AutismKB 2.0

Annotation Detail for GPRC5B


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Basic Information Top
Gene Symbol:GPRC5B ( RAIG-2,RAIG2 )
Gene Full Name: G protein-coupled receptor, family C, group 5, member B
Band: 16p12.3
Quick LinksEntrez ID:51704; OMIM: 605948; Uniprot ID:GPC5B_HUMAN; ENSEMBL ID: ENSG00000167191; HGNC ID: 13308
Relate to Another Database: SFARIGene; denovo-db
Related Pathway Information Top
Related Diseases/Disorders Top
Comparative Toxicogenomics Database Top
Chemical ID Chemical Name Interaction Interaction Action Publication
C548651 2-(1'H-indolo-3'-carbonyl)thiazole-4-carboxylic acid methyl ester 2-(1'H-indolo-3'-carbonyl)thiazole-4-carboxylic acid methyl ester results in decreased expression of GPRC5B mRNAdecreases expression 19933214
D000082 Acetaminophen Acetaminophen affects the expression of GPRC5B mRNAaffects expression 17562736
D016604 Aflatoxin B1 Aflatoxin B1 affects the expression of GPRC5B proteinaffects expression 20106945
D001564 Benzo(a)pyrene Benzo(a)pyrene results in increased expression of GPRC5B mRNAincreases expression 20106945
D020122 tert-Butylhydroperoxide tert-Butylhydroperoxide results in increased expression of GPRC5B mRNAincreases expression 15336504
D002251 Carbon Tetrachloride Carbon Tetrachloride affects the expression of GPRC5B mRNAaffects expression 17484886
D002251 Carbon Tetrachloride Carbon Tetrachloride results in decreased expression of GPRC5B mRNAdecreases expression 16239168
C014347 decitabine decitabine affects the expression of GPRC5B mRNAaffects expression 17145863
D002117 Calcitriol Calcitriol results in decreased expression of GPRC5B mRNAdecreases expression 16002434
C006253 pirinixic acid [pirinixic acid binds to and results in increased activity of PPARA protein] which results in decreased expression of GPRC5B mRNAaffects binding|decreases expression|increases activity 19710929
C009250 sevoflurane sevoflurane affects the expression of GPRC5B mRNAaffects expression 15967596
D013749 Tetrachlorodibenzodioxin Tetrachlorodibenzodioxin results in decreased expression of GPRC5B mRNAdecreases expression 19933214
Disease ID Disease Name Direct Evidence Inference Chemical Name Inference Score Publication
MESH:D000014 Abnormalities, Drug-Induced Tetrachlorodibenzodioxin 3.0411752688 15322242 14514962
MESH:D055371 Acute Lung Injury pirinixic acid 3.2718653653
MESH:D000230 Adenocarcinoma Benzo(a)pyrene 2.0120127859 20464547
MESH:D000236 Adenoma Benzo(a)pyrene 2.736695378
MESH:D018248 Adenoma, Liver Cell pirinixic acid 10.5616434500
MESH:D018248 Adenoma, Liver Cell Tetrachlorodibenzodioxin 10.5616835633
MESH:D000740 Anemia Tetrachlorodibenzodioxin 3.0811748828
MESH:D000799 Angioedema Acetaminophen 4.0610982225
MESH:D017544 Aortic Aneurysm, Abdominal Benzo(a)pyrene 4.2519183758
MESH:D001321 Autistic Disorder Acetaminophen 1.4118445737
MESH:D001778 Blood Coagulation Disorders pirinixic acid 9.2419483382
MESH:D001778 Blood Coagulation Disorders Tetrachlorodibenzodioxin 9.2412125929
MESH:D001836 Body Weight Changes Tetrachlorodibenzodioxin 4.0115340226
MESH:D001848 Bone Diseases, Developmental Tetrachlorodibenzodioxin 2.8515746008
MESH:D001943 Breast Neoplasms Benzo(a)pyrene 1.9720146248 17474063
MESH:D001943 Breast Neoplasms Calcitriol 1.9711237771
MESH:D001943 Breast Neoplasms decitabine 1.9718320071 19208741
MESH:D001943 Breast Neoplasms Tetrachlorodibenzodioxin 1.9720435547
MESH:D002252 Carbon Tetrachloride Poisoning Carbon Tetrachloride 3.9518705752 16227642 16050911 15673190 16097048 15700767 16011737 16192424 16124888 15721981 10355542 3786805
MESH:D002277 Carcinoma Tetrachlorodibenzodioxin 2.9116835633
MESH:D006528 Carcinoma, Hepatocellular Acetaminophen 4.653084413
MESH:D006528 Carcinoma, Hepatocellular Aflatoxin B1 4.6521507988 12619106 12907637
MESH:D006528 Carcinoma, Hepatocellular Carbon Tetrachloride 4.6518788625
MESH:D002294 Carcinoma, Squamous Cell Benzo(a)pyrene 7.8020419170
MESH:D002294 Carcinoma, Squamous Cell Calcitriol 7.8011237771
MESH:D002294 Carcinoma, Squamous Cell decitabine 7.8019215824
MESH:D006332 Cardiomegaly Tetrachlorodibenzodioxin 2.4418670907 18850075 16120746
MESH:D002386 Cataract Acetaminophen 2.6610977129
MESH:D018281 Cholangiocarcinoma Tetrachlorodibenzodioxin 3.2916835633
MESH:D002779 Cholestasis pirinixic acid 2.9319176532
MESH:D002972 Cleft Palate Tetrachlorodibenzodioxin 2.1515668235 15340226 12621046 8697196 16354765
MESH:D003110 Colonic Neoplasms decitabine 2.3517616700
MESH:D015179 Colorectal Neoplasms decitabine 2.1018981723
MESH:D000013 Congenital Abnormalities Tetrachlorodibenzodioxin 3.1817141729 14669216
MESH:D019465 Craniofacial Abnormalities Tetrachlorodibenzodioxin 1.2615322242 10048152 20055451
MESH:D003876 Dermatitis, Atopic pirinixic acid 2.4818249437
MESH:D003924 Diabetes Mellitus, Type 2 Tetrachlorodibenzodioxin 1.6917107852
MESH:D056486 Drug-Induced Liver Injury Acetaminophen 6.3416177239 15619225 19085960 18713872 15968718 19164858 16227642 19923254 11834606 12540782 17522070 14550746 12958197 11739529 17906064 16485898 12705907 12153990 16109766 11529661 11287661 19370779 18071297 17562736 10915739 10774834 16081117 12594235 11421492 2444490 19739265 14986274 19416960 10663392 16781746 12392966 11461765 16393943 14725611 11743745 19420014
MESH:D056486 Drug-Induced Liver Injury Carbon Tetrachloride 6.3415968718 15998439 9327722 7120509 19085960 10092053 17522070 3786805 10915739 11566570 16177239 7179309 2869522 19336974 7440962 6623471 16227642 3732212 4309450 6884620 21278145 15027814
MESH:D056486 Drug-Induced Liver Injury Tetrachlorodibenzodioxin 6.3420420201
MESH:D056487 Drug-Induced Liver Injury, Chronic Acetaminophen 4.3219426721
MESH:D004362 Drug Toxicity Tetrachlorodibenzodioxin 2.8611462148
MESH:D004487 Edema pirinixic acid 7.0012083418
MESH:D004487 Edema Tetrachlorodibenzodioxin 7.0012711302 11000095
MESH:D004489 Edema, Cardiac Tetrachlorodibenzodioxin 4.1215322242 18230668 16714409
MESH:D004681 Encephalomyelitis, Autoimmune, Experimental Calcitriol 4.0915138306
MESH:D004701 Endocrine Gland Neoplasms decitabine 5.3319294695
MESH:D004715 Endometriosis Tetrachlorodibenzodioxin 3.1510568697 9294722
MESH:D004938 Esophageal Neoplasms Benzo(a)pyrene 2.0416530937
MESH:D005124 Eye Abnormalities Tetrachlorodibenzodioxin 3.1211564622
MESH:D005234 Fatty Liver Carbon Tetrachloride 8.1412631006 19224547 12795759 17595544 15959796 16239168 16045604 61145
MESH:D005234 Fatty Liver pirinixic acid 8.1420131406 19236843
MESH:D005313 Fetal Death Tetrachlorodibenzodioxin 3.6311858732
MESH:D005355 Fibrosis Carbon Tetrachloride 9.1918705752
MESH:D005355 Fibrosis Tetrachlorodibenzodioxin 9.1920067830
MESH:D005756 Gastritis Acetaminophen 3.8916983495
MESH:D006058 Gonadal Disorders Tetrachlorodibenzodioxin 4.8110696789
MESH:D006258 Head and Neck Neoplasms decitabine 3.5819215824
MESH:D006330 Heart Defects, Congenital Benzo(a)pyrene 6.6720471113
MESH:D006330 Heart Defects, Congenital Tetrachlorodibenzodioxin 6.6711294989 10048152
MESH:D006333 Heart Failure pirinixic acid 2.6220558911
MESH:D006470 Hemorrhage Tetrachlorodibenzodioxin 3.4811000095
MESH:D006505 Hepatitis Carbon Tetrachloride 3.7619900420 19110552
MESH:D006529 Hepatomegaly pirinixic acid 8.8518467677 16221962 19772884 19176532
MESH:D006529 Hepatomegaly Tetrachlorodibenzodioxin 8.8515340226 16120746 12621046
MESH:D006869 Hydronephrosis Tetrachlorodibenzodioxin 4.268697196 16354765 15340226 16959395 18606429
MESH:D006930 Hyperalgesia Acetaminophen 2.8116870215
MESH:D006932 Hyperbilirubinemia Carbon Tetrachloride 4.7316899240
MESH:D006943 Hyperglycemia pirinixic acid 3.3120558911
MESH:D006973 Hypertension Tetrachlorodibenzodioxin 1.9518670907 18850075
MESH:D006975 Hypertension, Portal Carbon Tetrachloride 4.2615338365
MESH:D007248 Infertility, Male decitabine 3.2917581917
MESH:D007249 Inflammation Tetrachlorodibenzodioxin 1.9212878042 12200463
MESH:D007333 Insulin Resistance pirinixic acid 2.7216306350
MESH:D007569 Jaw Abnormalities Tetrachlorodibenzodioxin 3.4816580747
MESH:D007674 Kidney Diseases Acetaminophen 2.2715629191 12587719
MESH:D007859 Learning Disorders sevoflurane 4.9519212262
MESH:D007938 Leukemia decitabine 3.1318980019 19235587
MESH:D007951 Leukemia, Myeloid decitabine 4.1419117987 18454857 17236224
MESH:D015470 Leukemia, Myeloid, Acute decitabine 2.4019387464 18460780 18206229 19010910 18704418 17679729
MESH:D015477 Leukemia, Myelomonocytic, Chronic decitabine 5.6818055864
MESH:D008103 Liver Cirrhosis Carbon Tetrachloride 2.8811408273 17157831 16943688 11903743 16221502 16239168 17174718 21278145 17334410
MESH:D008106 Liver Cirrhosis, Experimental Carbon Tetrachloride 3.4616027843 12666154 17565644 18277467 15052691 15959796 11481614 14716833 12958196 18395914 16097048 17557913 15996030 18263696 15893842 12898905 15650968 12649538 17976157 18251166 18429990 16248980 14724832 14512876 18420326 18006644 12586293 15370692 12609069 16638106 20821823 18054572 18279442 17698563 15123356 18376398 12741479 17761835 18339082 17714472 15362042 16015684 16033810 17869086 18205269 14716496 18166357 18472332 18481824 15730626 17721639 17708605 16011737 15673190 17900296 14748882 18705752 15818738 15057751 14620537 16116963 15931870 17944888 15925388 18317297 12389079 10355542 17823541 18395095 16136751 17640975 17922224 15338365 17481882 12632512 18210741 17766677 12445418 18187930 12546737 15876570 18472094 16192424 12632514 17525996 13678700 18418968 17805973 18412020 17631135 18156304 12445421 12667390
MESH:D008106 Liver Cirrhosis, Experimental pirinixic acid 3.4615474484
MESH:D008106 Liver Cirrhosis, Experimental Tetrachlorodibenzodioxin 3.4612878042
MESH:D008107 Liver Diseases Acetaminophen 4.0019784758 12969438 19014921 16610002 11587558 16611625 19460945 12587719
MESH:D008107 Liver Diseases Carbon Tetrachloride 4.0016246199 17285989 15830285 16964402 15720792
MESH:D017093 Liver Failure Carbon Tetrachloride 4.3415123358
MESH:D017114 Liver Failure, Acute Acetaminophen 9.8516871587 17185352
MESH:D017114 Liver Failure, Acute Carbon Tetrachloride 9.8514706259 16899240
MESH:D008113 Liver Neoplasms Aflatoxin B1 14.752125692 18177683 9163691 15890375
MESH:D008113 Liver Neoplasms Benzo(a)pyrene 14.7521137059 20195826
MESH:D008113 Liver Neoplasms Carbon Tetrachloride 14.7519294768
MESH:D008113 Liver Neoplasms pirinixic acid 14.7516377806 20007298 15890375
MESH:D008113 Liver Neoplasms Tetrachlorodibenzodioxin 14.7516984957
MESH:D008114 Liver Neoplasms, Experimental Aflatoxin B1 10.308603461
MESH:D008114 Liver Neoplasms, Experimental Carbon Tetrachloride 10.3015583823 12014681
MESH:D008114 Liver Neoplasms, Experimental Tetrachlorodibenzodioxin 10.3012151625
MESH:D008175 Lung Neoplasms Aflatoxin B1 3.4414755239
MESH:D008175 Lung Neoplasms Benzo(a)pyrene 3.4418816296 20869020 18569708 20135361 20464547 20064080 17053015 6695378 18520028
MESH:D008175 Lung Neoplasms Tetrachlorodibenzodioxin 3.4411884234 19555203
MESH:D008223 Lymphoma decitabine 3.5219470736
MESH:D008545 Melanoma decitabine 2.2617785578 16505122
MESH:D008546 Melanoma, Experimental Acetaminophen 3.7419513568
MESH:D008569 Memory Disorders sevoflurane 4.9119212262
MESH:D009062 Mouth Neoplasms Benzo(a)pyrene 3.3016381670
MESH:D009101 Multiple Myeloma decitabine 3.4418172295
MESH:D009135 Muscular Diseases pirinixic acid 3.6816239165
MESH:D009190 Myelodysplastic Syndromes decitabine 3.4618608210 16882708 19157545 19010910
MESH:D009203 Myocardial Infarction pirinixic acid 2.1919151258
MESH:D017202 Myocardial Ischemia Tetrachlorodibenzodioxin 3.1312213967
MESH:D015428 Myocardial Reperfusion Injury pirinixic acid 3.0516411023
MESH:D009369 Neoplasms Benzo(a)pyrene 8.6111141357
MESH:D009369 Neoplasms decitabine 8.6117925555 19116145 19470736
MESH:D009369 Neoplasms pirinixic acid 8.6117405874
MESH:D009421 Nervous System Malformations Tetrachlorodibenzodioxin 3.3714600291
MESH:D019636 Neurodegenerative Diseases Acetaminophen 2.9918514411
MESH:D009765 Obesity pirinixic acid 1.8420558911
MESH:D010051 Ovarian Neoplasms decitabine 2.6819331143 19259094
MESH:D010146 Pain Acetaminophen 2.5016870215
MESH:D010190 Pancreatic Neoplasms decitabine 2.8119294695
MESH:D010382 Peliosis Hepatis Tetrachlorodibenzodioxin 4.4712520081
MESH:D017119 Porphyria Cutanea Tarda Tetrachlorodibenzodioxin 3.7218163543
MESH:D011297 Prenatal Exposure Delayed Effects Tetrachlorodibenzodioxin 3.3811118676 11896295 11222880 11399792
MESH:D055728 Primary Myelofibrosis decitabine 4.9017616702
MESH:D011470 Prostatic Hyperplasia Calcitriol 4.9715572423
MESH:D011471 Prostatic Neoplasms Benzo(a)pyrene 3.2417292933
MESH:D011471 Prostatic Neoplasms Calcitriol 3.2416289102 15754350 12479363 18247401 16644109
MESH:D015427 Reperfusion Injury pirinixic acid 2.4519058328
MESH:D015619 Respiratory System Abnormalities Tetrachlorodibenzodioxin 4.0018990726
MESH:D012208 Rhabdomyosarcoma decitabine 4.5519155313
MESH:D012878 Skin Neoplasms Benzo(a)pyrene 9.7510029692 19755658
MESH:D012878 Skin Neoplasms tert-Butylhydroperoxide 9.758532709
MESH:D012878 Skin Neoplasms Tetrachlorodibenzodioxin 9.7516192470
MESH:D013274 Stomach Neoplasms Benzo(a)pyrene 2.492093021 20155912
MESH:D013274 Stomach Neoplasms decitabine 2.4919037991
MESH:D013959 Thyroid Diseases Tetrachlorodibenzodioxin 4.1212697716
MESH:D013964 Thyroid Neoplasms decitabine 3.4317967635
MESH:D001749 Urinary Bladder Neoplasms Benzo(a)pyrene 5.2917053015
MESH:D001749 Urinary Bladder Neoplasms decitabine 5.2917616700 19087683
MESH:D014581 Urticaria Acetaminophen 3.1210982225
MESH:D014604 Uveal Neoplasms decitabine 5.1317785578
MESH:D054079 Vascular Malformations Tetrachlorodibenzodioxin 4.8112125929
MESH:D019282 Wasting Syndrome Tetrachlorodibenzodioxin 4.4715886252
No data
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Syndromic Genes

Non-syndromic Genes

AutismKB Statistics

  • Studies: 1,036
  • Genes: 1,379
  • CNVs/SVs: 5,420
  • SNVs/Indels: 11,669
  • de novo Mutations: 5,669
  • Mosaics: 789
  • Linkage Regions: 172
  • Paper Collected: 6/30/2018
  • Last Update: 8/26/2018


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