxorubicin 9.8117418594
MESH:D000230 Adenocarcinoma Estradiol 9.8111473722
MESH:D000230 Adenocarcinoma Ethinyl Estradiol 9.8114692618
MESH:D000236 Adenoma 4,4'-diaminodiphenylmethane 6.513712494
MESH:D000236 Adenoma resveratrol 6.5115688382
MESH:D018248 Adenoma, Liver Cell pirinixic acid 9.3316434500
MESH:D018248 Adenoma, Liver Cell Tetrachlorodibenzodioxin 9.3316835633
MESH:D011125 Adenomatous Polyposis Coli celecoxib 4.9316215675 19003578
MESH:D000419 Albuminuria Doxorubicin 4.3821441931
MESH:D000544 Alzheimer Disease resveratrol 2.5316162502 16183991
MESH:D000740 Anemia Tetrachlorodibenzodioxin 2.8011748828
MESH:D001161 Arteriosclerosis Ethinyl Estradiol 3.2911256880
MESH:D001169 Arthritis, Experimental Ethinyl Estradiol 11.9015885639
MESH:D001169 Arthritis, Experimental resveratrol 11.9017115116
MESH:D001169 Arthritis, Experimental Tosylphenylalanyl Chloromethyl Ketone 11.9018706406
MESH:D050197 Atherosclerosis resveratrol 3.1716873680 17967414
MESH:D001660 Biliary Tract Diseases 4,4'-diaminodiphenylmethane 4.851440618 11289319
MESH:D001778 Blood Coagulation Disorders arsenic trioxide 14.3716206674
MESH:D001778 Blood Coagulation Disorders pirinixic acid 14.3719483382
MESH:D001778 Blood Coagulation Disorders Tetrachlorodibenzodioxin 14.3712125929
MESH:D001836 Body Weight Changes Tetrachlorodibenzodioxin 3.6215340226
MESH:D001848 Bone Diseases, Developmental Tetrachlorodibenzodioxin 2.6515746008
MESH:D019046 Bone Marrow Neoplasms Doxorubicin 4.5314601052
MESH:D001859 Bone Neoplasms Paclitaxel 4.4115867366
MESH:D020201 Brain Hemorrhage, Traumatic Progesterone 5.1717868700
MESH:D001930 Brain Injuries Progesterone 4.0915380490 15845082 15665606
MESH:D002545 Brain Ischemia resveratrol 4.1117600658
MESH:D001932 Brain Neoplasms Doxorubicin 3.6617150277
MESH:D001943 Breast Neoplasms Doxorubicin 3.6617426702 16264153 15994142 15993339 11325840 16322301 18628466 15136595 17983394 15939500 18382427 18695136 16115903 16595493 16935488 19526202 15668708 16826403 15567936 16096432 17369602 15634643 18234424 15692762
MESH:D001943 Breast Neoplasms Estradiol 3.6617289903 16675129 17261762 12948864 14630087 17018787 18497071 19861407
MESH:D001943 Breast Neoplasms gemcitabine 3.6617039268 18382427
MESH:D001943 Breast Neoplasms Paclitaxel 3.6611325840 18234424 16115903 18323546 16244791 16273361 18223236 15136595
MESH:D001943 Breast Neoplasms Progesterone 3.6616175315 15562024 17614352
MESH:D001943 Breast Neoplasms resveratrol 3.6617651959 16393696 17534123
MESH:D001943 Breast Neoplasms Tetrachlorodibenzodioxin 3.6620435547
MESH:D002051 Burkitt Lymphoma arsenic trioxide 4.1711589617
MESH:D002181 Candidiasis, Vulvovaginal Estradiol 4.2916111702
MESH:D002252 Carbon Tetrachloride Poisoning Vitamin E 3.7616050911
MESH:D002276 Carcinoid Tumor Doxorubicin 4.6416051944
MESH:D002277 Carcinoma Tetrachlorodibenzodioxin 2.6616835633
MESH:D006528 Carcinoma, Hepatocellular 2,4-dinitrotoluene 16.4516705839
MESH:D006528 Carcinoma, Hepatocellular 2,6-dinitrotoluene 16.4516705839
MESH:D006528 Carcinoma, Hepatocellular 4,4'-diaminodiphenylmethane 16.453581430 7296757
MESH:D006528 Carcinoma, Hepatocellular arsenic trioxide 16.4514691202 15073043 15553829 16217749 11135700
MESH:D006528 Carcinoma, Hepatocellular Doxorubicin 16.4516023760 17876044 16234567 18059187
MESH:D006528 Carcinoma, Hepatocellular Estradiol 16.4516924424
MESH:D006528 Carcinoma, Hepatocellular Paclitaxel 16.4516313753
MESH:D006528 Carcinoma, Hepatocellular resveratrol 16.4519321006 16227395
MESH:D018827 Carcinoma, Lewis Lung resveratrol 4.4216675471
MESH:D002291 Carcinoma, Papillary arsenic trioxide 4.7019014326
MESH:D002292 Carcinoma, Renal Cell 4,4'-diaminodiphenylmethane 10.487296757
MESH:D002292 Carcinoma, Renal Cell celecoxib 10.4816369983
MESH:D002292 Carcinoma, Renal Cell Doxorubicin 10.4816201981 1485588
MESH:D018288 Carcinoma, Small Cell arsenic trioxide 3.9712490120
MESH:D002294 Carcinoma, Squamous Cell Doxorubicin 4.776189445
MESH:D002294 Carcinoma, Squamous Cell resveratrol 4.7716227395
MESH:D002295 Carcinoma, Transitional Cell Amiloride 4.9314644129
MESH:D006332 Cardiomegaly Tetrachlorodibenzodioxin 2.2718670907 16120746 18850075
MESH:D009202 Cardiomyopathies Doxorubicin 3.4215476868 15792986 15811867 16731534 17329180 17519947 17974986 18627295 17007740 16269455 17924179 16651473 17308081 17351982 16455267 16364871 17382496 17131338 16612575 15505089 16242529 16109756 16278810 17928571 16952015
MESH:D002311 Cardiomyopathy, Dilated Doxorubicin 2.8916243910 17334414
MESH:D002318 Cardiovascular Diseases resveratrol 3.3615458977
MESH:D002471 Cell Transformation, Neoplastic 2,6-dinitrotoluene 15.056135515
MESH:D002471 Cell Transformation, Neoplastic 4,4'-diaminodiphenylmethane 15.057505956
MESH:D002471 Cell Transformation, Neoplastic 7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide 15.0520889678
MESH:D002471 Cell Transformation, Neoplastic Estradiol 15.0518566989
MESH:D018281 Cholangiocarcinoma Tetrachlorodibenzodioxin 3.0216835633
MESH:D002779 Cholestasis 4,4'-diaminodiphenylmethane 12.6419486331 9022650
MESH:D002779 Cholestasis Ethinyl Estradiol 12.6415861022 16105132 17110522 17681005 17333356 16919318 11677210
MESH:D002779 Cholestasis pirinixic acid 12.6419176532
MESH:D002972 Cleft Palate Tetrachlorodibenzodioxin 2.038697196 16354765 12621046 15668235 15340226
MESH:D003092 Colitis Amiloride 15.2512065299
MESH:D003092 Colitis resveratrol 15.2516474422
MESH:D003092 Colitis Selenium 15.2517936198
MESH:D003110 Colonic Neoplasms celecoxib 5.9216004971
MESH:D003110 Colonic Neoplasms polyphenols 5.9216293270
MESH:D003110 Colonic Neoplasms resveratrol 5.9216338953
MESH:D015179 Colorectal Neoplasms arsenic trioxide 6.3320501625
MESH:D015179 Colorectal Neoplasms celecoxib 6.3318349538 11197048
MESH:D015179 Colorectal Neoplasms Doxorubicin 6.3318259882 18802399
MESH:D015179 Colorectal Neoplasms Paclitaxel 6.3318802399
MESH:D015179 Colorectal Neoplasms resveratrol 6.3316550006
MESH:D000013 Congenital Abnormalities Tetrachlorodibenzodioxin 2.9117141729 14669216
MESH:D003327 Coronary Disease resveratrol 3.6416507316
MESH:D023903 Coronary Restenosis arsenic trioxide 4.0212609071
MESH:D019465 Craniofacial Abnormalities arsenic trioxide 3.6610525206
MESH:D019465 Craniofacial Abnormalities Tetrachlorodibenzodioxin 3.6610048152 20055451 15322242
MESH:D019465 Craniofacial Abnormalities Vitamin E 3.6619769572
MESH:D003490 Cyanosis 2,4-dinitrotoluene 10.3318551238
MESH:D003490 Cyanosis 2,6-dinitrotoluene 10.3318551238
MESH:D016757 Death, Sudden, Cardiac arsenic trioxide 3.9315213294
MESH:D017449 Dermatitis, Allergic Contact 4,4'-diaminodiphenylmethane 2.6418759878 2524372 12868966 11906362 11298694 8156756 14531868 8970840
MESH:D003876 Dermatitis, Atopic pirinixic acid 2.3518249437
MESH:D003877 Dermatitis, Contact 4,4'-diaminodiphenylmethane 3.332952479 3621924
MESH:D003921 Diabetes Mellitus, Experimental resveratrol 3.6316873680
MESH:D003924 Diabetes Mellitus, Type 2 Tetrachlorodibenzodioxin 1.6317107852
MESH:D003928 Diabetic Nephropathies Estradiol 8.5319279558
MESH:D003928 Diabetic Nephropathies resveratrol 8.5316286809
MESH:D003929 Diabetic Neuropathies Progesterone 4.3217187935
MESH:D056486 Drug-Induced Liver Injury 2,4-dinitrotoluene 17.9021346803 18551238
MESH:D056486 Drug-Induced Liver Injury 2,6-dinitrotoluene 17.9021346803 18551238
MESH:D056486 Drug-Induced Liver Injury 4,4'-diaminodiphenylmethane 17.908291058 1440618 18289764 16192314 18648102 6679447 9653073 9022650 18692083 7440962 6482804 9328219 11289319
MESH:D056486 Drug-Induced Liver Injury Doxorubicin 17.9017416283
MESH:D056486 Drug-Induced Liver Injury polyphenols 17.9019370779
MESH:D056486 Drug-Induced Liver Injury Selenium 17.9015131321
MESH:D056486 Drug-Induced Liver Injury Tetrachlorodibenzodioxin 17.9020420201
MESH:D004362 Drug Toxicity Doxorubicin 7.6918602426
MESH:D004362 Drug Toxicity Tetrachlorodibenzodioxin 7.6911462148
MESH:C538011 Eales disease Vitamin E 4.539068938
MESH:D004487 Edema pirinixic acid 10.5312083418
MESH:D004487 Edema resveratrol 10.538985016
MESH:D004487 Edema Tetrachlorodibenzodioxin 10.5312711302 11000095
MESH:D004489 Edema, Cardiac Tetrachlorodibenzodioxin 3.7316714409 15322242 18230668
MESH:D004681 Encephalomyelitis, Autoimmune, Experimental Ethinyl Estradiol 14.4312538720
MESH:D004681 Encephalomyelitis, Autoimmune, Experimental Progesterone 14.4317692515
MESH:D004681 Encephalomyelitis, Autoimmune, Experimental resveratrol 14.4317872969
MESH:D016889 Endometrial Neoplasms Doxorubicin 7.1717359293
MESH:D016889 Endometrial Neoplasms Estradiol 7.1718566989 11473722 19148513
MESH:D004715 Endometriosis celecoxib 14.5415652904
MESH:D004715 Endometriosis Progesterone 14.5416134523
MESH:D004715 Endometriosis Tetrachlorodibenzodioxin 14.5410568697 9294722
MESH:D004719 Endomyocardial Fibrosis Doxorubicin 4.9818037988
MESH:D020345 Enterocolitis, Necrotizing resveratrol 4.6817923197
MESH:D004938 Esophageal Neoplasms 4,4'-diaminodiphenylmethane 10.053581430
MESH:D004938 Esophageal Neoplasms 7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide 10.0520426865
MESH:D004938 Esophageal Neoplasms arsenic trioxide 10.0512903497
MESH:D004938 Esophageal Neoplasms Paclitaxel 10.0516481741
MESH:D005124 Eye Abnormalities Tetrachlorodibenzodioxin 2.8911564622
MESH:D005234 Fatty Liver arsenic trioxide 12.1515073043
MESH:D005234 Fatty Liver Ethinyl Estradiol 12.1515345470
MESH:D005234 Fatty Liver pirinixic acid 12.1520131406 19236843
MESH:D005313 Fetal Death Tetrachlorodibenzodioxin 3.2911858732
MESH:D005350 Fibroma 4,4'-diaminodiphenylmethane 4.856705139
MESH:D018222 Fibromatosis, Aggressive Doxorubicin 4.4219069698
MESH:D005355 Fibrosis Tetrachlorodibenzodioxin 2.7820067830
MESH:D005706 Gallbladder Neoplasms arsenic trioxide 4.1016904648
MESH:D005909 Glioblastoma Doxorubicin 3.2417150277
MESH:D006042 Goiter 4,4'-diaminodiphenylmethane 3.887505956
MESH:D006058 Gonadal Disorders Tetrachlorodibenzodioxin 4.4210696789
MESH:D006130 Growth Disorders Amiloride 4.6419703807
MESH:D006258 Head and Neck Neoplasms Doxorubicin 3.4115692506
MESH:D006330 Heart Defects, Congenital Tetrachlorodibenzodioxin 6.2711294989 10048152
MESH:D006330 Heart Defects, Congenital Vitamin E 6.2716080930
MESH:D006331 Heart Diseases Doxorubicin 3.3716244372 17888722 16495754 16879835 18006777 16144979 17875725 12587719 14766674 16330681 16244371 16707910 18674790
MESH:D006333 Heart Failure marker/mechanism 19429709
MESH:D006333 Heart Failure Doxorubicin 11.2017481944
MESH:D006333 Heart Failure pirinixic acid 11.2020558911
MESH:D006333 Heart Failure Selenium 11.2017162251
MESH:D006394 Hemangiosarcoma Doxorubicin 3.7415692506
MESH:D006470 Hemorrhage Tetrachlorodibenzodioxin 3.1811000095
MESH:D006505 Hepatitis 4,4'-diaminodiphenylmethane 3.356705139
MESH:D006529 Hepatomegaly pirinixic acid 7.7019772884 19176532 16221962 18467677
MESH:D006529 Hepatomegaly Tetrachlorodibenzodioxin 7.7012621046 16120746 15340226
MESH:D006548 Hernia, Diaphragmatic Vitamin E 2.6416863852 16490937
MESH:D006558 Herpes Genitalis Estradiol 4.8615709030
MESH:D006561 Herpes Simplex resveratrol 4.0116876885
MESH:D006689 Hodgkin Disease Doxorubicin 3.2715147373 17606976 18501091
MESH:D019584 Hot Flashes Estradiol 9.4717088409
MESH:D019584 Hot Flashes Vitamin E 9.4714716179
MESH:D006869 Hydronephrosis Tetrachlorodibenzodioxin 3.8716354765 18606429 16959395 8697196 15340226
MESH:D006937 Hypercholesterolemia resveratrol 3.8517188708
MESH:D006943 Hyperglycemia pirinixic acid 3.0320558911
MESH:D006949 Hyperlipidemias resveratrol 3.8716873680
MESH:D006965 Hyperplasia 4,4'-diaminodiphenylmethane 3.7715034207
MESH:D006973 Hypertension Amiloride 5.3818524855 19344079 15174897
MESH:D006973 Hypertension Tetrachlorodibenzodioxin 5.3818670907 18850075
MESH:D017379 Hypertrophy, Left Ventricular resveratrol 4.1517488730
MESH:D020514 Hypokalemic Periodic Paralysis Amiloride 5.6819822448
MESH:D007021 Hypospadias Ethinyl Estradiol 3.6416945680 16569931
MESH:D020244 Infarction, Middle Cerebral Artery Progesterone 10.9215869954
MESH:D020244 Infarction, Middle Cerebral Artery resveratrol 10.9217600658
MESH:D007247 Infertility, Female Ethinyl Estradiol 3.3012013081
MESH:D007248 Infertility, Male Ethinyl Estradiol 2.3717937319
MESH:D007249 Inflammation Amiloride 14.9617237260
MESH:D007249 Inflammation polyphenols 14.9616366677
MESH:D007249 Inflammation Progesterone 14.9615869954
MESH:D007249 Inflammation resveratrol 14.9616366677
MESH:D007249 Inflammation Tetrachlorodibenzodioxin 14.9612878042 12200463
MESH:D007251 Influenza, Human resveratrol 17.6316624496
MESH:D007251 Influenza, Human Selenium 17.6316624496
MESH:D007251 Influenza, Human Vitamin E 17.6316624496
MESH:D007333 Insulin Resistance Estradiol 6.8316627594 16393666
MESH:D007333 Insulin Resistance pirinixic acid 6.8316306350
MESH:D007565 Jaundice 4,4'-diaminodiphenylmethane 4.858074119 9022650
MESH:D007569 Jaw Abnormalities Tetrachlorodibenzodioxin 3.1816580747
MESH:D007674 Kidney Diseases Doxorubicin 9.5815699352 16775033 15369732
MESH:D007674 Kidney Diseases Estradiol 9.5815618244
MESH:D007674 Kidney Diseases Vitamin E 9.5812488133
MESH:D007676 Kidney Failure, Chronic Doxorubicin 9.4616707910
MESH:D007676 Kidney Failure, Chronic Selenium 9.4616518626
MESH:D007680 Kidney Neoplasms 2,4-dinitrotoluene 16.6016705839
MESH:D007680 Kidney Neoplasms 2,6-dinitrotoluene 16.6016705839
MESH:D007680 Kidney Neoplasms 4,4'-diaminodiphenylmethane 16.606582329
MESH:D007680 Kidney Neoplasms Estradiol 16.6015610895
MESH:D007938 Leukemia arsenic trioxide 2.7515070760
MESH:D004915 Leukemia, Erythroblastic, Acute Doxorubicin 4.9816085563
MESH:D015459 Leukemia-Lymphoma, Adult T-Cell arsenic trioxide 3.6417077332 12560223
MESH:D007948 Leukemia, Monocytic, Acute arsenic trioxide 4.1316972261
MESH:D015464 Leukemia, Myelogenous, Chronic, BCR-ABL Positive arsenic trioxide 3.3014633726
MESH:D007951 Leukemia, Myeloid arsenic trioxide 3.6019077051
MESH:D015470 Leukemia, Myeloid, Acute arsenic trioxide 2.1116467208 16968895 20471514 19850784 17050201
MESH:D015473 Leukemia, Promyelocytic, Acute arsenic trioxide 7.4219225113 15622746 9834237 12712474 16891316 19642359 17107899 17712046 11468182 17217047 17649720 12679006 15213294 16331271 11161223 15748426 19075265 17869043 16823087 15336539 16966277 12018890 19035177 16330433 16112521
MESH:D015473 Leukemia, Promyelocytic, Acute resveratrol 7.4216087638
MESH:D015458 Leukemia, T-Cell arsenic trioxide 4.1916882451
MESH:D056929 Liddle Syndrome Amiloride 5.8019344079
MESH:D008080 Liposarcoma Paclitaxel 4.6617353645
MESH:D008105 Liver Cirrhosis, Biliary 4,4'-diaminodiphenylmethane 3.0915034207 9327722
MESH:D008106 Liver Cirrhosis, Experimental Doxorubicin 6.5016595196 16439617
MESH:D008106 Liver Cirrhosis, Experimental Estradiol 6.5014716833 14659978
MESH:D008106 Liver Cirrhosis, Experimental pirinixic acid 6.5015474484
MESH:D008106 Liver Cirrhosis, Experimental Tetrachlorodibenzodioxin 6.5012878042
MESH:D008106 Liver Cirrhosis, Experimental Vitamin E 6.5016169303
MESH:D008107 Liver Diseases polyphenols 2.7416698588
MESH:D008113 Liver Neoplasms 2,6-dinitrotoluene 13.547678174
MESH:D008113 Liver Neoplasms arsenic trioxide 13.5414682389
MESH:D008113 Liver Neoplasms pirinixic acid 13.5420007298 16377806 15890375
MESH:D008113 Liver Neoplasms resveratrol 13.5419812893 19073162 19321006 20405173
MESH:D008113 Liver Neoplasms Tetrachlorodibenzodioxin 13.5416984957
MESH:D008114 Liver Neoplasms, Experimental 2,6-dinitrotoluene 17.522876784 2876786 6135515
MESH:D008114 Liver Neoplasms, Experimental 4,4'-diaminodiphenylmethane 17.521399818 3712494 598648 6587162
MESH:D008114 Liver Neoplasms, Experimental arsenic trioxide 17.5220377131
MESH:D008114 Liver Neoplasms, Experimental Doxorubicin 17.5216842330 17085340
MESH:D008114 Liver Neoplasms, Experimental Tetrachlorodibenzodioxin 17.5212151625
MESH:D008133 Long QT Syndrome arsenic trioxide 3.2215213294
MESH:D008171 Lung Diseases Vitamin E 3.0616863852
MESH:D008175 Lung Neoplasms arsenic trioxide 4.6919825857 11798837
MESH:D008175 Lung Neoplasms Doxorubicin 4.696189445 17418594
MESH:D008175 Lung Neoplasms Tetrachlorodibenzodioxin 4.6911884234 19555203
MESH:D008175 Lung Neoplasms Vitamin E 4.6911062179
MESH:D008223 Lymphoma Doxorubicin 3.3416098063
MESH:D016393 Lymphoma, B-Cell resveratrol 4.1417088997
MESH:D008228 Lymphoma, Non-Hodgkin Doxorubicin 13.8217654614
MESH:D008228 Lymphoma, Non-Hodgkin Paclitaxel 13.8214749477
MESH:D008228 Lymphoma, Non-Hodgkin resveratrol 13.8214749477
MESH:D016399 Lymphoma, T-Cell Doxorubicin 4.4015621674
MESH:D015674 Mammary Neoplasms, Animal resveratrol 4.0715688416
MESH:D008325 Mammary Neoplasms, Experimental celecoxib 22.1719196722 12104042
MESH:D008325 Mammary Neoplasms, Experimental Doxorubicin 22.1715458769
MESH:D008325 Mammary Neoplasms, Experimental Estradiol 22.1711807958 17203775 16891317 11408345
MESH:D008325 Mammary Neoplasms, Experimental Progesterone 22.1717203775 11408345
MESH:D008325 Mammary Neoplasms, Experimental resveratrol 22.178985016 11606380
MESH:D008325 Mammary Neoplasms, Experimental Selenium 22.1715318939
MESH:D020149 Manganese Poisoning Estradiol 4.3119453300
MESH:D008545 Melanoma Doxorubicin 5.1016827129
MESH:D008545 Melanoma Paclitaxel 5.1012040289 12025231 16342250
MESH:D008545 Melanoma resveratrol 5.1017992120
MESH:D008654 Mesothelioma Doxorubicin 6.0617638057
MESH:D008654 Mesothelioma Selenium 6.0615107826
MESH:D008659 Metabolic Diseases resveratrol 4.2217112576
MESH:D028361 Mitochondrial Diseases Doxorubicin 4.3415792986
MESH:D052016 Mucositis Doxorubicin 4.6217415656
MESH:D009101 Multiple Myeloma arsenic trioxide 16.3619549372 14977855 11468182 19417148 15949261
MESH:D009101 Multiple Myeloma celecoxib 16.3616123214
MESH:D009101 Multiple Myeloma Paclitaxel 16.3614749477
MESH:D009101 Multiple Myeloma resveratrol 16.3617935668 16490592 16267019 17049120 14749477 17164350
MESH:D009134 Muscular Atrophy, Spinal resveratrol 4.7017962980
MESH:D009135 Muscular Diseases pirinixic acid 3.3416239165
MESH:D009182 Mycosis Fungoides arsenic trioxide 4.5018349030
MESH:D009190 Myelodysplastic Syndromes arsenic trioxide 3.0516105982 16882451
MESH:D009203 Myocardial Infarction Doxorubicin 9.1015857846 19429709
MESH:D009203 Myocardial Infarction pirinixic acid 9.1019151258
MESH:D009203 Myocardial Infarction resveratrol 9.1016525036 16456233 17188708 16317513 17015251 17125593
MESH:D017202 Myocardial Ischemia resveratrol 8.5617015251 17125593
MESH:D017202 Myocardial Ischemia Tetrachlorodibenzodioxin 8.5612213967
MESH:D015428 Myocardial Reperfusion Injury Estradiol 7.8116810080
MESH:D015428 Myocardial Reperfusion Injury pirinixic acid 7.8116411023
MESH:D009205 Myocarditis resveratrol 4.5917322642
MESH:D009336 Necrosis 2,4-dinitrotoluene 9.7718551238
MESH:D009336 Necrosis 2,6-dinitrotoluene 9.777678174 18551238
MESH:D009361 Neoplasm Invasiveness Amiloride 10.1114644129
MESH:D009361 Neoplasm Invasiveness arsenic trioxide 10.1116624393
MESH:D009362 Neoplasm Metastasis 4,4'-diaminodiphenylmethane 9.213581430
MESH:D009362 Neoplasm Metastasis Doxorubicin 9.2118259882
MESH:D009362 Neoplasm Metastasis Paclitaxel 9.2115867366
MESH:D009369 Neoplasms pirinixic acid 1.8717405874
MESH:D009374 Neoplasms, Experimental resveratrol 3.838985016
MESH:D009376 Neoplasms, Hormone-Dependent celecoxib 5.2619196722
MESH:D009389 Neovascularization, Pathologic Estradiol 3.5617289903
MESH:D009401 Nephrosis Doxorubicin 4.6016899518 16636307
MESH:D009404 Nephrotic Syndrome Doxorubicin 3.8515640375 16889571
MESH:D009421 Nervous System Malformations Estradiol 8.9111399458 16427766
MESH:D009421 Nervous System Malformations Tetrachlorodibenzodioxin 8.9114600291
MESH:D009436 Neural Tube Defects 4,4'-diaminodiphenylmethane 6.886679447
MESH:D009436 Neural Tube Defects arsenic trioxide 6.8810525206
MESH:D009447 Neuroblastoma Doxorubicin 3.1815555623
MESH:D019636 Neurodegenerative Diseases resveratrol 3.6717652729
MESH:D020078 Neurogenic Inflammation resveratrol 4.2417929310
MESH:D009765 Obesity pirinixic acid 1.7720558911
MESH:D009784 Occupational Diseases 2,4-dinitrotoluene 14.1916049721 12819281
MESH:D009784 Occupational Diseases 2,6-dinitrotoluene 14.1916049721
MESH:D009784 Occupational Diseases 4,4'-diaminodiphenylmethane 14.194026338 6482804
MESH:D009902 Optic Neuritis 4,4'-diaminodiphenylmethane 4.853988306
MESH:D010014 Osteolysis Paclitaxel 4.8115867366
MESH:D015663 Osteoporosis, Postmenopausal resveratrol 4.0917513867
MESH:D012516 Osteosarcoma Doxorubicin 3.9815930896
MESH:D010051 Ovarian Neoplasms arsenic trioxide 10.8819769630 16624393 12452020
MESH:D010051 Ovarian Neoplasms Estradiol 10.8819401270
MESH:D010051 Ovarian Neoplasms Paclitaxel 10.8811161223
MESH:D010051 Ovarian Neoplasms Progesterone 10.8817393432 16525653
MESH:D010190 Pancreatic Neoplasms arsenic trioxide 5.4815580305
MESH:D010190 Pancreatic Neoplasms gemcitabine 5.4817440100 18383843 11504793 16929163 18992248
MESH:D016584 Panic Disorder Ethinyl Estradiol 3.5311578682
MESH:D010212 Papilloma 4,4'-diaminodiphenylmethane 3.317296757
MESH:D010235 Paraganglioma arsenic trioxide 4.0019927285
MESH:D010382 Peliosis Hepatis Tetrachlorodibenzodioxin 4.0812520081
MESH:D010787 Photosensitivity Disorders 4,4'-diaminodiphenylmethane 4.306228378
MESH:D003557 Phyllodes Tumor Doxorubicin 4.9817983394
MESH:D010954 Plasmacytoma Selenium 4.7215087411
MESH:D010997 Pleural Neoplasms Doxorubicin 4.9817638057
MESH:D017119 Porphyria Cutanea Tarda Tetrachlorodibenzodioxin 3.3918163543
MESH:D011297 Prenatal Exposure Delayed Effects resveratrol 9.0216679765
MESH:D011297 Prenatal Exposure Delayed Effects Tetrachlorodibenzodioxin 9.0211399792 11896295 11118676 11222880
MESH:D019048 Prostatic Intraepithelial Neoplasia Estradiol 3.7320887781
MESH:D011471 Prostatic Neoplasms arsenic trioxide 2.0819131511
MESH:D011471 Prostatic Neoplasms celecoxib 2.0815570007 17908994
MESH:D011471 Prostatic Neoplasms Doxorubicin 2.0815897917 16729912 16868541 15749863 16888761 18437689
MESH:D011471 Prostatic Neoplasms Estradiol 2.0816740699
MESH:D011471 Prostatic Neoplasms Paclitaxel 2.0817136230 16729912 17172428 16356831
MESH:D011471 Prostatic Neoplasms resveratrol 2.0817675339 17636462 16731767 17804756 17718901 15767336
MESH:D011471 Prostatic Neoplasms Vitamin E 2.0815084515
MESH:D011537 Pruritus Ethinyl Estradiol 3.1416919318 15861022
MESH:D051437 Renal Insufficiency Doxorubicin 4.0517922066
MESH:D051436 Renal Insufficiency, Chronic resveratrol 5.4116325855
MESH:D015427 Reperfusion Injury pirinixic acid 6.2919058328
MESH:D015427 Reperfusion Injury resveratrol 6.2917520802 17058453 16314181 15827377 16317513
MESH:D015619 Respiratory System Abnormalities Tetrachlorodibenzodioxin 3.6718990726
MESH:D012162 Retinal Degeneration 4,4'-diaminodiphenylmethane 3.253692021
MESH:D012468 Salivary Gland Neoplasms Progesterone 2.8018045962
MESH:D012509 Sarcoma Doxorubicin 3.8417203757 17710206 16767912 15675481 18313854 15625365
MESH:D012512 Sarcoma, Ewing's arsenic trioxide 9.7216646077
MESH:D012512 Sarcoma, Ewing's Doxorubicin 9.7214601052 16326096
MESH:D012514 Sarcoma, Kaposi Doxorubicin 4.6217846226
MESH:D012640 Seizures 2,4-dinitrotoluene 5.4818551238
MESH:D012640 Seizures 2,6-dinitrotoluene 5.4818551238
MESH:D012871 Skin Diseases Vitamin E 2.4018709164
MESH:D012878 Skin Neoplasms Doxorubicin 9.0615692506
MESH:D012878 Skin Neoplasms resveratrol 9.068985016 15837718
MESH:D012878 Skin Neoplasms Tetrachlorodibenzodioxin 9.0616192470
MESH:D012983 Soft Tissue Neoplasms Doxorubicin 4.4015625365 17203757 16767912
MESH:D013088 Spermatocele Ethinyl Estradiol 3.7716709447
MESH:D013119 Spinal Cord Injuries Progesterone 4.1115862959 16503802
MESH:D013274 Stomach Neoplasms arsenic trioxide 3.5517007042
MESH:D013274 Stomach Neoplasms celecoxib 3.5515609394
MESH:D013274 Stomach Neoplasms Paclitaxel 3.5518396642 18506536
MESH:D020521 Stroke Vitamin E 3.3816517955
OMIM:601367 STROKE, ISCHEMIC resveratrol 4.3316321402
MESH:D024801 Tauopathies Paclitaxel 4.6416930453
MESH:D013705 Temporomandibular Joint Disorders polyphenols 5.0817997062
MESH:D019851 Thrombophilia Ethinyl Estradiol 3.4611994571
MESH:D013927 Thrombosis Ethinyl Estradiol 3.0115669648
MESH:D013959 Thyroid Diseases Tetrachlorodibenzodioxin 3.7312697716
MESH:D013964 Thyroid Neoplasms 4,4'-diaminodiphenylmethane 11.261399818 6582329 3712494 6587162 7505956
MESH:D013964 Thyroid Neoplasms arsenic trioxide 11.2619014326
MESH:D013964 Thyroid Neoplasms Doxorubicin 11.2617909728 16010429
MESH:D013978 Tibial Fractures Estradiol 4.5119048282
MESH:D014062 Tongue Neoplasms resveratrol 4.0616227395
MESH:D016171 Torsades de Pointes arsenic trioxide 3.7915213294
MESH:D001749 Urinary Bladder Neoplasms 2,4-dinitrotoluene 15.0916049721
MESH:D001749 Urinary Bladder Neoplasms 2,6-dinitrotoluene 15.0916049721
MESH:D001749 Urinary Bladder Neoplasms 4,4'-diaminodiphenylmethane 15.098074119
MESH:D001749 Urinary Bladder Neoplasms arsenic trioxide 15.0912973940 20435036 11780464 12845720
MESH:D001749 Urinary Bladder Neoplasms Doxorubicin 15.0917653716
MESH:D014571 Urologic Neoplasms 2,4-dinitrotoluene 11.4110091137
MESH:D014571 Urologic Neoplasms 2,6-dinitrotoluene 11.4110091137
MESH:D002583 Uterine Cervical Neoplasms resveratrol 3.9517473185
MESH:D014594 Uterine Neoplasms celecoxib 15.2518645019
MESH:D014594 Uterine Neoplasms Ethinyl Estradiol 15.2514692618
MESH:D014594 Uterine Neoplasms resveratrol 15.2517044934
MESH:D054079 Vascular Malformations Tetrachlorodibenzodioxin 4.4212125929
MESH:D020246 Venous Thrombosis Ethinyl Estradiol 3.3815869587 14671159
MESH:D018487 Ventricular Dysfunction, Left Doxorubicin 9.7717638931 17334414 16364871 17678736
MESH:D018487 Ventricular Dysfunction, Left resveratrol 9.7717488730
MESH:D019282 Wasting Syndrome Tetrachlorodibenzodioxin 4.0815886252
Pathway ID Pathway Name
KEGG:04960 Aldosterone-regulated sodium reabsorption
KEGG:05213 Endometrial cancer
KEGG:04510 Focal adhesion
REACT:604 Hemostasis
KEGG:04910 Insulin signaling pathway
REACT:13552 Integrin cell surface interactions
KEGG:04150 mTOR signaling pathway
KEGG:05223 Non-small cell lung cancer
KEGG:03320 PPAR signaling pathway
KEGG:05215 Prostate cancer
REACT:14797 Signaling by GPCR
REACT:498 Signaling by Insulin receptor
REACT:6900 Signaling in Immune system
REACT:11061 Signalling by NGF
REACT:13685 Synaptic Transmission
Pharmacogenomics Knowledge Base Top
  • PharmGKB Accession:PA33160
    • No data
    No data
    Releated drug ID Related drug Name
    PA449167cyclosporine
    PA451578tacrolimus
    PA164743471adenosine triphosphate
    PA10804imatinib
    PA451365sirolimus
    PA448547beclomethasone
    PA164754818betamethasone
    PA448681budesonide
    PA164781399ciclesonide
    PA164776996desonide
    PA449247dexamethasone
    PA449661flunisolide
    PA449686fluticasone propionate
    PA452347glucocorticoids
    PA449905hydrocortisone
    PA450466methylprednisolone
    PA450541mometasone
    PA164777035paramethasone
    PA451096prednisolone
    PA451100prednisone
    PA164752251rimexolone
    PA451749triamcinolone
    PA164744376adenosine monophosphate
    PA448478l-arginine
    PA164747225l-citrulline
    PA450635nitric oxide
    PA450191lecithin
    Drug Bank Top
    Drugbank ID Action Drug Name Description
    DB00482 antagonist Celecoxib Cyclooxygenase Inhibitors
    DB01933 - 7-Hydroxystaurosporine Antineoplastic Agents;Protein Kinase Inhibitors
    DB01946 - 3-[1-(3-Aminopropyl)-1h-Indol-3-Yl]-4-(1-Methyl-1h-Indol-3-Yl)-1h-Pyrrole-2,5-Dione
    DB02010 - Staurosporine Enzyme Inhibitors
    DB03265 - Inositol-(1,3,4,5)-Tetrakisphosphate
    DB03777 - Rbt205 Inhibitor
    DB04522 - Phosphonoserine
    DB06932 - 10,11-dimethoxy-4-methyldibenzo[c,f]-2,7-naphthyridine-3,6-diamine
    DB07033 - 5-HYDROXY-3-[(1R)-1-(1H-PYRROL-2-YL)ETHYL]-2H-INDOL-2-ONE
    DB07132 - 1-{2-OXO-3-[(1R)-1-(1H-PYRROL-2-YL)ETHYL]-2H-INDOL-5-YL}UREA
    DB07300 - 2-(1H-imidazol-1-yl)-9-methoxy-8-(2-methoxyethoxy)benzo[c][2,7]naphthyridin-4-amine
    DB07456 - 3-(1H-INDOL-3-YL)-4-(1-{2-[(2S)-1-METHYLPYRROLIDINYL]ETHYL}-1H-INDOL-3-YL)-1H-PYRROLE-2,5-DIONE
    DB07457 - 3-[1-(3-AMINOPROPYL)-1H-INDOL-3-YL]-4-(1H-INDOL-3-YL)-1H-PYRROLE-2,5-DIONE
    No data
    No data
    No data

    Simple Query:


      (e.g. CHD8)

    Syndromic Genes

    Non-syndromic Genes

    AutismKB Statistics

    • Studies: 1,036
    • Genes: 1,379
    • CNVs/SVs: 5,420
    • SNVs/Indels: 11,669
    • de novo Mutations: 5,669
    • Mosaics: 789
    • Linkage Regions: 172
    • Paper Collected: 6/30/2018
    • Last Update: 8/26/2018


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