AutismKB 2.0

Annotation Detail for PDYN


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Basic Information Top
Gene Symbol:PDYN ( MGC26418,PENKB )
Gene Full Name: prodynorphin
Band: 20p13
Quick LinksEntrez ID:5173; OMIM: 131340; Uniprot ID:PDYN_HUMAN; ENSEMBL ID: ENSG00000101327; HGNC ID: 8820
Relate to Another Database: SFARIGene; denovo-db
Related Pathway Information Top
No data
No data
Pathway IDPathway Name
Signaling by GPCR
Opioid Signalling
No data
No data
No data
Related Diseases/Disorders Top
No data
No data
Desease Name
cocaine dependence or abuse
CHEMDEPENDENCY
Alcohol-Related Disorders
epilepsy
PSYCH
Cocaine-Related Disorders
alcohol abuse
NEUROLOGICAL
schizophrenia
cocaine dependence
cocaine dependence/abuse
No data
No data
Comparative Toxicogenomics Database Top
Chemical ID Chemical Name Interaction Interaction Action Publication
C027576 4-hydroxy-2-nonenal 4-hydroxy-2-nonenal results in decreased expression of PDYN mRNAdecreases expression 12419474
D000638 Amiodarone Amiodarone results in increased expression of PDYN mRNAincreases expression 19774075
D000643 Ammonium Chloride Ammonium Chloride affects the expression of PDYN mRNAaffects expression 16483693
D003913 Dextroamphetamine Dextroamphetamine results in increased expression of PDYN mRNAincreases expression 18681898
11566502
D003913 Dextroamphetamine GRM1 protein affects the reaction [Dextroamphetamine results in increased expression of PDYN mRNA]affects reaction|increases expression 11566502
D003913 Dextroamphetamine Dextroamphetamine results in increased expression of PDYN mRNAincreases expression 11897087
12105094
11532335
16459022
12523490
D003913 Dextroamphetamine LY 306740 inhibits the reaction [Dextroamphetamine results in increased expression of PDYN mRNA]decreases reaction|increases expression 11897087
D003913 Dextroamphetamine SL 327 inhibits the reaction [Dextroamphetamine results in increased expression of PDYN mRNA]decreases reaction|increases expression 16459022
D003913 Dextroamphetamine U 0126 inhibits the reaction [Dextroamphetamine results in increased expression of PDYN mRNA]decreases reaction|increases expression 16459022
D003913 Dextroamphetamine U 69593 inhibits the reaction [Dextroamphetamine results in increased expression of PDYN mRNA]decreases reaction|increases expression 11532335
D000661 Amphetamine ADORA2A protein affects the reaction [Amphetamine results in increased expression of PDYN mRNA]affects reaction|increases expression 12700712
D000661 Amphetamine Amphetamine results in increased expression of PDYN mRNAincreases expression 12700712
D000661 Amphetamine Amphetamine results in increased expression of PDYN mRNAincreases expression 15033416
14521997
15592348
D000661 Amphetamine Baclofen inhibits the reaction [Amphetamine results in increased expression of PDYN mRNA]decreases reaction|increases expression 15592348
15033416
D000661 Amphetamine CTAP octapeptide inhibits the reaction [Amphetamine results in increased expression of PDYN mRNA]decreases reaction|increases expression 14521997
D000661 Amphetamine tyrosyl-tetrahydroisoquinolinecarbonyl-psi(methylamino)phenylalanyl-phenylalanine inhibits the reaction [Amphetamine results in increased expression of PDYN mRNA]decreases reaction|increases expression 14521997
D001418 Baclofen Baclofen inhibits the reaction [Amphetamine results in increased expression of PDYN mRNA]decreases reaction|increases expression 15033416
15592348
D003042 Cocaine Cocaine results in increased expression of PDYN mRNAincreases expression 12523490
C529311 CTAP octapeptide CTAP octapeptide inhibits the reaction [Amphetamine results in increased expression of PDYN mRNA]decreases reaction|increases expression 14521997
D003975 Diazepam Diazepam inhibits the reaction [Kainic Acid results in increased expression of PDYN mRNA]decreases reaction|increases expression 8417141
D000431 Ethanol Ethanol results in decreased expression of PDYN mRNAdecreases expression 17934066
D000431 Ethanol fomepizole inhibits the reaction [Ethanol results in decreased expression of PDYN mRNA]decreases expression|decreases reaction 17934066
C010238 fomepizole fomepizole inhibits the reaction [Ethanol results in decreased expression of PDYN mRNA]decreases expression|decreases reaction 17934066
D006861 Hydrogen Peroxide Hydrogen Peroxide results in decreased expression of PDYN mRNAdecreases expression 12419474
D016627 Oxidopamine Oxidopamine results in decreased expression of PDYN mRNAdecreases expression 14622157
D016627 Oxidopamine Oxidopamine results in increased expression of PDYN mRNAincreases expression 14622157
D016627 Oxidopamine Oxidopamine results in increased expression of PDYN mRNAincreases expression 15610165
D007608 Kainic Acid Diazepam inhibits the reaction [Kainic Acid results in increased expression of PDYN mRNA]decreases reaction|increases expression 8417141
D007608 Kainic Acid Kainic Acid results in increased expression of PDYN mRNAincreases expression 8417141
D007608 Kainic Acid Pentobarbital inhibits the reaction [Kainic Acid results in increased expression of PDYN mRNA]decreases reaction|increases expression 8417141
D007608 Kainic Acid Valproic Acid inhibits the reaction [Kainic Acid results in increased expression of PDYN mRNA]decreases reaction|increases expression 8417141
D008070 Lipopolysaccharides Lipopolysaccharides results in increased expression of PDYN mRNAincreases expression 12057914
C102280 LY 306740 LY 306740 inhibits the reaction [Dextroamphetamine results in increased expression of PDYN mRNA]decreases reaction|increases expression 11897087
D018817 N-Methyl-3,4-methylenedioxyamphetamine N-Methyl-3,4-methylenedioxyamphetamine results in increased expression of PDYN mRNAincreases expression 15661373
D009020 Morphine [Zymosan co-treated with Morphine] results in increased expression of PDYN mRNAaffects cotreatment|increases expression 15979727
D009020 Morphine Morphine results in decreased expression of PDYN mRNAdecreases expression 17401159
D010424 Pentobarbital Pentobarbital inhibits the reaction [Kainic Acid results in increased expression of PDYN mRNA]decreases reaction|increases expression 8417141
D010795 Phthalic Acids Phthalic Acids results in decreased expression of PDYN mRNAdecreases expression 15728792
D011374 Progesterone Progesterone results in increased expression of PDYN mRNAincreases expression 15650077
D020849 Raloxifene Raloxifene affects the expression of PDYN mRNAaffects expression 16079270
C424127 SL 327 SL 327 inhibits the reaction [Dextroamphetamine results in increased expression of PDYN mRNA]decreases reaction|increases expression 16459022
D013749 Tetrachlorodibenzodioxin Tetrachlorodibenzodioxin results in decreased expression of PDYN mRNAdecreases expression 15703262
D015647 2,3,4,5-Tetrahydro-7,8-dihydroxy-1-phenyl-1H-3-benzazepine 2,3,4,5-Tetrahydro-7,8-dihydroxy-1-phenyl-1H-3-benzazepine results in increased expression of PDYN mRNAincreases expression 14622157
D014147 Tramadol Tramadol results in decreased expression of PDYN mRNAdecreases expression 17401159
C092721 tyrosyl-tetrahydroisoquinolinecarbonyl-psi(methylamino)phenylalanyl-phenylalanine tyrosyl-tetrahydroisoquinolinecarbonyl-psi(methylamino)phenylalanyl-phenylalanine inhibits the reaction [Amphetamine results in increased expression of PDYN mRNA]decreases reaction|increases expression 14521997
C113580 U 0126 U 0126 inhibits the reaction [Dextroamphetamine results in increased expression of PDYN mRNA]decreases reaction|increases expression 16459022
C045444 U 69593 U 69593 inhibits the reaction [Dextroamphetamine results in increased expression of PDYN mRNA]decreases reaction|increases expression 11532335
D014635 Valproic Acid Valproic Acid inhibits the reaction [Kainic Acid results in increased expression of PDYN mRNA]decreases reaction|increases expression 8417141
D015054 Zymosan [Zymosan co-treated with Morphine] results in increased expression of PDYN mRNAaffects cotreatment|increases expression 15979727
D015054 Zymosan Zymosan results in increased expression of PDYN mRNAincreases expression 15979727
Disease ID Disease Name Direct Evidence Inference Chemical Name Inference Score Publication
MESH:D000014 Abnormalities, Drug-Induced Ethanol 12.5518926900 17676605
MESH:D000014 Abnormalities, Drug-Induced Tetrachlorodibenzodioxin 12.5515322242 11752688 14514962
MESH:D000014 Abnormalities, Drug-Induced Valproic Acid 12.558875741
MESH:D000015 Abnormalities, Multiple Valproic Acid 3.6619490988
MESH:D000138 Acidosis Ammonium Chloride 9.4918287403
MESH:D000138 Acidosis Ethanol 9.4911192467
MESH:D000168 Acrocephalosyndactylia U 0126 5.1817694057
MESH:D055371 Acute Lung Injury Lipopolysaccharides 3.7611850527 18653653
MESH:D018248 Adenoma, Liver Cell Tetrachlorodibenzodioxin 3.0816835633
MESH:D000419 Albuminuria Raloxifene 4.3117308373 17451421
MESH:D020268 Alcohol-Induced Disorders, Nervous System Ethanol 5.0215451039 15451040
MESH:D000544 Alzheimer Disease Raloxifene 2.4815800139
MESH:D000550 Amblyopia Valproic Acid 4.9317688650
MESH:D019969 Amphetamine-Related Disorders Amphetamine 5.7616916582 18475255 15010207 16459022
MESH:D000690 Amyotrophic Lateral Sclerosis 4-hydroxy-2-nonenal 3.9210965797
MESH:D000740 Anemia Tetrachlorodibenzodioxin 8.1511748828
MESH:D000740 Anemia Zymosan 8.1518664788
MESH:D000853 Anophthalmos Ethanol 4.5315513904
MESH:D000855 Anorexia 2,3,4,5-Tetrahydro-7,8-dihydroxy-1-phenyl-1H-3-benzazepine 15.4512183048
MESH:D000855 Anorexia Amphetamine 15.4512005258 12183048 16101753 16084549
MESH:D000855 Anorexia N-Methyl-3,4-methylenedioxyamphetamine 15.4515146954
MESH:D001008 Anxiety Disorders Diazepam 19.3418313124 16284244
MESH:D001008 Anxiety Disorders Ethanol 19.3411141031
MESH:D001008 Anxiety Disorders Pentobarbital 19.3418313124 11141031
MESH:D001008 Anxiety Disorders Valproic Acid 19.3417497229
MESH:D001145 Arrhythmias, Cardiac Amiodarone 3.5520041841 18057881 18218290
MESH:D001169 Arthritis, Experimental Zymosan 3.9415944321 15142272 17659584 15188379 16872482
MESH:D001281 Atrial Fibrillation Amiodarone 3.6918651412 19698954
MESH:D001289 Attention Deficit Disorder with Hyperactivity Oxidopamine 8.2714699433
MESH:D001289 Attention Deficit Disorder with Hyperactivity Phthalic Acids 8.2720106747
MESH:D001321 Autistic Disorder Valproic Acid 2.0317157402 20603192 17688650 18940202 18177632 18985861 19460635 18396377 16609825 18558336 19232924 15238991 18775368 18316065 17507914
MESH:D001714 Bipolar Disorder Valproic Acid 2.9320046352 17594078
MESH:D001778 Blood Coagulation Disorders Amiodarone 8.1719483382
MESH:D001778 Blood Coagulation Disorders Tetrachlorodibenzodioxin 8.1712125929
MESH:D001836 Body Weight Changes Tetrachlorodibenzodioxin 3.4915340226
MESH:D001848 Bone Diseases, Developmental Tetrachlorodibenzodioxin 7.4015746008
MESH:D001848 Bone Diseases, Developmental Valproic Acid 7.408888407
MESH:D020201 Brain Hemorrhage, Traumatic Progesterone 5.0417868700
MESH:D001930 Brain Injuries Progesterone 10.0015380490 15845082 15665606
MESH:D001930 Brain Injuries Raloxifene 10.0016580743
MESH:D002545 Brain Ischemia Morphine 4.8519211983
MESH:D001943 Breast Neoplasms Progesterone 1.9215562024 17614352 16175315
MESH:D001943 Breast Neoplasms Raloxifene 1.9217952589 17893378 17242785 15572757 17261762 16912660 17049068 15758505 16837676 17595753 17440819 15775269
MESH:D001943 Breast Neoplasms Tetrachlorodibenzodioxin 1.9220435547
MESH:D002056 Burns Ethanol 4.3616374292
MESH:D002277 Carcinoma Tetrachlorodibenzodioxin 2.5716835633
MESH:D006528 Carcinoma, Hepatocellular Ethanol 2.3618788625 15289165 15763234
MESH:D002295 Carcinoma, Transitional Cell Raloxifene 3.8217572228
MESH:D006332 Cardiomegaly Ethanol 6.3019332462
MESH:D006332 Cardiomegaly Tetrachlorodibenzodioxin 6.3016120746 18670907 18850075
MESH:D002311 Cardiomyopathy, Dilated Amiodarone 2.7915710769 19225199
MESH:D002318 Cardiovascular Diseases Hydrogen Peroxide 6.9116936243
MESH:D002318 Cardiovascular Diseases Raloxifene 6.9115775269
MESH:D002341 Carotid Artery Thrombosis Amiodarone 4.7918974383
MESH:D002659 Child Development Disorders, Pervasive Valproic Acid 2.6020734317
MESH:D018281 Cholangiocarcinoma Tetrachlorodibenzodioxin 2.9216835633
MESH:D002779 Cholestasis marker/mechanism 16919318
MESH:D002971 Cleft Lip Ethanol 3.4315513904
MESH:D002972 Cleft Palate Diazepam 9.343629520
MESH:D002972 Cleft Palate Ethanol 9.3415513904
MESH:D002972 Cleft Palate Tetrachlorodibenzodioxin 9.3415668235 8697196 12621046 15340226 16354765
MESH:D019970 Cocaine-Related Disorders Cocaine 5.4219606084
MESH:D003072 Cognition Disorders Raloxifene 4.3315800139
MESH:D000013 Congenital Abnormalities Tetrachlorodibenzodioxin 2.8114669216 17141729
MESH:D019465 Craniofacial Abnormalities Ethanol 3.6315513904 19302082 10194807 15451039 11198716 11873399 15451040
MESH:D019465 Craniofacial Abnormalities Tetrachlorodibenzodioxin 3.6320055451 10048152 15322242
MESH:D019465 Craniofacial Abnormalities Valproic Acid 3.6316575769 8888407 17688650
MESH:D003865 Depressive Disorder, Major Raloxifene 3.9217474826
MESH:D003924 Diabetes Mellitus, Type 2 Tetrachlorodibenzodioxin 1.6017107852
MESH:D003928 Diabetic Nephropathies Raloxifene 3.6917451421 15920148 17308373
MESH:D003929 Diabetic Neuropathies Progesterone 4.2017187935
MESH:D003967 Diarrhea Morphine 4.252540324
MESH:D056486 Drug-Induced Liver Injury Amiodarone 8.2515265979 18218290
MESH:D056486 Drug-Induced Liver Injury Ethanol 8.2511566570
MESH:D056486 Drug-Induced Liver Injury Tetrachlorodibenzodioxin 8.2520420201
MESH:D056486 Drug-Induced Liver Injury Valproic Acid 8.251733752 19641884
MESH:D004362 Drug Toxicity Tetrachlorodibenzodioxin 2.5511462148
MESH:D004421 Dystonia Diazepam 10.141851702
MESH:D004421 Dystonia Valproic Acid 10.141851702
MESH:D004487 Edema Raloxifene 10.1215860553
MESH:D004487 Edema Tetrachlorodibenzodioxin 10.1211000095 12711302
MESH:D004487 Edema Zymosan 10.127907874
MESH:D004489 Edema, Cardiac Tetrachlorodibenzodioxin 3.6016714409 18230668 15322242
MESH:D004681 Encephalomyelitis, Autoimmune, Experimental Progesterone 8.4017692515
MESH:D004681 Encephalomyelitis, Autoimmune, Experimental Raloxifene 8.4015845917
MESH:D004715 Endometriosis Progesterone 8.0816134523
MESH:D004715 Endometriosis Tetrachlorodibenzodioxin 8.0810568697 9294722
MESH:D019446 Endotoxemia Lipopolysaccharides 4.1015821434 17637181 15328337
MESH:D004831 Epilepsies, Myoclonic Valproic Acid 3.863659116 17275665
MESH:D004828 Epilepsies, Partial Diazepam 9.593922381
MESH:D004828 Epilepsies, Partial Valproic Acid 9.5916628512 3922381
MESH:D004827 Epilepsy Diazepam 6.77821787
MESH:D004827 Epilepsy Valproic Acid 6.7720417680 18234410
MESH:D004832 Epilepsy, Absence Diazepam 8.666401628 6426943
MESH:D004832 Epilepsy, Absence Valproic Acid 8.667562514 6426943 6254150
MESH:D017029 Epilepsy, Complex Partial Valproic Acid 4.017750514
MESH:D004830 Epilepsy, Tonic-Clonic Valproic Acid 3.773659116
MESH:D004938 Esophageal Neoplasms Ethanol 2.6816704527
MESH:D005124 Eye Abnormalities Tetrachlorodibenzodioxin 2.8011564622
MESH:D005221 Fatigue Amphetamine 5.3019890266
MESH:D005234 Fatty Liver Amiodarone 16.7014986274
MESH:D005234 Fatty Liver Ethanol 16.7018620774 19236843 16409862
MESH:D005234 Fatty Liver Raloxifene 16.7017473493
MESH:D005234 Fatty Liver Valproic Acid 16.7014986274 19224547
MESH:D005235 Fatty Liver, Alcoholic Ethanol 5.3617920746
MESH:D005310 Fetal Alcohol Syndrome Ethanol 5.0016946407 10194807 15513904 15451040
MESH:D005313 Fetal Death Tetrachlorodibenzodioxin 3.1711858732
MESH:D005315 Fetal Diseases Valproic Acid 4.5916575769
MESH:D005317 Fetal Growth Retardation Valproic Acid 3.8518558336 8888407
MESH:D005334 Fever Lipopolysaccharides 3.7611852909 9205823
MESH:D005355 Fibrosis Tetrachlorodibenzodioxin 2.6620067830
MESH:D005756 Gastritis Ethanol 4.3915046732
MESH:D006058 Gonadal Disorders Tetrachlorodibenzodioxin 4.2910696789
MESH:D006330 Heart Defects, Congenital Tetrachlorodibenzodioxin 2.1810048152 11294989
MESH:D006331 Heart Diseases Raloxifene 3.3311110106
MESH:D006463 Hemolytic-Uremic Syndrome Lipopolysaccharides 4.1316366002
MESH:D006470 Hemorrhage Tetrachlorodibenzodioxin 3.0711000095
MESH:D006505 Hepatitis Zymosan 4.4219110552
MESH:D006529 Hepatomegaly Amiodarone 7.5815265979
MESH:D006529 Hepatomegaly Tetrachlorodibenzodioxin 7.5812621046 15340226 16120746
MESH:D006849 Hydrocephalus Valproic Acid 4.5717688650
MESH:D006869 Hydronephrosis Tetrachlorodibenzodioxin 3.7515340226 16959395 8697196 16354765 18606429
MESH:D006930 Hyperalgesia Ethanol 3.4918783367
MESH:D006937 Hypercholesterolemia Amiodarone 3.618137927 9751232
MESH:D006948 Hyperkinesis Amphetamine 5.1414960337 1977408
MESH:D006973 Hypertension Raloxifene 4.8415787275 17577099
MESH:D006973 Hypertension Tetrachlorodibenzodioxin 4.8418670907 18850075
MESH:D007037 Hypothyroidism Amiodarone 4.2218020914 17991464
MESH:D020244 Infarction, Middle Cerebral Artery Progesterone 4.1115869954
MESH:D007249 Inflammation Lipopolysaccharides 10.7512878042 9205823 17237260 17255318 17963957
MESH:D007249 Inflammation Progesterone 10.7515869954
MESH:D007249 Inflammation Tetrachlorodibenzodioxin 10.7512200463 12878042
MESH:D007249 Inflammation Zymosan 10.758014878 11289658
MESH:D019189 Iron Metabolism Disorders Lipopolysaccharides 4.3617255318
MESH:D043183 Irritable Bowel Syndrome Zymosan 5.5417553498
MESH:D007569 Jaw Abnormalities Ethanol 9.2415513904
MESH:D007569 Jaw Abnormalities Tetrachlorodibenzodioxin 9.2416580747
MESH:D007676 Kidney Failure, Chronic Hydrogen Peroxide 4.0116518626
MESH:D007859 Learning Disorders Ethanol 3.9215451040
MESH:D007889 Leiomyoma Raloxifene 4.2216973256
MESH:D007948 Leukemia, Monocytic, Acute U 0126 5.0116972261
MESH:D015470 Leukemia, Myeloid, Acute Valproic Acid 2.1017596541 16294345
MESH:D007970 Leukopenia Lipopolysaccharides 4.4015821434
MESH:D017880 Limb Deformities, Congenital Ethanol 3.6017676605
MESH:D008064 Lipidoses Amiodarone 3.3015342952 17567588
MESH:D008103 Liver Cirrhosis Ethanol 3.2115289165
MESH:D008104 Liver Cirrhosis, Alcoholic Ethanol 4.8018295389
MESH:D008106 Liver Cirrhosis, Experimental Ethanol 3.3818166357
MESH:D008106 Liver Cirrhosis, Experimental Lipopolysaccharides 3.3812878042
MESH:D008106 Liver Cirrhosis, Experimental Tetrachlorodibenzodioxin 3.3812878042
MESH:D008108 Liver Diseases, Alcoholic Ethanol 4.3617207112 17347304
MESH:D008113 Liver Neoplasms Tetrachlorodibenzodioxin 1.6116984957
MESH:D008114 Liver Neoplasms, Experimental Tetrachlorodibenzodioxin 1.9312151625
MESH:D008133 Long QT Syndrome Amiodarone 3.3617391786 15350150 11989578
MESH:D008171 Lung Diseases Amiodarone 3.1812587719
MESH:D017563 Lung Diseases, Interstitial Amiodarone 10.2618516814
MESH:D017563 Lung Diseases, Interstitial Valproic Acid 10.2617228818
MESH:D055370 Lung Injury Lipopolysaccharides 3.7221114838
MESH:D008175 Lung Neoplasms Tetrachlorodibenzodioxin 1.2319555203 11884234
MESH:D008325 Mammary Neoplasms, Experimental Progesterone 2.6817203775 11408345
MESH:D008569 Memory Disorders Ethanol 3.9118411066 15451040
MESH:D008881 Migraine Disorders Valproic Acid 2.9818803445 18765137
MESH:D018200 Mixed Tumor, Mullerian Raloxifene 5.2515863610
MESH:D009041 Motion Sickness Dextroamphetamine 5.221613127
MESH:D009101 Multiple Myeloma Raloxifene 3.2316497877
MESH:D009102 Multiple Organ Failure Zymosan 4.9312130978 15259001 15241586 17724436 10479408 12879239 15213630 10890648 18160304 15834315
MESH:D009139 Musculoskeletal Abnormalities Valproic Acid 3.768888407
MESH:D009181 Mycoses Amiodarone 4.6012754197 17974566
MESH:D009190 Myelodysplastic Syndromes Valproic Acid 2.9917596541
MESH:D009203 Myocardial Infarction Cocaine 3.8618072171
MESH:D017202 Myocardial Ischemia Tetrachlorodibenzodioxin 2.7912213967
MESH:D009232 Myxoma Raloxifene 5.2516343187
MESH:D009421 Nervous System Malformations Tetrachlorodibenzodioxin 2.9314600291
MESH:D009436 Neural Tube Defects Valproic Acid 2.948888407 16359493
MESH:D019636 Neurodegenerative Diseases Amphetamine 8.5715183010
MESH:D019636 Neurodegenerative Diseases Oxidopamine 8.5718514411
MESH:D010024 Osteoporosis Raloxifene 3.2119059307 17882678 15775268
MESH:D015663 Osteoporosis, Postmenopausal Raloxifene 3.9615758505 17893378 17823083 15579764
MESH:D010051 Ovarian Neoplasms Progesterone 4.9916525653 17393432
MESH:D010051 Ovarian Neoplasms U 0126 4.9916211241
MESH:D010146 Pain Morphine 7.3618699797 20225289 16273134 15275824 6776300 15215642
MESH:D010146 Pain Tramadol 7.3618204346
MESH:D010190 Pancreatic Neoplasms Ethanol 2.8612384795
MESH:D010212 Papilloma Hydrogen Peroxide 3.8012065085
MESH:D010302 Parkinson Disease, Secondary Oxidopamine 5.1711771942 15893579
MESH:D010382 Peliosis Hepatis Tetrachlorodibenzodioxin 3.9512520081
MESH:D010538 Peritonitis Zymosan 4.5917826846 19088179 18977430 19641140 17371808 14761945 15979727 11985352 15259001 18557954 18760300
MESH:D010787 Photosensitivity Disorders 4-hydroxy-2-nonenal 5.2011550810
MESH:D011014 Pneumonia Lipopolysaccharides 4.2611605937 12224865
MESH:D017119 Porphyria Cutanea Tarda Tetrachlorodibenzodioxin 3.2818163543
MESH:D011297 Prenatal Exposure Delayed Effects Tetrachlorodibenzodioxin 8.4811896295 11118676 11222880 11399792
MESH:D011297 Prenatal Exposure Delayed Effects Valproic Acid 8.4820603192
MESH:D011471 Prostatic Neoplasms Raloxifene 3.6916220300 15731164 16536755
MESH:D019310 Pseudolymphoma Valproic Acid 4.2412752131 11422049
MESH:D011618 Psychotic Disorders Cocaine 4.6116134406
MESH:D011658 Pulmonary Fibrosis Amiodarone 2.7412490602 12832656 11597910
MESH:D011693 Purpura Raloxifene 5.2515770314
MESH:D012021 Reflex, Abnormal Pentobarbital 5.7310930210
MESH:D015427 Reperfusion Injury Morphine 3.9919211983
MESH:D012130 Respiratory Hypersensitivity Lipopolysaccharides 3.5410835634
MESH:D015619 Respiratory System Abnormalities Tetrachlorodibenzodioxin 3.5618990726
MESH:D012208 Rhabdomyosarcoma Valproic Acid 3.9019155313
MESH:D012468 Salivary Gland Neoplasms Progesterone 2.7518045962
MESH:D012559 Schizophrenia Valproic Acid 2.0315737665 19110320
MESH:D012640 Seizures Cocaine 20.7410454489
MESH:D012640 Seizures Diazepam 20.749754883 15946322 10087439
MESH:D012640 Seizures Ethanol 20.749754883
MESH:D012640 Seizures Kainic Acid 20.741641125 10686065 16336964 17827730 19414003 15686955 18657176 14637104 19186208
MESH:D012640 Seizures Pentobarbital 20.749754883 10087439
MESH:D012640 Seizures Valproic Acid 20.7416876388 17978042 11044598 11738929 1511512 15475178 14763951 3137016
MESH:D018805 Sepsis Zymosan 4.4111441115
OMIM:609620 SHORT QT SYNDROME 1 Amiodarone 4.7918724381
MESH:D012878 Skin Neoplasms Hydrogen Peroxide 5.2612065085
MESH:D012878 Skin Neoplasms Tetrachlorodibenzodioxin 5.2616192470
MESH:D012893 Sleep Disorders Kainic Acid 5.4019414003
MESH:D013119 Spinal Cord Injuries Progesterone 3.9815862959 16503802
MESH:D016135 Spinal Dysraphism Valproic Acid 3.5619490988
MESH:D020754 Spinocerebellar Ataxias marker/mechanism
MESH:D013226 Status Epilepticus Valproic Acid 4.2412833885
MESH:D019956 Stereotypic Movement Disorder Amphetamine 6.121977408
MESH:D013274 Stomach Neoplasms Ethanol 2.3018456281
MESH:D013276 Stomach Ulcer Amiodarone 6.6218087811
MESH:D013276 Stomach Ulcer Ethanol 6.6217918041 9211565 11906479 9562338 16755016 17189318
MESH:D020521 Stroke Raloxifene 3.5916837676
MESH:D013375 Substance Withdrawal Syndrome Diazepam 15.249754883
MESH:D013375 Substance Withdrawal Syndrome Ethanol 15.249754883
MESH:D013375 Substance Withdrawal Syndrome Pentobarbital 15.2411529278 9754883
MESH:D013610 Tachycardia Amiodarone 4.0111238279
MESH:D017180 Tachycardia, Ventricular Amiodarone 3.9119225199
MESH:D013921 Thrombocytopenia Lipopolysaccharides 3.9115821434
MESH:D013959 Thyroid Diseases Amiodarone 11.0519731979
MESH:D013959 Thyroid Diseases Tetrachlorodibenzodioxin 11.0512697716
MESH:D013971 Thyrotoxicosis Amiodarone 4.5718020914 19584973
MESH:D013978 Tibial Fractures Raloxifene 4.9119048282
MESH:D016171 Torsades de Pointes Amiodarone 3.9017467628 11989578
MESH:D014178 Translocation, Genetic Valproic Acid 4.9317262798
MESH:D020194 Unverricht-Lundborg Syndrome Valproic Acid 4.233119515
MESH:D001749 Urinary Bladder Neoplasms Raloxifene 2.7017572228
MESH:D014564 Urogenital Abnormalities Valproic Acid 4.358888407
MESH:D014605 Uveitis Zymosan 5.1011006244
MESH:D054079 Vascular Malformations Tetrachlorodibenzodioxin 4.2912125929
MESH:D054556 Venous Thromboembolism Raloxifene 4.9116837676
MESH:D014846 Vulvar Neoplasms Raloxifene 5.2516343187
MESH:D019282 Wasting Syndrome Tetrachlorodibenzodioxin 3.9515886252
Pathway ID Pathway Name
REACT:15295 Opioid Signalling
REACT:14797 Signaling by GPCR
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Simple Query:


  (e.g. CHD8)

Syndromic Genes

Non-syndromic Genes

AutismKB Statistics

  • Studies: 1,036
  • Genes: 1,379
  • CNVs/SVs: 5,420
  • SNVs/Indels: 11,669
  • de novo Mutations: 5,669
  • Mosaics: 789
  • Linkage Regions: 172
  • Paper Collected: 6/30/2018
  • Last Update: 8/26/2018


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