AutismKB 2.0

Annotation Detail for SEPX1


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Basic Information Top
Gene Symbol:SEPX1 ( MGC3344,MSRB1,SELR,SELX )
Gene Full Name: selenoprotein X, 1
Band: 16p13.3
Quick LinksEntrez ID:51734; OMIM: 606216; Uniprot ID:MSRB1_HUMAN; ENSEMBL ID: ENSG00000198736; HGNC ID:
Relate to Another Database: SFARIGene; denovo-db
Related Pathway Information Top
Related Diseases/Disorders Top
Comparative Toxicogenomics Database Top
Chemical ID Chemical Name Interaction Interaction Action Publication
D000082 Acetaminophen Acetaminophen affects the expression of SEPX1 mRNAaffects expression 17562736
D016604 Aflatoxin B1 Aflatoxin B1 affects the expression of SEPX1 proteinaffects expression 20106945
D001149 Arsenates Arsenates results in decreased expression of SEPX1 mRNAdecreases expression 19895865
D020122 tert-Butylhydroperoxide SEPX1 protein results in decreased susceptibility to tert-Butylhydroperoxidedecreases response to substance 15914630
D020122 tert-Butylhydroperoxide tert-Butylhydroperoxide results in increased expression of SEPX1 mRNAincreases expression 15003993
D002251 Carbon Tetrachloride Carbon Tetrachloride affects the expression of SEPX1 mRNAaffects expression 17484886
C057862 cyanoginosin LR cyanoginosin LR results in decreased expression of SEPX1 mRNAdecreases expression 17654400
D016572 Cyclosporine Cyclosporine results in decreased expression of SEPX1 mRNAdecreases expression 20106945
D004041 Dietary Fats Dietary Fats results in decreased expression of SEPX1 mRNAdecreases expression 18042831
D004997 Ethinyl Estradiol Ethinyl Estradiol results in increased expression of SEPX1 mRNAincreases expression 17942748
C056933 fumonisin B1 fumonisin B1 results in decreased expression of SEPX1 mRNAdecreases expression 16221962
C041786 palm oil palm oil results in decreased expression of SEPX1 mRNAdecreases expression 18042831
D012643 Selenium Selenium deficiency results in decreased expression of and results in decreased activity of SEPX1 proteindecreases activity|decreases expression 16170372
12792026
D012643 Selenium Selenium deficiency results in decreased expression of SEPX1 mRNAdecreases expression 12792026
C002979 selenomethylselenocysteine selenomethylselenocysteine results in increased expression of SEPX1 mRNAincreases expression 18514395
C423915 TO-901317 TO-901317 results in decreased expression of SEPX1 mRNAdecreases expression 15302862
D014501 Uranium Uranium affects the expression of SEPX1 mRNAaffects expression 15672453
C005460 uranyl acetate uranyl acetate affects the expression of SEPX1 mRNAaffects expression 15672453
Disease ID Disease Name Direct Evidence Inference Chemical Name Inference Score Publication
MESH:D000152 Acne Vulgaris Ethinyl Estradiol 3.9717505938
MESH:D000230 Adenocarcinoma Ethinyl Estradiol 1.8114692618
MESH:D000799 Angioedema Acetaminophen 3.8710982225
MESH:D001161 Arteriosclerosis Dietary Fats 9.9515238619
MESH:D001161 Arteriosclerosis Ethinyl Estradiol 9.9511256880
MESH:D001169 Arthritis, Experimental Ethinyl Estradiol 2.6615885639
MESH:D001321 Autistic Disorder Acetaminophen 1.4218445737
MESH:D001943 Breast Neoplasms Dietary Fats 2.7620435547
MESH:D001943 Breast Neoplasms selenomethylselenocysteine 2.7618855134
MESH:D002252 Carbon Tetrachloride Poisoning Carbon Tetrachloride 3.7915673190 10355542 18705752 3786805 15721981 16124888 16227642 16097048 16011737 15700767 16050911 16192424
MESH:D006528 Carcinoma, Hepatocellular Acetaminophen 4.553084413
MESH:D006528 Carcinoma, Hepatocellular Aflatoxin B1 4.5521507988 12619106 12907637
MESH:D006528 Carcinoma, Hepatocellular Carbon Tetrachloride 4.5518788625
MESH:D002386 Cataract Acetaminophen 2.5810977129
MESH:D002471 Cell Transformation, Neoplastic Cyclosporine 2.5312371664
MESH:D002779 Cholestasis Cyclosporine 7.7819486331
MESH:D002779 Cholestasis Ethinyl Estradiol 7.7816105132 11677210 16919318 17110522 17681005 15861022 17333356
MESH:D003092 Colitis Selenium 3.7917936198
MESH:D056486 Drug-Induced Liver Injury Acetaminophen 12.0717522070 12392966 14986274 17562736 19164858 19420014 17906064 14725611 16081117 10663392 11834606 11743745 2444490 16485898 12958197 11529661 16177239 10915739 16109766 19416960 16227642 16393943 19085960 16781746 12594235 12705907 15968718 11461765 11421492 12153990 11287661 18713872 19739265 12540782 19923254 18071297 10774834 14550746 11739529 15619225 19370779
MESH:D056486 Drug-Induced Liver Injury Carbon Tetrachloride 12.0721278145 6623471 6884620 19085960 2869522 19336974 7179309 3732212 4309450 15027814 17522070 16227642 10915739 15968718 16177239 3786805 15998439 10092053 7440962 11566570 7120509 9327722
MESH:D056486 Drug-Induced Liver Injury cyanoginosin LR 12.0717654400
MESH:D056486 Drug-Induced Liver Injury fumonisin B1 12.0716221962
MESH:D056486 Drug-Induced Liver Injury Selenium 12.0715131321
MESH:D056487 Drug-Induced Liver Injury, Chronic Acetaminophen 4.1319426721
MESH:D050171 Dyslipidemias Dietary Fats 3.4518367378
MESH:D004681 Encephalomyelitis, Autoimmune, Experimental Ethinyl Estradiol 3.2012538720
MESH:D005234 Fatty Liver Carbon Tetrachloride 18.8112631006 17595544 12795759 15959796 19224547 16239168 16045604 61145
MESH:D005234 Fatty Liver Cyclosporine 18.8119224547
MESH:D005234 Fatty Liver Dietary Fats 18.8117967931 19551842 18296743 19004024
MESH:D005234 Fatty Liver Ethinyl Estradiol 18.8115345470
MESH:D005355 Fibrosis Carbon Tetrachloride 14.8818705752
MESH:D005355 Fibrosis Cyclosporine 14.8812639820 12168785
MESH:D005355 Fibrosis Dietary Fats 14.8818296743
MESH:D005756 Gastritis Acetaminophen 3.7116983495
MESH:D005885 Gingival Hyperplasia Cyclosporine 4.248708960
MESH:D006333 Heart Failure Selenium 3.0717162251
MESH:D006457 Hemoglobinuria, Paroxysmal Cyclosporine 4.4415720958
MESH:D006505 Hepatitis Carbon Tetrachloride 3.6019110552 19900420
MESH:D006529 Hepatomegaly fumonisin B1 4.2816221962
MESH:D006930 Hyperalgesia Acetaminophen 2.7016870215
MESH:D006932 Hyperbilirubinemia Carbon Tetrachloride 4.5516899240
MESH:D006937 Hypercholesterolemia Dietary Fats 3.6021332399
MESH:D006949 Hyperlipidemias Dietary Fats 3.6221332399
MESH:D006973 Hypertension Cyclosporine 2.1010903974
MESH:D006975 Hypertension, Portal Carbon Tetrachloride 4.1015338365
MESH:D007021 Hypospadias Ethinyl Estradiol 3.8216945680 16569931
MESH:D007247 Infertility, Female Ethinyl Estradiol 3.4712013081
MESH:D007248 Infertility, Male Ethinyl Estradiol 2.4917937319
MESH:D007249 Inflammation Dietary Fats 2.4320412841
MESH:D007251 Influenza, Human Selenium 4.2316624496
MESH:D007333 Insulin Resistance Dietary Fats 3.1111836018 18457598
MESH:D007638 Keratoconjunctivitis Sicca Cyclosporine 4.4715604871
MESH:D007674 Kidney Diseases Acetaminophen 5.8012587719 15629191
MESH:D007674 Kidney Diseases Cyclosporine 5.808314463 18776723 10903974
MESH:D007676 Kidney Failure, Chronic Selenium 3.8916518626
MESH:D007680 Kidney Neoplasms Cyclosporine 2.7412371664
MESH:D008103 Liver Cirrhosis Carbon Tetrachloride 6.6311408273 16943688 17157831 11903743 17334410 16221502 17174718 21278145 16239168
MESH:D008103 Liver Cirrhosis Dietary Fats 6.6318296743
MESH:D008106 Liver Cirrhosis, Experimental Carbon Tetrachloride 1.7416011737 12898905 14716833 16638106 17565644 17823541 16097048 17922224 18317297 18395914 14724832 16027843 15959796 18006644 17976157 18472094 18395095 18187930 18705752 12389079 12586293 17869086 18472332 18412020 20821823 18418968 15893842 15818738 17944888 12632514 15052691 17698563 18166357 17761835 18263696 18339082 16033810 18205269 17631135 17766677 18277467 17721639 12741479 15362042 12609069 18429990 18420326 17708605 14748882 17557913 12958196 16248980 17900296 15673190 18481824 17805973 11481614 14716496 12632512 14512876 15996030 15338365 16116963 15931870 15057751 17525996 16192424 12666154 15650968 18156304 16015684 15730626 15370692 13678700 17714472 12445418 17640975 18210741 12546737 18054572 12445421 10355542 12667390 17481882 18251166 15876570 18376398 12649538 15123356 15925388 16136751 18279442 14620537
MESH:D008107 Liver Diseases Acetaminophen 3.9012969438 16610002 19784758 11587558 16611625 19460945 12587719 19014921
MESH:D008107 Liver Diseases Carbon Tetrachloride 3.9017285989 15830285 15720792 16964402 16246199
MESH:D017093 Liver Failure Carbon Tetrachloride 4.1815123358
MESH:D017114 Liver Failure, Acute Acetaminophen 9.4216871587 17185352
MESH:D017114 Liver Failure, Acute Carbon Tetrachloride 9.4214706259 16899240
MESH:D008113 Liver Neoplasms Aflatoxin B1 4.632125692 9163691 15890375 18177683
MESH:D008113 Liver Neoplasms Carbon Tetrachloride 4.6319294768
MESH:D008114 Liver Neoplasms, Experimental Aflatoxin B1 6.008603461
MESH:D008114 Liver Neoplasms, Experimental Carbon Tetrachloride 6.0012014681 15583823
MESH:D008175 Lung Neoplasms Aflatoxin B1 1.8714755239
MESH:D008325 Mammary Neoplasms, Experimental Selenium 6.6315318939
MESH:D008325 Mammary Neoplasms, Experimental selenomethylselenocysteine 6.6315318939
MESH:D008546 Melanoma, Experimental Acetaminophen 3.5819513568
MESH:D008654 Mesothelioma Selenium 2.7915107826
MESH:D008664 Metal Metabolism, Inborn Errors Cyclosporine 4.8216801185
MESH:D009402 Nephrosis, Lipoid Cyclosporine 4.4717954296
MESH:D009404 Nephrotic Syndrome Cyclosporine 3.2919348381 18481113
MESH:D019636 Neurodegenerative Diseases Acetaminophen 2.8718514411
MESH:D009765 Obesity Dietary Fats 2.2920132043 19632207 11836018 18674790 16723640 17217161 18457598 20518802 21332399
MESH:D010146 Pain Acetaminophen 2.3916870215
MESH:D016584 Panic Disorder Ethinyl Estradiol 3.6911578682
MESH:D010954 Plasmacytoma Selenium 4.9215087411
MESH:D011230 Precancerous Conditions Cyclosporine 3.2212371664
MESH:D011537 Pruritus Ethinyl Estradiol 3.3316919318 15861022
MESH:D011565 Psoriasis Cyclosporine 2.2316882103
MESH:D012878 Skin Neoplasms tert-Butylhydroperoxide 2.698532709
MESH:D013088 Spermatocele Ethinyl Estradiol 3.9716709447
MESH:D019851 Thrombophilia Ethinyl Estradiol 3.6311994571
MESH:D013927 Thrombosis Ethinyl Estradiol 3.1515669648
MESH:D014581 Urticaria Acetaminophen 2.9810982225
MESH:D014594 Uterine Neoplasms Ethinyl Estradiol 3.3114692618
MESH:D014605 Uveitis Cyclosporine 4.011336536
MESH:D020246 Venous Thrombosis Ethinyl Estradiol 3.5415869587 14671159
MESH:D015430 Weight Gain Dietary Fats 3.7416723640
MESH:D014985 Xerophthalmia Cyclosporine 4.4717120751
No data
Pharmacogenomics Knowledge Base Top
Drug Bank Top
Drugbank ID Action Drug Name Description
DB00134 - L-Methionine Dietary supplement;Micronutrient;Essential Amino Acids
No data
No data
No data

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Syndromic Genes

Non-syndromic Genes

AutismKB Statistics

  • Studies: 1,036
  • Genes: 1,379
  • CNVs/SVs: 5,420
  • SNVs/Indels: 11,669
  • de novo Mutations: 5,669
  • Mosaics: 789
  • Linkage Regions: 172
  • Paper Collected: 6/30/2018
  • Last Update: 8/26/2018


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