AutismKB 2.0

Annotation Detail for SERPINF1


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Basic Information Top
Gene Symbol:SERPINF1 ( EPC-1,PEDF )
Gene Full Name: serpin peptidase inhibitor, clade F (alpha-2 antiplasmin, pigment epithelium derived factor), member 1
Band: 17p13.3
Quick LinksEntrez ID:5176; OMIM: 172860; Uniprot ID:PEDF_HUMAN; ENSEMBL ID: ENSG00000132386; HGNC ID: 8824
Relate to Another Database: SFARIGene; denovo-db
Related Pathway Information Top
Related Diseases/Disorders Top
Comparative Toxicogenomics Database Top
Chemical ID Chemical Name Interaction Interaction Action Publication
C023514 2,6-dinitrotoluene 2,6-dinitrotoluene affects the expression of SERPINF1 mRNAaffects expression 21346803
D000082 Acetaminophen Acetaminophen affects the expression of SERPINF1 mRNAaffects expression 17562736
D016604 Aflatoxin B1 Aflatoxin B1 affects the expression of SERPINF1 proteinaffects expression 20106945
D000643 Ammonium Chloride Ammonium Chloride affects the expression of SERPINF1 mRNAaffects expression 16483693
D002104 Cadmium Cadmium results in increased expression of SERPINF1 mRNAincreases expression 17327699
D019256 Cadmium Chloride Cadmium Chloride results in increased expression of SERPINF1 mRNAincreases expression 17327699
C055494 caffeic acid phenethyl ester [Diethylnitrosamine co-treated with caffeic acid phenethyl ester] results in decreased expression of SERPINF1 mRNAaffects cotreatment|decreases expression 20360939
D002251 Carbon Tetrachloride Carbon Tetrachloride affects the expression of SERPINF1 mRNAaffects expression 17484886
D016572 Cyclosporine Cyclosporine results in decreased expression of SERPINF1 mRNAdecreases expression 20106945
D003907 Dexamethasone Dexamethasone results in increased expression of SERPINF1 mRNAincreases expression 15051476
D003907 Dexamethasone Dexamethasone results in increased expression of SERPINF1 mRNAincreases expression 15051476
D004052 Diethylnitrosamine [Diethylnitrosamine co-treated with caffeic acid phenethyl ester] results in decreased expression of SERPINF1 mRNAaffects cotreatment|decreases expression 20360939
D004997 Ethinyl Estradiol [Tetrachlorodibenzodioxin co-treated with Ethinyl Estradiol] results in increased expression of SERPINF1 mRNAaffects cotreatment|increases expression 17942748
D004997 Ethinyl Estradiol Ethinyl Estradiol results in decreased expression of SERPINF1 mRNAdecreases expression 17557909
D005665 Furosemide Furosemide affects the expression of SERPINF1 mRNAaffects expression 16526316
C419708 gefitinib gefitinib inhibits the reaction [TGFA protein results in increased expression of SERPINF1 mRNA]decreases reaction|increases expression 18424623
C013038 hydroxyhydroquinone hydroxyhydroquinone results in decreased expression of SERPINF1 mRNAdecreases expression 17572062
C008493 methylselenic acid methylselenic acid results in increased expression of SERPINF1 mRNAincreases expression 18548127
D015735 Mifepristone Mifepristone results in decreased expression of SERPINF1 mRNAdecreases expression 17584828
D017239 Paclitaxel Paclitaxel results in increased expression of SERPINF1 mRNAincreases expression 19682730
D012643 Selenium Selenium results in increased expression of SERPINF1 mRNAincreases expression 19244175
D013749 Tetrachlorodibenzodioxin [Tetrachlorodibenzodioxin co-treated with Ethinyl Estradiol] results in increased expression of SERPINF1 mRNAaffects cotreatment|increases expression 17942748
D013749 Tetrachlorodibenzodioxin Tetrachlorodibenzodioxin results in decreased expression of SERPINF1 mRNAdecreases expression 18465118
D013749 Tetrachlorodibenzodioxin Tetrachlorodibenzodioxin results in increased expression of SERPINF1 mRNAincreases expression 15644576
D014212 Tretinoin Tretinoin results in increased expression of SERPINF1 mRNAincreases expression 15051476
D014212 Tretinoin Tretinoin results in increased expression of SERPINF1 proteinincreases expression 15051476
D014212 Tretinoin Tretinoin results in increased expression of SERPINF1 mRNAincreases expression 15051476
D014212 Tretinoin Tretinoin results in increased expression of SERPINF1 proteinincreases expression 15051476
D014212 Tretinoin Tretinoin results in increased expression of SERPINF1 mRNAincreases expression 15051476
D014212 Tretinoin Tretinoin results in increased expression of SERPINF1 mRNAincreases expression 15051476
D014635 Valproic Acid Valproic Acid results in decreased expression of SERPINF1 mRNAdecreases expression 19101580
D014810 Vitamin E Vitamin E results in increased expression of SERPINF1 mRNAincreases expression 19244175
Disease ID Disease Name Direct Evidence Inference Chemical Name Inference Score Publication
MESH:D000014 Abnormalities, Drug-Induced Tetrachlorodibenzodioxin 7.8115322242 14514962 11752688
MESH:D000014 Abnormalities, Drug-Induced Valproic Acid 7.818875741
MESH:D000015 Abnormalities, Multiple Valproic Acid 3.7919490988
MESH:D000138 Acidosis Ammonium Chloride 3.4118287403
MESH:D000152 Acne Vulgaris Ethinyl Estradiol 3.7917505938
MESH:D000230 Adenocarcinoma Ethinyl Estradiol 1.7814692618
MESH:D000236 Adenoma Diethylnitrosamine 2.766695378 10737359
MESH:D018248 Adenoma, Liver Cell Diethylnitrosamine 9.5517620307 19052882 17162532 16434500 18056438 19061943
MESH:D018248 Adenoma, Liver Cell Tetrachlorodibenzodioxin 9.5516835633
MESH:D000505 Alopecia Tretinoin 3.4915955085
MESH:D000550 Amblyopia Valproic Acid 5.0817688650
MESH:D000740 Anemia Tetrachlorodibenzodioxin 2.8111748828
MESH:D000799 Angioedema Acetaminophen 3.6910982225
MESH:D001008 Anxiety Disorders Valproic Acid 3.4517497229
MESH:D001161 Arteriosclerosis Ethinyl Estradiol 3.3111256880
MESH:D001169 Arthritis, Experimental Dexamethasone 11.7417659584
MESH:D001169 Arthritis, Experimental Ethinyl Estradiol 11.7415885639
MESH:D001169 Arthritis, Experimental Tretinoin 11.7416412693
MESH:D001172 Arthritis, Rheumatoid Tretinoin 2.2316292516
MESH:D001249 Asthma Tretinoin 2.3016456186
MESH:D050197 Atherosclerosis Cadmium 3.5515687053
MESH:D001321 Autistic Disorder Acetaminophen 1.8518445737
MESH:D001321 Autistic Disorder Valproic Acid 1.8518985861 18177632 15238991 18940202 18316065 20603192 17157402 16609825 17688650 18775368 17507914 19460635 18558336 18396377 19232924
MESH:D001471 Barrett Esophagus Tretinoin 4.2516935849
MESH:D001714 Bipolar Disorder Valproic Acid 3.0017594078 20046352
MESH:D001778 Blood Coagulation Disorders Tetrachlorodibenzodioxin 8.4812125929
MESH:D001778 Blood Coagulation Disorders Tretinoin 8.4816206674 16197459
MESH:D001836 Body Weight Changes Tetrachlorodibenzodioxin 3.6415340226
MESH:D001848 Bone Diseases, Developmental Tetrachlorodibenzodioxin 7.7015746008
MESH:D001848 Bone Diseases, Developmental Valproic Acid 7.708888407
MESH:D001859 Bone Neoplasms Paclitaxel 4.4215867366
MESH:D001943 Breast Neoplasms Diethylnitrosamine 1.9417474063
MESH:D001943 Breast Neoplasms Paclitaxel 1.9418234424 16273361 18223236 16244791 11325840 15136595 16115903 18323546
MESH:D001943 Breast Neoplasms Tetrachlorodibenzodioxin 1.9420435547
MESH:D001943 Breast Neoplasms Tretinoin 1.9416166294 16443354 16873071
MESH:D001997 Bronchopulmonary Dysplasia Tretinoin 4.4416813970
MESH:D002252 Carbon Tetrachloride Poisoning Carbon Tetrachloride 9.4318705752 16011737 16050911 16124888 10355542 16097048 3786805 16227642 16192424 15721981 15700767 15673190
MESH:D002252 Carbon Tetrachloride Poisoning Vitamin E 9.4316050911
MESH:D002277 Carcinoma Tetrachlorodibenzodioxin 2.6816835633
MESH:D003528 Carcinoma, Adenoid Cystic marker/mechanism 16762588
MESH:D018236 Carcinoma, Embryonal Tretinoin 5.0116168501
MESH:D006528 Carcinoma, Hepatocellular 2,6-dinitrotoluene 13.7116705839
MESH:D006528 Carcinoma, Hepatocellular Acetaminophen 13.713084413
MESH:D006528 Carcinoma, Hepatocellular Aflatoxin B1 13.7121507988 12619106 12907637
MESH:D006528 Carcinoma, Hepatocellular Carbon Tetrachloride 13.7118788625
MESH:D006528 Carcinoma, Hepatocellular Diethylnitrosamine 13.7120101231 16807293 17162532 18971187 18978308 21159647 19107877 20935162 19208518 20084675 16502159 19335982 16935385 17138121 20514400 3084413 16698587 11831363 16328049 16779866 18494052 18665156 19919837 19394651 19539802 19519916 19701751 17761372 18788625 18785209 10672840 18393292 17978847 19418558 16830150 19171122 19383236 20512989 16540662 17173139 16878318 19052882 16569478 3581430 20214788 20007298 20727157 20432363 18506893 20524982 17055752 18056438 19822196 16681979 18691550 18210153 16288022 10737359 17428255
MESH:D006528 Carcinoma, Hepatocellular Paclitaxel 13.7116313753
MESH:D006528 Carcinoma, Hepatocellular Tretinoin 13.711917145
MESH:D002289 Carcinoma, Non-Small-Cell Lung gefitinib 3.9016230376 17290066 15496427 20005069 19233551 18347146
MESH:D002294 Carcinoma, Squamous Cell Tretinoin 2.2516051514 16096774
MESH:D006332 Cardiomegaly Tetrachlorodibenzodioxin 2.2818670907 18850075 16120746
MESH:D002386 Cataract Acetaminophen 6.9310977129
MESH:D002386 Cataract Tretinoin 6.9317460283
MESH:D002471 Cell Transformation, Neoplastic 2,6-dinitrotoluene 15.206135515
MESH:D002471 Cell Transformation, Neoplastic Cadmium 15.2017332340
MESH:D002471 Cell Transformation, Neoplastic Cyclosporine 15.2012371664
MESH:D002471 Cell Transformation, Neoplastic Diethylnitrosamine 15.2017174075 7505956 2727394 21159647
MESH:D018290 Cervical Intraepithelial Neoplasia Tretinoin 4.4416129372
MESH:D002659 Child Development Disorders, Pervasive Valproic Acid 2.6520734317
MESH:D018281 Cholangiocarcinoma Diethylnitrosamine 8.8919052882
MESH:D018281 Cholangiocarcinoma Tetrachlorodibenzodioxin 8.8916835633
MESH:D002779 Cholestasis Cyclosporine 7.4019486331
MESH:D002779 Cholestasis Ethinyl Estradiol 7.4017110522 15861022 17333356 16919318 17681005 11677210 16105132
MESH:D002822 Choriocarcinoma Tretinoin 5.0116461808
MESH:D002972 Cleft Palate Tetrachlorodibenzodioxin 5.5612621046 16354765 15668235 15340226 8697196
MESH:D002972 Cleft Palate Tretinoin 5.569407595
MESH:D003092 Colitis Selenium 9.0017936198
MESH:D003092 Colitis Tretinoin 9.0017035595
MESH:D003110 Colonic Neoplasms Dexamethasone 2.4715824018
MESH:D015179 Colorectal Neoplasms gefitinib 3.1817594712
MESH:D015179 Colorectal Neoplasms Paclitaxel 3.1818802399
MESH:D000013 Congenital Abnormalities Tetrachlorodibenzodioxin 2.9317141729 14669216
MESH:D019465 Craniofacial Abnormalities Dexamethasone 7.1517728286
MESH:D019465 Craniofacial Abnormalities Tetrachlorodibenzodioxin 7.1515322242 20055451 10048152
MESH:D019465 Craniofacial Abnormalities Tretinoin 7.158800419 10589399 9211117 17551590 14991402 9224671 9125849 9142499 16925845 9664655
MESH:D019465 Craniofacial Abnormalities Valproic Acid 7.1517688650 8888407 16575769
MESH:D019465 Craniofacial Abnormalities Vitamin E 7.1519769572
MESH:D003490 Cyanosis 2,6-dinitrotoluene 3.8718551238
MESH:D017449 Dermatitis, Allergic Contact Dexamethasone 3.2612438553
MESH:D003924 Diabetes Mellitus, Type 2 Diethylnitrosamine 4.0920387270
MESH:D003924 Diabetes Mellitus, Type 2 Tetrachlorodibenzodioxin 4.0917107852
MESH:D003967 Diarrhea Dexamethasone 3.557237001
MESH:D056486 Drug-Induced Liver Injury 2,6-dinitrotoluene 17.9921346803 18551238
MESH:D056486 Drug-Induced Liver Injury Acetaminophen 17.9918713872 12958197 2444490 17562736 10915739 19739265 11739529 11834606 14550746 16227642 12540782 15968718 17906064 14986274 11743745 12392966 19923254 12594235 11287661 19370779 12153990 16177239 15619225 16485898 12705907 16081117 19164858 19420014 10663392 19416960 11529661 16109766 18071297 11461765 16393943 17522070 11421492 10774834 14725611 16781746 19085960
MESH:D056486 Drug-Induced Liver Injury Carbon Tetrachloride 17.993786805 2869522 19336974 15027814 16227642 21278145 11566570 9327722 3732212 7440962 7120509 15968718 16177239 17522070 6623471 4309450 19085960 7179309 15998439 10915739 6884620 10092053
MESH:D056486 Drug-Induced Liver Injury Diethylnitrosamine 17.9919107877
MESH:D056486 Drug-Induced Liver Injury Selenium 17.9915131321
MESH:D056486 Drug-Induced Liver Injury Tetrachlorodibenzodioxin 17.9920420201
MESH:D056486 Drug-Induced Liver Injury Valproic Acid 17.9919641884 1733752
MESH:D056487 Drug-Induced Liver Injury, Chronic Acetaminophen 3.9519426721
MESH:D004362 Drug Toxicity Tetrachlorodibenzodioxin 2.6511462148
MESH:D004417 Dyspnea Furosemide 4.7916935035
MESH:D004421 Dystonia Valproic Acid 3.911851702
MESH:C538011 Eales disease Vitamin E 4.559068938
MESH:D004485 Eczema Dexamethasone 4.3112438553
MESH:D004487 Edema Dexamethasone 10.8419703484
MESH:D004487 Edema Furosemide 10.8411834646
MESH:D004487 Edema Tetrachlorodibenzodioxin 10.8412711302 11000095
MESH:D004489 Edema, Cardiac Tetrachlorodibenzodioxin 11.4415322242 16714409 18230668
MESH:D004489 Edema, Cardiac Tretinoin 11.4418230668
MESH:D004681 Encephalomyelitis, Autoimmune, Experimental Ethinyl Estradiol 3.0412538720
MESH:D016889 Endometrial Neoplasms Tretinoin 3.0116569247
MESH:D004715 Endometriosis Mifepristone 8.7116134523
MESH:D004715 Endometriosis Tetrachlorodibenzodioxin 8.719294722 10568697
MESH:D004831 Epilepsies, Myoclonic Valproic Acid 4.0017275665 3659116
MESH:D004828 Epilepsies, Partial Valproic Acid 3.773922381 16628512
MESH:D004827 Epilepsy Valproic Acid 2.8620417680 18234410
MESH:D004832 Epilepsy, Absence Valproic Acid 3.466254150 6426943 7562514
MESH:D017029 Epilepsy, Complex Partial Valproic Acid 4.157750514
MESH:D004830 Epilepsy, Tonic-Clonic Valproic Acid 3.913659116
MESH:D004931 Esophageal Achalasia Diethylnitrosamine 4.9716302075
MESH:D004938 Esophageal Neoplasms Paclitaxel 2.8616481741
MESH:D005124 Eye Abnormalities Tetrachlorodibenzodioxin 8.4611564622
MESH:D005124 Eye Abnormalities Tretinoin 8.4616938888 9664655
MESH:D005234 Fatty Liver Carbon Tetrachloride 23.1719224547 15959796 61145 12631006 16239168 12795759 17595544 16045604
MESH:D005234 Fatty Liver Cyclosporine 23.1719224547
MESH:D005234 Fatty Liver Diethylnitrosamine 23.1721071580 20387270
MESH:D005234 Fatty Liver Ethinyl Estradiol 23.1715345470
MESH:D005234 Fatty Liver Valproic Acid 23.1719224547 14986274
MESH:D005313 Fetal Death Tetrachlorodibenzodioxin 3.3111858732
MESH:D005315 Fetal Diseases Valproic Acid 4.7416575769
MESH:D005317 Fetal Growth Retardation Valproic Acid 3.9818558336 8888407
MESH:D005355 Fibrosis Carbon Tetrachloride 19.8918705752
MESH:D005355 Fibrosis Cyclosporine 19.8912168785 12639820
MESH:D005355 Fibrosis Tetrachlorodibenzodioxin 19.8920067830
MESH:D005355 Fibrosis Tretinoin 19.8917994277
MESH:D005756 Gastritis Acetaminophen 3.5216983495
MESH:D005885 Gingival Hyperplasia Cyclosporine 4.078708960
MESH:D005909 Glioblastoma Tretinoin 2.9117312396
MESH:D006058 Gonadal Disorders Tetrachlorodibenzodioxin 4.4410696789
MESH:D006258 Head and Neck Neoplasms Tretinoin 3.0816096774
MESH:D034381 Hearing Loss Furosemide 4.7017868369
MESH:D006317 Hearing Loss, Noise-Induced Tretinoin 5.0116084493
MESH:D006330 Heart Defects, Congenital Tetrachlorodibenzodioxin 10.6810048152 11294989
MESH:D006330 Heart Defects, Congenital Tretinoin 10.689664655 14991402
MESH:D006330 Heart Defects, Congenital Vitamin E 10.6816080930
MESH:D006333 Heart Failure Furosemide 7.2012660669 16011733 16845234
MESH:D006333 Heart Failure Selenium 7.2017162251
MESH:D006457 Hemoglobinuria, Paroxysmal Cyclosporine 4.2715720958
MESH:D006470 Hemorrhage Tetrachlorodibenzodioxin 3.2011000095
MESH:D006505 Hepatitis Carbon Tetrachloride 3.4519900420 19110552
MESH:D006529 Hepatomegaly Tetrachlorodibenzodioxin 2.7412621046 15340226 16120746
MESH:D006548 Hernia, Diaphragmatic Dexamethasone 5.807520565
MESH:D006548 Hernia, Diaphragmatic Vitamin E 5.8016863852 16490937
MESH:D019584 Hot Flashes Vitamin E 3.8214716179
MESH:D006849 Hydrocephalus Valproic Acid 4.7117688650
MESH:D006869 Hydronephrosis Tetrachlorodibenzodioxin 3.8918606429 16959395 15340226 8697196 16354765
MESH:D006930 Hyperalgesia Acetaminophen 7.2216870215
MESH:D006930 Hyperalgesia Tretinoin 7.2216870215
MESH:D006932 Hyperbilirubinemia Carbon Tetrachloride 4.3816899240
MESH:D006934 Hypercalcemia Furosemide 4.9317652376
MESH:D053565 Hypercalciuria Furosemide 5.5017652376
MESH:D017681 Hypereosinophilic Syndrome Tretinoin 4.4216778211
MESH:D006962 Hyperparathyroidism, Secondary Furosemide 5.7215086907
MESH:D006973 Hypertension Cyclosporine 8.2510903974
MESH:D006973 Hypertension Dexamethasone 8.2517042910
MESH:D006973 Hypertension Tetrachlorodibenzodioxin 8.2518670907 18850075
MESH:D006975 Hypertension, Portal Carbon Tetrachloride 3.9415338365
MESH:D046110 Hypertension, Pregnancy-Induced Furosemide 5.1316612254
MESH:D006976 Hypertension, Pulmonary gefitinib 4.5918424623
MESH:D017380 Hypertrophy, Right Ventricular gefitinib 6.0818424623
MESH:C537153 Hypomagnesemia primary Furosemide 5.5011041285
MESH:D007019 Hypoproteinemia Furosemide 5.7216096441
MESH:D007021 Hypospadias Ethinyl Estradiol 3.6616945680 16569931
MESH:D007022 Hypotension Furosemide 4.4711041285
MESH:D007024 Hypotension, Orthostatic Furosemide 5.2715811171
MESH:D007247 Infertility, Female Ethinyl Estradiol 3.3212013081
MESH:D007248 Infertility, Male Ethinyl Estradiol 2.3917937319
MESH:D007249 Inflammation Dexamethasone 7.888960868 11099482
MESH:D007249 Inflammation Diethylnitrosamine 7.8818785209
MESH:D007249 Inflammation Tetrachlorodibenzodioxin 7.8812200463 12878042
MESH:D007251 Influenza, Human Selenium 10.4516624496
MESH:D007251 Influenza, Human Vitamin E 10.4516624496
MESH:D007410 Intestinal Diseases Tretinoin 3.6217994277
MESH:D007414 Intestinal Neoplasms caffeic acid phenethyl ester 4.4510783313
MESH:D007569 Jaw Abnormalities Tetrachlorodibenzodioxin 9.4716580747
MESH:D007569 Jaw Abnormalities Tretinoin 9.4715992940 17551590
MESH:D007638 Keratoconjunctivitis Sicca Cyclosporine 4.2915604871
MESH:D007674 Kidney Diseases Acetaminophen 27.5415629191 12587719
MESH:D007674 Kidney Diseases Cadmium 27.5416322080 16226777 16962696
MESH:D007674 Kidney Diseases Cadmium Chloride 27.5416962696
MESH:D007674 Kidney Diseases caffeic acid phenethyl ester 27.5415369732
MESH:D007674 Kidney Diseases Cyclosporine 27.5418776723 10903974 8314463
MESH:D007674 Kidney Diseases Furosemide 27.5411041285
MESH:D007674 Kidney Diseases Vitamin E 27.5412488133
MESH:D007676 Kidney Failure, Chronic Selenium 3.7516518626
MESH:D007680 Kidney Neoplasms 2,6-dinitrotoluene 11.8616705839
MESH:D007680 Kidney Neoplasms Cyclosporine 11.8612371664
MESH:D007680 Kidney Neoplasms gefitinib 11.8618625569
MESH:D007938 Leukemia Tretinoin 2.7017143497
MESH:D007951 Leukemia, Myeloid Tretinoin 3.5616932348 16482212 19285840
MESH:D015470 Leukemia, Myeloid, Acute Tretinoin 3.7917596541 19850784 16294345
MESH:D015470 Leukemia, Myeloid, Acute Valproic Acid 3.7917596541 16294345
MESH:D015473 Leukemia, Promyelocytic, Acute caffeic acid phenethyl ester 7.5916766008
MESH:D015473 Leukemia, Promyelocytic, Acute Tretinoin 7.5919225113 17294898 17506722 17217047 17368321 15748426 19029980 16823087 12679006 16766008 17301526 16891316 16935935 19035177 17649720 16331271 16788101 17361223 19642359 17107899 9834237 19075265 17712046 17339181 16140955
MESH:D017880 Limb Deformities, Congenital Tretinoin 3.209224671
MESH:D008080 Liposarcoma Paclitaxel 4.6817353645
MESH:D008103 Liver Cirrhosis Carbon Tetrachloride 6.3317157831 16239168 16943688 17174718 21278145 16221502 11903743 11408273 17334410
MESH:D008103 Liver Cirrhosis Diethylnitrosamine 6.3319638242 18407596 18665156 20032147 18522880
MESH:D008106 Liver Cirrhosis, Experimental Carbon Tetrachloride 6.5410355542 15370692 17922224 12667390 18412020 17823541 17805973 12649538 12898905 12609069 16638106 17869086 16136751 12958196 17714472 17944888 12632514 18429990 15362042 18187930 15123356 14512876 15818738 18156304 12546737 15959796 15931870 12389079 18376398 15925388 18339082 12666154 18395914 14716833 15730626 18263696 17708605 16015684 18251166 18277467 15338365 16011737 18279442 18166357 12586293 18395095 15673190 18418968 17557913 17481882 16027843 15893842 12741479 14716496 14748882 14620537 17761835 17976157 18210741 15057751 15996030 11481614 18205269 13678700 16248980 17640975 17721639 18317297 12445421 18054572 15876570 12445418 17900296 17766677 18705752 17565644 16097048 18481824 16033810 18420326 16192424 12632512 18472094 20821823 16116963 15052691 15650968 14724832 18472332 17631135 17698563 17525996 18006644
MESH:D008106 Liver Cirrhosis, Experimental Dexamethasone 6.5416718785
MESH:D008106 Liver Cirrhosis, Experimental Tetrachlorodibenzodioxin 6.5412878042
MESH:D008106 Liver Cirrhosis, Experimental Tretinoin 6.5418397230 16248980
MESH:D008106 Liver Cirrhosis, Experimental Vitamin E 6.5416169303
MESH:D008107 Liver Diseases Acetaminophen 6.2416611625 19014921 16610002 12969438 11587558 19460945 12587719 19784758
MESH:D008107 Liver Diseases Carbon Tetrachloride 6.2415720792 17285989 15830285 16964402 16246199
MESH:D008107 Liver Diseases Diethylnitrosamine 6.2417034775
MESH:D017093 Liver Failure Carbon Tetrachloride 4.0115123358
MESH:D017114 Liver Failure, Acute Acetaminophen 8.9617185352 16871587
MESH:D017114 Liver Failure, Acute Carbon Tetrachloride 8.9616899240 14706259
MESH:D008113 Liver Neoplasms 2,6-dinitrotoluene 13.627678174
MESH:D008113 Liver Neoplasms Aflatoxin B1 13.6218177683 9163691 15890375 2125692
MESH:D008113 Liver Neoplasms Carbon Tetrachloride 13.6219294768
MESH:D008113 Liver Neoplasms Diethylnitrosamine 13.6212771043 19996281 20501860 19294768 18754104 20101389 19090486 19255062 19073162 21167192 21047994 12112319 9163691 21278145 20405173 18977376 19256749 15885732 21071580 19499222 20118626 18648771 18978307 19254457 19551842 20583210 19833225 19638242 10737359 19426721 20452335 15175105 16942905 19690152 20492335 19642983 19812893 19850985 18644402 19427195 20137499 2862719 2422723 20434301
MESH:D008113 Liver Neoplasms Tetrachlorodibenzodioxin 13.6216984957
MESH:D008114 Liver Neoplasms, Experimental 2,6-dinitrotoluene 17.642876784 2876786 6135515
MESH:D008114 Liver Neoplasms, Experimental Aflatoxin B1 17.648603461
MESH:D008114 Liver Neoplasms, Experimental Carbon Tetrachloride 17.6412014681 15583823
MESH:D008114 Liver Neoplasms, Experimental Diethylnitrosamine 17.6419539802 3124819 21159647 18544905 19009564 17854601 16267830 18093689 16842330 2563599 18282651 17174075 18308698 19519916 18079962 9362446 18775883 19126423 19004024 18164116 18253720 17942915
MESH:D008114 Liver Neoplasms, Experimental Tetrachlorodibenzodioxin 17.6412151625
MESH:D008171 Lung Diseases Vitamin E 3.0816863852
MESH:D017563 Lung Diseases, Interstitial Valproic Acid 4.1117228818
MESH:D008175 Lung Neoplasms Aflatoxin B1 6.3914755239
MESH:D008175 Lung Neoplasms Dexamethasone 6.3915824018 11195469
MESH:D008175 Lung Neoplasms Diethylnitrosamine 6.3920970405 21163286 20512841 6695378
MESH:D008175 Lung Neoplasms Tetrachlorodibenzodioxin 6.3911884234 19555203
MESH:D008175 Lung Neoplasms Vitamin E 6.3911062179
MESH:D008228 Lymphoma, Non-Hodgkin Paclitaxel 3.9714749477
MESH:D008325 Mammary Neoplasms, Experimental gefitinib 6.2818375820
MESH:D008325 Mammary Neoplasms, Experimental Selenium 6.2815318939
MESH:D008527 Medulloblastoma Tretinoin 2.7317453147
MESH:D008545 Melanoma Paclitaxel 3.4616342250 12025231 12040289
MESH:D008545 Melanoma Tretinoin 3.4616752155
MESH:D008546 Melanoma, Experimental Acetaminophen 3.4219513568
MESH:D008591 Meningomyelocele Tretinoin 4.2716940565
MESH:D008654 Mesothelioma Selenium 2.7315107826
MESH:D008664 Metal Metabolism, Inborn Errors Cyclosporine 4.6416801185
MESH:D008881 Migraine Disorders Valproic Acid 3.0818765137 18803445
MESH:D009101 Multiple Myeloma Dexamethasone 7.2915744524 16118317 15867202
MESH:D009101 Multiple Myeloma Paclitaxel 7.2914749477
MESH:D009139 Musculoskeletal Abnormalities Valproic Acid 3.898888407
MESH:D009190 Myelodysplastic Syndromes Dexamethasone 11.879809623
MESH:D009190 Myelodysplastic Syndromes Tretinoin 11.8717596541
MESH:D009190 Myelodysplastic Syndromes Valproic Acid 11.8717596541
MESH:D017202 Myocardial Ischemia Tetrachlorodibenzodioxin 2.9012213967
MESH:D009336 Necrosis 2,6-dinitrotoluene 3.717678174 18551238
MESH:D009362 Neoplasm Metastasis Diethylnitrosamine 5.799029167 3581430
MESH:D009362 Neoplasm Metastasis Paclitaxel 5.7915867366
MESH:D009369 Neoplasms Tretinoin 2.3416594593 16946489
MESH:D009397 Nephrocalcinosis Furosemide 5.7215086907
MESH:D009402 Nephrosis, Lipoid Cyclosporine 4.2917954296
MESH:D009404 Nephrotic Syndrome Cyclosporine 3.1518481113 19348381
MESH:D009421 Nervous System Malformations Tetrachlorodibenzodioxin 9.0214600291
MESH:D009421 Nervous System Malformations Tretinoin 9.029125849
MESH:D009436 Neural Tube Defects Tretinoin 6.989142499
MESH:D009436 Neural Tube Defects Valproic Acid 6.988888407 16359493
MESH:D019636 Neurodegenerative Diseases Acetaminophen 7.7718514411
MESH:D019636 Neurodegenerative Diseases Diethylnitrosamine 7.7720387270
MESH:D009461 Neurologic Manifestations Diethylnitrosamine 4.9720387270
MESH:D053206 Nocturnal Enuresis Furosemide 5.7217945291
MESH:D009784 Occupational Diseases 2,6-dinitrotoluene 3.3016049721
MESH:D010014 Osteolysis Paclitaxel 4.8315867366
MESH:D010051 Ovarian Neoplasms Mifepristone 7.7916525653
MESH:D010051 Ovarian Neoplasms Paclitaxel 7.7911161223
MESH:D010051 Ovarian Neoplasms Tretinoin 7.7916936753
MESH:D010146 Pain Acetaminophen 6.1816870215
MESH:D010146 Pain Tretinoin 6.1816870215
MESH:D010190 Pancreatic Neoplasms Diethylnitrosamine 5.0716540662
MESH:D010190 Pancreatic Neoplasms Tretinoin 5.0715976015
MESH:D016584 Panic Disorder Ethinyl Estradiol 3.5411578682
MESH:D010382 Peliosis Hepatis Tetrachlorodibenzodioxin 4.1012520081
MESH:D016491 Peripheral Vascular Diseases Cadmium 5.2315687053
MESH:D010954 Plasmacytoma Selenium 4.7415087411
MESH:D011141 Polyuria Furosemide 5.5017945291
MESH:D017119 Porphyria Cutanea Tarda Tetrachlorodibenzodioxin 3.4118163543
MESH:D011230 Precancerous Conditions Cyclosporine 8.5112371664
MESH:D011230 Precancerous Conditions Diethylnitrosamine 8.512563599
MESH:D054198 Precursor Cell Lymphoblastic Leukemia-Lymphoma Dexamethasone 3.4621297632
MESH:D011297 Prenatal Exposure Delayed Effects Tetrachlorodibenzodioxin 8.9611222880 11896295 11399792 11118676
MESH:D011297 Prenatal Exposure Delayed Effects Valproic Acid 8.9620603192
MESH:D011471 Prostatic Neoplasms Cadmium 1.9317075824
MESH:D011471 Prostatic Neoplasms gefitinib 1.9316685379 17914592 15651060
MESH:D011471 Prostatic Neoplasms methylselenic acid 1.9316205645
MESH:D011471 Prostatic Neoplasms Paclitaxel 1.9317136230 16356831 16729912 17172428
MESH:D011471 Prostatic Neoplasms Vitamin E 1.9315084515
MESH:D011507 Proteinuria Tretinoin 3.4616636307
MESH:D011537 Pruritus Ethinyl Estradiol 3.1615861022 16919318
MESH:D019310 Pseudolymphoma Valproic Acid 4.3912752131 11422049
MESH:D011565 Psoriasis Cyclosporine 2.1816882103
MESH:D011625 Pterygium Tretinoin 4.6416723453
MESH:D011658 Pulmonary Fibrosis gefitinib 3.9518424623
MESH:D015427 Reperfusion Injury Furosemide 3.8416526316
MESH:D012128 Respiratory Distress Syndrome, Adult Dexamethasone 9.0511700416 18379247
MESH:D012128 Respiratory Distress Syndrome, Adult Furosemide 9.0512394941 15912074 16096441
MESH:D015619 Respiratory System Abnormalities Tetrachlorodibenzodioxin 3.6918990726
MESH:D012208 Rhabdomyosarcoma Tretinoin 10.3916283617 16116481
MESH:D012208 Rhabdomyosarcoma Valproic Acid 10.3919155313
MESH:D012468 Salivary Gland Neoplasms marker/mechanism 16762588
MESH:D012559 Schizophrenia Valproic Acid 2.0515737665 19110320
MESH:D012640 Seizures 2,6-dinitrotoluene 5.6018551238
MESH:D012640 Seizures Valproic Acid 5.603137016 15475178 11044598 14763951 1511512 11738929 17978042 16876388
MESH:D012871 Skin Diseases Vitamin E 2.4018709164
MESH:D012878 Skin Neoplasms Tetrachlorodibenzodioxin 5.3316192470
MESH:D012878 Skin Neoplasms Tretinoin 5.3316467112
MESH:D013088 Spermatocele Ethinyl Estradiol 3.7916709447
MESH:D016135 Spinal Dysraphism Valproic Acid 3.6619490988
MESH:D013226 Status Epilepticus Valproic Acid 4.3912833885
MESH:D013272 Stomach Diseases Dexamethasone 4.1715472012
MESH:D013274 Stomach Neoplasms Diethylnitrosamine 4.6718456281
MESH:D013274 Stomach Neoplasms Furosemide 4.6717052386
MESH:D013274 Stomach Neoplasms Paclitaxel 4.6718506536 18396642
MESH:D013274 Stomach Neoplasms Tretinoin 4.6717261132
MESH:D013276 Stomach Ulcer Dexamethasone 3.3515138204
MESH:D020521 Stroke Vitamin E 3.4016517955
MESH:D024801 Tauopathies Paclitaxel 4.6616930453
MESH:D019851 Thrombophilia Ethinyl Estradiol 3.4811994571
MESH:D013927 Thrombosis Ethinyl Estradiol 3.0215669648
MESH:D013959 Thyroid Diseases Tetrachlorodibenzodioxin 3.7512697716
MESH:D013964 Thyroid Neoplasms Diethylnitrosamine 11.507505956
MESH:D013964 Thyroid Neoplasms gefitinib 11.5016940797
MESH:D013964 Thyroid Neoplasms Tretinoin 11.5016026305 17045167
MESH:D014062 Tongue Neoplasms Tretinoin 3.6516051514
MESH:D014178 Translocation, Genetic Valproic Acid 5.0817262798
MESH:D014376 Tuberculosis Tretinoin 3.1316040207
MESH:D020194 Unverricht-Lundborg Syndrome Valproic Acid 4.373119515
MESH:D001749 Urinary Bladder Neoplasms 2,6-dinitrotoluene 2.2316049721
MESH:D014564 Urogenital Abnormalities Valproic Acid 4.498888407
MESH:D014571 Urologic Neoplasms 2,6-dinitrotoluene 4.1710091137
MESH:D014581 Urticaria Acetaminophen 2.8310982225
MESH:D002583 Uterine Cervical Neoplasms Tretinoin 3.5416129372
MESH:D014594 Uterine Neoplasms Ethinyl Estradiol 3.1514692618
MESH:D014604 Uveal Neoplasms Tretinoin 4.4616752155
MESH:D014605 Uveitis Cyclosporine 11.261336536
MESH:D014605 Uveitis Dexamethasone 11.261336536
MESH:D054079 Vascular Malformations Tetrachlorodibenzodioxin 4.4412125929
MESH:D020246 Venous Thrombosis Ethinyl Estradiol 3.4014671159 15869587
MESH:D014820 Vitiligo Tretinoin 3.9116761959
MESH:D019282 Wasting Syndrome Tetrachlorodibenzodioxin 4.1015886252
MESH:D009396 Wilms Tumor Tretinoin 3.8416287080
MESH:D014985 Xerophthalmia Cyclosporine 4.2917120751
No data
Pharmacogenomics Knowledge Base Top
  • PharmGKB Accession:PA35508
    • No data
    Releated disease ID Related disease Name
    PA443560Breast Neoplasms
    PA446155Precursor Cell Lymphoblastic Leukemia-Lymphoma
    Releated drug ID Related drug Name
    PA450196letrozole
    Drug Bank Top

    Simple Query:


      (e.g. CHD8)

    Syndromic Genes

    Non-syndromic Genes

    AutismKB Statistics

    • Studies: 1,036
    • Genes: 1,379
    • CNVs/SVs: 5,420
    • SNVs/Indels: 11,669
    • de novo Mutations: 5,669
    • Mosaics: 789
    • Linkage Regions: 172
    • Paper Collected: 6/30/2018
    • Last Update: 8/26/2018


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