AutismKB 2.0

Annotation Detail for ACSL5


View Evidences View Variants View Annotations
Basic Information Top
Gene Symbol:ACSL5 ( ACS2,ACS5,FACL5 )
Gene Full Name: acyl-CoA synthetase long-chain family member 5
Band: 10q25.2
Quick LinksEntrez ID:51703; OMIM: 605677; Uniprot ID:ACSL5_HUMAN; ENSEMBL ID: ENSG00000197142; HGNC ID: 16526
Relate to Another Database: SFARIGene; denovo-db
Related Pathway Information Top
Pathway IDPathway Name
PWY-5972stearate biosynthesis I (animals)
FAO-PWYfatty acid beta-oxidation I
Pathway IDPathway Name
hsa04920Adipocytokine signaling pathway
hsa03320PPAR signaling pathway
hsa01100Metabolic pathways
hsa04146Peroxisome
hsa00071Fatty acid metabolism
Pathway IDPathway Name
Metabolism of lipids and lipoproteins
No data
No data
Pathway IDPathway Name
500802Synthesis of very long-chain fatty acyl-CoAs
Related Diseases/Disorders Top
Comparative Toxicogenomics Database Top
Chemical ID Chemical Name Interaction Interaction Action Publication
C016403 2,4-dinitrotoluene 2,4-dinitrotoluene affects the expression of ACSL5 mRNAaffects expression 21346803
C023514 2,6-dinitrotoluene 2,6-dinitrotoluene affects the expression of ACSL5 mRNAaffects expression 21346803
D016604 Aflatoxin B1 Aflatoxin B1 affects the expression of ACSL5 proteinaffects expression 20106945
D001564 Benzo(a)pyrene Benzo(a)pyrene affects the expression of ACSL5 mRNAaffects expression 20106945
D001629 Bezafibrate Bezafibrate results in increased expression of ACSL5 mRNAincreases expression 17118139
D002251 Carbon Tetrachloride Carbon Tetrachloride results in increased expression of ACSL5 mRNAincreases expression 17484886
D016572 Cyclosporine Cyclosporine results in decreased expression of ACSL5 mRNAdecreases expression 20106945
D004041 Dietary Fats Dietary Fats results in decreased expression of ACSL5 mRNAdecreases expression 18042831
D004052 Diethylnitrosamine Diethylnitrosamine results in decreased expression of ACSL5 mRNAdecreases expression 19638242
D004054 Diethylstilbestrol Diethylstilbestrol results in increased expression of ACSL5 mRNAincreases expression 17005392
D004958 Estradiol Estradiol results in decreased expression of ACSL5 mRNAdecreases expression 20106945
D004997 Ethinyl Estradiol Ethinyl Estradiol results in decreased expression of ACSL5 mRNAdecreases expression 17108234
D004997 Ethinyl Estradiol Ethinyl Estradiol results in increased expression of ACSL5 mRNAincreases expression 16174780
D011345 Fenofibrate Fenofibrate results in increased expression of ACSL5 mRNAincreases expression 17118139
D005485 Flutamide Flutamide results in decreased expression of ACSL5 mRNAdecreases expression 17702527
D001556 Lindane Lindane results in decreased expression of ACSL5 mRNAdecreases expression 17785943
D008094 Lithium Lithium inhibits the reaction [Methamphetamine results in increased expression of ACSL5 mRNA]decreases reaction|increases expression 19149911
D008694 Methamphetamine Lithium inhibits the reaction [Methamphetamine results in increased expression of ACSL5 mRNA]decreases reaction|increases expression 19149911
D008694 Methamphetamine Methamphetamine results in increased expression of ACSL5 mRNAincreases expression 19149911
C014707 nitrosobenzylmethylamine nitrosobenzylmethylamine results in increased expression of ACSL5 mRNAincreases expression 17616710
C041786 palm oil palm oil results in decreased expression of ACSL5 mRNAdecreases expression 18042831
C023036 perfluorooctanoic acid perfluorooctanoic acid results in increased expression of ACSL5 mRNAincreases expression 17681415
18467677
C023036 perfluorooctanoic acid PPARA protein promotes the reaction [perfluorooctanoic acid results in increased expression of ACSL5 mRNA]increases expression|increases reaction 18467677
D010852 Picrotoxin Picrotoxin results in decreased expression of ACSL5 mRNAdecreases expression 15170462
C006253 pirinixic acid [pirinixic acid binds to and results in increased activity of PPARA protein] which results in increased expression of ACSL5 mRNAaffects binding|increases activity|increases expression 19710929
C006253 pirinixic acid pirinixic acid results in increased expression of ACSL5 mRNAincreases expression 20059764
18301758
17118139
18467677
15375163
C006253 pirinixic acid PPARA protein promotes the reaction [pirinixic acid results in increased expression of ACSL5 mRNA]increases expression|increases reaction 20059764
18467677
C045950 propiconazole propiconazole results in decreased expression of ACSL5 mRNAdecreases expression 19423681
D014284 Triiodothyronine Triiodothyronine results in increased expression of ACSL5 mRNAincreases expression 15953391
D013749 Tetrachlorodibenzodioxin Tetrachlorodibenzodioxin results in decreased expression of ACSL5 mRNAdecreases expression 20106945
D014415 Tunicamycin Tunicamycin results in increased expression of ACSL5 mRNAincreases expression 17127020
C025643 vinclozolin vinclozolin affects the expression of ACSL5 mRNAaffects expression 19015723
Disease ID Disease Name Direct Evidence Inference Chemical Name Inference Score Publication
MESH:D000014 Abnormalities, Drug-Induced Tetrachlorodibenzodioxin 2.6211752688 15322242 14514962
MESH:D000152 Acne Vulgaris Ethinyl Estradiol 3.7117505938
MESH:D055371 Acute Lung Injury pirinixic acid 2.9118653653
MESH:D000230 Adenocarcinoma Benzo(a)pyrene 6.6520127859 20464547
MESH:D000230 Adenocarcinoma Estradiol 6.6511473722
MESH:D000230 Adenocarcinoma Ethinyl Estradiol 6.6514692618
MESH:D000236 Adenoma Benzo(a)pyrene 6.206695378
MESH:D000236 Adenoma Diethylnitrosamine 6.206695378 10737359
MESH:D018248 Adenoma, Liver Cell Diethylnitrosamine 15.9517162532 19052882 17620307 16434500 18056438 19061943
MESH:D018248 Adenoma, Liver Cell pirinixic acid 15.9516434500
MESH:D018248 Adenoma, Liver Cell Tetrachlorodibenzodioxin 15.9516835633
MESH:D000382 Agricultural Workers' Diseases Lindane 4.1512661182
MESH:D000544 Alzheimer Disease Lithium 3.4219621015
MESH:D000686 Amyloidosis Diethylstilbestrol 4.2615469931
MESH:D000740 Anemia Tetrachlorodibenzodioxin 2.7511748828
MESH:D001008 Anxiety Disorders vinclozolin 3.4619015723
MESH:D017544 Aortic Aneurysm, Abdominal Benzo(a)pyrene 3.8519183758
MESH:D001161 Arteriosclerosis Dietary Fats 9.1615238619
MESH:D001161 Arteriosclerosis Ethinyl Estradiol 9.1611256880
MESH:D001169 Arthritis, Experimental marker/mechanism 18988084
MESH:D001169 Arthritis, Experimental Ethinyl Estradiol 2.5315885639
MESH:D001714 Bipolar Disorder Lithium 4.2117594078 20046352 19153942 20338123
MESH:D001778 Blood Coagulation Disorders pirinixic acid 8.0919483382
MESH:D001778 Blood Coagulation Disorders Tetrachlorodibenzodioxin 8.0912125929
MESH:D001836 Body Weight Changes Tetrachlorodibenzodioxin 3.5615340226
MESH:D001848 Bone Diseases, Developmental Tetrachlorodibenzodioxin 2.6215746008
MESH:D001943 Breast Neoplasms Benzo(a)pyrene 3.6220146248 17474063
MESH:D001943 Breast Neoplasms Dietary Fats 3.6220435547
MESH:D001943 Breast Neoplasms Diethylnitrosamine 3.6217474063
MESH:D001943 Breast Neoplasms Diethylstilbestrol 3.6215324884 17129689
MESH:D001943 Breast Neoplasms Estradiol 3.6219861407 12948864 17261762 16675129 18497071 17018787 14630087 17289903
MESH:D001943 Breast Neoplasms Lindane 3.6214688026
MESH:D001943 Breast Neoplasms Tetrachlorodibenzodioxin 3.6220435547
MESH:D002181 Candidiasis, Vulvovaginal Estradiol 4.2316111702
MESH:D002252 Carbon Tetrachloride Poisoning Carbon Tetrachloride 3.563786805 16097048 15673190 16011737 10355542 16124888 15721981 16192424 15700767 18705752 16227642 16050911
MESH:D002277 Carcinoma Tetrachlorodibenzodioxin 2.6216835633
MESH:D006528 Carcinoma, Hepatocellular 2,4-dinitrotoluene 13.4916705839
MESH:D006528 Carcinoma, Hepatocellular 2,6-dinitrotoluene 13.4916705839
MESH:D006528 Carcinoma, Hepatocellular Aflatoxin B1 13.4921507988 12619106 12907637
MESH:D006528 Carcinoma, Hepatocellular Carbon Tetrachloride 13.4918788625
MESH:D006528 Carcinoma, Hepatocellular Diethylnitrosamine 13.4916328049 20935162 16698587 19171122 16935385 19394651 20214788 18785209 20514400 11831363 18506893 17761372 19701751 17428255 16830150 19052882 18788625 16288022 16540662 20084675 20727157 3084413 17055752 16807293 19919837 19539802 10672840 17138121 16502159 18393292 16569478 17173139 16878318 17978847 19208518 18210153 18978308 19519916 10737359 19107877 19383236 17162532 20101231 20007298 18056438 18691550 16681979 20432363 19335982 18494052 3581430 16779866 21159647 18971187 19822196 19418558 20524982 20512989 18665156
MESH:D006528 Carcinoma, Hepatocellular Diethylstilbestrol 13.4916924424 15948411
MESH:D006528 Carcinoma, Hepatocellular Estradiol 13.4916924424
MESH:D002294 Carcinoma, Squamous Cell Benzo(a)pyrene 1.9920419170
MESH:D006332 Cardiomegaly Tetrachlorodibenzodioxin 2.2416120746 18670907 18850075
MESH:D002471 Cell Transformation, Neoplastic 2,6-dinitrotoluene 14.736135515
MESH:D002471 Cell Transformation, Neoplastic Cyclosporine 14.7312371664
MESH:D002471 Cell Transformation, Neoplastic Diethylnitrosamine 14.7317174075 7505956 21159647 2727394
MESH:D002471 Cell Transformation, Neoplastic Estradiol 14.7318566989
MESH:D018281 Cholangiocarcinoma Diethylnitrosamine 8.6919052882
MESH:D018281 Cholangiocarcinoma Tetrachlorodibenzodioxin 8.6916835633
MESH:D002779 Cholestasis Cyclosporine 12.3819486331
MESH:D002779 Cholestasis Ethinyl Estradiol 12.3817681005 16105132 17333356 16919318 17110522 11677210 15861022
MESH:D002779 Cholestasis pirinixic acid 12.3819176532
MESH:D002972 Cleft Palate Tetrachlorodibenzodioxin 2.018697196 15340226 16354765 12621046 15668235
MESH:D000013 Congenital Abnormalities Tetrachlorodibenzodioxin 2.8714669216 17141729
MESH:D019465 Craniofacial Abnormalities Tetrachlorodibenzodioxin 1.2415322242 20055451 10048152
MESH:D003456 Cryptorchidism Diethylstilbestrol 10.6412952375 16002989
MESH:D003456 Cryptorchidism vinclozolin 10.6414966744
MESH:D003490 Cyanosis 2,4-dinitrotoluene 10.1418551238
MESH:D003490 Cyanosis 2,6-dinitrotoluene 10.1418551238
MESH:D007644 Darier Disease Lithium 5.6820338123
MESH:D003876 Dermatitis, Atopic pirinixic acid 2.3218249437
MESH:D018500 Diabetes Insipidus, Nephrogenic Lithium 5.5219244398
MESH:D003924 Diabetes Mellitus, Type 2 Diethylnitrosamine 4.0320387270
MESH:D003924 Diabetes Mellitus, Type 2 Tetrachlorodibenzodioxin 4.0317107852
MESH:D003928 Diabetic Nephropathies Estradiol 3.2219279558
MESH:D056486 Drug-Induced Liver Injury 2,4-dinitrotoluene 11.2621346803 18551238
MESH:D056486 Drug-Induced Liver Injury 2,6-dinitrotoluene 11.2621346803 18551238
MESH:D056486 Drug-Induced Liver Injury Carbon Tetrachloride 11.2617522070 19085960 3786805 15968718 4309450 16177239 9327722 10915739 15998439 7440962 6884620 15027814 3732212 21278145 16227642 7179309 7120509 2869522 10092053 19336974 6623471 11566570
MESH:D056486 Drug-Induced Liver Injury Diethylnitrosamine 11.2619107877
MESH:D056486 Drug-Induced Liver Injury Tetrachlorodibenzodioxin 11.2620420201
MESH:D004362 Drug Toxicity Tetrachlorodibenzodioxin 2.5911462148
MESH:D050171 Dyslipidemias Dietary Fats 8.4118367378
MESH:D050171 Dyslipidemias Fenofibrate 8.4116707586
MESH:D004487 Edema perfluorooctanoic acid 10.2812083418 17259670
MESH:D004487 Edema pirinixic acid 10.2812083418
MESH:D004487 Edema Tetrachlorodibenzodioxin 10.2812711302 11000095
MESH:D004489 Edema, Cardiac Tetrachlorodibenzodioxin 3.6715322242 16714409 18230668
MESH:D004681 Encephalomyelitis, Autoimmune, Experimental Ethinyl Estradiol 2.9712538720
MESH:D004714 Endometrial Hyperplasia Diethylstilbestrol 4.4616402032
MESH:D016889 Endometrial Neoplasms Diethylstilbestrol 11.7616804899 15700306
MESH:D016889 Endometrial Neoplasms Estradiol 11.7611473722 18566989 19148513
MESH:D016889 Endometrial Neoplasms Fenofibrate 11.7616569247
MESH:D004715 Endometriosis Tetrachlorodibenzodioxin 2.829294722 10568697
MESH:D004931 Esophageal Achalasia Diethylnitrosamine 4.8916302075
MESH:D004938 Esophageal Neoplasms Benzo(a)pyrene 4.4116530937
MESH:D004938 Esophageal Neoplasms nitrosobenzylmethylamine 4.4116805852 15623463 15547721 16510608 16704527 15264214 15878914 15150132 15547733
MESH:D005124 Eye Abnormalities Tetrachlorodibenzodioxin 2.8411564622
MESH:D005234 Fatty Liver Carbon Tetrachloride 28.0419224547 16045604 17595544 12631006 16239168 61145 15959796 12795759
MESH:D005234 Fatty Liver Cyclosporine 28.0419224547
MESH:D005234 Fatty Liver Dietary Fats 28.0419551842 17967931 18296743 19004024
MESH:D005234 Fatty Liver Diethylnitrosamine 28.0421071580 20387270
MESH:D005234 Fatty Liver Ethinyl Estradiol 28.0415345470
MESH:D005234 Fatty Liver pirinixic acid 28.0419236843 20131406
MESH:D052776 Female Urogenital Diseases Diethylstilbestrol 3.5216513791 16611131 15751030 16534752 16002989
MESH:D005313 Fetal Death Tetrachlorodibenzodioxin 3.2311858732
MESH:D005355 Fibrosis Carbon Tetrachloride 19.2818705752
MESH:D005355 Fibrosis Cyclosporine 19.2812168785 12639820
MESH:D005355 Fibrosis Dietary Fats 19.2818296743
MESH:D005355 Fibrosis Tetrachlorodibenzodioxin 19.2820067830
MESH:D030342 Genetic Diseases, Inborn vinclozolin 4.7016973722
MESH:D005832 Genital Diseases, Male vinclozolin 5.0716417039
MESH:D005833 Genital Neoplasms, Female Diethylstilbestrol 4.7216452187
MESH:D005885 Gingival Hyperplasia Cyclosporine 3.998708960
MESH:D006058 Gonadal Disorders Tetrachlorodibenzodioxin 4.3610696789
MESH:D006330 Heart Defects, Congenital Benzo(a)pyrene 10.5820471113
MESH:D006330 Heart Defects, Congenital Lithium 10.5819638421
MESH:D006330 Heart Defects, Congenital Tetrachlorodibenzodioxin 10.5811294989 10048152
MESH:D006333 Heart Failure pirinixic acid 2.4020558911
MESH:D006457 Hemoglobinuria, Paroxysmal Cyclosporine 4.1915720958
MESH:D006470 Hemorrhage Tetrachlorodibenzodioxin 3.1311000095
MESH:D006505 Hepatitis Carbon Tetrachloride 3.3819900420 19110552
MESH:D006529 Hepatomegaly perfluorooctanoic acid 18.903609246
MESH:D006529 Hepatomegaly pirinixic acid 18.9019176532 18467677 19772884 16221962
MESH:D006529 Hepatomegaly propiconazole 18.9017178688 17178689
MESH:D006529 Hepatomegaly Tetrachlorodibenzodioxin 18.9015340226 12621046 16120746
MESH:D006558 Herpes Genitalis Estradiol 4.8015709030
MESH:D019584 Hot Flashes Estradiol 3.5217088409
MESH:D006869 Hydronephrosis Tetrachlorodibenzodioxin 3.8116354765 18606429 16959395 15340226 8697196
MESH:D006930 Hyperalgesia perfluorooctanoic acid 3.6712083418
MESH:D017588 Hyperandrogenism Flutamide 5.2315356085
MESH:D006932 Hyperbilirubinemia Carbon Tetrachloride 4.3016899240
MESH:D006937 Hypercholesterolemia Dietary Fats 3.3921332399
MESH:D006943 Hyperglycemia pirinixic acid 2.9920558911
MESH:D006948 Hyperkinesis Methamphetamine 5.2817658665
MESH:D006949 Hyperlipidemias Dietary Fats 3.4021332399
MESH:D006965 Hyperplasia Diethylstilbestrol 4.2114722030 12960047
MESH:D006973 Hypertension Cyclosporine 4.6610903974
MESH:D006973 Hypertension Tetrachlorodibenzodioxin 4.6618850075 18670907
MESH:D006975 Hypertension, Portal Carbon Tetrachloride 3.8615338365
MESH:D007021 Hypospadias Diethylstilbestrol 10.4916002989
MESH:D007021 Hypospadias Ethinyl Estradiol 10.4916945680 16569931
MESH:D007246 Infertility Diethylstilbestrol 4.1415036965
MESH:D007247 Infertility, Female Ethinyl Estradiol 3.2512013081
MESH:D007248 Infertility, Male Ethinyl Estradiol 6.1617937319
MESH:D007248 Infertility, Male vinclozolin 6.1616467254
MESH:D007249 Inflammation Dietary Fats 11.0020412841
MESH:D007249 Inflammation Diethylnitrosamine 11.0018785209
MESH:D007249 Inflammation perfluorooctanoic acid 11.0012083418
MESH:D007249 Inflammation Tetrachlorodibenzodioxin 11.0012878042 12200463
MESH:D007333 Insulin Resistance Dietary Fats 11.4411836018 18457598
MESH:D007333 Insulin Resistance Estradiol 11.4416393666 16627594
MESH:D007333 Insulin Resistance pirinixic acid 11.4416306350
MESH:D007569 Jaw Abnormalities Tetrachlorodibenzodioxin 3.1316580747
MESH:D007638 Keratoconjunctivitis Sicca Cyclosporine 4.2115604871
MESH:D007674 Kidney Diseases Cyclosporine 5.508314463 10903974 18776723
MESH:D007674 Kidney Diseases Estradiol 5.5015618244
MESH:D007680 Kidney Neoplasms 2,4-dinitrotoluene 21.3716705839
MESH:D007680 Kidney Neoplasms 2,6-dinitrotoluene 21.3716705839
MESH:D007680 Kidney Neoplasms Cyclosporine 21.3712371664
MESH:D007680 Kidney Neoplasms Diethylstilbestrol 21.3716762066 15003126 14681315
MESH:D007680 Kidney Neoplasms Estradiol 21.3715610895
MESH:D007859 Learning Disorders Diethylstilbestrol 3.8417184923
MESH:D007984 Leydig Cell Tumor perfluorooctanoic acid 12.178812269
MESH:D007984 Leydig Cell Tumor vinclozolin 12.1716417039
MESH:D008103 Liver Cirrhosis Carbon Tetrachloride 10.2917157831 16239168 11903743 11408273 16943688 17334410 17174718 16221502 21278145
MESH:D008103 Liver Cirrhosis Dietary Fats 10.2918296743
MESH:D008103 Liver Cirrhosis Diethylnitrosamine 10.2918665156 18407596 18522880 20032147 19638242
MESH:D008106 Liver Cirrhosis, Experimental Carbon Tetrachloride 6.4215931870 16011737 15730626 15959796 16638106 12666154 17761835 14748882 17631135 17823541 12546737 18263696 15818738 17976157 15338365 15650968 18251166 12389079 18187930 15925388 15996030 18472094 17766677 18317297 18412020 16136751 17922224 14512876 17805973 17565644 12632514 18054572 18210741 15893842 15673190 17698563 12632512 12445418 17708605 18277467 12958196 12649538 16192424 17481882 15123356 14716496 12586293 18006644 17557913 18472332 18376398 17869086 12898905 16015684 18339082 14620537 17714472 16116963 15362042 15370692 16248980 17525996 18395914 12667390 17900296 13678700 18205269 18481824 16097048 10355542 18166357 17721639 18279442 12741479 14716833 15052691 11481614 18429990 18156304 18395095 12609069 15057751 18705752 16027843 18420326 20821823 17944888 14724832 12445421 17640975 15876570 16033810 18418968
MESH:D008106 Liver Cirrhosis, Experimental Estradiol 6.4214716833 14659978
MESH:D008106 Liver Cirrhosis, Experimental Fenofibrate 6.4215474484
MESH:D008106 Liver Cirrhosis, Experimental pirinixic acid 6.4215474484
MESH:D008106 Liver Cirrhosis, Experimental Tetrachlorodibenzodioxin 6.4212878042
MESH:D008107 Liver Diseases Carbon Tetrachloride 8.9815720792 16964402 15830285 16246199 17285989
MESH:D008107 Liver Diseases Diethylnitrosamine 8.9817034775
MESH:D008107 Liver Diseases Lindane 8.981715830
MESH:D008107 Liver Diseases propiconazole 8.9819363144
MESH:D017093 Liver Failure Carbon Tetrachloride 3.9415123358
MESH:D017114 Liver Failure, Acute Carbon Tetrachloride 3.4916899240 14706259
MESH:D008113 Liver Neoplasms 2,6-dinitrotoluene 36.887678174
MESH:D008113 Liver Neoplasms Aflatoxin B1 36.882125692 15890375 18177683 9163691
MESH:D008113 Liver Neoplasms Benzo(a)pyrene 36.8820195826 21137059
MESH:D008113 Liver Neoplasms Carbon Tetrachloride 36.8819294768
MESH:D008113 Liver Neoplasms Diethylnitrosamine 36.8820434301 19426721 19850985 18648771 20118626 19499222 18978307 19254457 20501860 19294768 16942905 15175105 21047994 20101389 15885732 18977376 19255062 21167192 19073162 19642983 19427195 21071580 19090486 21278145 2422723 19996281 19551842 19638242 19833225 2862719 12771043 20583210 19256749 20452335 18644402 10737359 19690152 19812893 20137499 20492335 12112319 9163691 20405173 18754104
MESH:D008113 Liver Neoplasms Diethylstilbestrol 36.8815890375 16712894
MESH:D008113 Liver Neoplasms Fenofibrate 36.8818978307
MESH:D008113 Liver Neoplasms perfluorooctanoic acid 36.8818709148 14757943
MESH:D008113 Liver Neoplasms pirinixic acid 36.8820007298 15890375 16377806
MESH:D008113 Liver Neoplasms propiconazole 36.8819028983
MESH:D008113 Liver Neoplasms Tetrachlorodibenzodioxin 36.8816984957
MESH:D008114 Liver Neoplasms, Experimental 2,6-dinitrotoluene 26.122876784 2876786 6135515
MESH:D008114 Liver Neoplasms, Experimental Aflatoxin B1 26.128603461
MESH:D008114 Liver Neoplasms, Experimental Carbon Tetrachloride 26.1215583823 12014681
MESH:D008114 Liver Neoplasms, Experimental Diethylnitrosamine 26.1217942915 17854601 18775883 19126423 18544905 17174075 18079962 21159647 9362446 3124819 19539802 19004024 18308698 18164116 19009564 18253720 16267830 18093689 19519916 2563599 18282651 16842330
MESH:D008114 Liver Neoplasms, Experimental Fenofibrate 26.1218253720 18775883
MESH:D008114 Liver Neoplasms, Experimental propiconazole 26.1217178689
MESH:D008114 Liver Neoplasms, Experimental Tetrachlorodibenzodioxin 26.1212151625
MESH:D008175 Lung Neoplasms Aflatoxin B1 4.5914755239
MESH:D008175 Lung Neoplasms Benzo(a)pyrene 4.5918569708 20064080 18816296 6695378 20464547 20135361 18520028 20869020 17053015
MESH:D008175 Lung Neoplasms Diethylnitrosamine 4.5920970405 20512841 21163286 6695378
MESH:D008175 Lung Neoplasms Tetrachlorodibenzodioxin 4.5911884234 19555203
MESH:D008181 Lupus Nephritis Diethylstilbestrol 4.9215166399
MESH:D008223 Lymphoma Diethylstilbestrol 3.3115700306
MESH:D052801 Male Urogenital Diseases Diethylstilbestrol 5.2816002989
MESH:D008325 Mammary Neoplasms, Experimental Estradiol 2.4217203775 16891317 11408345 11807958
MESH:D020149 Manganese Poisoning Estradiol 4.2519453300
MESH:D008664 Metal Metabolism, Inborn Errors Cyclosporine 4.5616801185
MESH:D009062 Mouth Neoplasms Benzo(a)pyrene 3.0216381670
MESH:D009135 Muscular Diseases Bezafibrate 9.9916239165
MESH:D009135 Muscular Diseases pirinixic acid 9.9916239165
MESH:D009203 Myocardial Infarction Lithium 5.7516288908
MESH:D009203 Myocardial Infarction pirinixic acid 5.7519151258
MESH:D017202 Myocardial Ischemia Tetrachlorodibenzodioxin 2.8412213967
MESH:D015428 Myocardial Reperfusion Injury Estradiol 7.6716810080
MESH:D015428 Myocardial Reperfusion Injury pirinixic acid 7.6716411023
MESH:D009336 Necrosis 2,4-dinitrotoluene 9.5818551238
MESH:D009336 Necrosis 2,6-dinitrotoluene 9.5818551238 7678174
MESH:D009362 Neoplasm Metastasis Diethylnitrosamine 2.489029167 3581430
MESH:D009369 Neoplasms Benzo(a)pyrene 10.9711141357
MESH:D009369 Neoplasms Diethylstilbestrol 10.9715313581
MESH:D009369 Neoplasms Lindane 10.9712807735 16818664
MESH:D009369 Neoplasms pirinixic acid 10.9717405874
MESH:D009389 Neovascularization, Pathologic Estradiol 3.5017289903
MESH:D009402 Nephrosis, Lipoid Cyclosporine 4.2117954296
MESH:D009404 Nephrotic Syndrome Cyclosporine 3.0919348381 18481113
MESH:D009421 Nervous System Malformations Diethylstilbestrol 15.1111399458
MESH:D009421 Nervous System Malformations Estradiol 15.1116427766 11399458
MESH:D009421 Nervous System Malformations Tetrachlorodibenzodioxin 15.1114600291
MESH:D019636 Neurodegenerative Diseases Diethylnitrosamine 3.1620387270
MESH:D009461 Neurologic Manifestations Diethylnitrosamine 4.8920387270
MESH:D052556 Niemann-Pick Disease, Type C perfluorooctanoic acid 4.739802331
MESH:D009765 Obesity Dietary Fats 4.2420132043 20518802 18674790 17217161 18457598 21332399 16723640 19632207 11836018
MESH:D009765 Obesity pirinixic acid 4.2420558911
MESH:D009784 Occupational Diseases 2,4-dinitrotoluene 8.2316049721 12819281
MESH:D009784 Occupational Diseases 2,6-dinitrotoluene 8.2316049721
MESH:D010051 Ovarian Neoplasms Estradiol 2.1519401270
MESH:D010190 Pancreatic Neoplasms Diethylnitrosamine 2.3416540662
MESH:D016584 Panic Disorder Ethinyl Estradiol 3.4711578682
MESH:D010382 Peliosis Hepatis Tetrachlorodibenzodioxin 4.0212520081
MESH:D010900 Pituitary Diseases Diethylstilbestrol 4.9414722030
MESH:D010911 Pituitary Neoplasms Diethylstilbestrol 4.4516977796 15687265
MESH:D011085 Polycystic Ovary Syndrome Flutamide 4.8015356085
MESH:D017119 Porphyria Cutanea Tarda Tetrachlorodibenzodioxin 3.3418163543
MESH:D011230 Precancerous Conditions Cyclosporine 8.3112371664
MESH:D011230 Precancerous Conditions Diethylnitrosamine 8.312563599
MESH:D011297 Prenatal Exposure Delayed Effects Diethylstilbestrol 21.3917184923
MESH:D011297 Prenatal Exposure Delayed Effects perfluorooctanoic acid 21.3917132714
MESH:D011297 Prenatal Exposure Delayed Effects Tetrachlorodibenzodioxin 21.3911896295 11118676 11222880 11399792
MESH:D011297 Prenatal Exposure Delayed Effects vinclozolin 21.3918220299 19015723 18042343
MESH:D011469 Prostatic Diseases vinclozolin 4.7018220299
MESH:D019048 Prostatic Intraepithelial Neoplasia Estradiol 3.6820887781
MESH:D011471 Prostatic Neoplasms Benzo(a)pyrene 1.9117292933
MESH:D011471 Prostatic Neoplasms Diethylstilbestrol 1.9115046698 15846301 17136230
MESH:D011471 Prostatic Neoplasms Estradiol 1.9116740699
MESH:D011471 Prostatic Neoplasms Flutamide 1.913169114
MESH:D011471 Prostatic Neoplasms Lindane 1.9114688026 12661182
MESH:D011472 Prostatitis vinclozolin 4.7018629315
MESH:D011537 Pruritus Ethinyl Estradiol 3.0916919318 15861022
MESH:D011565 Psoriasis Cyclosporine 2.1516882103
MESH:D015427 Reperfusion Injury pirinixic acid 2.2819058328
MESH:D015619 Respiratory System Abnormalities Tetrachlorodibenzodioxin 3.6218990726
MESH:D012640 Seizures 2,4-dinitrotoluene 17.0118551238
MESH:D012640 Seizures 2,6-dinitrotoluene 17.0118551238
MESH:D012640 Seizures Lindane 17.0112842176 7539098 15475178
MESH:D012640 Seizures Lithium 17.0119660546
MESH:D012640 Seizures Picrotoxin 17.018954991 8635557
MESH:D012878 Skin Neoplasms Benzo(a)pyrene 5.1219755658 10029692
MESH:D012878 Skin Neoplasms Tetrachlorodibenzodioxin 5.1216192470
MESH:D013088 Spermatocele Diethylstilbestrol 10.9416709447 16002989
MESH:D013088 Spermatocele Ethinyl Estradiol 10.9416709447
MESH:D013226 Status Epilepticus Lithium 5.5619570321 19951488 19430551
MESH:D013274 Stomach Neoplasms Benzo(a)pyrene 3.2720155912 2093021
MESH:D013274 Stomach Neoplasms Diethylnitrosamine 3.2718456281
MESH:D013274 Stomach Neoplasms nitrosobenzylmethylamine 3.2717575124 12958204
MESH:D019851 Thrombophilia Ethinyl Estradiol 3.4111994571
MESH:D013927 Thrombosis Ethinyl Estradiol 2.9615669648
MESH:D013959 Thyroid Diseases Tetrachlorodibenzodioxin 3.6712697716
MESH:D013964 Thyroid Neoplasms Diethylnitrosamine 2.817505956
MESH:D013978 Tibial Fractures Estradiol 4.4519048282
MESH:D001749 Urinary Bladder Neoplasms 2,4-dinitrotoluene 11.1816049721
MESH:D001749 Urinary Bladder Neoplasms 2,6-dinitrotoluene 11.1816049721
MESH:D001749 Urinary Bladder Neoplasms Benzo(a)pyrene 11.1817053015
MESH:D001749 Urinary Bladder Neoplasms Diethylstilbestrol 11.1816452187 17306315 16712894
MESH:D014571 Urologic Neoplasms 2,4-dinitrotoluene 11.2210091137
MESH:D014571 Urologic Neoplasms 2,6-dinitrotoluene 11.2210091137
MESH:D002583 Uterine Cervical Neoplasms Diethylstilbestrol 3.8416175088
MESH:D014591 Uterine Diseases Diethylstilbestrol 4.9414652134
MESH:D014594 Uterine Neoplasms Diethylstilbestrol 8.7515809267 16690809
MESH:D014594 Uterine Neoplasms Ethinyl Estradiol 8.7514692618
MESH:D014605 Uveitis Cyclosporine 3.751336536
MESH:D014625 Vaginal Neoplasms Diethylstilbestrol 4.2116513791 16002989
MESH:D054079 Vascular Malformations Tetrachlorodibenzodioxin 4.3612125929
MESH:D020246 Venous Thrombosis Ethinyl Estradiol 3.3314671159 15869587
MESH:D019282 Wasting Syndrome Tetrachlorodibenzodioxin 4.0215886252
MESH:D015430 Weight Gain Dietary Fats 3.5516723640
MESH:D014985 Xerophthalmia Cyclosporine 4.2117120751
Pathway ID Pathway Name
KEGG:04920 Adipocytokine signaling pathway
KEGG:00071 Fatty acid metabolism
KEGG:01100 Metabolic pathways
REACT:22258 Metabolism of lipids and lipoproteins
KEGG:04146 Peroxisome
KEGG:03320 PPAR signaling pathway
Pharmacogenomics Knowledge Base Top
  • PharmGKB Accession:PA27969
    • No data
    Releated disease ID Related disease Name
    PA443756Colonic Neoplasms
    No data
    Drug Bank Top

    Simple Query:


      (e.g. CHD8)

    Syndromic Genes

    Non-syndromic Genes

    AutismKB Statistics

    • Studies: 1,036
    • Genes: 1,379
    • CNVs/SVs: 5,420
    • SNVs/Indels: 11,669
    • de novo Mutations: 5,669
    • Mosaics: 789
    • Linkage Regions: 172
    • Paper Collected: 6/30/2018
    • Last Update: 8/26/2018


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