AutismKB 2.0

Annotation Detail for RAB8B


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Basic Information Top
Gene Symbol:RAB8B ( FLJ38125 )
Gene Full Name: RAB8B, member RAS oncogene family
Band: 15q22.2
Quick LinksEntrez ID:51762; OMIM: 613532; Uniprot ID:RAB8B_HUMAN; ENSEMBL ID: ENSG00000166128; HGNC ID: 30273
Relate to Another Database: SFARIGene; denovo-db
Related Pathway Information Top
Related Diseases/Disorders Top
Comparative Toxicogenomics Database Top
Chemical ID Chemical Name Interaction Interaction Action Publication
C026114 2-xylene 2-xylene results in increased expression of RAB8B mRNAincreases expression 20359517
D000643 Ammonium Chloride Ammonium Chloride affects the expression of RAB8B mRNAaffects expression 16483693
D001554 Benzene Benzene results in increased expression of RAB8B mRNAincreases expression 20359517
D015123 7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide 7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide results in decreased expression of RAB8B mRNAdecreases expression 19150397
D016572 Cyclosporine Cyclosporine results in increased expression of RAB8B mRNAincreases expression 20106945
D004041 Dietary Fats Dietary Fats results in decreased expression of RAB8B mRNAdecreases expression 18042831
C004912 ethylbenzene ethylbenzene results in increased expression of RAB8B mRNAincreases expression 20359517
D008752 Methylene Chloride Methylene Chloride results in increased expression of RAB8B mRNAincreases expression 20359517
C029938 nickel sulfate nickel sulfate results in increased expression of RAB8B mRNAincreases expression 16780908
C041786 palm oil palm oil results in decreased expression of RAB8B mRNAdecreases expression 18042831
C006253 pirinixic acid pirinixic acid results in decreased expression of RAB8B mRNAdecreases expression 17426115
C402769 tipifarnib tipifarnib results in increased expression of RAB8B mRNAincreases expression 16403772
D014050 Toluene Toluene results in increased expression of RAB8B mRNAincreases expression 20359517
D014241 Trichloroethylene Trichloroethylene results in increased expression of RAB8B mRNAincreases expression 20359517
C025643 vinclozolin vinclozolin affects the expression of RAB8B mRNAaffects expression 19015723
Disease ID Disease Name Direct Evidence Inference Chemical Name Inference Score Publication
MESH:D000138 Acidosis Ammonium Chloride 3.6118287403
MESH:D055371 Acute Lung Injury nickel sulfate 9.2516100012 12718980 19131640 11954676
MESH:D055371 Acute Lung Injury pirinixic acid 9.2518653653
MESH:D018248 Adenoma, Liver Cell pirinixic acid 3.5316434500
MESH:D000741 Anemia, Aplastic Benzene 4.3914761424 11369114 17661222
MESH:D001008 Anxiety Disorders vinclozolin 3.6619015723
MESH:D001161 Arteriosclerosis Dietary Fats 3.9315238619
MESH:D001778 Blood Coagulation Disorders pirinixic acid 3.1719483382
MESH:D001836 Body Weight Changes 2-xylene 5.987457028
MESH:D001855 Bone Marrow Diseases Benzene 5.2916183116
MESH:D001943 Breast Neoplasms Benzene 2.1317162533 11921183
MESH:D001943 Breast Neoplasms Dietary Fats 2.1320435547
MESH:D001943 Breast Neoplasms Methylene Chloride 2.1315986119
MESH:D001943 Breast Neoplasms Trichloroethylene 2.1315986119
MESH:D002471 Cell Transformation, Neoplastic 7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide 6.6220889678
MESH:D002471 Cell Transformation, Neoplastic Cyclosporine 6.6212371664
MESH:D002547 Cerebral Palsy Toluene 5.909294310
MESH:D002779 Cholestasis Cyclosporine 7.8319486331
MESH:D002779 Cholestasis pirinixic acid 7.8319176532
MESH:D019465 Craniofacial Abnormalities Benzene 3.2815643154
MESH:D019465 Craniofacial Abnormalities Toluene 3.289294310
MESH:D003456 Cryptorchidism vinclozolin 4.3814966744
MESH:D003643 Death Toluene 5.736431079
MESH:D003872 Dermatitis Benzene 4.8115902427
MESH:D017449 Dermatitis, Allergic Contact nickel sulfate 3.7111298694 16780908 16823706
MESH:D003876 Dermatitis, Atopic pirinixic acid 2.4418249437
MESH:D056486 Drug-Induced Liver Injury Trichloroethylene 3.257120509
MESH:D050171 Dyslipidemias Dietary Fats 3.4718367378
MESH:D004487 Edema pirinixic acid 2.5112083418
MESH:D004938 Esophageal Neoplasms 7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide 2.0820426865
MESH:D005234 Fatty Liver Cyclosporine 13.2319224547
MESH:D005234 Fatty Liver Dietary Fats 13.2318296743 19004024 19551842 17967931
MESH:D005234 Fatty Liver pirinixic acid 13.2320131406 19236843
MESH:D005355 Fibrosis Cyclosporine 8.8312168785 12639820
MESH:D005355 Fibrosis Dietary Fats 8.8318296743
MESH:D030342 Genetic Diseases, Inborn vinclozolin 4.9816973722
MESH:D005832 Genital Diseases, Male vinclozolin 5.3616417039
MESH:D005885 Gingival Hyperplasia Cyclosporine 4.278708960
MESH:D006333 Heart Failure pirinixic acid 2.5520558911
MESH:D006402 Hematologic Diseases Benzene 4.6916183116
MESH:D006457 Hemoglobinuria, Paroxysmal Cyclosporine 4.4715720958
MESH:D006529 Hepatomegaly 2-xylene 9.187457013 7457028
MESH:D006529 Hepatomegaly pirinixic acid 9.1816221962 18467677 19772884 19176532
MESH:D006937 Hypercholesterolemia Dietary Fats 3.6221332399
MESH:D006943 Hyperglycemia pirinixic acid 3.2120558911
MESH:D006949 Hyperlipidemias Dietary Fats 3.6521332399
MESH:D006973 Hypertension Benzene 5.4117940673
MESH:D006973 Hypertension Cyclosporine 5.4110903974
MESH:D007248 Infertility, Male vinclozolin 3.0616467254
MESH:D007249 Inflammation Dietary Fats 2.4420412841
MESH:D007333 Insulin Resistance Dietary Fats 7.3111836018 18457598
MESH:D007333 Insulin Resistance pirinixic acid 7.3116306350
MESH:D007638 Keratoconjunctivitis Sicca Cyclosporine 4.5015604871
MESH:D007674 Kidney Diseases Cyclosporine 2.3518776723 10903974 8314463
MESH:D007680 Kidney Neoplasms Cyclosporine 2.7612371664
MESH:D007938 Leukemia Benzene 3.4017119257 14694614 15935818 18335105
MESH:D007951 Leukemia, Myeloid Benzene 4.3517506065
MESH:D015470 Leukemia, Myeloid, Acute Benzene 2.7019478238
MESH:D007984 Leydig Cell Tumor vinclozolin 4.7816417039
MESH:D008103 Liver Cirrhosis Dietary Fats 2.8918296743
MESH:D008106 Liver Cirrhosis, Experimental pirinixic acid 1.3415474484
MESH:D008113 Liver Neoplasms pirinixic acid 1.8315890375 20007298 16377806
MESH:D008114 Liver Neoplasms, Experimental Benzene 6.6912562636
MESH:D008114 Liver Neoplasms, Experimental Trichloroethylene 6.697955063
MESH:D017563 Lung Diseases, Interstitial Benzene 4.8714698565
MESH:D008175 Lung Neoplasms Benzene 3.9912562636
MESH:D008175 Lung Neoplasms Methylene Chloride 3.9915172992
MESH:D008175 Lung Neoplasms tipifarnib 3.9916885199
MESH:D008223 Lymphoma Benzene 3.7517584886 17119257
MESH:D015674 Mammary Neoplasms, Animal Benzene 4.4912562636
MESH:D008325 Mammary Neoplasms, Experimental Benzene 6.9311921183
MESH:D008325 Mammary Neoplasms, Experimental tipifarnib 6.9316648579
MESH:D008607 Mental Retardation Toluene 3.669294310
MESH:D008664 Metal Metabolism, Inborn Errors Cyclosporine 4.8516801185
MESH:D019957 Motor Skills Disorders Toluene 5.279294310
MESH:D009101 Multiple Myeloma Benzene 3.6817119195
MESH:D009135 Muscular Diseases pirinixic acid 3.5516239165
MESH:D009203 Myocardial Infarction pirinixic acid 2.1519151258
MESH:D015428 Myocardial Reperfusion Injury pirinixic acid 2.9716411023
MESH:D009369 Neoplasms pirinixic acid 5.3717405874
MESH:D009369 Neoplasms Trichloroethylene 5.3711911487
MESH:D009402 Nephrosis, Lipoid Cyclosporine 4.5017954296
MESH:D009404 Nephrotic Syndrome Cyclosporine 3.3119348381 18481113
MESH:D009436 Neural Tube Defects Benzene 3.6915643154
MESH:D009765 Obesity Dietary Fats 4.4519632207 20518802 21332399 16723640 17217161 18457598 11836018 20132043 18674790
MESH:D009765 Obesity pirinixic acid 4.4520558911
MESH:D009784 Occupational Diseases Benzene 4.2115727169 15612468 17119257 15913788 17178637 15935809 17479406 16737584 15576619
MESH:D010051 Ovarian Neoplasms Benzene 2.9712562636
MESH:D011230 Precancerous Conditions Cyclosporine 3.2512371664
MESH:D011297 Prenatal Exposure Delayed Effects vinclozolin 3.9519015723 18220299 18042343
MESH:D011469 Prostatic Diseases vinclozolin 4.9818220299
MESH:D011472 Prostatitis vinclozolin 4.9818629315
MESH:D011565 Psoriasis Cyclosporine 2.2416882103
MESH:D015427 Reperfusion Injury pirinixic acid 2.4019058328
MESH:D012640 Seizures Toluene 3.746431079 9294310
MESH:D013274 Stomach Neoplasms Benzene 2.4212562636
MESH:D013733 Testicular Diseases Toluene 5.0110048760 10514026
MESH:D013953 Thymus Neoplasms Benzene 5.0110850423
MESH:D014594 Uterine Neoplasms Benzene 4.3712562636
MESH:D014605 Uveitis Cyclosporine 4.051336536
MESH:D015430 Weight Gain Dietary Fats 3.7616723640
MESH:D014985 Xerophthalmia Cyclosporine 4.5017120751
No data
Pharmacogenomics Knowledge Base Top
Drug Bank Top
Drugbank ID Action Drug Name Description
DB02082 - Phosphoaminophosphonic Acid Guanylate Ester
DB04315 - Guanosine-5'-Diphosphate
No data
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Syndromic Genes

Non-syndromic Genes

AutismKB Statistics

  • Studies: 1,036
  • Genes: 1,379
  • CNVs/SVs: 5,420
  • SNVs/Indels: 11,669
  • de novo Mutations: 5,669
  • Mosaics: 789
  • Linkage Regions: 172
  • Paper Collected: 6/30/2018
  • Last Update: 8/26/2018


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