AutismKB 2.0

Annotation Detail for WWOX


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Basic Information Top
Gene Symbol:WWOX ( D16S432E,FOR,FRA16D,HHCMA56,PRO0128,SDR41C1,WOX1 )
Gene Full Name: WW domain containing oxidoreductase
Band: 16q23.1-q23.2
Quick LinksEntrez ID:51741; OMIM: 605131; Uniprot ID:WWOX_HUMAN; ENSEMBL ID: ENSG00000186153; HGNC ID: 12799
Relate to Another Database: SFARIGene; denovo-db
Related Pathway Information Top
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Pathway IDPathway Name
200009ErbB4 signaling events
No data
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Related Diseases/Disorders Top
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Desease Name
CARDIOVASCULAR
CHEMDEPENDENCY
smoking cessation
Cardiac structure and function
Desease Name
Cardiac structure and function
Desease Name
Esophageal squamous cell carcinoma
Comparative Toxicogenomics Database Top
Chemical ID Chemical Name Interaction Interaction Action Publication
C029955 2-nitrotoluene 2-nitrotoluene results in decreased expression of WWOX mRNAdecreases expression 15618236
C029955 2-nitrotoluene 2-nitrotoluene results in decreased expression of WWOX proteindecreases expression 15618236
D016604 Aflatoxin B1 Aflatoxin B1 affects the expression of WWOX proteinaffects expression 20106945
C006632 arsenic trioxide arsenic trioxide results in increased expression of WWOX mRNAincreases expression 20458559
D001564 Benzo(a)pyrene Benzo(a)pyrene results in decreased expression of WWOX mRNAdecreases expression 20106945
D001564 Benzo(a)pyrene Benzo(a)pyrene results in increased expression of WWOX mRNAincreases expression 20064835
D001564 Benzo(a)pyrene Benzo(a)pyrene results in decreased expression of WWOX mRNAdecreases expression 20713471
D002251 Carbon Tetrachloride Carbon Tetrachloride affects the expression of WWOX mRNAaffects expression 17484886
C014347 decitabine decitabine affects the expression of WWOX proteinaffects expression 17200365
C014347 decitabine [decitabine co-treated with trichostatin A] affects the expression of WWOX proteinaffects cotreatment|affects expression 17019711
D004052 Diethylnitrosamine Diethylnitrosamine results in increased expression of WWOX mRNAincreases expression 17942915
D004052 Diethylnitrosamine MET protein inhibits the reaction [Diethylnitrosamine results in increased expression of WWOX mRNA]decreases reaction|increases expression 17942915
C071834 glycidamide glycidamide results in decreased expression of WWOX mRNAdecreases expression 17822822
D008748 Methylcholanthrene Methylcholanthrene results in decreased expression of WWOX mRNAdecreases expression 20713471
C005223 methyleugenol methyleugenol results in decreased expression of WWOX proteindecreases expression 15618236
D010634 Phenobarbital NR1I3 protein affects the reaction [Phenobarbital results in decreased expression of WWOX mRNA]affects reaction|decreases expression 19482888
D010634 Phenobarbital Phenobarbital results in decreased expression of WWOX mRNAdecreases expression 19482888
C012589 trichostatin A [decitabine co-treated with trichostatin A] affects the expression of WWOX proteinaffects cotreatment|affects expression 17019711
Disease ID Disease Name Direct Evidence Inference Chemical Name Inference Score Publication
MESH:D000014 Abnormalities, Drug-Induced Phenobarbital 3.596195326
MESH:D000230 Adenocarcinoma arsenic trioxide 4.4311798837 19825857
MESH:D000230 Adenocarcinoma Benzo(a)pyrene 4.4320464547 20127859
MESH:D000236 Adenoma Benzo(a)pyrene 11.596695378
MESH:D000236 Adenoma Diethylnitrosamine 11.596695378 10737359
MESH:D000236 Adenoma Methylcholanthrene 11.596695378 10545420
MESH:D018248 Adenoma, Liver Cell Diethylnitrosamine 10.8019052882 17162532 19061943 17620307 18056438 16434500
MESH:D018248 Adenoma, Liver Cell Phenobarbital 10.8017620307
MESH:D017544 Aortic Aneurysm, Abdominal Benzo(a)pyrene 4.2119183758
MESH:D050197 Atherosclerosis Methylcholanthrene 3.5111922910
MESH:D001778 Blood Coagulation Disorders arsenic trioxide 3.7816206674
MESH:D001943 Breast Neoplasms marker/mechanism 17200365
MESH:D001943 Breast Neoplasms Benzo(a)pyrene 2.4220146248 17474063
MESH:D001943 Breast Neoplasms decitabine 2.4218320071 19208741
MESH:D001943 Breast Neoplasms Diethylnitrosamine 2.4217474063
MESH:D001943 Breast Neoplasms Methylcholanthrene 2.4217474063
MESH:D001943 Breast Neoplasms methyleugenol 2.4211921183
MESH:D002051 Burkitt Lymphoma arsenic trioxide 4.4511589617
MESH:D002252 Carbon Tetrachloride Poisoning Carbon Tetrachloride 3.9216011737 16227642 16124888 15673190 18705752 10355542 16097048 16050911 3786805 16192424 15721981 15700767
MESH:D002277 Carcinoma Methylcholanthrene 4.0510545420
MESH:D006528 Carcinoma, Hepatocellular Aflatoxin B1 9.0512907637 12619106 21507988
MESH:D006528 Carcinoma, Hepatocellular arsenic trioxide 9.0515073043 15553829 14691202 16217749 11135700
MESH:D006528 Carcinoma, Hepatocellular Carbon Tetrachloride 9.0518788625
MESH:D006528 Carcinoma, Hepatocellular Diethylnitrosamine 9.0519701751 17428255 3084413 16502159 18506893 19208518 19539802 17162532 16288022 16540662 16779866 18494052 17978847 16569478 17138121 20514400 19822196 20935162 17173139 18056438 19171122 18210153 17761372 10737359 20007298 16830150 19335982 10672840 3581430 18788625 21159647 19418558 18393292 16328049 18691550 17055752 16878318 20101231 19107877 16698587 20432363 19519916 18971187 19394651 19052882 20214788 16935385 20084675 19919837 19383236 18665156 18785209 20524982 18978308 16807293 11831363 20727157 16681979 20512989
MESH:D006528 Carcinoma, Hepatocellular Phenobarbital 9.0517173139 1701930 20007298 20935162 6705139
MESH:D002291 Carcinoma, Papillary arsenic trioxide 5.0519014326
MESH:D018288 Carcinoma, Small Cell arsenic trioxide 4.2212490120
MESH:D002294 Carcinoma, Squamous Cell marker/mechanism 17575124
MESH:D002294 Carcinoma, Squamous Cell Benzo(a)pyrene 4.7720419170
MESH:D002294 Carcinoma, Squamous Cell decitabine 4.7719215824
MESH:D002430 Cecal Neoplasms 2-nitrotoluene 5.7914688030
MESH:D002471 Cell Transformation, Neoplastic Diethylnitrosamine 7.212727394 17174075 21159647 7505956
MESH:D002471 Cell Transformation, Neoplastic Methylcholanthrene 7.2116192471
MESH:D002493 Central Nervous System Diseases Phenobarbital 4.394080065
MESH:D018281 Cholangiocarcinoma Diethylnitrosamine 3.7819052882
MESH:D003110 Colonic Neoplasms decitabine 2.3517616700
MESH:D015179 Colorectal Neoplasms arsenic trioxide 2.6120501625
MESH:D015179 Colorectal Neoplasms decitabine 2.6118981723
MESH:D023903 Coronary Restenosis arsenic trioxide 4.3112609071
MESH:D003328 Coronary Thrombosis methyleugenol 5.9816048847
MESH:D019465 Craniofacial Abnormalities arsenic trioxide 1.8810525206
MESH:D016757 Death, Sudden, Cardiac arsenic trioxide 4.2115213294
MESH:D003924 Diabetes Mellitus, Type 2 Diethylnitrosamine 2.2120387270
MESH:D056486 Drug-Induced Liver Injury Carbon Tetrachloride 4.016884620 9327722 7179309 4309450 10092053 7120509 15027814 19336974 10915739 19085960 21278145 3786805 16177239 2869522 15998439 15968718 7440962 16227642 3732212 11566570 17522070 6623471
MESH:D056486 Drug-Induced Liver Injury Diethylnitrosamine 4.0119107877
MESH:D004421 Dystonia Phenobarbital 4.121851702
MESH:D004701 Endocrine Gland Neoplasms decitabine 14.6219294695
MESH:D004701 Endocrine Gland Neoplasms trichostatin A 14.6219294695
MESH:D004831 Epilepsies, Myoclonic Phenobarbital 4.253659116
MESH:D004828 Epilepsies, Partial Phenobarbital 4.0411558140 3922381
MESH:D004827 Epilepsy Phenobarbital 2.9420417680
MESH:D004832 Epilepsy, Absence Phenobarbital 3.646401628
MESH:D017029 Epilepsy, Complex Partial Phenobarbital 4.397750514
MESH:D004830 Epilepsy, Tonic-Clonic Phenobarbital 4.173659116
MESH:D004931 Esophageal Achalasia Diethylnitrosamine 5.2916302075
MESH:D004938 Esophageal Neoplasms marker/mechanism
MESH:D004938 Esophageal Neoplasms arsenic trioxide 4.5212903497
MESH:D004938 Esophageal Neoplasms Benzo(a)pyrene 4.5216530937
MESH:D005234 Fatty Liver arsenic trioxide 13.8215073043
MESH:D005234 Fatty Liver Carbon Tetrachloride 13.8261145 16239168 16045604 12631006 19224547 15959796 12795759 17595544
MESH:D005234 Fatty Liver Diethylnitrosamine 13.8221071580 20387270
MESH:D005354 Fibrosarcoma Methylcholanthrene 5.0914633661 10962813
MESH:D005355 Fibrosis Carbon Tetrachloride 3.5918705752
MESH:D005706 Gallbladder Neoplasms arsenic trioxide 4.3916904648
MESH:D005909 Glioblastoma trichostatin A 3.9018801729
MESH:D006258 Head and Neck Neoplasms decitabine 3.5619215824
MESH:D006330 Heart Defects, Congenital Benzo(a)pyrene 2.7120471113
MESH:D006394 Hemangiosarcoma 2-nitrotoluene 5.1913678655
MESH:D006505 Hepatitis Carbon Tetrachloride 3.7219110552 19900420
MESH:D006529 Hepatomegaly Phenobarbital 3.6216109766
MESH:D006932 Hyperbilirubinemia Carbon Tetrachloride 4.6916899240
MESH:D006975 Hypertension, Portal Carbon Tetrachloride 4.2315338365
MESH:D007248 Infertility, Male decitabine 3.2717581917
MESH:D007249 Inflammation Diethylnitrosamine 2.4318785209
MESH:D007938 Leukemia arsenic trioxide 6.6215070760
MESH:D007938 Leukemia decitabine 6.6219235587 18980019
MESH:D015459 Leukemia-Lymphoma, Adult T-Cell arsenic trioxide 3.9017077332 12560223
MESH:D007948 Leukemia, Monocytic, Acute arsenic trioxide 4.4616972261
MESH:D015464 Leukemia, Myelogenous, Chronic, BCR-ABL Positive arsenic trioxide 3.5114633726
MESH:D007951 Leukemia, Myeloid arsenic trioxide 9.9519077051
MESH:D007951 Leukemia, Myeloid decitabine 9.9517236224 18454857 19117987
MESH:D015470 Leukemia, Myeloid, Acute arsenic trioxide 6.3719850784 17050201 16968895 20471514 16467208
MESH:D015470 Leukemia, Myeloid, Acute decitabine 6.3717679729 19010910 18206229 18460780 18704418 19387464
MESH:D015470 Leukemia, Myeloid, Acute trichostatin A 6.3718206229
MESH:D015477 Leukemia, Myelomonocytic, Chronic decitabine 5.6418055864
MESH:D015473 Leukemia, Promyelocytic, Acute arsenic trioxide 3.2815748426 19225113 16330433 17712046 11468182 16823087 16112521 16331271 12018890 19642359 17217047 19075265 15336539 11161223 19035177 15213294 9834237 12679006 16891316 17107899 12712474 17869043 16966277 15622746 17649720
MESH:D015458 Leukemia, T-Cell arsenic trioxide 4.4816882451
MESH:D008103 Liver Cirrhosis Carbon Tetrachloride 11.3617334410 11903743 17174718 16943688 16239168 11408273 17157831 21278145 16221502
MESH:D008103 Liver Cirrhosis Diethylnitrosamine 11.3618407596 18522880 19638242 20032147 18665156
MESH:D008103 Liver Cirrhosis Phenobarbital 11.3621047994
MESH:D008106 Liver Cirrhosis, Experimental Carbon Tetrachloride 1.7517823541 18418968 18395095 12958196 18472332 18054572 18472094 20821823 18420326 17976157 16097048 18210741 14716833 18156304 15370692 12586293 16638106 18376398 18277467 15673190 14716496 10355542 15925388 12741479 14512876 11481614 17698563 17714472 17869086 17721639 12609069 12632514 16015684 15893842 17922224 18205269 16136751 17525996 15057751 15818738 18166357 15996030 17944888 15650968 18705752 15338365 14748882 16116963 12389079 12667390 18006644 18317297 17481882 12546737 12666154 17565644 12649538 17761835 14620537 14724832 18481824 17631135 16033810 12632512 12445418 16192424 15931870 16248980 17900296 17557913 15730626 12898905 18412020 15876570 15052691 16027843 15959796 18429990 18263696 17766677 17640975 12445421 18395914 18279442 15123356 17708605 17805973 13678700 18187930 18339082 16011737 15362042 18251166
MESH:D008107 Liver Diseases Carbon Tetrachloride 6.7015830285 16246199 17285989 16964402 15720792
MESH:D008107 Liver Diseases Diethylnitrosamine 6.7017034775
MESH:D008107 Liver Diseases Phenobarbital 6.7019363144
MESH:D017093 Liver Failure Carbon Tetrachloride 4.3015123358
MESH:D017114 Liver Failure, Acute Carbon Tetrachloride 3.7914706259 16899240
MESH:D008113 Liver Neoplasms Aflatoxin B1 18.5118177683 15890375 2125692 9163691
MESH:D008113 Liver Neoplasms arsenic trioxide 18.5114682389
MESH:D008113 Liver Neoplasms Benzo(a)pyrene 18.5120195826 21137059
MESH:D008113 Liver Neoplasms Carbon Tetrachloride 18.5119294768
MESH:D008113 Liver Neoplasms Diethylnitrosamine 18.5112112319 9163691 16942905 18754104 19499222 20492335 19833225 2422723 19638242 19256749 19427195 19254457 19690152 19255062 21047994 19996281 20452335 20101389 19073162 18977376 20137499 10737359 19426721 20501860 21278145 15885732 18644402 20118626 19812893 18648771 12771043 19090486 20434301 2862719 18978307 20583210 19294768 20405173 21167192 19850985 21071580 19642983 19551842 15175105
MESH:D008113 Liver Neoplasms Phenobarbital 18.5121047994 19482888 19812893 8742319 15975961 19073162
MESH:D008114 Liver Neoplasms, Experimental Aflatoxin B1 24.298603461
MESH:D008114 Liver Neoplasms, Experimental arsenic trioxide 24.2920377131
MESH:D008114 Liver Neoplasms, Experimental Carbon Tetrachloride 24.2912014681 15583823
MESH:D008114 Liver Neoplasms, Experimental Diethylnitrosamine 24.2918544905 19519916 18775883 17174075 18079962 21159647 3124819 18282651 19126423 17942915 18093689 19004024 19539802 2563599 9362446 16267830 18253720 16842330 17854601 18308698 19009564 18164116
MESH:D008114 Liver Neoplasms, Experimental Methylcholanthrene 24.29598648 1399818
MESH:D008114 Liver Neoplasms, Experimental Phenobarbital 24.2918308698 17172636 6150874 1399818 2563599
MESH:D008133 Long QT Syndrome arsenic trioxide 3.4315213294
MESH:D008175 Lung Neoplasms Aflatoxin B1 6.7314755239
MESH:D008175 Lung Neoplasms arsenic trioxide 6.7319825857 11798837
MESH:D008175 Lung Neoplasms Benzo(a)pyrene 6.7317053015 6695378 18520028 18569708 20135361 18816296 20064080 20869020 20464547
MESH:D008175 Lung Neoplasms Diethylnitrosamine 6.7320970405 21163286 6695378 20512841
MESH:D008175 Lung Neoplasms Methylcholanthrene 6.7316271038 6695378 17909032 16337739 20512841 1399818 7750092 20970405 11893704 15390079 9230183 10545420 21163286
MESH:D008223 Lymphoma decitabine 3.4919470736
MESH:D008325 Mammary Neoplasms, Experimental methyleugenol 4.7511921183
MESH:D008545 Melanoma decitabine 3.7816505122 17785578
MESH:D008545 Melanoma trichostatin A 3.7816505122
MESH:D009062 Mouth Neoplasms Benzo(a)pyrene 3.2716381670
MESH:D009101 Multiple Myeloma arsenic trioxide 12.6914977855 19549372 15949261 11468182 19417148
MESH:D009101 Multiple Myeloma decitabine 12.6918172295
MESH:D009101 Multiple Myeloma trichostatin A 12.6918172295
MESH:D019042 Muscle Neoplasms 2-nitrotoluene 6.8613678655
MESH:D009182 Mycosis Fungoides arsenic trioxide 4.8518349030
MESH:D009190 Myelodysplastic Syndromes arsenic trioxide 7.7016105982 16882451
MESH:D009190 Myelodysplastic Syndromes decitabine 7.7018608210 19157545 19010910 16882708
MESH:D020191 Myoclonic Epilepsies, Progressive Phenobarbital 4.6317484760
MESH:D009361 Neoplasm Invasiveness arsenic trioxide 4.0916624393
MESH:D009362 Neoplasm Metastasis Diethylnitrosamine 2.603581430 9029167
MESH:D009369 Neoplasms Benzo(a)pyrene 5.2711141357
MESH:D009369 Neoplasms decitabine 5.2719116145 17925555 19470736
MESH:D009436 Neural Tube Defects arsenic trioxide 3.1810525206
MESH:D019636 Neurodegenerative Diseases Diethylnitrosamine 3.4320387270
MESH:D009461 Neurologic Manifestations Diethylnitrosamine 5.2920387270
MESH:D010018 Osteomalacia Phenobarbital 4.5217016548
MESH:D010051 Ovarian Neoplasms arsenic trioxide 8.2316624393 12452020 19769630
MESH:D010051 Ovarian Neoplasms decitabine 8.2319331143 19259094
MESH:D010051 Ovarian Neoplasms trichostatin A 8.2319331143
MESH:D010190 Pancreatic Neoplasms arsenic trioxide 16.7215580305
MESH:D010190 Pancreatic Neoplasms decitabine 16.7219294695
MESH:D010190 Pancreatic Neoplasms Diethylnitrosamine 16.7216540662
MESH:D010190 Pancreatic Neoplasms Phenobarbital 16.7216965848
MESH:D010190 Pancreatic Neoplasms trichostatin A 16.7219294695
MESH:D010235 Paraganglioma arsenic trioxide 4.2819927285
MESH:D011230 Precancerous Conditions Diethylnitrosamine 9.422563599
MESH:D011230 Precancerous Conditions Phenobarbital 9.422563599
MESH:D055728 Primary Myelofibrosis decitabine 12.9017616702
MESH:D055728 Primary Myelofibrosis trichostatin A 12.9017616702
MESH:D011471 Prostatic Neoplasms arsenic trioxide 2.6319131511
MESH:D011471 Prostatic Neoplasms Benzo(a)pyrene 2.6317292933
MESH:D011471 Prostatic Neoplasms trichostatin A 2.6318798265 19789329
MESH:D019310 Pseudolymphoma Phenobarbital 4.6712752131
MESH:D012208 Rhabdomyosarcoma decitabine 4.5219155313
MESH:D012512 Sarcoma, Ewing's arsenic trioxide 4.0916646077
MESH:D012640 Seizures Phenobarbital 2.7616876388 11442880 3137016 4039156
MESH:D003294 Seizures, Febrile Phenobarbital 4.986407741
MESH:D012878 Skin Neoplasms Benzo(a)pyrene 2.4110029692 19755658
MESH:D013274 Stomach Neoplasms marker/mechanism 17575124
MESH:D013274 Stomach Neoplasms arsenic trioxide 4.8017007042
MESH:D013274 Stomach Neoplasms Benzo(a)pyrene 4.8020155912 2093021
MESH:D013274 Stomach Neoplasms decitabine 4.8019037991
MESH:D013274 Stomach Neoplasms Diethylnitrosamine 4.8018456281
MESH:D013964 Thyroid Neoplasms arsenic trioxide 17.8419014326
MESH:D013964 Thyroid Neoplasms decitabine 17.8417967635
MESH:D013964 Thyroid Neoplasms Diethylnitrosamine 17.847505956
MESH:D013964 Thyroid Neoplasms Phenobarbital 17.841399818
MESH:D016171 Torsades de Pointes arsenic trioxide 4.1115213294
MESH:D001749 Urinary Bladder Neoplasms arsenic trioxide 8.5812845720 11780464 20435036 12973940
MESH:D001749 Urinary Bladder Neoplasms Benzo(a)pyrene 8.5817053015
MESH:D001749 Urinary Bladder Neoplasms decitabine 8.5819087683 17616700
MESH:D014604 Uveal Neoplasms decitabine 5.0917785578
Pathway ID Pathway Name
KEGG:00650 Butanoate metabolism
KEGG:00051 Fructose and mannose metabolism
KEGG:00591 Linoleic acid metabolism
KEGG:01100 Metabolic pathways
Pharmacogenomics Knowledge Base Top
  • PharmGKB Accession:PA37398
    • No data
    Releated disease ID Related disease Name
    PA443796Coronary Artery Disease
    PA444528Hyperlipidemias
    No data
    Drug Bank Top

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    Syndromic Genes

    Non-syndromic Genes

    AutismKB Statistics

    • Studies: 1,036
    • Genes: 1,379
    • CNVs/SVs: 5,420
    • SNVs/Indels: 11,669
    • de novo Mutations: 5,669
    • Mosaics: 789
    • Linkage Regions: 172
    • Paper Collected: 6/30/2018
    • Last Update: 8/26/2018


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