AutismKB 2.0

Annotation Detail for UPB1


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Basic Information Top
Gene Symbol:UPB1 ( BUP1 )
Gene Full Name: ureidopropionase, beta
Band: 22q11.23
Quick LinksEntrez ID:51733; OMIM: 606673; Uniprot ID:BUP1_HUMAN; ENSEMBL ID: ENSG00000100024; HGNC ID: 16297
Relate to Another Database: SFARIGene; denovo-db
Related Pathway Information Top
No data
Pathway IDPathway Name
hsa00240Pyrimidine metabolism
hsa00410beta-Alanine metabolism
hsa00770Pantothenate and CoA biosynthesis
hsa00983Drug metabolism - other enzymes
hsa01100Metabolic pathways
Pathway IDPathway Name
Metabolism of nucleotides
No data
Pathway IDPathway Name
P02771Pyrimidine Metabolism
No data
Related Diseases/Disorders Top
Desease IDDesease Name
H00200Beta-ureidopropionase deficiency
Inherited disorders of nucleotide metabolism
Genetic disorders
No data
No data
No data
Desease Name
Beta-ureidopropionase deficiency
Comparative Toxicogenomics Database Top
Chemical ID Chemical Name Interaction Interaction Action Publication
C016403 2,4-dinitrotoluene 2,4-dinitrotoluene affects the expression of UPB1 mRNAaffects expression 21346803
C023514 2,6-dinitrotoluene 2,6-dinitrotoluene results in decreased expression of UPB1 mRNAdecreases expression 20406850
D000082 Acetaminophen Acetaminophen results in decreased expression of UPB1 mRNAdecreases expression 18346771
D016604 Aflatoxin B1 Aflatoxin B1 affects the expression of UPB1 proteinaffects expression 20106945
D000643 Ammonium Chloride Ammonium Chloride affects the expression of UPB1 mRNAaffects expression 16483693
D001564 Benzo(a)pyrene Benzo(a)pyrene results in decreased expression of UPB1 mRNAdecreases expression 20106945
C032036 bromobenzene bromobenzene metabolite binds to UPB1 proteinaffects binding 17305373
D002251 Carbon Tetrachloride Carbon Tetrachloride results in decreased expression of UPB1 mRNAdecreases expression 18346771
D016572 Cyclosporine Cyclosporine results in decreased expression of UPB1 mRNAdecreases expression 20106945
D004052 Diethylnitrosamine Diethylnitrosamine results in decreased expression of UPB1 mRNAdecreases expression 19638242
D005419 Flavonoids Flavonoids results in increased expression of UPB1 mRNAincreases expression 18035473
C039281 furan furan results in decreased expression of UPB1 mRNAdecreases expression 15120968
D005912 Gliotoxin Gliotoxin results in decreased expression of UPB1 mRNAdecreases expression 18346771
C482199 lipopolysaccharide, E coli O55-B5 lipopolysaccharide, E coli O55-B5 results in decreased expression of UPB1 mRNAdecreases expression 18346771
D008701 Methapyrilene Methapyrilene results in decreased expression of UPB1 mRNAdecreases expression 16393664
D008767 Methylmercury Compounds Methylmercury Compounds results in increased expression of UPB1 mRNAincreases expression 16966085
C014707 nitrosobenzylmethylamine nitrosobenzylmethylamine results in increased expression of UPB1 mRNAincreases expression 17616710
D010634 Phenobarbital Phenobarbital results in increased expression of UPB1 mRNAincreases expression 12082028
C006253 pirinixic acid [pirinixic acid binds to and results in increased activity of PPARA protein] which results in decreased expression of UPB1 mRNAaffects binding|decreases expression|increases activity 19710929
D013749 Tetrachlorodibenzodioxin Tetrachlorodibenzodioxin results in decreased expression of UPB1 mRNAdecreases expression 20106945
D013749 Tetrachlorodibenzodioxin Tetrachlorodibenzodioxin results in increased expression of UPB1 mRNAincreases expression 18796159
D014303 Trinitrotoluene Trinitrotoluene affects the expression of UPB1 mRNAaffects expression 21346803
D014415 Tunicamycin Tunicamycin results in decreased expression of UPB1 mRNAdecreases expression 17127020
Disease ID Disease Name Direct Evidence Inference Chemical Name Inference Score Publication
MESH:D000014 Abnormalities, Drug-Induced Phenobarbital 13.536195326
MESH:D000014 Abnormalities, Drug-Induced Tetrachlorodibenzodioxin 13.5314514962 15322242 11752688
MESH:D000014 Abnormalities, Drug-Induced Trinitrotoluene 13.537525203
MESH:D000138 Acidosis Ammonium Chloride 3.4318287403
MESH:D055371 Acute Lung Injury pirinixic acid 2.9918653653
MESH:D000230 Adenocarcinoma Benzo(a)pyrene 1.9520127859 20464547
MESH:D000236 Adenoma Benzo(a)pyrene 6.386695378
MESH:D000236 Adenoma Diethylnitrosamine 6.386695378 10737359
MESH:D018248 Adenoma, Liver Cell Diethylnitrosamine 23.7817162532 16434500 18056438 19061943 17620307 19052882
MESH:D018248 Adenoma, Liver Cell Phenobarbital 23.7817620307
MESH:D018248 Adenoma, Liver Cell pirinixic acid 23.7816434500
MESH:D018248 Adenoma, Liver Cell Tetrachlorodibenzodioxin 23.7816835633
MESH:D000740 Anemia Tetrachlorodibenzodioxin 2.8311748828
MESH:D000799 Angioedema Acetaminophen 3.7110982225
MESH:D017544 Aortic Aneurysm, Abdominal Benzo(a)pyrene 3.9419183758
MESH:D001321 Autistic Disorder marker/mechanism 18853477
MESH:D001321 Autistic Disorder Acetaminophen 1.4318445737
OMIM:613161 BETA-UREIDOPROPIONASE DEFICIENCY marker/mechanism
MESH:D001778 Blood Coagulation Disorders pirinixic acid 8.3719483382
MESH:D001778 Blood Coagulation Disorders Tetrachlorodibenzodioxin 8.3712125929
MESH:D001836 Body Weight Changes Tetrachlorodibenzodioxin 3.6615340226
MESH:D001848 Bone Diseases, Developmental Tetrachlorodibenzodioxin 2.6815746008
MESH:D001943 Breast Neoplasms Benzo(a)pyrene 1.8017474063 20146248
MESH:D001943 Breast Neoplasms Diethylnitrosamine 1.8017474063
MESH:D001943 Breast Neoplasms Tetrachlorodibenzodioxin 1.8020435547
MESH:D002252 Carbon Tetrachloride Poisoning Carbon Tetrachloride 3.6518705752 15673190 16227642 15700767 16011737 16050911 16097048 15721981 16124888 16192424 10355542 3786805
MESH:D002277 Carcinoma Tetrachlorodibenzodioxin 2.6916835633
MESH:D006528 Carcinoma, Hepatocellular 2,4-dinitrotoluene 13.7716705839
MESH:D006528 Carcinoma, Hepatocellular 2,6-dinitrotoluene 13.7716705839
MESH:D006528 Carcinoma, Hepatocellular Acetaminophen 13.773084413
MESH:D006528 Carcinoma, Hepatocellular Aflatoxin B1 13.7712619106 12907637 21507988
MESH:D006528 Carcinoma, Hepatocellular Carbon Tetrachloride 13.7718788625
MESH:D006528 Carcinoma, Hepatocellular Diethylnitrosamine 13.7719383236 16779866 19919837 20727157 10672840 18506893 10737359 19171122 18971187 19394651 20432363 18210153 20512989 19519916 19418558 21159647 18665156 3084413 16698587 3581430 16830150 19052882 16681979 16569478 17055752 16540662 19208518 20935162 18494052 16878318 18056438 19335982 18978308 17138121 20101231 19701751 19107877 20524982 17162532 16807293 18691550 16935385 20214788 18785209 16288022 17173139 17428255 20514400 20084675 19539802 11831363 16502159 18788625 17761372 16328049 20007298 18393292 17978847 19822196
MESH:D006528 Carcinoma, Hepatocellular Phenobarbital 13.771701930 20935162 20007298 6705139 17173139
MESH:D002294 Carcinoma, Squamous Cell Benzo(a)pyrene 2.0120419170
MESH:D006332 Cardiomegaly Tetrachlorodibenzodioxin 2.3018670907 18850075 16120746
MESH:D002386 Cataract Acetaminophen 7.2610977129
MESH:D002386 Cataract Trinitrotoluene 7.2614694615 15817613
MESH:D002471 Cell Transformation, Neoplastic 2,6-dinitrotoluene 10.636135515
MESH:D002471 Cell Transformation, Neoplastic Cyclosporine 10.6312371664
MESH:D002471 Cell Transformation, Neoplastic Diethylnitrosamine 10.6321159647 7505956 2727394 17174075
MESH:D002493 Central Nervous System Diseases Phenobarbital 4.124080065
MESH:D018281 Cholangiocarcinoma Diethylnitrosamine 8.9519052882
MESH:D018281 Cholangiocarcinoma Tetrachlorodibenzodioxin 8.9516835633
MESH:D002779 Cholestasis Cyclosporine 7.4319486331
MESH:D002779 Cholestasis pirinixic acid 7.4319176532
MESH:D002972 Cleft Palate Tetrachlorodibenzodioxin 2.058697196 12621046 16354765 15668235 15340226
MESH:D000013 Congenital Abnormalities Tetrachlorodibenzodioxin 8.9014669216 17141729
MESH:D000013 Congenital Abnormalities Trinitrotoluene 8.9015095906
MESH:D019465 Craniofacial Abnormalities Tetrachlorodibenzodioxin 1.2510048152 20055451 15322242
MESH:D003490 Cyanosis 2,4-dinitrotoluene 18.0518551238
MESH:D003490 Cyanosis 2,6-dinitrotoluene 18.0518551238
MESH:D003490 Cyanosis Trinitrotoluene 18.0518551238
MESH:D003704 Dementia Methylmercury Compounds 4.8716140633
MESH:D003876 Dermatitis, Atopic pirinixic acid 2.3718249437
MESH:D003924 Diabetes Mellitus, Type 2 Diethylnitrosamine 4.1120387270
MESH:D003924 Diabetes Mellitus, Type 2 Tetrachlorodibenzodioxin 4.1117107852
MESH:D056486 Drug-Induced Liver Injury 2,4-dinitrotoluene 25.2221346803 18551238
MESH:D056486 Drug-Induced Liver Injury 2,6-dinitrotoluene 25.2221346803 18551238
MESH:D056486 Drug-Induced Liver Injury Acetaminophen 25.2219370779 10663392 12958197 16781746 17562736 19416960 14986274 10915739 16109766 17906064 14550746 18071297 10774834 19739265 11834606 11461765 15968718 11287661 16177239 18713872 12540782 14725611 19420014 12705907 2444490 17522070 15619225 12153990 11529661 19164858 16393943 19923254 11743745 12594235 16081117 12392966 11739529 16227642 16485898 19085960 11421492
MESH:D056486 Drug-Induced Liver Injury bromobenzene 25.2212628495 10092053
MESH:D056486 Drug-Induced Liver Injury Carbon Tetrachloride 25.2216177239 7179309 9327722 6623471 16227642 4309450 15968718 2869522 17522070 15027814 19085960 7120509 7440962 19336974 11566570 10092053 6884620 3786805 15998439 3732212 10915739 21278145
MESH:D056486 Drug-Induced Liver Injury Diethylnitrosamine 25.2219107877
MESH:D056486 Drug-Induced Liver Injury Gliotoxin 25.2219739265
MESH:D056486 Drug-Induced Liver Injury Tetrachlorodibenzodioxin 25.2220420201
MESH:D056486 Drug-Induced Liver Injury Trinitrotoluene 25.2218551238 21346803
MESH:D056487 Drug-Induced Liver Injury, Chronic Acetaminophen 3.9719426721
MESH:D004362 Drug Toxicity Tetrachlorodibenzodioxin 2.6611462148
MESH:D004421 Dystonia Phenobarbital 3.881851702
MESH:D004487 Edema pirinixic acid 6.1412083418
MESH:D004487 Edema Tetrachlorodibenzodioxin 6.1411000095 12711302
MESH:D004489 Edema, Cardiac Tetrachlorodibenzodioxin 3.7718230668 16714409 15322242
MESH:D004715 Endometriosis Tetrachlorodibenzodioxin 2.919294722 10568697
MESH:D004831 Epilepsies, Myoclonic Phenobarbital 3.983659116
MESH:D004828 Epilepsies, Partial Phenobarbital 3.743922381 11558140
MESH:D004827 Epilepsy Phenobarbital 2.8220417680
MESH:D004832 Epilepsy, Absence Phenobarbital 3.436401628
MESH:D017029 Epilepsy, Complex Partial Phenobarbital 4.127750514
MESH:D004830 Epilepsy, Tonic-Clonic Phenobarbital 3.893659116
MESH:D004931 Esophageal Achalasia Diethylnitrosamine 4.9916302075
MESH:D004938 Esophageal Neoplasms Benzo(a)pyrene 4.4916530937
MESH:D004938 Esophageal Neoplasms nitrosobenzylmethylamine 4.4915150132 15547721 16805852 15623463 16510608 15264214 15878914 16704527 15547733
MESH:D005124 Eye Abnormalities Tetrachlorodibenzodioxin 2.9111564622
MESH:D005234 Fatty Liver Carbon Tetrachloride 17.7615959796 17595544 19224547 16045604 61145 12631006 16239168 12795759
MESH:D005234 Fatty Liver Cyclosporine 17.7619224547
MESH:D005234 Fatty Liver Diethylnitrosamine 17.7620387270 21071580
MESH:D005234 Fatty Liver pirinixic acid 17.7619236843 20131406
MESH:D005313 Fetal Death Tetrachlorodibenzodioxin 3.3311858732
MESH:D005355 Fibrosis Carbon Tetrachloride 13.9618705752
MESH:D005355 Fibrosis Cyclosporine 13.9612168785 12639820
MESH:D005355 Fibrosis Tetrachlorodibenzodioxin 13.9620067830
MESH:D005756 Gastritis Acetaminophen 3.5516983495
MESH:D005885 Gingival Hyperplasia Cyclosporine 4.098708960
MESH:D006058 Gonadal Disorders Tetrachlorodibenzodioxin 4.4710696789
MESH:D006330 Heart Defects, Congenital Benzo(a)pyrene 6.2220471113
MESH:D006330 Heart Defects, Congenital Tetrachlorodibenzodioxin 6.2211294989 10048152
MESH:D006333 Heart Failure pirinixic acid 2.4620558911
MESH:D006457 Hemoglobinuria, Paroxysmal Cyclosporine 4.2915720958
MESH:D006470 Hemorrhage Tetrachlorodibenzodioxin 3.2111000095
MESH:D006505 Hepatitis Carbon Tetrachloride 3.4719900420 19110552
MESH:D006529 Hepatomegaly Phenobarbital 19.6316109766
MESH:D006529 Hepatomegaly pirinixic acid 19.6319176532 16221962 19772884 18467677
MESH:D006529 Hepatomegaly Tetrachlorodibenzodioxin 19.6315340226 12621046 16120746
MESH:D006529 Hepatomegaly Trinitrotoluene 19.6315817613
MESH:D006869 Hydronephrosis Tetrachlorodibenzodioxin 3.9215340226 8697196 16354765 16959395 18606429
MESH:D006930 Hyperalgesia Acetaminophen 2.6016870215
MESH:D006932 Hyperbilirubinemia Carbon Tetrachloride 4.4016899240
MESH:D006943 Hyperglycemia pirinixic acid 3.0720558911
MESH:D006973 Hypertension Cyclosporine 4.7810903974
MESH:D006973 Hypertension Tetrachlorodibenzodioxin 4.7818850075 18670907
MESH:D006975 Hypertension, Portal Carbon Tetrachloride 3.9615338365
MESH:D007248 Infertility, Male Trinitrotoluene 3.5912150543
MESH:D007249 Inflammation Diethylnitrosamine 7.9118785209
MESH:D007249 Inflammation Flavonoids 7.9117296493
MESH:D007249 Inflammation Tetrachlorodibenzodioxin 7.9112200463 12878042
MESH:D007333 Insulin Resistance pirinixic acid 2.5516306350
MESH:D007569 Jaw Abnormalities Tetrachlorodibenzodioxin 3.2116580747
MESH:D007638 Keratoconjunctivitis Sicca Cyclosporine 4.3115604871
MESH:D007674 Kidney Diseases Acetaminophen 5.5512587719 15629191
MESH:D007674 Kidney Diseases Cyclosporine 5.5518776723 8314463 10903974
MESH:D007680 Kidney Neoplasms 2,4-dinitrotoluene 11.7416705839
MESH:D007680 Kidney Neoplasms 2,6-dinitrotoluene 11.7416705839
MESH:D007680 Kidney Neoplasms Cyclosporine 11.7412371664
MESH:D008103 Liver Cirrhosis Carbon Tetrachloride 10.6116239168 16221502 17334410 16943688 11408273 17157831 21278145 11903743 17174718
MESH:D008103 Liver Cirrhosis Diethylnitrosamine 10.6120032147 18522880 18665156 18407596 19638242
MESH:D008103 Liver Cirrhosis Phenobarbital 10.6121047994
MESH:D008106 Liver Cirrhosis, Experimental Carbon Tetrachloride 3.3015996030 16638106 18205269 18251166 18418968 12445418 12445421 14620537 15876570 12609069 13678700 18006644 12958196 18166357 18339082 18317297 15362042 16136751 18429990 18705752 18156304 15959796 17805973 17557913 17640975 12898905 17761835 15052691 17766677 18395914 12632512 18263696 16027843 18472094 17525996 18054572 16192424 14724832 18279442 17481882 15673190 16015684 15123356 15650968 12667390 14748882 10355542 18481824 16248980 12586293 17721639 18395095 18210741 14716833 15730626 17869086 18187930 15893842 12632514 17714472 17708605 18376398 12741479 16011737 17631135 12546737 15338365 14716496 18472332 15818738 18277467 17976157 20821823 17823541 12666154 17944888 15370692 14512876 17565644 18412020 17900296 12649538 11481614 15931870 16116963 15057751 18420326 12389079 16097048 16033810 17922224 17698563 15925388
MESH:D008106 Liver Cirrhosis, Experimental pirinixic acid 3.3015474484
MESH:D008106 Liver Cirrhosis, Experimental Tetrachlorodibenzodioxin 3.3012878042
MESH:D008107 Liver Diseases Acetaminophen 9.0919014921 12969438 16610002 16611625 12587719 11587558 19784758 19460945
MESH:D008107 Liver Diseases Carbon Tetrachloride 9.0915830285 16964402 15720792 17285989 16246199
MESH:D008107 Liver Diseases Diethylnitrosamine 9.0917034775
MESH:D008107 Liver Diseases Phenobarbital 9.0919363144
MESH:D017093 Liver Failure Carbon Tetrachloride 4.0315123358
MESH:D017114 Liver Failure, Acute Acetaminophen 9.0217185352 16871587
MESH:D017114 Liver Failure, Acute Carbon Tetrachloride 9.0216899240 14706259
MESH:D008113 Liver Neoplasms 2,6-dinitrotoluene 29.247678174
MESH:D008113 Liver Neoplasms Aflatoxin B1 29.249163691 15890375 18177683 2125692
MESH:D008113 Liver Neoplasms Benzo(a)pyrene 29.2421137059 20195826
MESH:D008113 Liver Neoplasms Carbon Tetrachloride 29.2419294768
MESH:D008113 Liver Neoplasms Diethylnitrosamine 29.2415885732 18977376 19642983 21047994 2862719 12771043 21071580 12112319 20101389 21278145 18978307 19427195 19090486 18754104 21167192 19690152 19254457 9163691 20583210 20137499 20501860 18644402 19255062 19499222 19551842 20492335 19996281 16942905 2422723 19638242 20434301 19294768 15175105 19256749 19850985 19833225 18648771 19073162 20118626 19812893 20405173 19426721 20452335 10737359
MESH:D008113 Liver Neoplasms Methapyrilene 29.2415890375
MESH:D008113 Liver Neoplasms Phenobarbital 29.2421047994 8742319 19812893 15975961 19073162 19482888
MESH:D008113 Liver Neoplasms pirinixic acid 29.2420007298 16377806 15890375
MESH:D008113 Liver Neoplasms Tetrachlorodibenzodioxin 29.2416984957
MESH:D008114 Liver Neoplasms, Experimental 2,6-dinitrotoluene 22.316135515 2876786 2876784
MESH:D008114 Liver Neoplasms, Experimental Aflatoxin B1 22.318603461
MESH:D008114 Liver Neoplasms, Experimental Carbon Tetrachloride 22.3115583823 12014681
MESH:D008114 Liver Neoplasms, Experimental Diethylnitrosamine 22.3119004024 19009564 9362446 19539802 21159647 19519916 16842330 17942915 2563599 18093689 17174075 3124819 18308698 18775883 18282651 18544905 17854601 18253720 19126423 18164116 18079962 16267830
MESH:D008114 Liver Neoplasms, Experimental Phenobarbital 22.311399818 6150874 18308698 2563599 17172636
MESH:D008114 Liver Neoplasms, Experimental Tetrachlorodibenzodioxin 22.3112151625
MESH:D008175 Lung Neoplasms Aflatoxin B1 4.7014755239
MESH:D008175 Lung Neoplasms Benzo(a)pyrene 4.7020135361 20064080 18569708 20869020 18816296 18520028 6695378 20464547 17053015
MESH:D008175 Lung Neoplasms Diethylnitrosamine 4.7020512841 20970405 6695378 21163286
MESH:D008175 Lung Neoplasms Tetrachlorodibenzodioxin 4.7019555203 11884234
MESH:D008546 Melanoma, Experimental Acetaminophen 3.4419513568
MESH:D008569 Memory Disorders Methylmercury Compounds 4.7818436314
MESH:D008659 Metabolic Diseases marker/mechanism 18853477
MESH:D008664 Metal Metabolism, Inborn Errors Cyclosporine 4.6616801185
MESH:D009062 Mouth Neoplasms Benzo(a)pyrene 3.0916381670
MESH:D009069 Movement Disorders Methylmercury Compounds 5.2018436314
MESH:D009135 Muscular Diseases pirinixic acid 3.3816239165
MESH:D009203 Myocardial Infarction pirinixic acid 2.0919151258
MESH:D017202 Myocardial Ischemia Tetrachlorodibenzodioxin 2.9112213967
MESH:D015428 Myocardial Reperfusion Injury pirinixic acid 2.8416411023
MESH:D020191 Myoclonic Epilepsies, Progressive Phenobarbital 4.3417484760
MESH:D009336 Necrosis 2,4-dinitrotoluene 17.0318551238
MESH:D009336 Necrosis 2,6-dinitrotoluene 17.0318551238 7678174
MESH:D009336 Necrosis Trinitrotoluene 17.0318551238
MESH:D009362 Neoplasm Metastasis Diethylnitrosamine 2.529029167 3581430
MESH:D009369 Neoplasms Benzo(a)pyrene 4.6111141357
MESH:D009369 Neoplasms pirinixic acid 4.6117405874
MESH:D009402 Nephrosis, Lipoid Cyclosporine 4.3117954296
MESH:D009404 Nephrotic Syndrome Cyclosporine 3.1719348381 18481113
MESH:D009421 Nervous System Malformations Tetrachlorodibenzodioxin 3.0914600291
MESH:D019636 Neurodegenerative Diseases Acetaminophen 7.8218514411
MESH:D019636 Neurodegenerative Diseases Diethylnitrosamine 7.8220387270
MESH:D009461 Neurologic Manifestations Diethylnitrosamine 4.9920387270
MESH:D009765 Obesity pirinixic acid 1.7820558911
MESH:D009784 Occupational Diseases 2,4-dinitrotoluene 14.5216049721 12819281
MESH:D009784 Occupational Diseases 2,6-dinitrotoluene 14.5216049721
MESH:D009784 Occupational Diseases Trinitrotoluene 14.5212819281 17852074 14694615
MESH:D010018 Osteomalacia Phenobarbital 4.2317016548
MESH:D010146 Pain Acetaminophen 2.2916870215
MESH:D010190 Pancreatic Neoplasms Diethylnitrosamine 5.1116540662
MESH:D010190 Pancreatic Neoplasms Phenobarbital 5.1116965848
MESH:D010382 Peliosis Hepatis Tetrachlorodibenzodioxin 4.1212520081
MESH:D017119 Porphyria Cutanea Tarda Tetrachlorodibenzodioxin 3.4318163543
MESH:D011230 Precancerous Conditions Cyclosporine 14.6212371664
MESH:D011230 Precancerous Conditions Diethylnitrosamine 14.622563599
MESH:D011230 Precancerous Conditions Phenobarbital 14.622563599
MESH:D011297 Prenatal Exposure Delayed Effects Methylmercury Compounds 9.4518436314
MESH:D011297 Prenatal Exposure Delayed Effects Tetrachlorodibenzodioxin 9.4511222880 11399792 11118676 11896295
MESH:D011471 Prostatic Neoplasms Benzo(a)pyrene 3.0117292933
MESH:D019310 Pseudolymphoma Phenobarbital 4.3712752131
MESH:D011565 Psoriasis Cyclosporine 2.1816882103
MESH:D015427 Reperfusion Injury pirinixic acid 2.3219058328
MESH:D015619 Respiratory System Abnormalities Tetrachlorodibenzodioxin 3.7118990726
MESH:D012640 Seizures 2,4-dinitrotoluene 13.3818551238
MESH:D012640 Seizures 2,6-dinitrotoluene 13.3818551238
MESH:D012640 Seizures Phenobarbital 13.384039156 16876388 11442880 3137016
MESH:D012640 Seizures Trinitrotoluene 13.3818551238
MESH:D003294 Seizures, Febrile Phenobarbital 4.696407741
MESH:D012878 Skin Neoplasms Benzo(a)pyrene 5.2719755658 10029692
MESH:D012878 Skin Neoplasms Tetrachlorodibenzodioxin 5.2716192470
MESH:D013036 Spasms, Infantile marker/mechanism 18853477
MESH:D013163 Splenomegaly Trinitrotoluene 5.0715817613
MESH:D013274 Stomach Neoplasms Benzo(a)pyrene 3.332093021 20155912
MESH:D013274 Stomach Neoplasms Diethylnitrosamine 3.3318456281
MESH:D013274 Stomach Neoplasms nitrosobenzylmethylamine 3.3317575124 12958204
MESH:D013959 Thyroid Diseases Tetrachlorodibenzodioxin 3.7712697716
MESH:D013964 Thyroid Neoplasms Diethylnitrosamine 6.857505956
MESH:D013964 Thyroid Neoplasms Phenobarbital 6.851399818
MESH:D001749 Urinary Bladder Neoplasms 2,4-dinitrotoluene 7.9716049721
MESH:D001749 Urinary Bladder Neoplasms 2,6-dinitrotoluene 7.9716049721
MESH:D001749 Urinary Bladder Neoplasms Benzo(a)pyrene 7.9717053015
MESH:D014571 Urologic Neoplasms 2,4-dinitrotoluene 11.5510091137
MESH:D014571 Urologic Neoplasms 2,6-dinitrotoluene 11.5510091137
MESH:D014581 Urticaria Acetaminophen 2.8510982225
MESH:D014605 Uveitis Cyclosporine 3.851336536
MESH:D054079 Vascular Malformations Tetrachlorodibenzodioxin 4.4712125929
MESH:D019282 Wasting Syndrome Tetrachlorodibenzodioxin 4.1215886252
MESH:D014985 Xerophthalmia Cyclosporine 4.3117120751
Pathway ID Pathway Name
KEGG:00410 beta-Alanine metabolism
KEGG:00983 Drug metabolism - other enzymes
KEGG:01100 Metabolic pathways
REACT:1698 Metabolism of nucleotides
KEGG:00770 Pantothenate and CoA biosynthesis
KEGG:00240 Pyrimidine metabolism
Pharmacogenomics Knowledge Base Top
  • PharmGKB Accession:PA418
    • No data
    Releated disease ID Related disease Name
    PA446108Colorectal Neoplasms
    Releated drug ID Related drug Name
    PA448771capecitabine
    PA128406956fluorouracil
    Drug Bank Top

    Simple Query:


      (e.g. CHD8)

    Syndromic Genes

    Non-syndromic Genes

    AutismKB Statistics

    • Studies: 1,036
    • Genes: 1,379
    • CNVs/SVs: 5,420
    • SNVs/Indels: 11,669
    • de novo Mutations: 5,669
    • Mosaics: 789
    • Linkage Regions: 172
    • Paper Collected: 6/30/2018
    • Last Update: 8/26/2018


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