Gene Symbol:	GHRL ( MTLRP )
Gene Full Name:	ghrelin/obestatin prepropeptide
Band:	3p25.3
Quick Links	Entrez ID:51738; OMIM: 605353; Uniprot ID:GHRL_HUMAN; ENSEMBL ID: ENSG00000157017; HGNC ID: 18129
Relate to Another Database:	SFARIGene; denovo-db

Chemical ID	Chemical Name	Interaction	Interaction Action	Publication
C009505	4,4'-diaminodiphenylmethane	4,4'-diaminodiphenylmethane results in increased expression of GHRL mRNA	increases expression	18648102
D000643	Ammonium Chloride	Ammonium Chloride affects the expression of GHRL mRNA	affects expression	16483693
C120841	astressin B	astressin B inhibits the reaction [GHRL protein results in decreased expression of LHB protein]	decreases expression\|decreases reaction	18063681
C120841	astressin B	astressin B inhibits the reaction [GHRL protein results in increased abundance of Hydrocortisone]	decreases reaction\|increases abundance	18063681
D001285	Atropine	Atropine inhibits the reaction [[Pentobarbital co-treated with L-pyroglutamyl-L-histidyl-3,3-dimethylprolinamide] results in increased expression of GHRL protein]	affects cotreatment\|decreases reaction\|increases expression	16959836
D002211	Capsaicin	GHRL protein inhibits the reaction [Capsaicin results in increased expression of FOS protein]	decreases reaction\|increases expression	18202139
C103490	dexloxiglumide	dexloxiglumide inhibits the reaction [osteum results in decreased expression of GHRL protein]	decreases expression\|decreases reaction	17138722
D004298	Dopamine	GHRL protein results in decreased export of Dopamine	decreases export	20553917
D004317	Doxorubicin	GHRL protein inhibits the reaction [Doxorubicin results in decreased expression of BCL2L1 mRNA]	decreases expression\|decreases reaction	18400355
D004317	Doxorubicin	GHRL protein inhibits the reaction [Doxorubicin results in decreased expression of BCL2 mRNA]	decreases expression\|decreases reaction	18400355
D004317	Doxorubicin	GHRL protein inhibits the reaction [Doxorubicin results in decreased expression of SOD2 protein]	decreases expression\|decreases reaction	18400355
D004317	Doxorubicin	GHRL protein inhibits the reaction [Doxorubicin results in decreased expression of TNF protein]	decreases expression\|decreases reaction	18400355
D004317	Doxorubicin	GHRL protein promotes the reaction [Doxorubicin results in increased localization of and results in increased activity of RELA protein]	increases activity\|increases localization\|increases reaction	18400355
D004317	Doxorubicin	TNF protein affects the reaction [GHRL protein inhibits the reaction [Doxorubicin results in decreased expression of BCL2L1 mRNA]]	affects reaction\|decreases expression\|decreases reaction	18400355
D004317	Doxorubicin	TNF protein affects the reaction [GHRL protein inhibits the reaction [Doxorubicin results in decreased expression of BCL2 mRNA]]	affects reaction\|decreases expression\|decreases reaction	18400355
D005419	Flavonoids	Flavonoids results in decreased expression of GHRL mRNA	decreases expression	18035473
D005632	Fructose	Fructose results in increased expression of GHRL protein	increases expression	18627777
D006854	Hydrocortisone	astressin B inhibits the reaction [GHRL protein results in increased abundance of Hydrocortisone]	decreases reaction\|increases abundance	18063681
D006854	Hydrocortisone	GHRL protein results in increased abundance of Hydrocortisone	increases abundance	18063681
D012701	Serotonin	GHRL protein results in decreased export of Serotonin	decreases export	20553917
D007213	Indomethacin	Indomethacin inhibits the reaction [Lipopolysaccharides affects the expression of GHRL protein]	affects expression\|decreases reaction	16959954
D008070	Lipopolysaccharides	IL1B protein affects the reaction [Lipopolysaccharides affects the expression of GHRL protein]	affects expression\|affects reaction	16959954
D008070	Lipopolysaccharides	IL1RN protein inhibits the reaction [Lipopolysaccharides affects the expression of GHRL protein]	affects expression\|decreases reaction	16959954
D008070	Lipopolysaccharides	Indomethacin inhibits the reaction [Lipopolysaccharides affects the expression of GHRL protein]	affects expression\|decreases reaction	16959954
D008070	Lipopolysaccharides	Lipopolysaccharides affects the expression of GHRL protein	affects expression	16959954
C027979	L-pyroglutamyl-L-histidyl-3,3-dimethylprolinamide	Atropine inhibits the reaction [[Pentobarbital co-treated with L-pyroglutamyl-L-histidyl-3,3-dimethylprolinamide] results in increased expression of GHRL protein]	affects cotreatment\|decreases reaction\|increases expression	16959836
C027979	L-pyroglutamyl-L-histidyl-3,3-dimethylprolinamide	[Pentobarbital co-treated with L-pyroglutamyl-L-histidyl-3,3-dimethylprolinamide] results in increased expression of GHRL protein	affects cotreatment\|increases expression	16959836
D009599	Nitroprusside	GHRL protein inhibits the reaction [Nitroprusside results in increased cleavage of and results in increased activity of CASP3 protein]	decreases reaction\|increases activity\|increases cleavage	17543279
D009599	Nitroprusside	GHRL protein inhibits the reaction [Nitroprusside results in increased phosphorylation of and results in increased activity of MAP3K5 protein]	decreases reaction\|increases activity\|increases phosphorylation	17543279
D009599	Nitroprusside	Quercetin inhibits the reaction [GHRL protein inhibits the reaction [Nitroprusside results in increased expression of MAP3K5 protein]]	decreases reaction\|increases expression	17543279
C042763	olive oil	olive oil results in decreased expression of GHRL protein	decreases expression	17138722
C042763	olive oil	orlistat inhibits the reaction [olive oil results in decreased expression of GHRL protein]	decreases expression\|decreases reaction	17138722
C055122	orlistat	orlistat inhibits the reaction [olive oil results in decreased expression of GHRL protein]	decreases expression\|decreases reaction	17138722
C013173	osteum	dexloxiglumide inhibits the reaction [osteum results in decreased expression of GHRL protein]	decreases expression\|decreases reaction	17138722
C013173	osteum	osteum results in decreased expression of GHRL protein	decreases expression	17138722
D010424	Pentobarbital	Atropine inhibits the reaction [[Pentobarbital co-treated with L-pyroglutamyl-L-histidyl-3,3-dimethylprolinamide] results in increased expression of GHRL protein]	affects cotreatment\|decreases reaction\|increases expression	16959836
D010424	Pentobarbital	[Pentobarbital co-treated with L-pyroglutamyl-L-histidyl-3,3-dimethylprolinamide] results in increased expression of GHRL protein	affects cotreatment\|increases expression	16959836
D011794	Quercetin	Quercetin inhibits the reaction [GHRL protein inhibits the reaction [Nitroprusside results in increased expression of MAP3K5 protein]]	decreases reaction\|increases expression	17543279
C017947	sodium arsenite	sodium arsenite results in increased expression of GHRL mRNA	increases expression	17350061
D013311	Streptozocin	GHRL protein promotes the reaction [Streptozocin results in decreased expression of CARTPT mRNA]	decreases expression\|increases reaction	20219977
D013311	Streptozocin	GHRL protein promotes the reaction [Streptozocin results in decreased expression of FASN mRNA]	decreases expression\|increases reaction	20219977
D013311	Streptozocin	GHRL protein promotes the reaction [Streptozocin results in decreased expression of SLC2A4 mRNA]	decreases expression\|increases reaction	20219977
D013549	Sweetening Agents	Sweetening Agents results in increased expression of GHRL protein	increases expression	18627777

Pathway ID	Pathway Name
REACT:15380	Diabetes pathways
KEGG:04080	Neuroactive ligand-receptor interaction
REACT:14797	Signaling by GPCR

Desease Name
glucose
eating disorder
CARDIOVASCULAR
CANCER
PSYCH
body mass cholesterol, HDL
body mass
nephropathy, diabetic
RENAL
Lymphoma, Non-Hodgkin
hypertension
metabolic syndrome
METABOLIC
obesity
depression
diabetes, type 2
insulin secretion

Disease ID	Disease Name	Direct Evidence	Inference Chemical Name	Inference Score	Publication
MESH:D000014	Abnormalities, Drug-Induced		Capsaicin	4.36	18926900
MESH:D000138	Acidosis		Ammonium Chloride	3.39	18287403
MESH:D058186	Acute Kidney Injury		Capsaicin	4.39	18460982
MESH:D055371	Acute Lung Injury		Lipopolysaccharides	3.87	18653653 11850527
MESH:D000230	Adenocarcinoma	marker/mechanism			21472143
MESH:D000230	Adenocarcinoma		Doxorubicin	4.60	17418594
MESH:D000230	Adenocarcinoma		Indomethacin	4.60	16537180
MESH:D000236	Adenoma		4,4'-diaminodiphenylmethane	6.56	3712494
MESH:D000236	Adenoma		Indomethacin	6.56	11497255
MESH:D000310	Adrenal Gland Neoplasms		sodium arsenite	4.53	15276417
MESH:D018246	Adrenocortical Adenoma		sodium arsenite	4.73	17306315 16712894
MESH:D000419	Albuminuria		Doxorubicin	4.38	21441931
MESH:D000505	Alopecia		astressin B	9.96	21359208
MESH:D000505	Alopecia		Capsaicin	9.96	17569567
MESH:D016301	Alveolar Bone Loss		Indomethacin	5.20	17225004
MESH:D000544	Alzheimer Disease		Indomethacin	2.67	17627676 15579461
MESH:D000743	Anemia, Hemolytic		Quercetin	4.08	17084956
MESH:D001008	Anxiety Disorders		Pentobarbital	4.59	11141031 18313124
MESH:D001014	Aortic Aneurysm		Indomethacin	4.68	10231640
MESH:D017544	Aortic Aneurysm, Abdominal		Indomethacin	4.70	10388637
MESH:D018771	Arthralgia		Indomethacin	5.00	2160914
MESH:D001172	Arthritis, Rheumatoid		Indomethacin	2.78	11248219
MESH:D001260	Ataxia Telangiectasia		Quercetin	4.80	15336622
MESH:D050197	Atherosclerosis		olive oil	4.24	16216721
MESH:D001321	Autistic Disorder		Serotonin	3.48	18405062 18361446 15132762 19221690 8570775 17157402 18062943
MESH:D001327	Autoimmune Diseases		Quercetin	4.24	19761891
MESH:D001477	Bartter Syndrome		Indomethacin	4.81	10684365
MESH:D001660	Biliary Tract Diseases		4,4'-diaminodiphenylmethane	4.85	11289319 1440618
MESH:D019046	Bone Marrow Neoplasms		Doxorubicin	4.53	14601052
MESH:D001919	Bradycardia		Capsaicin	10.68	18207255
MESH:D001919	Bradycardia		Serotonin	10.68	8112388
MESH:D001929	Brain Edema		Indomethacin	4.85	11481608
MESH:D001930	Brain Injuries		Nitroprusside	5.52	14637104
MESH:D002545	Brain Ischemia		Capsaicin	10.03	19211983
MESH:D002545	Brain Ischemia		Indomethacin	10.03	12524144
MESH:D001932	Brain Neoplasms		Doxorubicin	3.66	17150277
MESH:D001943	Breast Neoplasms		Atropine	2.09	12762645
MESH:D001943	Breast Neoplasms		Doxorubicin	2.09	17426702 18628466 16595493 16264153 15634643 15939500 16826403 18695136 15567936 15136595 17369602 16096432 16935488 19526202 16115903 15993339 15994142 18382427 15668708 11325840 15692762 16322301 18234424 17983394
MESH:D001943	Breast Neoplasms		Indomethacin	2.09	17401462
MESH:D001943	Breast Neoplasms		Quercetin	2.09	18628248

AutismKB 2.0

Annotation Detail for GHRL

Simple Query:

Syndromic Genes

Non-syndromic Genes

AutismKB Statistics