AutismKB 2.0

Annotation Detail for EMCN


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Basic Information Top
Gene Symbol:EMCN ( EMCN2,MUC14 )
Gene Full Name: endomucin
Band: 4q24
Quick LinksEntrez ID:51705; OMIM: 608350; Uniprot ID:MUCEN_HUMAN; ENSEMBL ID: ENSG00000164035; HGNC ID: 16041
Relate to Another Database: SFARIGene; denovo-db
Related Pathway Information Top
Related Diseases/Disorders Top
Comparative Toxicogenomics Database Top
Chemical ID Chemical Name Interaction Interaction Action Publication
C023514 2,6-dinitrotoluene 2,6-dinitrotoluene affects the expression of EMCN mRNAaffects expression 21346803
D000082 Acetaminophen Acetaminophen affects the expression of EMCN mRNAaffects expression 17562736
D001151 Arsenic Arsenic results in decreased expression of EMCN mRNAdecreases expression 19654921
D004041 Dietary Fats Dietary Fats results in increased expression of EMCN mRNAincreases expression 18042831
C041786 palm oil palm oil results in increased expression of EMCN mRNAincreases expression 18042831
D012402 Rotenone Rotenone results in increased expression of EMCN mRNAincreases expression 19013527
D013749 Tetrachlorodibenzodioxin Tetrachlorodibenzodioxin results in increased expression of EMCN mRNAincreases expression 15328365
C025643 vinclozolin vinclozolin affects the expression of EMCN mRNAaffects expression 19015723
Disease ID Disease Name Direct Evidence Inference Chemical Name Inference Score Publication
MESH:D000014 Abnormalities, Drug-Induced Tetrachlorodibenzodioxin 3.1811752688 15322242 14514962
MESH:D018248 Adenoma, Liver Cell Tetrachlorodibenzodioxin 3.7116835633
MESH:D018246 Adrenocortical Adenoma Arsenic 5.5917306315
MESH:D000740 Anemia Tetrachlorodibenzodioxin 3.1711748828
MESH:D000799 Angioedema Acetaminophen 4.2210982225
MESH:D001008 Anxiety Disorders vinclozolin 3.8319015723
MESH:D020261 Arsenic Poisoning Arsenic 2.9216835338 12569548 18414634 16251483
MESH:D001161 Arteriosclerosis Dietary Fats 4.1915238619
MESH:D050197 Atherosclerosis Arsenic 3.3812928151 19371607
MESH:D001321 Autistic Disorder Acetaminophen 1.4018445737
MESH:D001778 Blood Coagulation Disorders Tetrachlorodibenzodioxin 3.2912125929
MESH:D001836 Body Weight Changes Tetrachlorodibenzodioxin 4.1715340226
MESH:D001848 Bone Diseases, Developmental Tetrachlorodibenzodioxin 2.9115746008
MESH:D001943 Breast Neoplasms Dietary Fats 1.9620435547
MESH:D001943 Breast Neoplasms Tetrachlorodibenzodioxin 1.9620435547
MESH:D002277 Carcinoma Tetrachlorodibenzodioxin 2.9916835633
MESH:D002280 Carcinoma, Basal Cell Arsenic 3.7117687452 15504454
MESH:D006528 Carcinoma, Hepatocellular 2,6-dinitrotoluene 4.7616705839
MESH:D006528 Carcinoma, Hepatocellular Acetaminophen 4.763084413
MESH:D006528 Carcinoma, Hepatocellular Arsenic 4.7617306315 16507464
MESH:D002294 Carcinoma, Squamous Cell Arsenic 2.7418922899 15504454 17687452
MESH:D002295 Carcinoma, Transitional Cell Arsenic 4.3018640142
MESH:D006332 Cardiomegaly Tetrachlorodibenzodioxin 2.4918670907 16120746 18850075
MESH:D002318 Cardiovascular Diseases Arsenic 3.6115738583 19152805 17938729
MESH:D002340 Carotid Artery Diseases Arsenic 4.5218022660 16973168
MESH:D002386 Cataract Acetaminophen 2.7110977129
MESH:D002471 Cell Transformation, Neoplastic 2,6-dinitrotoluene 2.936135515
MESH:D018281 Cholangiocarcinoma Tetrachlorodibenzodioxin 3.3816835633
MESH:D002972 Cleft Palate Tetrachlorodibenzodioxin 2.1916354765 15668235 12621046 15340226 8697196
MESH:D000013 Congenital Abnormalities Tetrachlorodibenzodioxin 3.2717141729 14669216
MESH:D019465 Craniofacial Abnormalities Tetrachlorodibenzodioxin 1.2615322242 20055451 10048152
MESH:D003456 Cryptorchidism vinclozolin 4.6214966744
MESH:D003490 Cyanosis 2,6-dinitrotoluene 4.3218551238
MESH:D003924 Diabetes Mellitus, Type 2 Tetrachlorodibenzodioxin 1.7117107852
MESH:D056486 Drug-Induced Liver Injury 2,6-dinitrotoluene 6.4721346803 18551238
MESH:D056486 Drug-Induced Liver Injury Acetaminophen 6.4717522070 10663392 11287661 14725611 19416960 16781746 19739265 18713872 18071297 12705907 11421492 19923254 19164858 11739529 17906064 12540782 16227642 14550746 11834606 10774834 10915739 15619225 19085960 19370779 16109766 2444490 11461765 17562736 15968718 11529661 16177239 16485898 14986274 12392966 12958197 16393943 16081117 11743745 19420014 12153990 12594235
MESH:D056486 Drug-Induced Liver Injury Tetrachlorodibenzodioxin 6.4720420201
MESH:D056487 Drug-Induced Liver Injury, Chronic Acetaminophen 4.4719426721
MESH:D004362 Drug Toxicity Tetrachlorodibenzodioxin 2.9311462148
MESH:D050171 Dyslipidemias Dietary Fats 3.6218367378
MESH:D004487 Edema Tetrachlorodibenzodioxin 2.6112711302 11000095
MESH:D004489 Edema, Cardiac Tetrachlorodibenzodioxin 4.2818230668 16714409 15322242
MESH:D004715 Endometriosis Tetrachlorodibenzodioxin 3.259294722 10568697
MESH:D005124 Eye Abnormalities Tetrachlorodibenzodioxin 3.1911564622
MESH:D005234 Fatty Liver Dietary Fats 3.4818296743 19004024 17967931 19551842
MESH:D005313 Fetal Death Tetrachlorodibenzodioxin 3.7611858732
MESH:D005355 Fibrosis Dietary Fats 9.6618296743
MESH:D005355 Fibrosis Tetrachlorodibenzodioxin 9.6620067830
MESH:D005534 Foot Diseases Arsenic 5.946392382
MESH:D005756 Gastritis Acetaminophen 4.0516983495
MESH:D030342 Genetic Diseases, Inborn vinclozolin 5.2716973722
MESH:D005832 Genital Diseases, Male vinclozolin 5.6816417039
MESH:D006058 Gonadal Disorders Tetrachlorodibenzodioxin 4.9710696789
MESH:D006330 Heart Defects, Congenital Tetrachlorodibenzodioxin 2.4410048152 11294989
MESH:D006470 Hemorrhage Tetrachlorodibenzodioxin 3.5811000095
MESH:D006529 Hepatomegaly Tetrachlorodibenzodioxin 3.2012621046 15340226 16120746
MESH:D006869 Hydronephrosis Tetrachlorodibenzodioxin 4.4215340226 16959395 8697196 18606429 16354765
MESH:D006930 Hyperalgesia Acetaminophen 2.8916870215
MESH:D006937 Hypercholesterolemia Dietary Fats 3.8321332399
MESH:D017488 Hyperkeratosis, Epidermolytic Arsenic 4.6817050553
MESH:D006949 Hyperlipidemias Dietary Fats 3.8721332399
MESH:D006973 Hypertension Arsenic 5.4916076760 11953799 9931084
MESH:D006973 Hypertension Tetrachlorodibenzodioxin 5.4918670907 18850075
MESH:D006987 Hypesthesia Arsenic 5.9416093927
MESH:D007248 Infertility, Male vinclozolin 3.1916467254
MESH:D007249 Inflammation Dietary Fats 5.2920412841
MESH:D007249 Inflammation Tetrachlorodibenzodioxin 5.2912878042 12200463
MESH:D007333 Insulin Resistance Dietary Fats 3.2518457598 11836018
MESH:D007569 Jaw Abnormalities Tetrachlorodibenzodioxin 3.5816580747
MESH:D007642 Keratosis Arsenic 5.3316930632 12749816
MESH:D007674 Kidney Diseases Acetaminophen 2.3212587719 15629191
MESH:D007680 Kidney Neoplasms 2,6-dinitrotoluene 3.1816705839
MESH:D015473 Leukemia, Promyelocytic, Acute Arsenic 3.7017339181
MESH:D007984 Leydig Cell Tumor vinclozolin 5.0716417039
MESH:D008103 Liver Cirrhosis Dietary Fats 2.9918296743
MESH:D008106 Liver Cirrhosis, Experimental Tetrachlorodibenzodioxin 1.2412878042
MESH:D008107 Liver Diseases Acetaminophen 4.2412587719 16611625 16610002 12969438 11587558 19784758 19460945 19014921
MESH:D008107 Liver Diseases Arsenic 4.2411134558
MESH:D017114 Liver Failure, Acute Acetaminophen 3.4616871587 17185352
MESH:D008113 Liver Neoplasms 2,6-dinitrotoluene 7.907678174
MESH:D008113 Liver Neoplasms Arsenic 7.9016368122
MESH:D008113 Liver Neoplasms Tetrachlorodibenzodioxin 7.9016984957
MESH:D008114 Liver Neoplasms, Experimental 2,6-dinitrotoluene 6.202876784 2876786 6135515
MESH:D008114 Liver Neoplasms, Experimental Tetrachlorodibenzodioxin 6.2012151625
MESH:D008175 Lung Neoplasms Arsenic 2.4817306315 17976673 19168569
MESH:D008175 Lung Neoplasms Tetrachlorodibenzodioxin 2.4811884234 19555203
MESH:D008546 Melanoma, Experimental Acetaminophen 3.8719513568
MESH:D017202 Myocardial Ischemia Arsenic 9.6515371236
MESH:D017202 Myocardial Ischemia Tetrachlorodibenzodioxin 9.6512213967
MESH:D009336 Necrosis 2,6-dinitrotoluene 4.207678174 18551238
MESH:D009410 Nerve Degeneration Rotenone 4.0617356569 18619942 15790535
MESH:D009421 Nervous System Malformations Tetrachlorodibenzodioxin 3.4914600291
MESH:D009436 Neural Tube Defects Arsenic 3.6016620997
MESH:D019636 Neurodegenerative Diseases Acetaminophen 3.0718514411
MESH:D020078 Neurogenic Inflammation Arsenic 4.6417056641
MESH:D009765 Obesity Dietary Fats 2.3318674790 21332399 11836018 17217161 20518802 16723640 19632207 20132043 18457598
MESH:D009784 Occupational Diseases 2,6-dinitrotoluene 3.6616049721
MESH:D010051 Ovarian Neoplasms Arsenic 2.8017306315
MESH:D010146 Pain Acetaminophen 2.5916870215
MESH:D010300 Parkinson Disease Rotenone 3.0511535288 19232380 11445065 16140633 15451049 18619942 19114014 18191903 16412576
MESH:D020734 Parkinsonian Disorders Rotenone 4.3015795934 18197244 15927086 15574749
MESH:D010382 Peliosis Hepatis Tetrachlorodibenzodioxin 4.6212520081
MESH:D010523 Peripheral Nervous System Diseases Arsenic 4.4616093927
MESH:D016491 Peripheral Vascular Diseases Arsenic 5.336392382 15371236 16905509
MESH:D017119 Porphyria Cutanea Tarda Tetrachlorodibenzodioxin 3.8418163543
MESH:D011297 Prenatal Exposure Delayed Effects Tetrachlorodibenzodioxin 10.6411118676 11399792 11896295 11222880
MESH:D011297 Prenatal Exposure Delayed Effects vinclozolin 10.6419015723 18220299 18042343
MESH:D011469 Prostatic Diseases vinclozolin 5.2718220299
MESH:D011471 Prostatic Neoplasms Arsenic 3.5716140617
MESH:D011472 Prostatitis vinclozolin 5.2718629315
MESH:D011507 Proteinuria Arsenic 4.2621343184
MESH:D015619 Respiratory System Abnormalities Tetrachlorodibenzodioxin 4.1218990726
MESH:D012640 Seizures 2,6-dinitrotoluene 2.6918551238
MESH:D012871 Skin Diseases Arsenic 2.8019834688 16702368 17548696 6392382 17938729 18709164 17453740 16353154 15952646 16759981 17050553
MESH:D012878 Skin Neoplasms Arsenic 6.0417976673 16251483 17029826 17050553 15504454 19538983
MESH:D012878 Skin Neoplasms Tetrachlorodibenzodioxin 6.0416192470
MESH:D013959 Thyroid Diseases Tetrachlorodibenzodioxin 4.2812697716
MESH:D001749 Urinary Bladder Neoplasms 2,6-dinitrotoluene 5.4816049721
MESH:D001749 Urinary Bladder Neoplasms Arsenic 5.4817976673 17306315 19322015 19429237 11144890 15987713 18640142
MESH:D014571 Urologic Neoplasms 2,6-dinitrotoluene 4.6610091137
MESH:D014581 Urticaria Acetaminophen 3.2410982225
MESH:D014652 Vascular Diseases Arsenic 5.0717056641
MESH:D054079 Vascular Malformations Tetrachlorodibenzodioxin 4.9712125929
MESH:D019282 Wasting Syndrome Tetrachlorodibenzodioxin 4.6215886252
MESH:D015430 Weight Gain Dietary Fats 3.9516723640
No data
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Syndromic Genes

Non-syndromic Genes

AutismKB Statistics

  • Studies: 1,036
  • Genes: 1,379
  • CNVs/SVs: 5,420
  • SNVs/Indels: 11,669
  • de novo Mutations: 5,669
  • Mosaics: 789
  • Linkage Regions: 172
  • Paper Collected: 6/30/2018
  • Last Update: 8/26/2018


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